| Catalys Pacific, LLC | US$2.1亿 | 92.81% |
| RA CAPITAL MANAGEMENT, L.P. | US$2.1亿 | 2.21% |
| SAMSARA BIOCAPITAL, LLC | US$1.6亿 | 15.45% |
| FMR LLC | US$1.3亿 | 0.01% |
| BlackRock, Inc. | US$1.2亿 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$9099.7万 | 0.02% |
| Caption Management, LLC | US$8867.6万 | 0.52% |
| STATE STREET CORP | US$7953.5万 | 0.00% |
| Caligan Partners LP | US$7511.1万 | 5.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$6648.9万 | 0.00% |
| Laurion Capital Management LP | US$6046.6万 | 2.64% |
| ORBIMED ADVISORS LLC | US$5561.3万 | 1.14% |
| Point72 Asset Management, L.P. | US$5178.1万 | 0.07% |
| FRANKLIN RESOURCES INC | US$4834.6万 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$4663.9万 | 0.61% |
| ANDERA PARTNERS | US$4312.5万 | 24.38% |
| SR One Capital Management, LP | US$4236.8万 | 4.63% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$4168.2万 | 1.06% |
| Polar Capital Holdings Plc | US$4065.5万 | 0.14% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3885.4万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3639.1万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$3630.0万 | 5.76% |
| ALLIANCEBERNSTEIN L.P. | US$3541.8万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3525.5万 | 0.00% |
| JENNISON ASSOCIATES LLC | US$3430.1万 | 0.02% |
| Integral Health Asset Management, LLC | US$3386.3万 | 1.62% |
| ARMISTICE CAPITAL, LLC | US$3185.8万 | 0.57% |
| BANK OF AMERICA CORP /DE/ | US$2980.9万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$2846.2万 | 0.05% |
| Pictet Asset Management Holding SA | US$2802.3万 | 0.03% |
| Qube Research & Technologies Ltd | US$2478.0万 | 0.03% |
| Nantahala Capital Management, LLC | US$2425.9万 | 0.89% |
| D. E. Shaw & Co., Inc. | US$2403.4万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$2395.1万 | 0.01% |
| MORGAN STANLEY | US$2300.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2218.5万 | 0.00% |
| Candriam S.C.A. | US$2172.4万 | 0.11% |
| CITADEL ADVISORS LLC | US$2067.3万 | 0.00% |
| Affinity Asset Advisors, LLC | US$2031.8万 | 1.05% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1914.3万 | 0.00% |
| Troluce Capital Advisors LLC | US$1774.4万 | 1.09% |
| STEMPOINT CAPITAL LP | US$1444.9万 | 2.77% |
| MILLENNIUM MANAGEMENT LLC | US$1422.9万 | 0.01% |
| Davern Capital Partners, LP | US$1211.3万 | 3.32% |
| 22NW, LP | US$1203.7万 | 8.25% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1202.5万 | 0.00% |
| NORTHERN TRUST CORP | US$1199.7万 | 0.00% |
| Rock Springs Capital Management LP | US$1191.3万 | 0.70% |
| Catalio Capital Management, LP | US$1189.4万 | 2.48% |
| Capital World Investors | US$1078.7万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$1037.0万 | 0.02% |
| Parkman Healthcare Partners LLC | US$1029.8万 | 1.06% |
| VANGUARD FIDUCIARY TRUST CO | US$1016.6万 | 0.00% |
| Pale Fire Capital SE | US$990.5万 | 0.87% |
| TimesSquare Capital Management, LLC | US$917.8万 | 0.16% |
| TWO SIGMA INVESTMENTS, LP | US$843.8万 | 0.01% |
| LORD, ABBETT & CO. LLC | US$815.2万 | 0.03% |
| Rhenman & Partners Asset Management AB | US$712.7万 | 0.88% |
| ALGERT GLOBAL LLC | US$705.1万 | 0.11% |
| SG Americas Securities, LLC | US$611.8万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$599.5万 | 0.00% |
| Verition Fund Management LLC | US$596.3万 | 0.04% |
| VOYA INVESTMENT MANAGEMENT LLC | US$585.4万 | 0.01% |
| Russell Investments Group, Ltd. | US$551.3万 | 0.01% |
| FINDELL CAPITAL MANAGEMENT LLC | US$547.2万 | 1.60% |
| JANE STREET GROUP, LLC | US$502.2万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$481.1万 | 0.03% |
| Buckley Capital Advisors, LLC | US$468.9万 | 3.37% |
| ADAR1 Capital Management, LLC | US$419.0万 | 0.25% |
| Burkehill Global Management, LP | US$406.4万 | 0.20% |
| AQR CAPITAL MANAGEMENT LLC | US$403.9万 | 0.00% |
| MARK ASSET MANAGEMENT LP | US$392.5万 | 0.36% |
| PFM Health Sciences, LP | US$386.5万 | 0.35% |
| Artia Global Partners LP | US$373.3万 | 0.75% |
| DIMENSIONAL FUND ADVISORS LP | US$371.6万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$357.9万 | 0.07% |
| Bank of New York Mellon Corp | US$352.1万 | 0.00% |
| Swedbank AB | US$330.8万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$307.0万 | 0.00% |
| Ensign Peak Advisors, Inc | US$303.9万 | 0.01% |
| Nuveen, LLC | US$303.4万 | 0.00% |
| Squarepoint Ops LLC | US$285.8万 | 0.00% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$284.3万 | 0.24% |
| CAPITAL FUND MANAGEMENT S.A. | US$276.9万 | 0.01% |
| UBS Group AG | US$265.6万 | 0.00% |
| HRT FINANCIAL LP | US$259.8万 | 0.01% |
| Rafferty Asset Management, LLC | US$255.6万 | 0.01% |
| J. Goldman & Co LP | US$254.9万 | 0.07% |
| Brevan Howard Capital Management LP | US$246.3万 | 0.02% |
| Swiss National Bank | US$244.1万 | 0.00% |
| CenterBook Partners LP | US$242.0万 | 0.13% |
| Greenland Capital Management LP | US$226.2万 | 0.29% |
| Ishara Investments LP | US$222.1万 | 2.10% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$215.5万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$211.6万 | 0.03% |
| Hennion & Walsh Asset Management, Inc. | US$190.1万 | 0.06% |
| Seven Fleet Capital Management LP | US$188.5万 | 0.60% |
| XTX Topco Ltd | US$185.3万 | 0.03% |
| ALPS ADVISORS INC | US$174.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$173.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$166.0万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$161.3万 | 0.00% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$160.5万 | 0.00% |
| RHUMBLINE ADVISERS | US$155.6万 | 0.00% |
| Trexquant Investment LP | US$155.0万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$139.2万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$126.9万 | 0.00% |
| HighVista Strategies LLC | US$126.7万 | 0.35% |
| JPMORGAN CHASE & CO | US$122.1万 | 0.00% |
| Invesco Ltd. | US$114.6万 | 0.00% |
| PROFUND ADVISORS LLC | US$113.7万 | 0.04% |
| DEUTSCHE BANK AG\ | US$108.7万 | 0.00% |
| Erste Asset Management GmbH | US$105.8万 | 0.01% |
| DAFNA Capital Management LLC | US$104.3万 | 0.24% |
| Legal & General Group Plc | US$104.2万 | 0.00% |
| BARCLAYS PLC | US$91.8万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$89.8万 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | US$89.5万 | 0.74% |
| Vanguard Global Advisers, LLC | US$82.6万 | 0.00% |
| Bellevue Group AG | US$79.6万 | 0.02% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$79.2万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$76.7万 | 0.00% |
| MetLife Investment Management, LLC | US$72.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$71.5万 | 0.00% |
| DIADEMA PARTNERS LP | US$71.4万 | 0.12% |
| WELLS FARGO & COMPANY/MN | US$70.7万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$66.9万 | 0.00% |
| Creative Planning | US$65.8万 | 0.00% |
| Allianz Asset Management GmbH | US$59.3万 | 0.00% |
| Quantinno Capital Management LP | US$55.6万 | 0.00% |
| NOMURA HOLDINGS INC | US$54.2万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$53.7万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$53.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$53.2万 | 0.00% |
| SIMPLEX TRADING, LLC | US$53.0万 | 0.00% |
| Magnetar Financial LLC | US$50.2万 | 0.01% |
| Eleva Capital SAS | US$46.3万 | 0.13% |
| State of New Jersey Common Pension Fund D | US$42.3万 | 0.00% |
| Persistent Asset Partners Ltd | US$41.7万 | 0.16% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$41.6万 | 0.00% |
| CITIGROUP INC | US$40.9万 | 0.00% |
| Handelsbanken Fonder AB | US$38.2万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$38.0万 | 0.03% |
| Police & Firemen's Retirement System of New Jersey | US$34.4万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$34.0万 | 0.00% |
| MAI Capital Management | US$33.2万 | 0.00% |
| E Fund Management Co., Ltd. | US$32.1万 | 0.01% |
| SEI INVESTMENTS CO | US$31.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$30.5万 | 0.00% |
| Velan Capital Investment Management LP | US$29.8万 | 0.19% |