| BANK OF AMERICA CORP /DE/ | US$18.5亿 | 0.14% |
| GOLDMAN SACHS GROUP INC | US$18.1亿 | 0.21% |
| MORGAN STANLEY | US$15.8亿 | 0.09% |
| CITIGROUP INC | US$13.8亿 | 0.59% |
| Deep Track Capital, LP | US$12.8亿 | 20.86% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$12.4亿 | 2.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$11.0亿 | 0.12% |
| JANE STREET GROUP, LLC | US$9.3亿 | 0.12% |
| JPMORGAN CHASE & CO | US$7.4亿 | 0.05% |
| CITADEL ADVISORS LLC | US$5.8亿 | 0.09% |
| UBS Group AG | US$5.1亿 | 0.08% |
| BARCLAYS PLC | US$4.2亿 | 0.10% |
| WELLS FARGO & COMPANY/MN | US$3.5亿 | 0.07% |
| Jefferies Financial Group Inc. | US$3.0亿 | 2.05% |
| Jain Global LLC | US$2.8亿 | 1.14% |
| Squarepoint Ops LLC | US$2.7亿 | 0.31% |
| Two Seas Capital LP | US$2.5亿 | 3.44% |
| BESSEMER GROUP INC | US$2.3亿 | 0.36% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$2.2亿 | 0.14% |
| PEAK6 LLC | US$2.2亿 | 0.51% |
| Caption Management, LLC | US$2.0亿 | 1.16% |
| MILLENNIUM MANAGEMENT LLC | US$2.0亿 | 0.08% |
| D. E. Shaw & Co., Inc. | US$1.7亿 | 0.11% |
| Balyasny Asset Management L.P. | US$1.7亿 | 0.22% |
| HSBC HOLDINGS PLC | US$1.4亿 | 0.07% |
| Walleye Trading LLC | US$1.4亿 | 0.24% |
| Sofinnova Investments, Inc. | US$1.3亿 | 5.10% |
| BANK OF MONTREAL /CAN/ | US$1.1亿 | 0.04% |
| MEITAV INVESTMENT HOUSE LTD | US$1.0亿 | 1.13% |
| AMERIPRISE FINANCIAL INC | US$1.0亿 | 0.02% |
| Ikarian Capital, LLC | US$1.0亿 | 8.30% |
| Stonepine Capital Management, LLC | US$1.0亿 | 40.92% |
| LPL Financial LLC | US$1.0亿 | 0.03% |
| Eagle Health Investments LP | US$9324.3万 | 16.31% |
| Employees Retirement System of Texas | US$8791.3万 | 0.77% |
| Rokos Capital Management LLP | US$8429.5万 | 0.64% |
| Greenhouse Funds LLLP | US$8314.6万 | 3.72% |
| TUDOR INVESTMENT CORP ET AL | US$7970.4万 | 0.15% |
| ASSETMARK, INC | US$7957.8万 | 0.16% |
| CAPITAL FUND MANAGEMENT S.A. | US$7468.4万 | 0.34% |
| Main Street Research LLC | US$7248.4万 | 4.22% |
| ROYAL BANK OF CANADA | US$6674.7万 | 0.01% |
| NATIXIS | US$6243.5万 | 0.22% |
| Clal Insurance Enterprises Holdings Ltd | US$6188.5万 | 0.37% |
| Quadrature Capital Ltd | US$6176.2万 | 0.73% |
| PFM Health Sciences, LP | US$5815.5万 | 5.30% |
| Migdal Insurance & Financial Holdings Ltd. | US$5747.9万 | 0.50% |
| RAYMOND JAMES FINANCIAL INC | US$5532.4万 | 0.02% |
| Clearbridge Investments, LLC | US$5326.6万 | 0.05% |
| Investure, LLC | US$5265.7万 | 2.58% |
| STRS OHIO | US$5243.3万 | 0.21% |
| SG Americas Securities, LLC | US$4997.3万 | 0.05% |
| Point72 Asset Management, L.P. | US$4766.9万 | 0.06% |
| TWO SIGMA INVESTMENTS, LP | US$4357.8万 | 0.04% |
| DAFNA Capital Management LLC | US$4068.3万 | 9.25% |
| Nantahala Capital Management, LLC | US$3831.9万 | 1.41% |
| Hudson Bay Capital Management LP | US$3739.4万 | 0.13% |
| STIFEL FINANCIAL CORP | US$3716.5万 | 0.03% |
| PSP Research LLC | US$3639.0万 | 25.75% |
| Aptus Capital Advisors, LLC | US$3457.9万 | 0.27% |
| LMR Partners LLP | US$3457.7万 | 0.08% |
| CREDIT INDUSTRIEL ET COMMERCIAL | US$3387.8万 | 2.64% |
| GENDELL JEFFREY L | US$3350.1万 | 0.46% |
| WHITTIER TRUST CO | US$3319.2万 | 0.37% |
| Annex Advisory Services, LLC | US$3156.2万 | 0.59% |
| NEUBERGER BERMAN GROUP LLC | US$3049.6万 | 0.02% |
| Rockefeller Capital Management L.P. | US$3012.3万 | 0.05% |
| CREDIT AGRICOLE S A | US$2948.7万 | 0.08% |
| BNP PARIBAS FINANCIAL MARKETS | US$2706.1万 | 1.31% |
| SPHERA FUNDS MANAGEMENT LTD. | US$2554.6万 | 4.06% |
| Williams Jones Wealth Management, LLC. | US$2549.2万 | 0.31% |
| Qube Research & Technologies Ltd | US$2436.0万 | 0.03% |
| Centiva Capital, LP | US$2420.5万 | 0.18% |
| J. Goldman & Co LP | US$2415.4万 | 0.70% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$2399.6万 | 0.05% |
| GenTrust, LLC | US$2243.7万 | 0.96% |
| OSBORNE PARTNERS CAPITAL MANAGEMENT, LLC | US$2182.1万 | 1.15% |
| Cetera Investment Advisers | US$2094.6万 | 0.02% |
| Royal Fund Management, LLC | US$2081.4万 | 1.98% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$2032.4万 | 0.04% |
| WEATHERLY ASSET MANAGEMENT L. P. | US$2019.3万 | 1.63% |
| Sivik Global Healthcare LLC | US$1916.0万 | 14.55% |
| WS MANAGEMENT LLLP | US$1916.0万 | 1.69% |
| BlackRock, Inc. | US$1900.8万 | 0.00% |
| Curi Capital, LLC | US$1837.3万 | 0.33% |
| United Capital Management of KS, Inc. | US$1807.4万 | 2.74% |
| Nan Shan Life Insurance Co., Ltd. | US$1770.5万 | 0.64% |
| L. Roy Papp & Associates, LLP | US$1706.5万 | 1.97% |
| Madrona Financial Services, LLC | US$1686.5万 | 3.69% |
| Mivtachim The Workers Social Insurance Fund Ltd. (Under Special Management) | US$1664.4万 | 2.11% |
| OSAIC HOLDINGS, INC. | US$1660.7万 | 0.02% |
| E Fund Management Co., Ltd. | US$1641.3万 | 0.49% |
| Parallax Volatility Advisers, L.P. | US$1641.2万 | 0.04% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$1633.8万 | 0.01% |
| WHITTIER TRUST CO OF NEVADA INC | US$1628.8万 | 0.33% |
| Janney Montgomery Scott LLC | US$1539.8万 | 0.04% |
| Quantitative Investment Management, LLC | US$1426.9万 | 1.48% |
| Edge Wealth Management LLC | US$1419.5万 | 2.43% |
| Riggs Asset Managment Co. Inc. | US$1376.8万 | 2.83% |
| JBF Capital, Inc. | US$1341.2万 | 1.98% |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | US$1338.1万 | 0.09% |
| Yelin Lapidot Holdings Management Ltd. | US$1335.2万 | 2.78% |
| ENVESTNET ASSET MANAGEMENT INC | US$1307.4万 | 0.00% |
| MIRAE ASSET SECURITIES (USA) INC. | US$1277.3万 | 0.47% |
| Lalia Capital, LLC | US$1277.3万 | 8.07% |
| OXFORD ASSET MANAGEMENT LLP | US$1242.4万 | 5.35% |
| Focus Partners Wealth | US$1234.4万 | 0.01% |
| Thrivent Financial for Lutherans | US$1225.9万 | 0.02% |
| NOMURA HOLDINGS INC | US$1213.4万 | 0.03% |
| Lake Hills Wealth Management, LLC | US$1174.8万 | 6.57% |
| INVESTMENT HOUSE LLC | US$1167.7万 | 0.61% |
| Parkside Investments, LLC | US$1156.9万 | 1.41% |
| Ilmarinen Mutual Pension Insurance Co | US$1153.8万 | 0.09% |
| GROUP ONE TRADING LLC | US$1153.8万 | 0.02% |
| Strategic Wealth Partners, Ltd. | US$1144.0万 | 0.79% |
| Capula Management Ltd | US$1115.5万 | 0.08% |
| HRT FINANCIAL LP | US$1112.7万 | 0.03% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$1081.8万 | 0.02% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | US$1071.7万 | 0.16% |
| Cambridge Investment Research Advisors, Inc. | US$1069.6万 | 0.03% |
| HighTower Advisors, LLC | US$1048.5万 | 0.01% |
| BLAIR WILLIAM & CO/IL | US$1036.6万 | 0.03% |
| CASTLEARK MANAGEMENT LLC | US$1033.2万 | 0.34% |
| Twin Tree Management, LP | US$1014.8万 | 0.21% |
| FIFTH THIRD BANCORP | US$993.2万 | 0.02% |
| LHM, INC. | US$942.1万 | 3.71% |
| Allspring Global Investments Holdings, LLC | US$919.6万 | 0.02% |
| FIL Ltd | US$916.2万 | 0.01% |
| Tamar Securities, LLC | US$882.8万 | 0.95% |
| Spire Wealth Management | US$875.6万 | 0.30% |
| MONTAG A & ASSOCIATES INC | US$871.6万 | 0.40% |
| Marotta Asset Management | US$849.8万 | 1.56% |
| Crescent Grove Advisors, LLC | US$820.6万 | 0.79% |
| BANQUE PICTET & CIE SA | US$820.2万 | 0.06% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$819.4万 | 0.00% |
| Baird Financial Group, Inc. | US$773.6万 | 0.01% |
| FLOW TRADERS U.S. LLC | US$769.8万 | 0.24% |
| Exome Asset Management LLC | US$766.4万 | 3.96% |
| OPPENHEIMER & CO INC | US$729.0万 | 0.09% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$723.1万 | 0.01% |
| Fulcrum Capital LLC | US$714.9万 | 1.55% |
| NOMURA ASSET MANAGEMENT CO LTD | US$694.8万 | 0.02% |
| BROWN ADVISORY INC | US$688.7万 | 0.01% |
| PETREDIS INVESTMENT ADVISORS LLC | US$687.7万 | 0.56% |
| &PARTNERS | US$652.1万 | 0.03% |
| Carnegie Investment Counsel | US$637.3万 | 0.12% |
| Corient Private Wealth LLC | US$629.9万 | 0.01% |
| RH Tailwind Management, LLC | US$625.9万 | 0.80% |
| Verition Fund Management LLC | US$607.7万 | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$564.9万 | 0.07% |