| FMR LLC | US$21.6亿 | 0.11% |
| MORGAN STANLEY | US$14.4亿 | 0.09% |
| BlackRock, Inc. | US$12.3亿 | 0.02% |
| QVT Financial LP | US$7.0亿 | 51.04% |
| UBS Group AG | US$6.3亿 | 0.09% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5.7亿 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$5.5亿 | 0.03% |
| STATE STREET CORP | US$4.5亿 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3.5亿 | 0.55% |
| GOLDMAN SACHS GROUP INC | US$3.1亿 | 0.04% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.8亿 | 0.02% |
| Two Seas Capital LP | US$2.8亿 | 3.90% |
| FARALLON CAPITAL MANAGEMENT LLC | US$2.7亿 | 1.53% |
| PERCEPTIVE ADVISORS LLC | US$2.3亿 | 4.48% |
| Patient Square Capital LP | US$2.3亿 | 40.13% |
| DIMENSIONAL FUND ADVISORS LP | US$2.1亿 | 0.04% |
| Assenagon Asset Management S.A. | US$2.0亿 | 0.30% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.9亿 | 0.02% |
| VIKING GLOBAL INVESTORS LP | US$1.8亿 | 0.52% |
| Darwin Global Management, Ltd. | US$1.8亿 | 4.76% |
| Invesco Ltd. | US$1.8亿 | 0.03% |
| NATIONAL BANK OF CANADA /FI/ | US$1.7亿 | 0.17% |
| AQR CAPITAL MANAGEMENT LLC | US$1.6亿 | 0.07% |
| Rubric Capital Management LP | US$1.4亿 | 1.47% |
| BAKER BROS. ADVISORS LP | US$1.3亿 | 0.77% |
| NORTHERN TRUST CORP | US$9751.7万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$9577.1万 | 0.01% |
| Qube Research & Technologies Ltd | US$9559.0万 | 0.11% |
| ADAR1 Capital Management, LLC | US$9102.0万 | 5.36% |
| BANK OF AMERICA CORP /DE/ | US$8763.8万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$8579.0万 | 0.04% |
| JENNISON ASSOCIATES LLC | US$8262.4万 | 0.06% |
| VANGUARD FIDUCIARY TRUST CO | US$7786.8万 | 0.02% |
| Affinity Asset Advisors, LLC | US$7756.0万 | 4.01% |
| Bank of New York Mellon Corp | US$7578.2万 | 0.01% |
| CITADEL ADVISORS LLC | US$7543.3万 | 0.01% |
| Pictet Asset Management Holding SA | US$7404.9万 | 0.08% |
| SB INVESTMENT ADVISERS (UK) LTD | US$7400.7万 | 0.96% |
| BlackBarn Capital Partners LP | US$6329.8万 | 5.09% |
| MARSHALL WACE, LLP | US$6224.0万 | 0.06% |
| DME Capital Management, LP | US$5962.9万 | 1.87% |
| Clearbridge Investments, LLC | US$5555.4万 | 0.05% |
| Candriam S.C.A. | US$5545.5万 | 0.29% |
| Integral Health Asset Management, LLC | US$5540.0万 | 2.65% |
| Nuveen, LLC | US$5415.5万 | 0.01% |
| Woodline Partners LP | US$4847.5万 | 0.18% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$4823.9万 | 0.01% |
| MAVERICK CAPITAL LTD | US$4506.6万 | 0.52% |
| PENN DAVIS MCFARLAND INC | US$4411.6万 | 4.32% |
| CITIGROUP INC | US$4404.6万 | 0.02% |
| Polar Capital Holdings Plc | US$4371.9万 | 0.16% |
| Amundi | US$4102.3万 | 0.01% |
| JPMORGAN CHASE & CO | US$4060.6万 | 0.00% |
| Whitefort Capital Management, LP | US$3930.6万 | 11.59% |
| Gotham Asset Management, LLC | US$3922.6万 | 0.12% |
| BARCLAYS PLC | US$3921.9万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$3857.9万 | 0.02% |
| Parkside Financial Bank & Trust | US$3681.8万 | 2.82% |
| BANK OF NOVA SCOTIA | US$3629.8万 | 0.06% |
| JANE STREET GROUP, LLC | US$3298.0万 | 0.00% |
| First Turn Management, LLC | US$3296.6万 | 3.68% |
| RHUMBLINE ADVISERS | US$3083.7万 | 0.03% |
| Ensign Peak Advisors, Inc | US$2822.2万 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | US$2785.3万 | 0.01% |
| Point72 Asset Management, L.P. | US$2700.8万 | 0.03% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2668.3万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$2562.8万 | 0.11% |
| Davern Capital Partners, LP | US$2419.3万 | 6.64% |
| Man Group plc | US$2360.6万 | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2337.9万 | 0.00% |
| ALGERT GLOBAL LLC | US$2292.0万 | 0.34% |
| MILLENNIUM MANAGEMENT LLC | US$2226.5万 | 0.01% |
| Cormorant Asset Management, LP | US$2077.5万 | 1.04% |
| Swiss National Bank | US$2059.3万 | 0.01% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | US$2008.3万 | 0.13% |
| TD Asset Management Inc | US$1981.3万 | 0.02% |
| Russell Investments Group, Ltd. | US$1958.9万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1936.6万 | 0.02% |
| California Public Employees Retirement System | US$1915.4万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$1879.5万 | 0.01% |
| SG Americas Securities, LLC | US$1775.4万 | 0.02% |
| Dorsey Wright & Associates | US$1598.7万 | 1.98% |
| Legal & General Group Plc | US$1554.8万 | 0.00% |
| Retirement Systems of Alabama | US$1531.2万 | 0.05% |
| ALLIANCEBERNSTEIN L.P. | US$1467.7万 | 0.00% |
| Sofinnova Investments, Inc. | US$1324.0万 | 0.50% |
| FIRST TRUST ADVISORS LP | US$1262.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1220.6万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$1214.8万 | 0.00% |
| ING GROEP NV | US$1084.5万 | 0.07% |
| STEMPOINT CAPITAL LP | US$1068.7万 | 2.05% |
| LPL Financial LLC | US$1048.9万 | 0.00% |
| PDT Partners, LLC | US$1042.9万 | 0.62% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$974.7万 | 0.01% |
| DIADEMA PARTNERS LP | US$930.2万 | 1.58% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$902.3万 | 0.02% |
| VOYA INVESTMENT MANAGEMENT LLC | US$871.0万 | 0.01% |
| Impax Asset Management Group plc | US$831.0万 | 0.06% |
| Empowered Funds, LLC | US$792.0万 | 0.05% |
| Nicholas Investment Partners, LP | US$771.2万 | 0.56% |
| Consolidated Portfolio Review Corp | US$766.0万 | 0.70% |
| Pine Ridge Advisers LLC | US$766.0万 | 0.47% |
| Cinctive Capital Management LP | US$760.4万 | 0.50% |
| WELLS FARGO & COMPANY/MN | US$731.2万 | 0.00% |
| Engineers Gate Manager LP | US$710.4万 | 0.09% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$708.9万 | 0.01% |
| XTX Topco Ltd | US$707.5万 | 0.12% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$691.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$652.6万 | 0.01% |
| Pier Capital, LLC | US$629.0万 | 1.04% |
| MetLife Investment Management, LLC | US$613.2万 | 0.03% |
| Caption Management, LLC | US$608.8万 | 0.04% |
| Vanguard Global Advisers, LLC | US$575.4万 | 0.00% |
| PFM Health Sciences, LP | US$574.6万 | 0.52% |
| Erste Asset Management GmbH | US$565.2万 | 0.05% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | US$560.7万 | 0.02% |
| Mariner, LLC | US$560.4万 | 0.01% |
| AMALGAMATED BANK | US$555.3万 | 0.04% |
| MUFG Securities EMEA plc | US$554.0万 | 0.08% |
| CWM, LLC | US$503.9万 | 0.01% |
| Treasurer of the State of North Carolina | US$503.5万 | 0.02% |
| Police & Firemen's Retirement System of New Jersey | US$499.0万 | 0.04% |
| Prosight Management, LP | US$498.6万 | 0.82% |
| Walleye Capital LLC | US$491.4万 | 0.02% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$478.6万 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | US$475.1万 | 0.00% |
| Cetera Investment Advisers | US$469.4万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$443.2万 | 0.01% |
| Rafferty Asset Management, LLC | US$440.0万 | 0.02% |
| Allspring Global Investments Holdings, LLC | US$395.7万 | 0.01% |
| YOUSIF CAPITAL MANAGEMENT, LLC | US$379.4万 | 0.04% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$379.2万 | 0.00% |
| CenterBook Partners LP | US$379.0万 | 0.20% |
| GREAT LAKES ADVISORS, LLC | US$375.3万 | 0.03% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$374.6万 | 0.03% |
| AXQ CAPITAL, LP | US$366.9万 | 0.47% |
| Louisiana State Employees Retirement System | US$362.0万 | 0.06% |
| Artia Global Partners LP | US$359.5万 | 0.72% |
| State of Tennessee, Department of Treasury | US$358.1万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$355.6万 | 0.01% |
| Seven Fleet Capital Management LP | US$355.0万 | 1.13% |
| China Universal Asset Management Co., Ltd. | US$351.8万 | 0.27% |
| BAMCO INC /NY/ | US$346.3万 | 0.01% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$342.3万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$337.7万 | 0.07% |
| Creative Planning | US$336.7万 | 0.00% |
| SEI INVESTMENTS CO | US$333.3万 | 0.00% |
| Anfield Capital Management, LLC | US$330.9万 | 0.91% |
| Illinois Municipal Retirement Fund | US$330.7万 | 0.04% |
| Handelsbanken Fonder AB | US$324.1万 | 0.01% |