| FMR LLC | US$3.6亿 | 0.02% |
| RA CAPITAL MANAGEMENT, L.P. | US$1.6亿 | 1.66% |
| BlackRock, Inc. | US$1.5亿 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.1亿 | 0.02% |
| STATE STREET CORP | US$1.1亿 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$9906.7万 | 0.01% |
| Atlas Venture Life Science Advisors, LLC | US$9679.7万 | 12.25% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8794.5万 | 0.00% |
| Frazier Life Sciences Management, L.P. | US$8662.9万 | 2.23% |
| TCG Crossover Management, LLC | US$8579.9万 | 2.45% |
| JPMORGAN CHASE & CO | US$8335.9万 | 0.01% |
| BVF INC/IL | US$8135.2万 | 2.59% |
| ORBIMED ADVISORS LLC | US$6825.9万 | 1.40% |
| Siren, L.L.C. | US$6319.8万 | 1.75% |
| Woodline Partners LP | US$6127.2万 | 0.23% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4759.5万 | 0.00% |
| Vestal Point Capital, LP | US$4475.8万 | 1.25% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$4200.9万 | 0.50% |
| GOLDMAN SACHS GROUP INC | US$4091.1万 | 0.00% |
| JENNISON ASSOCIATES LLC | US$3902.8万 | 0.03% |
| Logos Global Management LP | US$3580.6万 | 1.79% |
| Assenagon Asset Management S.A. | US$3492.7万 | 0.05% |
| ARMISTICE CAPITAL, LLC | US$3427.2万 | 0.61% |
| Bellevue Group AG | US$2936.9万 | 0.70% |
| Saturn V Capital Management LP | US$2876.8万 | 5.21% |
| Opaleye Management Inc. | US$2691.9万 | 3.55% |
| Palo Alto Investors LP | US$2568.6万 | 3.93% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2529.2万 | 0.42% |
| DIMENSIONAL FUND ADVISORS LP | US$2521.2万 | 0.01% |
| Pictet Asset Management Holding SA | US$2474.5万 | 0.03% |
| Aberdeen Group plc | US$2401.7万 | 0.04% |
| Foresite Capital Management V, LLC | US$2391.8万 | 8.83% |
| BAKER BROS. ADVISORS LP | US$2235.7万 | 0.13% |
| LOOMIS SAYLES & CO L P | US$2028.3万 | 0.03% |
| Caption Management, LLC | US$1918.2万 | 0.11% |
| Checkpoint Capital L.P. | US$1832.9万 | 6.58% |
| Octagon Capital Advisors LP | US$1726.4万 | 1.91% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1606.1万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1581.5万 | 0.00% |
| NORTHERN TRUST CORP | US$1580.6万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1390.3万 | 0.00% |
| Bank of New York Mellon Corp | US$1310.6万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1253.4万 | 1.28% |
| Ensign Peak Advisors, Inc | US$1224.4万 | 0.02% |
| Integral Health Asset Management, LLC | US$1087.0万 | 0.52% |
| BANK OF AMERICA CORP /DE/ | US$1066.4万 | 0.00% |
| Bain Capital Life Sciences Investors, LLC | US$903.1万 | 0.81% |
| CITADEL ADVISORS LLC | US$838.4万 | 0.00% |
| Alyeska Investment Group, L.P. | US$799.3万 | 0.02% |
| Catalio Capital Management, LP | US$786.3万 | 1.64% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$709.0万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$692.4万 | 0.15% |
| UBS Group AG | US$630.6万 | 0.00% |
| DNB Asset Management AS | US$618.7万 | 0.02% |
| MORGAN STANLEY | US$602.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$532.4万 | 0.00% |
| Jump Financial, LLC | US$523.2万 | 0.07% |
| Sofinnova Investments, Inc. | US$500.8万 | 0.19% |
| Freestone Grove Partners LP | US$439.2万 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$436.7万 | 0.00% |
| Nantahala Capital Management, LLC | US$426.2万 | 0.16% |
| iA Global Asset Management Inc. | US$423.6万 | 0.06% |
| Sio Capital Management, LLC | US$416.9万 | 0.60% |
| Casdin Capital, LLC | US$415.6万 | 0.31% |
| KVP Capital Advisors, LP | US$372.5万 | 2.78% |
| MOORE CAPITAL MANAGEMENT, LP | US$369.5万 | 0.08% |
| Rafferty Asset Management, LLC | US$344.4万 | 0.01% |
| SPHERA FUNDS MANAGEMENT LTD. | US$342.3万 | 0.54% |
| NEXTBio Capital Management LP | US$336.7万 | 1.56% |
| Nuveen, LLC | US$328.5万 | 0.00% |
| Burkehill Global Management, LP | US$319.7万 | 0.16% |
| Atle Fund Management AB | US$318.9万 | 1.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$309.7万 | 0.00% |
| Swiss National Bank | US$306.9万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$293.1万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$273.1万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$255.2万 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$251.9万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$243.0万 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | US$223.8万 | 0.15% |
| XTX Topco Ltd | US$220.1万 | 0.04% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$219.8万 | 0.00% |
| BARCLAYS PLC | US$212.7万 | 0.00% |
| RHUMBLINE ADVISERS | US$211.4万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$207.8万 | 0.00% |
| Brevan Howard Capital Management LP | US$204.4万 | 0.02% |
| RENAISSANCE TECHNOLOGIES LLC | US$203.5万 | 0.00% |
| Squarepoint Ops LLC | US$202.7万 | 0.00% |
| ALPS ADVISORS INC | US$198.6万 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$198.2万 | 0.00% |
| Invesco Ltd. | US$195.9万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$194.9万 | 0.00% |
| TD Asset Management Inc | US$194.9万 | 0.00% |
| RTW INVESTMENTS, LP | US$191.8万 | 0.02% |
| VICTORY CAPITAL MANAGEMENT INC | US$186.8万 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$184.0万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$161.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$156.0万 | 0.00% |
| PROFUND ADVISORS LLC | US$153.3万 | 0.06% |
| ALGERT GLOBAL LLC | US$145.0万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$136.7万 | 0.02% |
| Legal & General Group Plc | US$123.9万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$121.4万 | 0.01% |
| Zimmer Partners, LP | US$106.8万 | 0.03% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$105.6万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$103.0万 | 0.00% |
| SEI INVESTMENTS CO | US$99.2万 | 0.00% |
| MetLife Investment Management, LLC | US$96.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$93.9万 | 0.00% |
| Headlands Technologies LLC | US$93.4万 | 0.11% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$91.4万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$90.5万 | 0.00% |
| SummitTX Capital, L.P. | US$88.4万 | 0.03% |
| Vanguard Global Advisers, LLC | US$80.0万 | 0.00% |
| Atom Investors LP | US$77.8万 | 0.06% |
| JANUS HENDERSON GROUP PLC | US$73.9万 | 0.00% |
| SG Americas Securities, LLC | US$71.8万 | 0.00% |
| Man Group plc | US$64.0万 | 0.00% |
| Ghisallo Capital Management LLC | US$63.9万 | 0.02% |
| Engineers Gate Manager LP | US$59.3万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$55.7万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$54.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$53.5万 | 0.04% |
| State of New Jersey Common Pension Fund D | US$53.2万 | 0.00% |
| Lion Point Capital, LP | US$51.8万 | 3.10% |
| PSP Research LLC | US$51.2万 | 0.36% |
| CITIGROUP INC | US$49.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$47.8万 | 0.00% |
| E Fund Management Co., Ltd. | US$43.3万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$42.7万 | 0.00% |
| INCEPTIONR LLC | US$41.5万 | 0.10% |
| EntryPoint Capital, LLC | US$40.7万 | 0.12% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$40.1万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$38.5万 | 0.01% |
| STRS OHIO | US$38.4万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$38.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$37.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$37.5万 | 0.00% |
| ProShare Advisors LLC | US$36.4万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$36.1万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$33.2万 | 0.00% |
| Eleva Capital SAS | US$32.7万 | 0.10% |
| Entropy Technologies, LP | US$30.6万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$28.3万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$27.3万 | 0.00% |
| Fiduciary Trust Co | US$25.9万 | 0.00% |
| AlphaCentric Advisors LLC | US$25.4万 | 0.25% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$25.3万 | 0.00% |
| Virtu Financial LLC | US$24.2万 | 0.01% |
| Creative Planning | US$24.1万 | 0.00% |