| BlackRock, Inc. | US$1.6亿 | 0.00% |
| ARCH Venture Management, LLC | US$1.2亿 | 17.09% |
| SB INVESTMENT ADVISERS (UK) LTD | US$9809.5万 | 1.27% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$8257.2万 | 0.00% |
| GSK plc | US$7661.7万 | 12.79% |
| STATE STREET CORP | US$6398.4万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4822.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2912.2万 | 0.00% |
| MORGAN STANLEY | US$2557.4万 | 0.00% |
| ADAR1 Capital Management, LLC | US$2459.3万 | 1.45% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2382.0万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$2310.7万 | 0.00% |
| CITADEL ADVISORS LLC | US$1974.7万 | 0.00% |
| FMR LLC | US$1856.4万 | 0.00% |
| Soleus Capital Management, L.P. | US$1793.8万 | 0.73% |
| Point72 Asset Management, L.P. | US$1749.2万 | 0.02% |
| Boxer Capital Management, LLC | US$1671.9万 | 2.20% |
| GordonMD Global Investments LP | US$1360.6万 | 9.48% |
| Sio Capital Management, LLC | US$1342.8万 | 1.93% |
| Pictet Asset Management Holding SA | US$1326.8万 | 0.01% |
| Hudson Bay Capital Management LP | US$1316.7万 | 0.05% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$1292.3万 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$1289.8万 | 0.01% |
| Qube Research & Technologies Ltd | US$1118.8万 | 0.01% |
| Clearstead Advisors, LLC | US$1089.9万 | 0.10% |
| Jones Hill Capital LP | US$1073.6万 | 2.30% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1049.8万 | 0.00% |
| Candriam S.C.A. | US$1017.6万 | 0.05% |
| Ensign Peak Advisors, Inc | US$959.4万 | 0.02% |
| JPMORGAN CHASE & CO | US$945.4万 | 0.00% |
| Nuveen, LLC | US$913.0万 | 0.00% |
| NORTHERN TRUST CORP | US$882.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$865.4万 | 0.00% |
| Avidity Partners Management LP | US$851.2万 | 1.72% |
| D. E. Shaw & Co., Inc. | US$732.6万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$682.2万 | 0.01% |
| UBS Group AG | US$666.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$655.6万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$654.6万 | 4.68% |
| Walleye Capital LLC | US$600.2万 | 0.02% |
| Bank of New York Mellon Corp | US$523.3万 | 0.00% |
| NORDEA INVESTMENT MANAGEMENT AB | US$509.3万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$507.1万 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$490.8万 | 0.00% |
| Empyrean Capital Partners, LP | US$472.9万 | 0.15% |
| Alta Partners Management Company, L.P. | US$456.9万 | 3.03% |
| Parkman Healthcare Partners LLC | US$448.0万 | 0.46% |
| MILLENNIUM MANAGEMENT LLC | US$438.5万 | 0.00% |
| ALGERT GLOBAL LLC | US$438.2万 | 0.07% |
| Invesco Ltd. | US$377.5万 | 0.00% |
| Public Sector Pension Investment Board | US$361.8万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$360.4万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$354.0万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$336.3万 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$331.6万 | 0.02% |
| WINTON GROUP Ltd | US$329.6万 | 0.12% |
| Susquehanna Portfolio Strategies, LLC | US$316.9万 | 0.05% |
| AMERICAN CENTURY COMPANIES INC | US$266.0万 | 0.00% |
| Corient Private Wealth LLC | US$263.1万 | 0.00% |
| Ikarian Capital, LLC | US$262.8万 | 0.21% |
| Legal & General Group Plc | US$230.0万 | 0.00% |
| CITIGROUP INC | US$229.5万 | 0.00% |
| Engineers Gate Manager LP | US$224.4万 | 0.03% |
| Eversept Partners, LP | US$224.0万 | 0.12% |
| JANE STREET GROUP, LLC | US$216.6万 | 0.00% |
| RHUMBLINE ADVISERS | US$208.4万 | 0.00% |
| Swiss National Bank | US$207.4万 | 0.00% |
| Man Group plc | US$159.4万 | 0.00% |
| Erste Asset Management GmbH | US$153.0万 | 0.01% |
| Tejara Capital Ltd | US$145.0万 | 0.48% |
| Hillsdale Investment Management Inc. | US$144.3万 | 0.04% |
| NOMURA HOLDINGS INC | US$127.4万 | 0.00% |
| ExodusPoint Capital Management, LP | US$122.8万 | 0.01% |
| BARCLAYS PLC | US$120.8万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$120.6万 | 0.02% |
| Rafferty Asset Management, LLC | US$120.4万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$116.9万 | 0.00% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$110.1万 | 0.00% |
| Jump Financial, LLC | US$109.4万 | 0.01% |
| Raiffeisen Bank International AG | US$105.8万 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$103.4万 | 0.00% |
| Thrivent Financial for Lutherans | US$101.8万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$101.1万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$101.0万 | 0.00% |
| Headlands Technologies LLC | US$92.5万 | 0.11% |
| Creative Planning | US$90.1万 | 0.00% |
| Monashee Investment Management LLC | US$89.6万 | 0.49% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$86.2万 | 0.00% |
| IEQ CAPITAL, LLC | US$86.0万 | 0.00% |
| Quantinno Capital Management LP | US$86.0万 | 0.00% |
| Trexquant Investment LP | US$84.9万 | 0.01% |
| THOMPSON SIEGEL & WALMSLEY LLC | US$82.4万 | 0.01% |
| DEUTSCHE BANK AG\ | US$81.3万 | 0.00% |
| DIADEMA PARTNERS LP | US$79.6万 | 0.14% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$78.3万 | 0.00% |
| Russell Investments Group, Ltd. | US$73.7万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$68.9万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$68.5万 | 0.04% |
| Quadrature Capital Ltd | US$67.8万 | 0.01% |
| Aquatic Capital Management LLC | US$67.5万 | 0.02% |
| TUDOR INVESTMENT CORP ET AL | US$65.9万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$65.0万 | 0.00% |
| Quinn Opportunity Partners LLC | US$63.6万 | 0.03% |
| LMR Partners LLP | US$60.7万 | 0.00% |
| XTX Topco Ltd | US$60.0万 | 0.01% |
| ACT CAPITAL MANAGEMENT, LLC | US$57.6万 | 0.45% |
| PROFUND ADVISORS LLC | US$57.2万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$56.7万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$55.3万 | 0.01% |
| State of Alaska, Department of Revenue | US$50.5万 | 0.01% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$50.3万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$49.1万 | 0.00% |
| LPL Financial LLC | US$46.6万 | 0.00% |
| MetLife Investment Management, LLC | US$45.3万 | 0.00% |
| Vanguard Global Advisers, LLC | US$45.1万 | 0.00% |
| Louisiana State Employees Retirement System | US$44.9万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$40.1万 | 0.01% |
| State of Tennessee, Department of Treasury | US$39.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$38.8万 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$38.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$37.2万 | 0.00% |
| Graham Capital Management, L.P. | US$36.8万 | 0.01% |
| Virtus Investment Advisers, LLC | US$36.5万 | 0.10% |
| Rockefeller Capital Management L.P. | US$35.2万 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$34.6万 | 0.00% |
| CWM, LLC | US$33.7万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$33.6万 | 0.00% |
| Mariner, LLC | US$32.3万 | 0.00% |
| Cerity Partners LLC | US$32.1万 | 0.00% |
| SEI INVESTMENTS CO | US$31.5万 | 0.00% |
| DRW Securities, LLC | US$30.1万 | 0.00% |
| Polymer Capital Management (US) LLC | US$30.1万 | 0.03% |
| Vanguard Investments Australia, Ltd. | US$30.0万 | 0.00% |
| Vontobel Holding Ltd. | US$29.6万 | 0.00% |
| Diversified Trust Co | US$28.7万 | 0.01% |
| AMALGAMATED BANK | US$28.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$27.7万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$27.7万 | 0.00% |
| BIT Capital GmbH | US$26.9万 | 0.01% |
| MERCER GLOBAL ADVISORS INC /ADV | US$26.8万 | 0.00% |
| Empowered Funds, LLC | US$26.7万 | 0.00% |
| Rathbones Group PLC | US$25.6万 | 0.00% |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | US$25.0万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$25.0万 | 0.02% |
| HSBC HOLDINGS PLC | US$24.9万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$24.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$24.4万 | 0.00% |
| YOUSIF CAPITAL MANAGEMENT, LLC | US$24.3万 | 0.00% |
| FIFTH THIRD BANCORP | US$23.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$23.4万 | 0.00% |