| Redmile Group, LLC | US$8060.6万 | 5.34% |
| BlackRock, Inc. | US$6059.9万 | 0.00% |
| FMR LLC | US$5892.1万 | 0.00% |
| BVF INC/IL | US$4818.8万 | 1.54% |
| STATE STREET CORP | US$3833.3万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3300.0万 | 0.00% |
| Bain Capital Life Sciences Investors, LLC | US$2887.8万 | 2.60% |
| Bellevue Group AG | US$2857.1万 | 0.68% |
| MAK CAPITAL ONE LLC | US$2617.1万 | 3.86% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2382.2万 | 0.04% |
| BANK OF AMERICA CORP /DE/ | US$2360.0万 | 0.00% |
| Nuveen, LLC | US$2352.5万 | 0.01% |
| Siren, L.L.C. | US$2193.1万 | 0.61% |
| Balyasny Asset Management L.P. | US$2153.3万 | 0.03% |
| AMERIPRISE FINANCIAL INC | US$1910.8万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1871.8万 | 0.00% |
| Qube Research & Technologies Ltd | US$1725.3万 | 0.02% |
| Palo Alto Investors LP | US$1633.2万 | 2.50% |
| MORGAN STANLEY | US$1515.7万 | 0.00% |
| GREAT POINT PARTNERS LLC | US$1385.0万 | 3.18% |
| Woodline Partners LP | US$1294.8万 | 0.05% |
| Opaleye Management Inc. | US$1291.8万 | 1.70% |
| GOLDMAN SACHS GROUP INC | US$1192.7万 | 0.00% |
| Point72 Asset Management, L.P. | US$1037.0万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$821.6万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$731.2万 | 0.14% |
| UBS Group AG | US$718.0万 | 0.00% |
| Tetragon Partners GP Ltd | US$716.0万 | 1.39% |
| MILLENNIUM MANAGEMENT LLC | US$686.2万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$610.8万 | 0.00% |
| NORTHERN TRUST CORP | US$602.1万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$511.5万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$505.4万 | 0.11% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$500.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$492.3万 | 0.00% |
| CITADEL ADVISORS LLC | US$491.6万 | 0.00% |
| MARSHALL WACE, LLP | US$477.3万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$430.6万 | 0.00% |
| Invesco Ltd. | US$422.7万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$419.6万 | 0.01% |
| Russell Investments Group, Ltd. | US$394.1万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$389.4万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$387.1万 | 0.00% |
| Parkman Healthcare Partners LLC | US$373.4万 | 0.39% |
| Ensign Peak Advisors, Inc | US$346.3万 | 0.01% |
| Longaeva Partners L.P. | US$343.7万 | 0.13% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$323.5万 | 0.04% |
| Ikarian Capital, LLC | US$321.5万 | 0.26% |
| SIRIOS CAPITAL MANAGEMENT L P | US$318.6万 | 0.39% |
| DEUTSCHE BANK AG\ | US$311.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$301.5万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$288.8万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$282.4万 | 0.10% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$275.0万 | 0.28% |
| DIADEMA PARTNERS LP | US$269.3万 | 0.46% |
| Board of Trustees of The Leland Stanford Junior University | US$267.3万 | 0.31% |
| TWO SIGMA INVESTMENTS, LP | US$261.2万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$256.0万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$253.5万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$237.6万 | 0.00% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$230.9万 | 0.03% |
| Trexquant Investment LP | US$223.6万 | 0.02% |
| Bank of New York Mellon Corp | US$218.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$199.6万 | 0.03% |
| JPMORGAN CHASE & CO | US$160.7万 | 0.00% |
| Cinctive Capital Management LP | US$148.8万 | 0.10% |
| Swiss National Bank | US$130.7万 | 0.00% |
| Rafferty Asset Management, LLC | US$112.6万 | 0.00% |
| SEI INVESTMENTS CO | US$112.6万 | 0.00% |
| Rosalind Advisors, Inc. | US$110.8万 | 0.45% |
| IEQ CAPITAL, LLC | US$108.5万 | 0.01% |
| Ishara Investments LP | US$96.5万 | 0.91% |
| Engineers Gate Manager LP | US$96.5万 | 0.01% |
| J. Goldman & Co LP | US$94.6万 | 0.03% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$92.1万 | 0.01% |
| RHUMBLINE ADVISERS | US$88.5万 | 0.00% |
| ALGERT GLOBAL LLC | US$85.8万 | 0.01% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$82.5万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$74.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$72.4万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$68.3万 | 0.00% |
| DAFNA Capital Management LLC | US$65.3万 | 0.15% |
| VICTORY CAPITAL MANAGEMENT INC | US$64.0万 | 0.00% |
| Man Group plc | US$60.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$59.8万 | 0.00% |
| SCS Capital Management LLC | US$54.8万 | 0.01% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$54.2万 | 0.01% |
| JANE STREET GROUP, LLC | US$51.7万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$51.4万 | 0.00% |
| PROFUND ADVISORS LLC | US$50.4万 | 0.02% |
| J. Safra Sarasin Holding AG | US$50.1万 | 0.01% |
| DNB Asset Management AS | US$49.1万 | 0.00% |
| XTX Topco Ltd | US$44.6万 | 0.01% |
| Legal & General Group Plc | US$44.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$44.0万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$43.9万 | 0.00% |
| Persistent Asset Partners Ltd | US$43.2万 | 0.16% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$41.4万 | 0.00% |
| MetLife Investment Management, LLC | US$40.1万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | US$38.9万 | 0.00% |
| Squarepoint Ops LLC | US$37.6万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$34.4万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$32.8万 | 0.00% |
| Brevan Howard Capital Management LP | US$32.4万 | 0.00% |
| AXQ CAPITAL, LP | US$32.2万 | 0.04% |
| China Universal Asset Management Co., Ltd. | US$32.0万 | 0.02% |
| STRS OHIO | US$30.7万 | 0.00% |
| ADAR1 Capital Management, LLC | US$30.5万 | 0.02% |
| Virtus Investment Advisers, LLC | US$30.4万 | 0.08% |
| DRW Securities, LLC | US$30.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$29.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$29.8万 | 0.00% |
| Verdad Advisers, LP | US$29.5万 | 0.33% |
| Mariner, LLC | US$29.5万 | 0.00% |
| EntryPoint Capital, LLC | US$28.5万 | 0.08% |
| BIT Capital GmbH | US$27.7万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$27.6万 | 0.00% |
| Creative Planning | US$25.4万 | 0.00% |
| Allegheny Financial Group | US$23.8万 | 0.03% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$22.6万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$22.6万 | 0.00% |
| CWM, LLC | US$22.0万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$20.0万 | 0.00% |
| FIFTH THIRD BANCORP | US$19.6万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$19.4万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$18.1万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$17.6万 | 0.01% |
| Lido Advisors, LLC | US$17.2万 | 0.00% |
| CITIGROUP INC | US$17.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$16.6万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$16.4万 | 0.00% |
| MIRABELLA FINANCIAL SERVICES LLP | US$15.9万 | 0.02% |
| Virtu Financial LLC | US$15.8万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$14.6万 | 0.00% |
| ProShare Advisors LLC | US$14.2万 | 0.00% |
| E Fund Management Co., Ltd. | US$14.2万 | 0.00% |
| AlphaCentric Advisors LLC | US$13.6万 | 0.14% |
| BARCLAYS PLC | US$13.5万 | 0.00% |
| WINTON GROUP Ltd | US$13.4万 | 0.00% |
| SBI Securities Co., Ltd. | US$12.9万 | 0.00% |
| TD Asset Management Inc | US$12.6万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$12.3万 | 0.00% |
| Cygnus Capital Advisors, LLC | US$12.3万 | 0.08% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$12.3万 | 0.01% |
| CANADA LIFE ASSURANCE Co | US$12.1万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$12.1万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$11.9万 | 0.01% |
| Quarry LP | US$11.8万 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$11.2万 | 0.00% |
| Corient Private Wealth LLC | US$10.9万 | 0.00% |