| T. Rowe Price Investment Management, Inc. | US$5.6亿 | 0.38% |
| JANUS HENDERSON GROUP PLC | US$2.5亿 | 0.12% |
| BlackRock, Inc. | US$2.1亿 | 0.00% |
| Atlas Venture Life Science Advisors, LLC | US$1.7亿 | 20.95% |
| FMR LLC | US$1.6亿 | 0.01% |
| Orbis Allan Gray Ltd | US$1.2亿 | 0.52% |
| STATE STREET CORP | US$1.2亿 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.2亿 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$8464.6万 | 1.65% |
| FCPM III SERVICES B.V. | US$8420.3万 | 11.66% |
| TCG Crossover Management, LLC | US$8367.3万 | 2.39% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$7545.8万 | 0.00% |
| Vestal Point Capital, LP | US$7252.0万 | 2.03% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6354.3万 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$5756.5万 | 1.02% |
| Frazier Life Sciences Management, L.P. | US$5716.5万 | 1.47% |
| JPMORGAN CHASE & CO | US$5560.2万 | 0.00% |
| ORBIMED ADVISORS LLC | US$5290.1万 | 1.08% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$4221.5万 | 0.00% |
| Siren, L.L.C. | US$4041.4万 | 1.12% |
| Venrock Adviser, LLC | US$3941.3万 | 1.47% |
| FRANKLIN RESOURCES INC | US$3642.5万 | 0.01% |
| Deep Track Capital, LP | US$3626.0万 | 0.59% |
| SAMLYN CAPITAL, LLC | US$3485.6万 | 0.59% |
| GOLDMAN SACHS GROUP INC | US$3124.0万 | 0.00% |
| BRAIDWELL LP | US$3049.5万 | 1.02% |
| Palo Alto Investors LP | US$2996.8万 | 4.58% |
| Sofinnova Investments, Inc. | US$2962.3万 | 1.13% |
| Vivo Capital, LLC | US$2823.7万 | 2.35% |
| BANK OF AMERICA CORP /DE/ | US$2616.7万 | 0.00% |
| Aberdeen Group plc | US$2593.3万 | 0.04% |
| MPM BIOIMPACT LLC | US$2553.0万 | 1.97% |
| Logos Global Management LP | US$2538.2万 | 1.27% |
| Fiera Capital Corp | US$2503.1万 | 0.09% |
| Polar Capital Holdings Plc | US$2464.2万 | 0.09% |
| NORTHERN TRUST CORP | US$2173.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2100.2万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1813.0万 | 0.03% |
| Rock Springs Capital Management LP | US$1762.6万 | 1.04% |
| Saturn V Capital Management LP | US$1752.5万 | 3.17% |
| DIMENSIONAL FUND ADVISORS LP | US$1724.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1717.7万 | 0.00% |
| MORGAN STANLEY | US$1684.3万 | 0.00% |
| Squarepoint Ops LLC | US$1512.4万 | 0.02% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$1490.0万 | 0.15% |
| BAKER BROS. ADVISORS LP | US$1474.8万 | 0.08% |
| Nuveen, LLC | US$1302.3万 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$1221.9万 | 0.32% |
| Artisan Partners Limited Partnership | US$1123.1万 | 0.02% |
| RENAISSANCE TECHNOLOGIES LLC | US$967.4万 | 0.02% |
| TD Asset Management Inc | US$959.6万 | 0.01% |
| STEMPOINT CAPITAL LP | US$917.5万 | 1.76% |
| Ensign Peak Advisors, Inc | US$900.3万 | 0.02% |
| University of Wisconsin Foundation | US$878.8万 | 7.80% |
| ALGERT GLOBAL LLC | US$823.9万 | 0.12% |
| RAYMOND JAMES FINANCIAL INC | US$818.8万 | 0.00% |
| WASATCH ADVISORS LP | US$804.4万 | 0.05% |
| Clearbridge Investments, LLC | US$731.0万 | 0.01% |
| Bank of New York Mellon Corp | US$728.1万 | 0.00% |
| UBS Group AG | US$690.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$604.6万 | 0.01% |
| Fisher Asset Management, LLC | US$585.7万 | 0.00% |
| Catalio Capital Management, LP | US$513.0万 | 1.07% |
| Tetragon Partners GP Ltd | US$468.0万 | 0.91% |
| Qube Research & Technologies Ltd | US$459.0万 | 0.01% |
| Invesco Ltd. | US$451.3万 | 0.00% |
| CITADEL ADVISORS LLC | US$436.1万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$433.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$425.0万 | 0.00% |
| Swiss National Bank | US$413.5万 | 0.00% |
| DEUTSCHE BANK AG\ | US$400.9万 | 0.00% |
| SummitTX Capital, L.P. | US$355.7万 | 0.11% |
| RHUMBLINE ADVISERS | US$339.4万 | 0.00% |
| PDT Partners, LLC | US$331.8万 | 0.20% |
| Rafferty Asset Management, LLC | US$331.7万 | 0.01% |
| HighVista Strategies LLC | US$331.7万 | 0.92% |
| Neo Ivy Capital Management | US$305.9万 | 0.81% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$298.9万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$295.5万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$291.2万 | 0.46% |
| MILLENNIUM MANAGEMENT LLC | US$287.4万 | 0.00% |
| Burkehill Global Management, LP | US$281.0万 | 0.14% |
| Darwin Wealth Management, LLC | US$280.8万 | 0.87% |
| Woodline Partners LP | US$270.8万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$265.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$263.8万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$253.2万 | 0.00% |
| Aegis Wealth Management LLC | US$244.8万 | 1.40% |
| SG Americas Securities, LLC | US$204.2万 | 0.00% |
| Legal & General Group Plc | US$174.9万 | 0.00% |
| Man Group plc | US$173.5万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$157.0万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$152.7万 | 0.00% |
| MARSHALL WACE, LLP | US$150.7万 | 0.00% |
| PROFUND ADVISORS LLC | US$148.9万 | 0.05% |
| MOORE CAPITAL MANAGEMENT, LP | US$142.8万 | 0.03% |
| JANE STREET GROUP, LLC | US$140.7万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$139.7万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$135.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$132.9万 | 0.00% |
| MetLife Investment Management, LLC | US$132.1万 | 0.01% |
| CIBC WORLD MARKET INC. | US$125.5万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$124.3万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$124.0万 | 0.00% |
| ROYAL BANK OF CANADA | US$123.6万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$118.1万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$115.8万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$109.0万 | 0.00% |
| Blackstone Inc. | US$103.5万 | 0.00% |
| Vanguard Global Advisers, LLC | US$102.2万 | 0.00% |
| FIFTH THIRD BANCORP | US$98.3万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$96.1万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$94.6万 | 0.00% |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | US$89.7万 | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | US$88.6万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$86.9万 | 0.07% |
| ADAR1 Capital Management, LLC | US$86.1万 | 0.05% |
| SEI INVESTMENTS CO | US$81.5万 | 0.00% |
| Caption Management, LLC | US$78.9万 | 0.00% |
| XTX Topco Ltd | US$77.4万 | 0.01% |
| Russell Investments Group, Ltd. | US$72.6万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$71.4万 | 0.00% |
| CITIGROUP INC | US$68.5万 | 0.00% |
| Brevan Howard Capital Management LP | US$67.5万 | 0.01% |
| BARCLAYS PLC | US$66.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$65.8万 | 0.01% |
| SEVEN GRAND MANAGERS, LLC | US$63.5万 | 0.04% |
| ARIZONA STATE RETIREMENT SYSTEM | US$57.4万 | 0.00% |
| ASSETMARK, INC | US$56.3万 | 0.00% |
| Creative Planning | US$54.3万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$53.7万 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$53.0万 | 0.04% |
| Vanguard Investments Australia, Ltd. | US$50.3万 | 0.00% |
| Trexquant Investment LP | US$50.1万 | 0.00% |
| Orion Porfolio Solutions, LLC | US$49.0万 | 0.00% |
| ProShare Advisors LLC | US$48.4万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$46.5万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$46.1万 | 0.00% |
| Elevate Capital Advisors, LLC | US$44.6万 | 0.29% |
| Engineers Gate Manager LP | US$44.3万 | 0.01% |
| Atom Investors LP | US$43.7万 | 0.03% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$43.6万 | 0.00% |
| E Fund Management Co., Ltd. | US$41.7万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$37.3万 | 0.00% |
| PSP Research LLC | US$36.3万 | 0.26% |
| Pictet Asset Management Holding SA | US$35.1万 | 0.00% |
| Quantinno Capital Management LP | US$35.0万 | 0.00% |
| Z3 Capital Partners, LLC | US$34.7万 | 0.09% |
| LPL Financial LLC | US$33.3万 | 0.00% |
| Lion Point Capital, LP | US$32.6万 | 1.95% |