| Opaleye Management Inc. | US$9986.4万 | 13.15% |
| BlackRock, Inc. | US$9001.0万 | 0.00% |
| Private Capital Management, LLC | US$5652.2万 | 5.63% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$5187.0万 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4947.2万 | 0.00% |
| Luxor Capital Group, LP | US$3947.0万 | 2.75% |
| STATE STREET CORP | US$3014.9万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3004.8万 | 0.00% |
| MARSHALL WACE, LLP | US$2274.0万 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | US$2042.8万 | 0.00% |
| CITADEL ADVISORS LLC | US$2014.6万 | 0.00% |
| Ikarian Capital, LLC | US$1914.8万 | 1.55% |
| Penn Capital Management Company, LLC | US$1441.1万 | 1.12% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1298.2万 | 0.72% |
| GOLDMAN SACHS GROUP INC | US$1204.9万 | 0.00% |
| NORTHERN TRUST CORP | US$1046.7万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1018.6万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$953.9万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$946.8万 | 0.01% |
| STIFEL FINANCIAL CORP | US$827.4万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$802.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$703.8万 | 0.00% |
| Crawford Fund Management, LLC | US$699.2万 | 1.35% |
| Westside Investment Management, Inc. | US$655.6万 | 1.00% |
| UBS Group AG | US$618.2万 | 0.00% |
| Blackhawk Capital Partners, LLC | US$607.6万 | 2.23% |
| 12th Street Asset Management Company, LLC | US$594.9万 | 0.97% |
| Patient Square Capital LP | US$582.5万 | 1.03% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$557.5万 | 0.07% |
| BRAIDWELL LP | US$551.5万 | 0.18% |
| FIRST TRUST ADVISORS LP | US$543.3万 | 0.00% |
| FirstWave Capital Management LLC | US$507.5万 | 5.39% |
| MORGAN STANLEY | US$502.6万 | 0.00% |
| Diametric Capital, LP | US$390.3万 | 1.01% |
| WOODMONT INVESTMENT COUNSEL LLC | US$389.8万 | 0.24% |
| BANK OF AMERICA CORP /DE/ | US$333.5万 | 0.00% |
| GROUP ONE TRADING LLC | US$324.4万 | 0.01% |
| Steward Partners Investment Advisory, LLC | US$319.6万 | 0.02% |
| Lumbard & Kellner, LLC | US$312.3万 | 1.08% |
| WELLINGTON MANAGEMENT GROUP LLP | US$308.1万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$303.6万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$298.2万 | 0.00% |
| Russell Investments Group, Ltd. | US$282.0万 | 0.00% |
| Bank of New York Mellon Corp | US$277.4万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$261.8万 | 0.06% |
| Nuveen, LLC | US$231.0万 | 0.00% |
| DEUTSCHE BANK AG\ | US$227.9万 | 0.00% |
| Swiss National Bank | US$219.0万 | 0.00% |
| Jefferson Bridge Capital, LLC | US$201.6万 | 2.00% |
| CAPTRUST FINANCIAL ADVISORS | US$200.2万 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$182.9万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$179.7万 | 0.00% |
| Squarepoint Ops LLC | US$176.7万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$167.6万 | 0.00% |
| EQUITABLE TRUST CO | US$147.3万 | 0.07% |
| ALLIANCEBERNSTEIN L.P. | US$145.2万 | 0.00% |
| BARD ASSOCIATES INC | US$142.4万 | 0.36% |
| ROYCE & ASSOCIATES LP | US$140.0万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$137.6万 | 0.00% |
| LJI Wealth Management, LLC | US$136.5万 | 0.22% |
| SEI INVESTMENTS CO | US$134.1万 | 0.00% |
| RHUMBLINE ADVISERS | US$131.1万 | 0.00% |
| D.A. DAVIDSON & CO. | US$128.8万 | 0.01% |
| OSAIC HOLDINGS, INC. | US$123.6万 | 0.00% |
| STANSBERRY ASSET MANAGEMENT, LLC | US$122.5万 | 0.13% |
| JPMORGAN CHASE & CO | US$121.2万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$115.5万 | 0.00% |
| LPL Financial LLC | US$111.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$104.6万 | 0.00% |
| Brookstone Capital Management | US$101.8万 | 0.01% |
| KORNITZER CAPITAL MANAGEMENT INC /KS | US$95.9万 | 0.02% |
| GREAT LAKES ADVISORS, LLC | US$95.1万 | 0.01% |
| Gotham Asset Management, LLC | US$92.4万 | 0.00% |
| Legal & General Group Plc | US$86.5万 | 0.00% |
| Birchview Capital, LP | US$84.6万 | 0.48% |
| Militia Capital Management LLC | US$82.9万 | 0.19% |
| Creative Planning | US$78.5万 | 0.00% |
| Invesco Ltd. | US$77.4万 | 0.00% |
| IMC-Chicago, LLC | US$76.8万 | 0.00% |
| Focus Partners Wealth | US$75.6万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$75.1万 | 0.00% |
| FRANKLIN RESOURCES INC | US$72.7万 | 0.00% |
| SIMPLEX TRADING, LLC | US$69.1万 | 0.00% |
| CORSAIR CAPITAL MANAGEMENT, L.P. | US$67.0万 | 0.10% |
| MetLife Investment Management, LLC | US$64.8万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$63.5万 | 0.00% |
| Atria Investments, Inc | US$62.2万 | 0.01% |
| Round Rock Advisors LLC | US$61.6万 | 0.09% |
| COMMERCE BANK | US$61.5万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$59.4万 | 0.05% |
| Lido Advisors, LLC | US$58.1万 | 0.00% |
| Ahara Advisors LLC | US$57.6万 | 0.48% |
| Eddie Patel Inc | US$57.4万 | 0.44% |
| CITIGROUP INC | US$57.3万 | 0.00% |
| Cetera Investment Advisers | US$56.6万 | 0.00% |
| State of Alaska, Department of Revenue | US$55.6万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$53.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$53.6万 | 0.00% |
| VARCOV Co. | US$52.3万 | 0.20% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$52.1万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$52.1万 | 0.00% |
| Patriot Financial Group Insurance Agency, LLC | US$49.0万 | 0.03% |
| SG Americas Securities, LLC | US$48.7万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$47.6万 | 0.00% |
| Walleye Partners, LLC | US$47.5万 | 0.58% |
| Bleakley Financial Group, LLC | US$46.5万 | 0.01% |
| Phoenix Financial Ltd. | US$46.1万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$45.2万 | 0.00% |
| Massar Capital Management, LP | US$44.5万 | 0.05% |
| FEDERATED HERMES, INC. | US$43.2万 | 0.00% |
| XTX Topco Ltd | US$42.8万 | 0.01% |
| CFG Wealth Management Services, Inc. | US$41.8万 | 0.38% |
| CAISSE DES DEPOTS ET CONSIGNATIONS | US$41.6万 | 0.01% |
| BARCLAYS PLC | US$40.9万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$40.4万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$39.7万 | 0.00% |
| Perigon Wealth Management, LLC | US$39.6万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$37.9万 | 0.00% |
| OXFORD ASSET MANAGEMENT LLP | US$37.7万 | 0.16% |
| MML INVESTORS SERVICES, LLC | US$36.5万 | 0.00% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$36.1万 | 0.00% |
| T3 Companies, LLC | US$35.3万 | 0.46% |
| INTECH INVESTMENT MANAGEMENT LLC | US$33.8万 | 0.00% |
| OCCUDO QUANTITATIVE STRATEGIES LP | US$33.7万 | 0.02% |
| HighTower Advisors, LLC | US$32.9万 | 0.00% |
| Headlands Technologies LLC | US$32.6万 | 0.04% |
| ADVOCATE GROUP LLC | US$31.1万 | 0.05% |
| Police & Firemen's Retirement System of New Jersey | US$30.8万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$30.5万 | 0.00% |
| Pale Fire Capital SE | US$30.0万 | 0.03% |
| ROYAL BANK OF CANADA | US$30.0万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$30.0万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$29.5万 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | US$28.9万 | 0.00% |
| HUB Investment Partners, LLC | US$28.9万 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$27.7万 | 0.00% |
| CIBC WORLD MARKET INC. | US$27.5万 | 0.00% |
| IHT Wealth Management, LLC | US$27.4万 | 0.01% |
| Assenagon Asset Management S.A. | US$26.5万 | 0.00% |
| CORRADO ADVISORS, LLC | US$26.0万 | 0.14% |
| Procyon Advisors, LLC | US$25.9万 | 0.01% |
| Quantinno Capital Management LP | US$25.4万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$24.9万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$24.3万 | 0.00% |
| PROFUND ADVISORS LLC | US$24.1万 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$23.2万 | 0.02% |
| AQR CAPITAL MANAGEMENT LLC | US$23.1万 | 0.00% |
| ProShare Advisors LLC | US$22.0万 | 0.00% |
| SJS Investment Consulting Inc. | US$21.4万 | 0.03% |
| Stratos Wealth Partners, LTD. | US$20.8万 | 0.00% |