| BlackRock, Inc. | US$1.9亿 | 0.00% |
| Kynam Capital Management, LP | US$1.9亿 | 11.60% |
| GOLDMAN SACHS GROUP INC | US$1.2亿 | 0.01% |
| STATE STREET CORP | US$1.0亿 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$9927.6万 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8929.5万 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$8829.8万 | 1.04% |
| Eversept Partners, LP | US$6740.8万 | 3.55% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | US$5840.0万 | 6.41% |
| Hood River Capital Management LLC | US$5499.6万 | 0.55% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5039.9万 | 0.00% |
| FRANKLIN RESOURCES INC | US$5022.6万 | 0.01% |
| Point72 Asset Management, L.P. | US$4638.2万 | 0.06% |
| Elmind Capital, LP | US$4333.3万 | 12.30% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$4058.0万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$4047.2万 | 0.05% |
| Soleus Capital Management, L.P. | US$4034.1万 | 1.63% |
| D. E. Shaw & Co., Inc. | US$3742.0万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$3689.9万 | 0.03% |
| Nuveen, LLC | US$3491.5万 | 0.01% |
| MPM BIOIMPACT LLC | US$3132.0万 | 2.42% |
| Aisling Capital Management LP | US$3076.1万 | 6.46% |
| Woodline Partners LP | US$2921.8万 | 0.11% |
| STEMPOINT CAPITAL LP | US$2849.0万 | 5.45% |
| UBS Group AG | US$2695.0万 | 0.00% |
| Catalio Capital Management, LP | US$2438.0万 | 5.09% |
| Bank of New York Mellon Corp | US$2346.5万 | 0.00% |
| Ensign Peak Advisors, Inc | US$2314.9万 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$2290.0万 | 0.01% |
| ORBIMED ADVISORS LLC | US$2247.9万 | 0.46% |
| ALGERT GLOBAL LLC | US$2169.1万 | 0.33% |
| Candriam S.C.A. | US$2161.6万 | 0.11% |
| Parkman Healthcare Partners LLC | US$2105.9万 | 2.17% |
| MORGAN STANLEY | US$2088.2万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2076.7万 | 2.12% |
| Palo Alto Investors LP | US$2020.6万 | 3.09% |
| Prosight Management, LP | US$1798.7万 | 2.95% |
| CITADEL ADVISORS LLC | US$1793.0万 | 0.00% |
| NORTHERN TRUST CORP | US$1765.4万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$1692.6万 | 2.69% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1670.6万 | 0.00% |
| Trails Edge Capital Partners, LP | US$1639.5万 | 3.76% |
| VANGUARD FIDUCIARY TRUST CO | US$1402.8万 | 0.00% |
| Apis Capital Advisors, LLC | US$1284.8万 | 1.98% |
| RENAISSANCE TECHNOLOGIES LLC | US$1163.8万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1102.9万 | 0.00% |
| Knott David M Jr | US$985.8万 | 5.87% |
| Walleye Capital LLC | US$939.2万 | 0.04% |
| JANE STREET GROUP, LLC | US$899.4万 | 0.00% |
| Rhenman & Partners Asset Management AB | US$885.9万 | 1.09% |
| Integral Health Asset Management, LLC | US$817.6万 | 0.39% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$774.8万 | 0.01% |
| Granahan Investment Management, LLC | US$715.6万 | 0.35% |
| Aberdeen Group plc | US$670.4万 | 0.01% |
| SECTOR GAMMA AS | US$668.1万 | 1.58% |
| Pale Fire Capital SE | US$664.5万 | 0.58% |
| AMERIPRISE FINANCIAL INC | US$664.0万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$608.8万 | 0.04% |
| ALLIANCEBERNSTEIN L.P. | US$606.3万 | 0.00% |
| Invesco Ltd. | US$590.4万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$582.6万 | 0.02% |
| JPMORGAN CHASE & CO | US$581.2万 | 0.00% |
| PFM Health Sciences, LP | US$572.4万 | 0.52% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$536.3万 | 0.00% |
| SEI INVESTMENTS CO | US$508.3万 | 0.00% |
| DAFNA Capital Management LLC | US$507.7万 | 1.16% |
| Hennion & Walsh Asset Management, Inc. | US$501.8万 | 0.17% |
| Brevan Howard Capital Management LP | US$478.5万 | 0.04% |
| Pinnacle Financial Partners, Inc. | US$472.5万 | 0.04% |
| Trexquant Investment LP | US$471.4万 | 0.03% |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | US$467.2万 | 1.78% |
| MILLENNIUM MANAGEMENT LLC | US$466.1万 | 0.00% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$464.8万 | 0.74% |
| Man Group plc | US$425.2万 | 0.01% |
| Squarepoint Ops LLC | US$424.1万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$420.5万 | 0.01% |
| FMR LLC | US$406.4万 | 0.00% |
| Swiss National Bank | US$377.0万 | 0.00% |
| Atom Investors LP | US$364.3万 | 0.26% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$349.9万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$340.0万 | 0.02% |
| Rafferty Asset Management, LLC | US$291.4万 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$288.7万 | 0.00% |
| Cinctive Capital Management LP | US$274.1万 | 0.18% |
| RHUMBLINE ADVISERS | US$268.1万 | 0.00% |
| IEQ CAPITAL, LLC | US$256.1万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$250.3万 | 0.00% |
| ExodusPoint Capital Management, LP | US$245.4万 | 0.02% |
| Torray Investment Partners LLC | US$245.0万 | 0.36% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$240.6万 | 0.00% |
| Russell Investments Group, Ltd. | US$237.1万 | 0.00% |
| Yelin Lapidot Holdings Management Ltd. | US$224.9万 | 0.47% |
| TWINBEECH CAPITAL LP | US$210.3万 | 0.22% |
| HRT FINANCIAL LP | US$207.6万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$187.8万 | 0.00% |
| CITIGROUP INC | US$187.7万 | 0.00% |
| XTX Topco Ltd | US$184.6万 | 0.03% |
| DEUTSCHE BANK AG\ | US$175.2万 | 0.00% |
| Mariner, LLC | US$171.0万 | 0.00% |
| Aquatic Capital Management LLC | US$161.4万 | 0.05% |
| TUDOR INVESTMENT CORP ET AL | US$161.3万 | 0.00% |
| SummitTX Capital, L.P. | US$155.0万 | 0.05% |
| Tidal Investments LLC | US$152.6万 | 0.00% |
| Hudson Bay Capital Management LP | US$145.6万 | 0.01% |
| Legal & General Group Plc | US$138.0万 | 0.00% |
| Tema ETFs LLC | US$136.3万 | 0.09% |
| PROFUND ADVISORS LLC | US$130.6万 | 0.05% |
| MARSHALL WACE, LLP | US$126.8万 | 0.00% |
| Neo Ivy Capital Management | US$124.2万 | 0.33% |
| VOYA INVESTMENT MANAGEMENT LLC | US$124.0万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$121.7万 | 0.00% |
| BARCLAYS PLC | US$117.6万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$114.2万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$113.4万 | 0.07% |
| MetLife Investment Management, LLC | US$109.4万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$107.1万 | 0.00% |
| Clearline Capital LP | US$101.4万 | 0.05% |
| ENVESTNET ASSET MANAGEMENT INC | US$97.8万 | 0.00% |
| Assenagon Asset Management S.A. | US$97.5万 | 0.00% |
| STIFEL FINANCIAL CORP | US$97.4万 | 0.00% |
| Virtus Investment Advisers, LLC | US$96.8万 | 0.27% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$93.2万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$92.0万 | 0.00% |
| Cerity Partners LLC | US$91.3万 | 0.00% |
| SG Americas Securities, LLC | US$90.0万 | 0.00% |
| Engineers Gate Manager LP | US$89.7万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$89.5万 | 0.00% |
| Vanguard Global Advisers, LLC | US$87.4万 | 0.00% |
| Palumbo Wealth Management LLC | US$86.9万 | 0.21% |
| CWM, LLC | US$86.5万 | 0.00% |
| HighTower Advisors, LLC | US$86.5万 | 0.00% |
| WESBANCO BANK INC | US$86.4万 | 0.02% |
| Voleon Capital Management LP | US$85.6万 | 0.02% |
| Qube Research & Technologies Ltd | US$84.2万 | 0.00% |
| NOMURA HOLDINGS INC | US$84.1万 | 0.00% |
| Lion Point Capital, LP | US$84.1万 | 5.03% |
| SECTORAL ASSET MANAGEMENT INC | US$78.7万 | 0.65% |
| Caitong International Asset Management Co., Ltd | US$77.5万 | 0.14% |
| Creative Planning | US$74.5万 | 0.00% |
| Bridgefront Capital, LLC | US$72.7万 | 0.18% |
| INTECH INVESTMENT MANAGEMENT LLC | US$70.8万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$66.7万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$65.3万 | 0.00% |
| Headlands Technologies LLC | US$59.3万 | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$59.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$57.8万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$56.7万 | 0.00% |
| HSBC HOLDINGS PLC | US$55.6万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$55.2万 | 0.00% |
| ROYAL BANK OF CANADA | US$54.6万 | 0.00% |