| Avoro Capital Advisors LLC | US$9743.9万 | 0.96% |
| Aberdeen Group plc | US$8675.9万 | 0.14% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$5958.3万 | 0.01% |
| Nantahala Capital Management, LLC | US$4638.6万 | 1.71% |
| CITIGROUP INC | US$4596.8万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$4375.0万 | 0.04% |
| RTW INVESTMENTS, LP | US$4228.7万 | 0.42% |
| JPMORGAN CHASE & CO | US$4179.6万 | 0.00% |
| Caption Management, LLC | US$4128.8万 | 0.24% |
| STATE STREET CORP | US$3695.9万 | 0.00% |
| ORBIMED ADVISORS LLC | US$3492.6万 | 0.72% |
| CITADEL ADVISORS LLC | US$2993.8万 | 0.00% |
| 683 Capital Management, LLC | US$2867.1万 | 1.50% |
| FMR LLC | US$2851.1万 | 0.00% |
| BlackRock, Inc. | US$2834.2万 | 0.00% |
| MPM BIOIMPACT LLC | US$2238.7万 | 1.73% |
| Two Seas Capital LP | US$2125.5万 | 0.30% |
| GOLDMAN SACHS GROUP INC | US$2065.4万 | 0.00% |
| JENNISON ASSOCIATES LLC | US$2017.2万 | 0.01% |
| JANE STREET GROUP, LLC | US$1725.6万 | 0.00% |
| Siren, L.L.C. | US$1635.0万 | 0.45% |
| Balyasny Asset Management L.P. | US$1576.6万 | 0.02% |
| Integral Health Asset Management, LLC | US$1471.5万 | 0.70% |
| Fiera Capital Corp | US$1335.6万 | 0.05% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1316.1万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$1296.2万 | 0.01% |
| SG Americas Securities, LLC | US$1269.7万 | 0.01% |
| MAVERICK CAPITAL LTD | US$1140.6万 | 0.13% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1135.9万 | 0.00% |
| Boxer Capital Management, LLC | US$1082.4万 | 1.42% |
| Whitefort Capital Management, LP | US$1075.2万 | 3.17% |
| Voss Capital, LP | US$1070.9万 | 0.57% |
| First Turn Management, LLC | US$1006.3万 | 1.12% |
| DIADEMA PARTNERS LP | US$948.6万 | 1.61% |
| NOMURA HOLDINGS INC | US$874.7万 | 0.02% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$852.9万 | 0.72% |
| READYSTATE ASSET MANAGEMENT LP | US$825.2万 | 0.37% |
| UBS Group AG | US$822.1万 | 0.00% |
| Catalio Capital Management, LP | US$803.0万 | 1.68% |
| BARCLAYS PLC | US$800.2万 | 0.00% |
| Privium Fund Management B.V. | US$795.5万 | 1.66% |
| FRANKLIN RESOURCES INC | US$786.2万 | 0.00% |
| MAK CAPITAL ONE LLC | US$721.4万 | 1.06% |
| ExodusPoint Capital Management, LP | US$713.6万 | 0.06% |
| Massar Capital Management, LP | US$696.6万 | 0.75% |
| TUDOR INVESTMENT CORP ET AL | US$654.8万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$614.5万 | 0.00% |
| MORGAN STANLEY | US$598.6万 | 0.00% |
| Vestal Point Capital, LP | US$587.0万 | 0.16% |
| Squarepoint Ops LLC | US$565.7万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$543.7万 | 0.00% |
| Affinity Asset Advisors, LLC | US$490.5万 | 0.25% |
| Ally Bridge Group (NY) LLC | US$490.5万 | 3.96% |
| Engineers Gate Manager LP | US$490.1万 | 0.06% |
| Kalehua Capital Management LLC | US$476.0万 | 3.37% |
| D. E. Shaw & Co., Inc. | US$438.2万 | 0.00% |
| K2 PRINCIPAL FUND, L.P. | US$431.0万 | 0.30% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$422.2万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$403.6万 | 0.00% |
| SIMPLEX TRADING, LLC | US$378.9万 | 0.00% |
| Parkman Healthcare Partners LLC | US$338.2万 | 0.35% |
| Creek Drive Management Group LLC | US$327.0万 | 0.74% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$322.6万 | 0.04% |
| GROUP ONE TRADING LLC | US$292.7万 | 0.01% |
| ADAR1 Capital Management, LLC | US$288.1万 | 0.17% |
| NORTHERN TRUST CORP | US$277.9万 | 0.00% |
| Hudson Bay Capital Management LP | US$259.1万 | 0.01% |
| FLAX POND CAPITAL, LLC | US$248.6万 | 2.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$241.2万 | 0.00% |
| Assenagon Asset Management S.A. | US$239.9万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$227.2万 | 0.03% |
| MARSHALL WACE, LLP | US$200.7万 | 0.00% |
| MOORE CAPITAL MANAGEMENT, LP | US$199.8万 | 0.04% |
| Tejara Capital Ltd | US$199.6万 | 0.66% |
| Centiva Capital, LP | US$197.7万 | 0.01% |
| MYDA Advisors LLC | US$191.9万 | 0.32% |
| NAN FUNG TRINITY (HK) LTD | US$188.8万 | 0.21% |
| Y-Intercept (Hong Kong) Ltd | US$186.3万 | 0.04% |
| Walleye Capital LLC | US$185.0万 | 0.01% |
| Pekin Hardy Strauss, Inc. | US$184.1万 | 0.19% |
| Brevan Howard Capital Management LP | US$177.6万 | 0.02% |
| ROYAL BANK OF CANADA | US$176.3万 | 0.00% |
| Cinctive Capital Management LP | US$175.5万 | 0.11% |
| Propel Bio Management, LLC | US$171.3万 | 1.08% |
| WELLS FARGO & COMPANY/MN | US$169.1万 | 0.00% |
| Birchview Capital, LP | US$164.6万 | 0.94% |
| Marex Group plc | US$163.5万 | 0.01% |
| Irenic Capital Management LP | US$163.5万 | 0.11% |
| ENVESTNET ASSET MANAGEMENT INC | US$157.9万 | 0.00% |
| Shay Capital LLC | US$154.2万 | 0.13% |
| Militia Capital Management LLC | US$154.0万 | 0.35% |
| Ikarian Capital, LLC | US$148.9万 | 0.12% |
| Rafferty Asset Management, LLC | US$147.6万 | 0.01% |
| Newtyn Management, LLC | US$143.4万 | 0.15% |
| Clearline Capital LP | US$136.8万 | 0.07% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$135.1万 | 0.00% |
| Swiss National Bank | US$129.2万 | 0.00% |
| STEMPOINT CAPITAL LP | US$127.6万 | 0.24% |
| Senvest Management, LLC | US$118.2万 | 0.04% |
| SIG BROKERAGE, LP | US$114.5万 | 0.03% |
| Hennion & Walsh Asset Management, Inc. | US$112.1万 | 0.04% |
| Walleye Trading LLC | US$101.3万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$93.4万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$81.0万 | 0.00% |
| DCF Advisers, LLC | US$80.1万 | 0.21% |
| Schonfeld Strategic Advisors LLC | US$79.8万 | 0.01% |
| Havemeyer Place LP | US$79.2万 | 0.09% |
| PEAK6 LLC | US$77.9万 | 0.00% |
| STIFEL FINANCIAL CORP | US$77.0万 | 0.00% |
| IMC-Chicago, LLC | US$73.7万 | 0.00% |
| LMR Partners LLP | US$73.6万 | 0.00% |
| Bank of New York Mellon Corp | US$70.2万 | 0.00% |
| PFM Health Sciences, LP | US$69.7万 | 0.06% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$69.0万 | 0.00% |
| PROFUND ADVISORS LLC | US$64.3万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$60.1万 | 0.00% |
| Persistent Asset Partners Ltd | US$58.9万 | 0.22% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$58.8万 | 0.00% |
| MONIMUS CAPITAL MANAGEMENT, LP | US$56.3万 | 0.16% |
| DIAMOND HILL CAPITAL MANAGEMENT INC | US$54.5万 | 0.00% |
| Maxi Investments CY Ltd | US$53.8万 | 0.12% |
| GSA CAPITAL PARTNERS LLP | US$53.3万 | 0.03% |
| WINTON GROUP Ltd | US$51.6万 | 0.02% |
| SECTORAL ASSET MANAGEMENT INC | US$49.9万 | 0.41% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$49.8万 | 0.00% |
| Legal & General Group Plc | US$45.6万 | 0.00% |
| Monaco Asset Management SAM | US$45.0万 | 0.08% |
| MATAURO, LLC | US$42.7万 | 0.06% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$41.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$41.3万 | 0.00% |
| MML INVESTORS SERVICES, LLC | US$41.2万 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$36.9万 | 0.06% |
| FRED ALGER MANAGEMENT, LLC | US$35.4万 | 0.00% |
| DNB Asset Management AS | US$34.5万 | 0.00% |
| J. Goldman & Co LP | US$33.2万 | 0.01% |
| Palogic Value Management, L.P. | US$32.7万 | 0.14% |
| SANDERS MORRIS HARRIS LLC | US$31.6万 | 0.05% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$31.6万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$30.4万 | 0.00% |
| Diametric Capital, LP | US$30.1万 | 0.08% |
| Sigma Planning Corp | US$27.6万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$27.6万 | 0.00% |
| Patriot Financial Group Insurance Agency, LLC | US$27.5万 | 0.02% |
| LPL Financial LLC | US$27.2万 | 0.00% |
| ASSETMARK, INC | US$26.0万 | 0.00% |
| Graham Capital Management, L.P. | US$25.9万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$25.4万 | 0.00% |
| Handelsbanken Fonder AB | US$24.4万 | 0.00% |
| Lion Point Capital, LP | US$24.0万 | 1.44% |
| FARALLON CAPITAL MANAGEMENT LLC | US$22.9万 | 0.00% |