| FARALLON CAPITAL MANAGEMENT LLC | US$3.3亿 | 1.86% |
| Caligan Partners LP | US$3.1亿 | 20.39% |
| BlackRock, Inc. | US$2.1亿 | 0.00% |
| FINDELL CAPITAL MANAGEMENT LLC | US$1.3亿 | 39.26% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1亿 | 0.00% |
| Opaleye Management Inc. | US$8882.1万 | 11.70% |
| BANK OF AMERICA CORP /DE/ | US$8634.1万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7281.2万 | 0.00% |
| CITADEL ADVISORS LLC | US$7227.3万 | 0.01% |
| STATE STREET CORP | US$7101.2万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$6255.7万 | 0.01% |
| MPM BIOIMPACT LLC | US$5303.1万 | 4.10% |
| Caprock Group, LLC | US$5159.9万 | 1.25% |
| JANE STREET GROUP, LLC | US$4989.5万 | 0.01% |
| Buckley Capital Advisors, LLC | US$4467.1万 | 32.10% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3597.3万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$3431.6万 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$3064.5万 | 0.00% |
| DIADEMA PARTNERS LP | US$2687.5万 | 4.57% |
| Eversept Partners, LP | US$2556.5万 | 1.35% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2387.5万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$2358.9万 | 0.31% |
| FMR LLC | US$2197.2万 | 0.00% |
| NORTHERN TRUST CORP | US$2188.4万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$2125.6万 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2102.9万 | 0.00% |
| Sofinnova Investments, Inc. | US$1887.0万 | 0.72% |
| Invesco Ltd. | US$1817.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1782.4万 | 0.00% |
| FEDERATED HERMES, INC. | US$1655.9万 | 0.03% |
| Trexquant Investment LP | US$1544.5万 | 0.11% |
| TCG Crossover Management, LLC | US$1521.1万 | 0.44% |
| Pale Fire Capital SE | US$1465.7万 | 1.29% |
| OBERWEIS ASSET MANAGEMENT INC/ | US$1404.3万 | 0.41% |
| Purewater Capital LLC | US$1394.2万 | 13.35% |
| Caption Management, LLC | US$1383.5万 | 0.08% |
| MORGAN STANLEY | US$1300.8万 | 0.00% |
| Apis Capital Advisors, LLC | US$1117.1万 | 1.72% |
| MARSHALL WACE, LLP | US$1092.3万 | 0.01% |
| FIRST TRUST ADVISORS LP | US$1054.7万 | 0.01% |
| Hudson Bay Capital Management LP | US$994.4万 | 0.03% |
| Capricorn Fund Managers Ltd | US$933.7万 | 1.46% |
| Rangeley Capital, LLC | US$849.2万 | 8.25% |
| Greenland Capital Management LP | US$807.6万 | 1.03% |
| UBS Group AG | US$782.1万 | 0.00% |
| T3 Companies, LLC | US$776.5万 | 10.11% |
| ALGERT GLOBAL LLC | US$770.1万 | 0.12% |
| WELLINGTON MANAGEMENT GROUP LLP | US$751.3万 | 0.00% |
| CITIGROUP INC | US$735.0万 | 0.00% |
| Bank of New York Mellon Corp | US$731.9万 | 0.00% |
| Seven Fleet Capital Management LP | US$709.0万 | 2.25% |
| JPMORGAN CHASE & CO | US$686.4万 | 0.00% |
| Diametric Capital, LP | US$633.1万 | 1.65% |
| RAYMOND JAMES FINANCIAL INC | US$613.1万 | 0.00% |
| Squarepoint Ops LLC | US$610.2万 | 0.01% |
| Walleye Trading LLC | US$594.6万 | 0.01% |
| Nuveen, LLC | US$574.5万 | 0.00% |
| Insight Wealth Strategies, LLC | US$537.4万 | 0.60% |
| Aquatic Capital Management LLC | US$529.6万 | 0.15% |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | US$526.7万 | 0.04% |
| DEUTSCHE BANK AG\ | US$519.5万 | 0.00% |
| Swiss National Bank | US$454.4万 | 0.00% |
| CAXTON ASSOCIATES LLP | US$441.8万 | 0.10% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$440.1万 | 0.00% |
| CenterBook Partners LP | US$433.7万 | 0.23% |
| LGT Fund Management Co Ltd. | US$416.1万 | 0.18% |
| Verition Fund Management LLC | US$415.6万 | 0.03% |
| J. Goldman & Co LP | US$402.0万 | 0.12% |
| Woodline Partners LP | US$378.0万 | 0.01% |
| ADAR1 Capital Management, LLC | US$377.4万 | 0.22% |
| HighVista Strategies LLC | US$376.4万 | 1.04% |
| VICTORY CAPITAL MANAGEMENT INC | US$371.2万 | 0.00% |
| Empowered Funds, LLC | US$365.0万 | 0.02% |
| AWH Capital, L.P. | US$349.1万 | 3.17% |
| PATHWAY CAPITAL MANAGEMENT, LP | US$344.9万 | 80.26% |
| Alphadyne Asset Management LP | US$333.6万 | 0.06% |
| Russell Investments Group, Ltd. | US$327.9万 | 0.00% |
| HRT FINANCIAL LP | US$327.1万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$303.0万 | 0.00% |
| RHUMBLINE ADVISERS | US$301.9万 | 0.00% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$295.0万 | 0.47% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$285.3万 | 0.01% |
| Balyasny Asset Management L.P. | US$275.1万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$273.4万 | 0.00% |
| Legal & General Group Plc | US$262.8万 | 0.00% |
| Advisory Services Network, LLC | US$245.1万 | 0.03% |
| ALLIANCEBERNSTEIN L.P. | US$240.2万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$230.3万 | 0.01% |
| Sigma Planning Corp | US$226.8万 | 0.06% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$219.9万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | US$211.1万 | 0.03% |
| Engineers Gate Manager LP | US$202.4万 | 0.03% |
| WCG Wealth Advisors LLC | US$195.9万 | 0.05% |
| GROUP ONE TRADING LLC | US$185.1万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$184.9万 | 0.00% |
| BURNEY CO/ | US$183.0万 | 0.06% |
| CAPITAL FUND MANAGEMENT S.A. | US$181.6万 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$179.1万 | 0.00% |
| Exome Asset Management LLC | US$172.8万 | 0.89% |
| Walleye Capital LLC | US$167.5万 | 0.01% |
| TD Asset Management Inc | US$158.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$154.3万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$153.2万 | 0.12% |
| Creative Planning | US$151.1万 | 0.00% |
| Brevan Howard Capital Management LP | US$148.8万 | 0.01% |
| SAPIENT CAPITAL LLC | US$139.6万 | 0.02% |
| MetLife Investment Management, LLC | US$138.4万 | 0.01% |
| SEI INVESTMENTS CO | US$134.6万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$133.6万 | 0.08% |
| LPL Financial LLC | US$128.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$128.7万 | 0.00% |
| SG Americas Securities, LLC | US$128.6万 | 0.00% |
| BARCLAYS PLC | US$123.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$122.2万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$116.3万 | 0.00% |
| SIGNATUREFD, LLC | US$113.2万 | 0.02% |
| Whitcomb & Hess, Inc. | US$113.0万 | 0.26% |
| LGL PARTNERS, LLC | US$109.4万 | 0.45% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$108.5万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$105.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$96.8万 | 0.00% |
| Cinctive Capital Management LP | US$95.7万 | 0.06% |
| Blackstone Inc. | US$95.2万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$92.4万 | 0.01% |
| Bleakley Financial Group, LLC | US$86.3万 | 0.01% |
| Mariner, LLC | US$86.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$82.7万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$79.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$78.5万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$77.6万 | 0.01% |
| Valmark Advisers, Inc. | US$77.5万 | 0.01% |
| HANSEATIC MANAGEMENT SERVICES INC | US$77.2万 | 0.74% |
| INTECH INVESTMENT MANAGEMENT LLC | US$74.3万 | 0.01% |
| Blueshift Asset Management, LLC | US$71.0万 | 0.22% |
| MARK ASSET MANAGEMENT LP | US$68.0万 | 0.06% |
| XTX Topco Ltd | US$67.3万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$67.1万 | 0.01% |
| Vontobel Holding Ltd. | US$66.5万 | 0.00% |
| Quantbot Technologies LP | US$65.3万 | 0.03% |
| Quantinno Capital Management LP | US$64.8万 | 0.00% |
| DV Trading LLC | US$64.2万 | 0.02% |
| ARIZONA STATE RETIREMENT SYSTEM | US$63.1万 | 0.00% |
| Cetera Investment Advisers | US$61.7万 | 0.00% |
| JW Asset Management, LLC | US$61.0万 | 0.25% |
| Vanguard Investments Australia, Ltd. | US$57.5万 | 0.00% |
| CORSAIR CAPITAL MANAGEMENT, L.P. | US$56.6万 | 0.08% |
| Tradition Wealth Management, LLC | US$55.7万 | 0.04% |
| FOX RUN MANAGEMENT, L.L.C. | US$54.3万 | 0.09% |
| GREENLEAF TRUST | US$52.9万 | 0.01% |
| OCCUDO QUANTITATIVE STRATEGIES LP | US$52.2万 | 0.03% |