| FMR LLC | US$3.6亿 | 0.02% |
| Venrock Adviser, LLC | US$2.0亿 | 7.60% |
| Fairmount Funds Management LLC | US$1.8亿 | 13.13% |
| BlackRock, Inc. | US$1.7亿 | 0.00% |
| VIKING GLOBAL INVESTORS LP | US$1.3亿 | 0.37% |
| Paradigm Biocapital Advisors LP | US$1.1亿 | 2.33% |
| RTW INVESTMENTS, LP | US$1.0亿 | 1.00% |
| Deep Track Capital, LP | US$9977.8万 | 1.63% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$9121.5万 | 0.00% |
| STATE STREET CORP | US$7914.0万 | 0.00% |
| Remedium Capital Partners, LLC | US$7679.6万 | 27.31% |
| PERCEPTIVE ADVISORS LLC | US$6844.9万 | 1.34% |
| Polar Capital Holdings Plc | US$5138.9万 | 0.18% |
| CITADEL ADVISORS LLC | US$4995.9万 | 0.01% |
| FRANKLIN RESOURCES INC | US$4924.9万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4684.8万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$3936.1万 | 0.06% |
| Avidity Partners Management LP | US$3729.9万 | 7.55% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3568.2万 | 0.00% |
| Woodline Partners LP | US$2819.8万 | 0.11% |
| Cormorant Asset Management, LP | US$2616.0万 | 1.31% |
| Bellevue Group AG | US$2486.9万 | 0.59% |
| Affinity Asset Advisors, LLC | US$2450.9万 | 1.27% |
| Synergy Asset Management, LLC | US$2335.7万 | 2.48% |
| SR One Capital Management, LP | US$2110.8万 | 2.31% |
| Candriam S.C.A. | US$2016.0万 | 0.10% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1721.1万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1579.2万 | 0.00% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$1535.9万 | 0.06% |
| NORTHERN TRUST CORP | US$1466.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1260.9万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1210.1万 | 0.00% |
| Ikarian Capital, LLC | US$1187.1万 | 0.96% |
| Atika Capital Management LLC | US$1127.7万 | 1.78% |
| UBS Group AG | US$1041.2万 | 0.00% |
| Cable Car Capital, LP | US$981.0万 | 3.39% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$932.1万 | 0.01% |
| Holocene Advisors, LP | US$909.9万 | 0.02% |
| Alyeska Investment Group, L.P. | US$906.8万 | 0.03% |
| GREAT POINT PARTNERS LLC | US$899.2万 | 2.07% |
| JENNISON ASSOCIATES LLC | US$866.6万 | 0.01% |
| MORGAN STANLEY | US$860.6万 | 0.00% |
| PFM Health Sciences, LP | US$853.7万 | 0.78% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$740.2万 | 0.76% |
| Jones Hill Capital LP | US$690.8万 | 1.48% |
| DEUTSCHE BANK AG\ | US$690.6万 | 0.00% |
| Longaeva Partners L.P. | US$671.4万 | 0.25% |
| Moody Aldrich Partners LLC | US$662.5万 | 1.19% |
| Sio Capital Management, LLC | US$649.9万 | 0.93% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$619.8万 | 0.13% |
| WELLINGTON MANAGEMENT GROUP LLP | US$594.6万 | 0.00% |
| Kalehua Capital Management LLC | US$581.4万 | 4.11% |
| DIMENSIONAL FUND ADVISORS LP | US$554.3万 | 0.00% |
| Bank of New York Mellon Corp | US$524.3万 | 0.00% |
| ExodusPoint Capital Management, LP | US$497.1万 | 0.04% |
| BANK OF AMERICA CORP /DE/ | US$490.9万 | 0.00% |
| Invesco Ltd. | US$476.0万 | 0.00% |
| Nuveen, LLC | US$426.4万 | 0.00% |
| BARCLAYS PLC | US$420.5万 | 0.00% |
| Ensign Peak Advisors, Inc | US$389.4万 | 0.01% |
| HighVista Strategies LLC | US$387.1万 | 1.07% |
| TD Asset Management Inc | US$371.3万 | 0.00% |
| Aberdeen Group plc | US$371.2万 | 0.01% |
| B Group, Inc. | US$367.9万 | 2.73% |
| AMERICAN CENTURY COMPANIES INC | US$364.9万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$355.9万 | 0.00% |
| Secure Asset Management, LLC | US$355.2万 | 0.56% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$344.3万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$331.0万 | 0.04% |
| VOYA INVESTMENT MANAGEMENT LLC | US$326.7万 | 0.00% |
| JANE STREET GROUP, LLC | US$324.7万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$311.9万 | 2.23% |
| Palo Alto Investors LP | US$294.2万 | 0.45% |
| Informed Momentum Co LLC | US$294.0万 | 0.34% |
| RHUMBLINE ADVISERS | US$227.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$223.0万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$215.0万 | 0.01% |
| Swiss National Bank | US$210.9万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$209.6万 | 0.05% |
| Voleon Capital Management LP | US$198.8万 | 0.04% |
| Rafferty Asset Management, LLC | US$198.6万 | 0.01% |
| ALPS ADVISORS INC | US$193.3万 | 0.01% |
| Y-Intercept (Hong Kong) Ltd | US$181.1万 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$132.8万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$122.5万 | 0.00% |
| Squarepoint Ops LLC | US$120.0万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$116.1万 | 0.00% |
| SEI INVESTMENTS CO | US$112.0万 | 0.00% |
| GLENMEDE TRUST CO NA | US$106.8万 | 0.01% |
| Vanguard Global Advisers, LLC | US$104.8万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$104.8万 | 0.00% |
| MetLife Investment Management, LLC | US$104.8万 | 0.01% |
| JPMORGAN CHASE & CO | US$103.0万 | 0.00% |
| ADAR1 Capital Management, LLC | US$102.2万 | 0.06% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$101.8万 | 0.00% |
| XTX Topco Ltd | US$99.0万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$95.0万 | 0.00% |
| PROFUND ADVISORS LLC | US$89.9万 | 0.03% |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | US$89.4万 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$88.8万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$82.9万 | 0.00% |
| Brookwood Investment Group LLC | US$78.4万 | 0.10% |
| Legal & General Group Plc | US$78.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$72.7万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$71.6万 | 0.00% |
| Optimize Financial Inc | US$65.9万 | 0.32% |
| Creative Planning | US$62.5万 | 0.00% |
| Resolute Capital Asset Partners LLC | US$61.3万 | 0.32% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$59.8万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$59.4万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$57.2万 | 0.01% |
| AlphaCentric Advisors LLC | US$56.4万 | 0.56% |
| Advisory Services Network, LLC | US$53.0万 | 0.01% |
| CITIGROUP INC | US$50.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$50.1万 | 0.00% |
| Virtus Investment Advisers, LLC | US$44.3万 | 0.12% |
| China Universal Asset Management Co., Ltd. | US$42.1万 | 0.03% |
| KLP KAPITALFORVALTNING AS | US$39.2万 | 0.00% |
| Abacus Wealth Partners, LLC | US$38.3万 | 0.03% |
| ProShare Advisors LLC | US$38.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$36.5万 | 0.00% |
| Orion Porfolio Solutions, LLC | US$35.5万 | 0.00% |
| Allianz Asset Management GmbH | US$34.8万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$32.8万 | 0.00% |
| Archer Investment Corp | US$32.1万 | 0.07% |
| Tidal Investments LLC | US$32.1万 | 0.00% |
| MML INVESTORS SERVICES, LLC | US$30.8万 | 0.00% |
| STIFEL FINANCIAL CORP | US$30.2万 | 0.00% |
| EntryPoint Capital, LLC | US$30.0万 | 0.09% |
| PRUDENTIAL FINANCIAL INC | US$29.6万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$29.3万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$28.7万 | 0.02% |
| Vanguard Investments Australia, Ltd. | US$28.6万 | 0.00% |
| ALGERT GLOBAL LLC | US$25.5万 | 0.00% |
| Quantinno Capital Management LP | US$25.4万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$25.2万 | 0.22% |
| E Fund Management Co., Ltd. | US$25.0万 | 0.01% |
| Soleus Capital Management, L.P. | US$24.5万 | 0.01% |
| PSP Research LLC | US$24.4万 | 0.17% |
| US BANCORP \DE\ | US$23.9万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$22.9万 | 0.00% |
| VARCOV Co. | US$22.9万 | 0.09% |
| AQR CAPITAL MANAGEMENT LLC | US$20.6万 | 0.00% |
| Rock Springs Capital Management LP | US$20.2万 | 0.01% |
| Tower Research Capital LLC (TRC) | US$16.9万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$15.6万 | 0.00% |
| ROYAL BANK OF CANADA | US$15.5万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$15.4万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$12.4万 | 0.00% |
| SIMPLEX TRADING, LLC | US$12.1万 | 0.00% |