| GILEAD SCIENCES, INC. | US$6.8亿 | 32.05% |
| BlackRock, Inc. | US$3.3亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.3亿 | 0.02% |
| STATE STREET CORP | US$1.2亿 | 0.00% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$1.1亿 | 2.78% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$9227.6万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8330.5万 | 0.00% |
| Woodline Partners LP | US$8160.0万 | 0.31% |
| MARSHALL WACE, LLP | US$8124.7万 | 0.08% |
| Siren, L.L.C. | US$6495.3万 | 1.80% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4865.9万 | 0.00% |
| Fisher Asset Management, LLC | US$4731.3万 | 0.02% |
| SAMLYN CAPITAL, LLC | US$4122.2万 | 0.70% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$3574.3万 | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | US$3080.2万 | 0.01% |
| CITADEL ADVISORS LLC | US$3068.1万 | 0.00% |
| Parkman Healthcare Partners LLC | US$2607.7万 | 2.69% |
| Logos Global Management LP | US$2592.0万 | 1.29% |
| FMR LLC | US$2516.9万 | 0.00% |
| MORGAN STANLEY | US$2405.2万 | 0.00% |
| Trails Edge Capital Partners, LP | US$2263.5万 | 5.19% |
| GOLDMAN SACHS GROUP INC | US$2159.5万 | 0.00% |
| Sofinnova Investments, Inc. | US$1993.9万 | 0.76% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1951.9万 | 0.00% |
| NORTHERN TRUST CORP | US$1815.1万 | 0.00% |
| Invesco Ltd. | US$1773.0万 | 0.00% |
| Candriam S.C.A. | US$1707.7万 | 0.09% |
| Aberdeen Group plc | US$1662.7万 | 0.03% |
| BANK OF AMERICA CORP /DE/ | US$1395.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1259.1万 | 0.00% |
| Bank of New York Mellon Corp | US$1104.1万 | 0.00% |
| Decheng Capital LLC | US$1032.1万 | 1.56% |
| Soleus Capital Management, L.P. | US$976.3万 | 0.40% |
| DAFNA Capital Management LLC | US$958.7万 | 2.18% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$929.5万 | 0.04% |
| RENAISSANCE TECHNOLOGIES LLC | US$917.4万 | 0.01% |
| BAKER BROS. ADVISORS LP | US$897.7万 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | US$893.8万 | 0.00% |
| PDT Partners, LLC | US$838.8万 | 0.50% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$818.9万 | 0.01% |
| Hudson Bay Capital Management LP | US$770.1万 | 0.03% |
| TWO SIGMA INVESTMENTS, LP | US$675.4万 | 0.01% |
| Public Sector Pension Investment Board | US$655.2万 | 0.02% |
| UBS Group AG | US$623.9万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$608.4万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$560.3万 | 0.00% |
| Ensign Peak Advisors, Inc | US$546.3万 | 0.01% |
| RHUMBLINE ADVISERS | US$521.6万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$518.3万 | 0.08% |
| DIADEMA PARTNERS LP | US$514.4万 | 0.88% |
| Nuveen, LLC | US$478.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$467.6万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$467.2万 | 0.01% |
| Patient Square Capital LP | US$421.2万 | 0.75% |
| Schonfeld Strategic Advisors LLC | US$418.1万 | 0.03% |
| Legal & General Group Plc | US$407.5万 | 0.00% |
| JANE STREET GROUP, LLC | US$403.7万 | 0.00% |
| Rock Springs Capital Management LP | US$388.8万 | 0.23% |
| Swiss National Bank | US$370.0万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$345.8万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$341.9万 | 0.00% |
| NOMURA HOLDINGS INC | US$303.9万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$295.7万 | 0.00% |
| Jump Financial, LLC | US$293.3万 | 0.04% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$289.9万 | 0.73% |
| Point72 Asset Management, L.P. | US$279.2万 | 0.00% |
| Rafferty Asset Management, LLC | US$248.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$228.5万 | 0.00% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$193.6万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$190.0万 | 0.00% |
| Parallel Advisors, LLC | US$187.0万 | 0.03% |
| CITIGROUP INC | US$186.6万 | 0.00% |
| Tidal Investments LLC | US$186.5万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$186.4万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$186.2万 | 0.04% |
| Knott David M Jr | US$175.5万 | 1.04% |
| Man Group plc | US$174.7万 | 0.00% |
| Russell Investments Group, Ltd. | US$174.6万 | 0.00% |
| BARCLAYS PLC | US$172.8万 | 0.00% |
| JPMORGAN CHASE & CO | US$166.9万 | 0.00% |
| Caption Management, LLC | US$164.2万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$163.8万 | 0.00% |
| Tema ETFs LLC | US$162.5万 | 0.11% |
| DEUTSCHE BANK AG\ | US$159.5万 | 0.00% |
| CANADA LIFE ASSURANCE Co | US$152.7万 | 0.00% |
| Thrivent Financial for Lutherans | US$150.9万 | 0.00% |
| Squarepoint Ops LLC | US$144.0万 | 0.00% |
| Persistent Asset Partners Ltd | US$130.0万 | 0.49% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$127.9万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$120.8万 | 0.00% |
| PROFUND ADVISORS LLC | US$117.0万 | 0.04% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$110.2万 | 0.00% |
| Burkehill Global Management, LP | US$108.0万 | 0.05% |
| SECTORAL ASSET MANAGEMENT INC | US$103.6万 | 0.86% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$101.8万 | 0.00% |
| CANTOR FITZGERALD, L. P. | US$97.2万 | 0.01% |
| MetLife Investment Management, LLC | US$96.8万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$91.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$91.1万 | 0.00% |
| SG Americas Securities, LLC | US$90.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$90.7万 | 0.00% |
| State of Alaska, Department of Revenue | US$90.4万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$88.7万 | 0.01% |
| Qube Research & Technologies Ltd | US$83.3万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$81.6万 | 0.00% |
| Louisiana State Employees Retirement System | US$81.2万 | 0.01% |
| Illinois Municipal Retirement Fund | US$78.3万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$77.2万 | 0.00% |
| SummitTX Capital, L.P. | US$73.9万 | 0.02% |
| State of Tennessee, Department of Treasury | US$72.5万 | 0.00% |
| Creative Planning | US$72.2万 | 0.00% |
| WINTON GROUP Ltd | US$70.9万 | 0.02% |
| Quadrature Capital Ltd | US$69.4万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$68.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$63.9万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$56.3万 | 0.00% |
| Birchview Capital, LP | US$55.9万 | 0.32% |
| AMALGAMATED BANK | US$52.3万 | 0.00% |
| Corient Private Wealth LLC | US$52.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$51.4万 | 0.00% |
| YOUSIF CAPITAL MANAGEMENT, LLC | US$49.8万 | 0.01% |
| LPL Financial LLC | US$49.4万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$49.3万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$48.9万 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$46.0万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$45.8万 | 0.00% |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | US$45.3万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$45.2万 | 0.00% |
| FIFTH THIRD BANCORP | US$43.6万 | 0.00% |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | US$41.9万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$41.7万 | 0.00% |
| Quantinno Capital Management LP | US$37.4万 | 0.00% |
| STRS OHIO | US$36.3万 | 0.00% |
| Aquatic Capital Management LLC | US$33.0万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$32.6万 | 0.00% |
| E Fund Management Co., Ltd. | US$31.3万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$30.3万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$30.2万 | 0.01% |
| Entropy Technologies, LP | US$29.4万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$29.2万 | 0.00% |
| FIRST TRUST ADVISORS LP | US$28.3万 | 0.00% |
| ProShare Advisors LLC | US$28.2万 | 0.00% |
| Rockefeller Capital Management L.P. | US$27.9万 | 0.00% |
| Virtus Investment Advisers, LLC | US$27.4万 | 0.08% |
| Maryland State Retirement & Pension System | US$26.7万 | 0.01% |
| XTX Topco Ltd | US$26.5万 | 0.00% |
| Pictet Asset Management Holding SA | US$24.8万 | 0.00% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$24.2万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$23.3万 | 0.00% |
| SEI INVESTMENTS CO | US$22.2万 | 0.00% |