| FMR LLC | US$6.3亿 | 0.03% |
| Avoro Capital Advisors LLC | US$3.4亿 | 3.31% |
| BlackRock, Inc. | US$3.3亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2.8亿 | 0.05% |
| Driehaus Capital Management LLC | US$2.6亿 | 1.92% |
| Polar Capital Holdings Plc | US$2.6亿 | 0.91% |
| JANUS HENDERSON GROUP PLC | US$2.4亿 | 0.12% |
| CITADEL ADVISORS LLC | US$1.7亿 | 0.03% |
| Capital International Investors | US$1.6亿 | 0.04% |
| JPMORGAN CHASE & CO | US$1.1亿 | 0.01% |
| STATE STREET CORP | US$1.0亿 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$9856.6万 | 0.01% |
| Affinity Asset Advisors, LLC | US$9740.1万 | 5.03% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$9395.3万 | 1.11% |
| Holocene Advisors, LP | US$8831.2万 | 0.21% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$8149.6万 | 0.34% |
| Caligan Partners LP | US$8100.5万 | 5.39% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$7803.9万 | 0.09% |
| BRAIDWELL LP | US$7783.1万 | 2.60% |
| Caption Management, LLC | US$7779.9万 | 0.45% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$7731.7万 | 0.01% |
| JENNISON ASSOCIATES LLC | US$7668.9万 | 0.05% |
| Siren, L.L.C. | US$7667.4万 | 2.13% |
| Alyeska Investment Group, L.P. | US$7556.4万 | 0.21% |
| FRANKLIN RESOURCES INC | US$7446.6万 | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6354.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$6289.6万 | 0.02% |
| ORBIMED ADVISORS LLC | US$6163.7万 | 1.26% |
| FEDERATED HERMES, INC. | US$5653.6万 | 0.09% |
| T. Rowe Price Investment Management, Inc. | US$5535.7万 | 0.04% |
| Capital World Investors | US$4885.0万 | 0.01% |
| Commodore Capital LP | US$4797.4万 | 2.78% |
| First Turn Management, LLC | US$4575.5万 | 5.11% |
| GOLDMAN SACHS GROUP INC | US$4476.8万 | 0.01% |
| Rock Springs Capital Management LP | US$4437.0万 | 2.62% |
| Fiera Capital Corp | US$4125.9万 | 0.14% |
| AMERICAN CENTURY COMPANIES INC | US$3950.2万 | 0.02% |
| Pictet Asset Management Holding SA | US$3922.9万 | 0.04% |
| Trails Edge Capital Partners, LP | US$3721.6万 | 8.53% |
| Vestal Point Capital, LP | US$3721.0万 | 1.04% |
| Aberdeen Group plc | US$3546.7万 | 0.06% |
| TWO SIGMA INVESTMENTS, LP | US$3524.4万 | 0.03% |
| MPM BIOIMPACT LLC | US$3423.3万 | 2.64% |
| LOOMIS SAYLES & CO L P | US$3284.9万 | 0.04% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3157.9万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$3157.5万 | 0.06% |
| NORTHERN TRUST CORP | US$3069.1万 | 0.00% |
| Parkman Healthcare Partners LLC | US$2890.3万 | 2.98% |
| Octagon Capital Advisors LP | US$2849.4万 | 3.15% |
| NOVO HOLDINGS A/S | US$2822.8万 | 2.29% |
| Candriam S.C.A. | US$2770.8万 | 0.14% |
| MORGAN STANLEY | US$2754.9万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2733.1万 | 0.04% |
| Logos Global Management LP | US$2616.8万 | 1.31% |
| Bank of New York Mellon Corp | US$2303.5万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2181.6万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$2152.8万 | 0.12% |
| TimesSquare Capital Management, LLC | US$2089.3万 | 0.35% |
| JANE STREET GROUP, LLC | US$2031.6万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$1888.3万 | 0.13% |
| Sofinnova Investments, Inc. | US$1774.8万 | 0.67% |
| RENAISSANCE TECHNOLOGIES LLC | US$1747.4万 | 0.03% |
| Soleus Capital Management, L.P. | US$1698.0万 | 0.69% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1572.4万 | 0.20% |
| BANK OF AMERICA CORP /DE/ | US$1542.5万 | 0.00% |
| ALGERT GLOBAL LLC | US$1536.3万 | 0.23% |
| Redmile Group, LLC | US$1527.4万 | 1.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1479.8万 | 0.03% |
| DAFNA Capital Management LLC | US$1458.2万 | 3.32% |
| Nuveen, LLC | US$1454.0万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$1440.8万 | 1.58% |
| Nicholas Investment Partners, LP | US$1436.9万 | 1.04% |
| Allspring Global Investments Holdings, LLC | US$1396.3万 | 0.02% |
| Duquesne Family Office LLC | US$1387.5万 | 0.41% |
| BARCLAYS PLC | US$1385.2万 | 0.00% |
| Balyasny Asset Management L.P. | US$1360.2万 | 0.02% |
| ADAR1 Capital Management, LLC | US$1331.0万 | 0.78% |
| LMR Partners LLP | US$1325.8万 | 0.03% |
| Patient Square Capital LP | US$1320.0万 | 2.34% |
| MILLENNIUM MANAGEMENT LLC | US$1173.4万 | 0.00% |
| Integral Health Asset Management, LLC | US$1163.0万 | 0.56% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1150.0万 | 1.17% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1099.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1096.2万 | 0.02% |
| NEXTBio Capital Management LP | US$1065.5万 | 4.95% |
| DNB Asset Management AS | US$1053.0万 | 0.04% |
| ExodusPoint Capital Management, LP | US$1008.5万 | 0.08% |
| DEUTSCHE BANK AG\ | US$946.0万 | 0.00% |
| Foresite Capital Management IV, LLC | US$930.4万 | 3.92% |
| Swiss National Bank | US$917.0万 | 0.01% |
| Jump Financial, LLC | US$905.8万 | 0.12% |
| Woodline Partners LP | US$874.0万 | 0.03% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$832.3万 | 0.31% |
| STEMPOINT CAPITAL LP | US$818.5万 | 1.57% |
| NEUBERGER BERMAN GROUP LLC | US$758.5万 | 0.01% |
| Eversept Partners, LP | US$753.5万 | 0.40% |
| Russell Investments Group, Ltd. | US$752.5万 | 0.01% |
| KBC Group NV | US$750.2万 | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | US$738.5万 | 1.17% |
| HSBC HOLDINGS PLC | US$706.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$672.5万 | 0.00% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$672.2万 | 0.08% |
| SEI INVESTMENTS CO | US$665.2万 | 0.01% |
| Granahan Investment Management, LLC | US$607.5万 | 0.29% |
| RHUMBLINE ADVISERS | US$591.9万 | 0.01% |
| Burkehill Global Management, LP | US$581.5万 | 0.29% |
| UBS Group AG | US$579.3万 | 0.00% |
| AXIOM INVESTORS LLC /DE | US$579.0万 | 0.06% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$539.3万 | 0.01% |
| ROYAL BANK OF CANADA | US$525.5万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$515.2万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$496.5万 | 0.09% |
| Aquatic Capital Management LLC | US$460.5万 | 0.13% |
| AMERIPRISE FINANCIAL INC | US$458.8万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$450.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$436.8万 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | US$436.1万 | 0.29% |
| NOMURA HOLDINGS INC | US$436.1万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$433.1万 | 0.00% |
| Legal & General Group Plc | US$427.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$397.5万 | 0.00% |
| ALPS ADVISORS INC | US$393.8万 | 0.02% |
| Trexquant Investment LP | US$391.7万 | 0.03% |
| Informed Momentum Co LLC | US$387.0万 | 0.45% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$383.6万 | 0.00% |
| Artia Global Partners LP | US$378.0万 | 0.76% |
| CASTLEARK MANAGEMENT LLC | US$375.4万 | 0.12% |
| Atika Capital Management LLC | US$348.3万 | 0.55% |
| Invesco Ltd. | US$343.7万 | 0.00% |
| Quantinno Capital Management LP | US$322.4万 | 0.01% |
| Verition Fund Management LLC | US$319.8万 | 0.02% |
| Palo Alto Investors LP | US$298.6万 | 0.46% |
| LAZARD ASSET MANAGEMENT LLC | US$295.1万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$290.6万 | 0.00% |
| HighVista Strategies LLC | US$285.2万 | 0.79% |
| Erste Asset Management GmbH | US$277.8万 | 0.03% |
| MetLife Investment Management, LLC | US$275.3万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$273.5万 | 0.00% |
| Qube Research & Technologies Ltd | US$256.1万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$235.6万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$225.3万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$220.3万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$209.7万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$204.7万 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$194.8万 | 1.53% |
| TLS Advisors LLC | US$180.0万 | 4.27% |
| Calamos Advisors LLC | US$176.6万 | 0.01% |
| Creative Planning | US$173.4万 | 0.00% |
| Handelsbanken Fonder AB | US$173.3万 | 0.01% |
| Corient Private Wealth LLC | US$164.6万 | 0.00% |