| ARMISTICE CAPITAL, LLC | US$2.0亿 | 3.56% |
| BlackRock, Inc. | US$1.9亿 | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | US$1.9亿 | 1.10% |
| STATE STREET CORP | US$1.1亿 | 0.00% |
| D. E. Shaw & Co., Inc. | US$9070.4万 | 0.05% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8905.1万 | 0.00% |
| Lynx1 Capital Management LP | US$8834.9万 | 13.96% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$8833.1万 | 0.00% |
| Erste Asset Management GmbH | US$8009.2万 | 0.74% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$5348.0万 | 0.06% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$5265.1万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$5055.7万 | 0.09% |
| T. Rowe Price Investment Management, Inc. | US$5036.5万 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4967.0万 | 0.00% |
| MPM BIOIMPACT LLC | US$4419.1万 | 3.41% |
| Frazier Life Sciences Management, L.P. | US$4249.3万 | 1.09% |
| GW&K Investment Management, LLC | US$4110.1万 | 0.36% |
| DIMENSIONAL FUND ADVISORS LP | US$3894.0万 | 0.01% |
| MORGAN STANLEY | US$3273.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$2846.6万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2766.2万 | 0.00% |
| Rock Springs Capital Management LP | US$2703.6万 | 1.59% |
| CITADEL ADVISORS LLC | US$2602.9万 | 0.00% |
| Nuveen, LLC | US$2443.7万 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2170.1万 | 0.00% |
| SCS Capital Management LLC | US$2073.3万 | 0.22% |
| Foresite Capital Management VI LLC | US$1776.1万 | 3.86% |
| NORTHERN TRUST CORP | US$1722.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$1718.2万 | 0.00% |
| Artisan Partners Limited Partnership | US$1629.0万 | 0.03% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1613.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1522.7万 | 0.04% |
| Vestal Point Capital, LP | US$1522.4万 | 0.43% |
| MARSHALL WACE, LLP | US$1516.0万 | 0.02% |
| Legal & General Group Plc | US$1434.1万 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$1365.3万 | 0.36% |
| Parkman Healthcare Partners LLC | US$1365.1万 | 1.41% |
| VANGUARD FIDUCIARY TRUST CO | US$1292.4万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1010.9万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$931.9万 | 0.20% |
| ALGERT GLOBAL LLC | US$908.1万 | 0.14% |
| TWO SIGMA INVESTMENTS, LP | US$851.3万 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$847.3万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$806.7万 | 0.03% |
| Palo Alto Investors LP | US$722.6万 | 1.11% |
| Seven Fleet Capital Management LP | US$708.9万 | 2.25% |
| Squarepoint Ops LLC | US$706.7万 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$676.8万 | 0.05% |
| Eversept Partners, LP | US$676.6万 | 0.36% |
| HRT FINANCIAL LP | US$661.1万 | 0.02% |
| Qube Research & Technologies Ltd | US$634.9万 | 0.01% |
| Bank of New York Mellon Corp | US$631.9万 | 0.00% |
| GROUP ONE TRADING LLC | US$586.2万 | 0.01% |
| Tetragon Partners GP Ltd | US$557.7万 | 1.08% |
| XTX Topco Ltd | US$544.3万 | 0.09% |
| Invesco Ltd. | US$512.3万 | 0.00% |
| Man Group plc | US$488.2万 | 0.01% |
| Edgestream Partners, L.P. | US$486.2万 | 0.16% |
| CITIGROUP INC | US$483.4万 | 0.00% |
| ADAR1 Capital Management, LLC | US$475.9万 | 0.28% |
| JPMORGAN CHASE & CO | US$448.8万 | 0.00% |
| UBS Group AG | US$448.4万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$438.2万 | 0.02% |
| Exome Asset Management LLC | US$423.1万 | 2.19% |
| AMERICAN CENTURY COMPANIES INC | US$406.8万 | 0.00% |
| Pictet Asset Management Holding SA | US$384.9万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$374.4万 | 0.00% |
| Swiss National Bank | US$368.3万 | 0.00% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$349.0万 | 0.55% |
| Rafferty Asset Management, LLC | US$347.6万 | 0.01% |
| TANG CAPITAL MANAGEMENT LLC | US$338.3万 | 0.17% |
| Knott David M Jr | US$314.8万 | 1.87% |
| Caligan Partners LP | US$304.5万 | 0.20% |
| Trexquant Investment LP | US$254.7万 | 0.02% |
| Woodline Partners LP | US$251.8万 | 0.01% |
| RHUMBLINE ADVISERS | US$248.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$243.1万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$232.0万 | 0.00% |
| Assenagon Asset Management S.A. | US$227.2万 | 0.00% |
| SEI INVESTMENTS CO | US$215.0万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$205.3万 | 0.00% |
| Headlands Technologies LLC | US$200.5万 | 0.23% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$198.4万 | 0.00% |
| SG Americas Securities, LLC | US$193.7万 | 0.00% |
| BARCLAYS PLC | US$177.4万 | 0.00% |
| Hudson Bay Capital Management LP | US$175.3万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$174.9万 | 0.00% |
| DEUTSCHE BANK AG\ | US$170.4万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$169.3万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$167.4万 | 0.00% |
| Capital International Investors | US$164.5万 | 0.00% |
| ALPS ADVISORS INC | US$161.4万 | 0.01% |
| PROFUND ADVISORS LLC | US$154.9万 | 0.06% |
| HARBOR CAPITAL ADVISORS, INC. | US$145.5万 | 0.12% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$139.3万 | 0.00% |
| Russell Investments Group, Ltd. | US$134.3万 | 0.00% |
| NOMURA HOLDINGS INC | US$132.5万 | 0.00% |
| SIMPLEX TRADING, LLC | US$126.7万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$123.4万 | 0.08% |
| AQR CAPITAL MANAGEMENT LLC | US$123.2万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$121.2万 | 0.03% |
| EDGEWOOD MANAGEMENT LLC | US$118.4万 | 0.01% |
| Hennion & Walsh Asset Management, Inc. | US$114.6万 | 0.04% |
| MetLife Investment Management, LLC | US$111.2万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$108.7万 | 0.00% |
| Virtus Investment Advisers, LLC | US$104.7万 | 0.29% |
| Point72 Asset Management, L.P. | US$99.5万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$98.4万 | 0.08% |
| Engineers Gate Manager LP | US$97.8万 | 0.01% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$96.5万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$94.1万 | 0.00% |
| Quantinno Capital Management LP | US$93.3万 | 0.00% |
| Brevan Howard Capital Management LP | US$86.7万 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$86.6万 | 0.01% |
| OAK RIDGE INVESTMENTS LLC | US$84.1万 | 0.06% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$82.5万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$80.5万 | 0.00% |
| TD Asset Management Inc | US$80.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$79.9万 | 0.00% |
| Vanguard Global Advisers, LLC | US$79.0万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$77.0万 | 0.00% |
| Virtu Financial LLC | US$72.4万 | 0.03% |
| Handelsbanken Fonder AB | US$65.4万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$64.7万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$63.8万 | 0.00% |
| Balyasny Asset Management L.P. | US$60.9万 | 0.00% |
| CenterBook Partners LP | US$59.0万 | 0.03% |
| Caitong International Asset Management Co., Ltd | US$54.9万 | 0.10% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$53.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$52.9万 | 0.00% |
| Diversified Trust Co | US$51.8万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$51.3万 | 0.00% |
| PSP Research LLC | US$50.7万 | 0.36% |
| Rockefeller Capital Management L.P. | US$50.3万 | 0.00% |
| Tidal Investments LLC | US$48.6万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$47.5万 | 0.00% |
| AlphaCentric Advisors LLC | US$47.3万 | 0.47% |
| Atria Investments, Inc | US$46.9万 | 0.01% |
| Y-Intercept (Hong Kong) Ltd | US$46.9万 | 0.01% |
| Pale Fire Capital SE | US$46.2万 | 0.04% |
| Vanguard Investments Australia, Ltd. | US$45.8万 | 0.00% |
| Creative Planning | US$45.1万 | 0.00% |
| E Fund Management Co., Ltd. | US$43.7万 | 0.01% |
| COMMERCE BANK | US$42.1万 | 0.00% |
| Caption Management, LLC | US$41.8万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$41.4万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$39.9万 | 0.00% |
| ROYAL BANK OF CANADA | US$39.9万 | 0.00% |
| Aquatic Capital Management LLC | US$38.3万 | 0.01% |
| Gallagher Fiduciary Advisors, LLC | US$37.5万 | 0.01% |