| Pfizer Inc | US$4979.2万 | 20.85% |
| BlackRock, Inc. | US$4658.2万 | 0.00% |
| TPG GP A, LLC | US$4566.8万 | 1.24% |
| STATE STREET CORP | US$2113.1万 | 0.00% |
| PRIMECAP MANAGEMENT CO/CA/ | US$2044.7万 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1688.8万 | 0.00% |
| CITADEL ADVISORS LLC | US$1680.5万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1313.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$1311.6万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1006.5万 | 0.00% |
| Frazier Life Sciences Management, L.P. | US$926.4万 | 0.24% |
| Woodline Partners LP | US$854.3万 | 0.03% |
| Patient Square Capital LP | US$841.8万 | 1.49% |
| MARSHALL WACE, LLP | US$841.3万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$810.6万 | 0.00% |
| Candriam S.C.A. | US$731.3万 | 0.04% |
| Wildcat Capital Management, LLC | US$712.7万 | 6.71% |
| GOLDMAN SACHS GROUP INC | US$675.0万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$674.4万 | 0.00% |
| Boxer Capital Management, LLC | US$664.9万 | 0.87% |
| AQR CAPITAL MANAGEMENT LLC | US$606.3万 | 0.00% |
| Nuveen, LLC | US$564.9万 | 0.00% |
| MPM BIOIMPACT LLC | US$547.3万 | 0.42% |
| RENAISSANCE TECHNOLOGIES LLC | US$522.0万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$520.8万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$491.3万 | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$413.4万 | 0.00% |
| UBS Group AG | US$391.4万 | 0.00% |
| FMR LLC | US$387.9万 | 0.00% |
| Aberdeen Group plc | US$356.8万 | 0.01% |
| GordonMD Global Investments LP | US$348.9万 | 2.43% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$340.8万 | 0.00% |
| DAFNA Capital Management LLC | US$334.3万 | 0.76% |
| JPMORGAN CHASE & CO | US$318.5万 | 0.00% |
| NORTHERN TRUST CORP | US$313.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$292.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$288.6万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$266.4万 | 0.00% |
| MORGAN STANLEY | US$243.7万 | 0.00% |
| Invesco Ltd. | US$167.0万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$159.6万 | 0.00% |
| TD Asset Management Inc | US$159.2万 | 0.00% |
| Voleon Capital Management LP | US$156.3万 | 0.03% |
| Raiffeisen Bank International AG | US$155.9万 | 0.02% |
| IEQ CAPITAL, LLC | US$149.9万 | 0.01% |
| JANE STREET GROUP, LLC | US$130.7万 | 0.00% |
| ALGERT GLOBAL LLC | US$113.2万 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$104.6万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$98.8万 | 0.00% |
| Bank of New York Mellon Corp | US$96.4万 | 0.00% |
| Creative Planning | US$89.0万 | 0.00% |
| CITIGROUP INC | US$86.2万 | 0.00% |
| XTX Topco Ltd | US$77.0万 | 0.01% |
| Harold Davidson & Associates Inc. | US$70.6万 | 0.34% |
| Rafferty Asset Management, LLC | US$68.9万 | 0.00% |
| Headlands Technologies LLC | US$64.9万 | 0.07% |
| HSBC HOLDINGS PLC | US$63.8万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$61.0万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$59.7万 | 0.00% |
| Point72 Asset Management, L.P. | US$54.0万 | 0.00% |
| Tema ETFs LLC | US$53.5万 | 0.04% |
| Tidal Investments LLC | US$53.5万 | 0.00% |
| RHUMBLINE ADVISERS | US$49.0万 | 0.00% |
| Russell Investments Group, Ltd. | US$44.5万 | 0.00% |
| Virtus Investment Advisers, LLC | US$44.1万 | 0.12% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$43.4万 | 0.00% |
| OpenArc Corporate Advisory, LLC | US$42.0万 | 0.01% |
| LPL Financial LLC | US$42.0万 | 0.00% |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | US$39.4万 | 0.01% |
| BARCLAYS PLC | US$39.2万 | 0.00% |
| Cerity Partners LLC | US$38.4万 | 0.00% |
| Man Group plc | US$37.7万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$37.0万 | 0.02% |
| CWM, LLC | US$35.9万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$35.8万 | 0.00% |
| CHOREO, LLC | US$34.8万 | 0.00% |
| DEUTSCHE BANK AG\ | US$31.3万 | 0.00% |
| PROFUND ADVISORS LLC | US$30.7万 | 0.01% |
| Smartleaf Asset Management LLC | US$30.6万 | 0.01% |
| WINTON GROUP Ltd | US$29.6万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$28.4万 | 0.00% |
| Squarepoint Ops LLC | US$28.4万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$27.8万 | 0.00% |
| Mariner, LLC | US$26.5万 | 0.00% |
| Engineers Gate Manager LP | US$25.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$25.2万 | 0.00% |
| Polymer Capital Management (US) LLC | US$24.6万 | 0.02% |
| NWI MANAGEMENT LP | US$24.4万 | 0.01% |
| Virtu Financial LLC | US$24.1万 | 0.01% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$23.8万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$22.2万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$21.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$21.8万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$21.6万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$21.4万 | 0.00% |
| Quadrature Capital Ltd | US$19.9万 | 0.00% |
| AXQ CAPITAL, LP | US$18.0万 | 0.02% |
| MetLife Investment Management, LLC | US$18.0万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$17.6万 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$17.3万 | 0.03% |
| CANADA LIFE ASSURANCE Co | US$15.8万 | 0.00% |
| ExodusPoint Capital Management, LP | US$15.7万 | 0.00% |
| Brevan Howard Capital Management LP | US$15.2万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$14.1万 | 0.00% |
| ROYAL BANK OF CANADA | US$13.8万 | 0.00% |
| SIMPLEX TRADING, LLC | US$13.0万 | 0.00% |
| SEI INVESTMENTS CO | US$12.7万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$12.3万 | 0.00% |
| CFG Wealth Management Services, Inc. | US$12.2万 | 0.11% |
| Navalign, LLC | US$12.1万 | 0.03% |
| Police & Firemen's Retirement System of New Jersey | US$11.4万 | 0.00% |
| Scientech Research LLC | US$11.3万 | 0.09% |
| R Squared Ltd | US$11.0万 | 0.06% |
| Graham Capital Management, L.P. | US$10.6万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$10.5万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$9.9万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$9.7万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$8.8万 | 0.00% |
| E Fund Management Co., Ltd. | US$8.7万 | 0.00% |
| Vontobel Holding Ltd. | US$8.5万 | 0.00% |
| ProShare Advisors LLC | US$8.0万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$7.4万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$7.3万 | 0.00% |
| BBR PARTNERS, LLC | US$7.1万 | 0.00% |
| Erste Asset Management GmbH | US$7.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$6.8万 | 0.00% |
| Abel Hall, LLC | US$6.5万 | 0.01% |
| Pallas Capital Advisors LLC | US$6.4万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$6.3万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$6.1万 | 0.00% |
| Coastal Bridge Advisors, LLC | US$5.3万 | 0.00% |
| Phoenix Wealth Advisors | US$5.1万 | 0.02% |
| Essential Partners LLC | US$4.7万 | 0.02% |
| HRT FINANCIAL LP | US$4.7万 | 0.00% |
| Focus Partners Wealth | US$4.7万 | 0.00% |
| Dynamic Technology Lab Private Ltd | US$4.4万 | 0.01% |
| Focus Partners Advisor Solutions, LLC | US$4.3万 | 0.00% |
| HORIZON KINETICS ASSET MANAGEMENT LLC | US$4.3万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$4.2万 | 0.00% |
| INVESTMENT HOUSE LLC | US$4.0万 | 0.00% |
| Krilogy Financial LLC | US$4.0万 | 0.00% |
| Integrated Wealth Concepts LLC | US$3.8万 | 0.00% |
| SHIKIAR ASSET MANAGEMENT INC | US$3.8万 | 0.01% |
| SG Americas Securities, LLC | US$3.8万 | 0.00% |
| GAMMA Investing LLC | US$3.7万 | 0.00% |
| Ballentine Partners, LLC | US$3.6万 | 0.00% |
| NEUBERGER BERMAN GROUP LLC | US$3.6万 | 0.00% |
| Hudson Bay Capital Management LP | US$3.6万 | 0.00% |
| SEVEN MILE ADVISORY | US$3.5万 | 0.03% |
| Rockefeller Capital Management L.P. | US$3.4万 | 0.00% |