| FMR LLC | US$7291.4万 | 0.00% |
| ORBIMED ADVISORS LLC | US$5124.2万 | 1.05% |
| BlackRock, Inc. | US$3033.6万 | 0.00% |
| Decheng Capital LLC | US$2452.4万 | 3.71% |
| ENAVATE SCIENCES GP, LLC | US$2213.7万 | 6.30% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1686.2万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$900.6万 | 0.17% |
| FEDERATED HERMES, INC. | US$881.8万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$855.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$843.6万 | 0.00% |
| SEB Asset Management AB | US$790.6万 | 0.03% |
| Bain Capital Life Sciences Investors, LLC | US$780.5万 | 0.70% |
| Woodline Partners LP | US$748.3万 | 0.03% |
| D. E. Shaw & Co., Inc. | US$738.4万 | 0.00% |
| Parkman Healthcare Partners LLC | US$708.1万 | 0.73% |
| SAMSARA BIOCAPITAL, LLC | US$662.4万 | 0.64% |
| Pictet Asset Management Holding SA | US$660.1万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$654.9万 | 0.00% |
| STATE STREET CORP | US$634.8万 | 0.00% |
| HSBC HOLDINGS PLC | US$576.3万 | 0.00% |
| Qube Research & Technologies Ltd | US$557.4万 | 0.01% |
| MORGAN STANLEY | US$497.3万 | 0.00% |
| JPMORGAN CHASE & CO | US$406.5万 | 0.00% |
| Nantahala Capital Management, LLC | US$360.0万 | 0.13% |
| Altshuler Shaham Ltd | US$342.1万 | 0.06% |
| SPHERA FUNDS MANAGEMENT LTD. | US$322.2万 | 0.51% |
| Propel Bio Management, LLC | US$310.0万 | 1.95% |
| WELLINGTON MANAGEMENT GROUP LLP | US$308.1万 | 0.00% |
| Jump Financial, LLC | US$287.5万 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$284.9万 | 0.00% |
| Alyeska Investment Group, L.P. | US$268.5万 | 0.01% |
| NORTHERN TRUST CORP | US$234.9万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$232.0万 | 0.00% |
| Prosight Management, LP | US$217.0万 | 0.36% |
| UBS Group AG | US$208.1万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$201.7万 | 0.00% |
| XTX Topco Ltd | US$188.3万 | 0.03% |
| Point72 Asset Management, L.P. | US$170.7万 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$166.6万 | 0.00% |
| TCG Crossover Management, LLC | US$163.0万 | 0.05% |
| DEUTSCHE BANK AG\ | US$162.8万 | 0.00% |
| Trexquant Investment LP | US$159.0万 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$145.2万 | 0.01% |
| Boxer Capital Management, LLC | US$135.0万 | 0.18% |
| ALLIANCEBERNSTEIN L.P. | US$84.2万 | 0.00% |
| ExodusPoint Capital Management, LP | US$82.3万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$78.9万 | 0.00% |
| Bank of New York Mellon Corp | US$73.2万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$71.9万 | 0.00% |
| CITADEL ADVISORS LLC | US$70.7万 | 0.00% |
| Simplify Asset Management Inc. | US$70.0万 | 0.01% |
| Nuveen, LLC | US$68.0万 | 0.00% |
| EntryPoint Capital, LLC | US$66.2万 | 0.19% |
| AQR CAPITAL MANAGEMENT LLC | US$65.0万 | 0.00% |
| MARSHALL WACE, LLP | US$60.1万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$55.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$55.8万 | 0.00% |
| Quantinno Capital Management LP | US$44.5万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$43.6万 | 0.00% |
| Swiss National Bank | US$43.3万 | 0.00% |
| Squarepoint Ops LLC | US$40.2万 | 0.00% |
| ALPS ADVISORS INC | US$39.6万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$37.5万 | 0.00% |
| RHUMBLINE ADVISERS | US$37.1万 | 0.00% |
| Invesco Ltd. | US$36.5万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$35.7万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$35.3万 | 0.02% |
| Stonepine Capital Management, LLC | US$31.5万 | 0.13% |
| ADAR1 Capital Management, LLC | US$31.5万 | 0.02% |
| Aquatic Capital Management LLC | US$28.3万 | 0.01% |
| Bleakley Financial Group, LLC | US$26.0万 | 0.00% |
| AXQ CAPITAL, LP | US$24.8万 | 0.03% |
| Mariner, LLC | US$24.6万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$23.8万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$23.8万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$23.6万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$23.3万 | 0.00% |
| BARCLAYS PLC | US$22.2万 | 0.00% |
| DNB Asset Management AS | US$21.2万 | 0.00% |
| Entropy Technologies, LP | US$21.0万 | 0.01% |
| DIADEMA PARTNERS LP | US$19.4万 | 0.03% |
| Man Group plc | US$19.0万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$17.6万 | 0.00% |
| MetLife Investment Management, LLC | US$17.4万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$16.6万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$14.0万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$13.8万 | 0.00% |
| JANE STREET GROUP, LLC | US$13.8万 | 0.00% |
| FRANKLIN RESOURCES INC | US$13.1万 | 0.00% |
| Vanguard Global Advisers, LLC | US$11.8万 | 0.00% |
| Corient Private Wealth LLC | US$10.9万 | 0.00% |
| Creative Planning | US$9.8万 | 0.00% |
| Virtus Investment Advisers, LLC | US$9.0万 | 0.02% |
| Shay Capital LLC | US$9.0万 | 0.01% |
| STRS OHIO | US$8.8万 | 0.00% |
| Legal & General Group Plc | US$8.6万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$8.6万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$8.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$8.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$5.3万 | 0.00% |
| Persistent Asset Partners Ltd | US$4.9万 | 0.02% |
| CITIGROUP INC | US$4.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$3.7万 | 0.00% |
| CWM, LLC | US$3.5万 | 0.00% |
| Russell Investments Group, Ltd. | US$3.3万 | 0.00% |
| Wellington Grp LLC | US$2.7万 | 0.01% |
| Mirae Asset Global Investments Co., Ltd. | US$2.5万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.3万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1.1万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.1万 | 0.00% |
| Larson Financial Group LLC | US$9963.0 | 0.00% |
| Sterling Capital Management LLC | US$9846.0 | 0.00% |
| Versant Capital Management, Inc | US$6858.0 | 0.00% |
| Rockefeller Capital Management L.P. | US$6642.0 | 0.00% |
| GAMMA Investing LLC | US$6435.0 | 0.00% |
| Quantbot Technologies LP | US$5967.0 | 0.00% |
| US BANCORP \DE\ | US$5310.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$5292.0 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$4293.0 | 0.00% |
| Essential Partners LLC | US$3618.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$3501.0 | 0.00% |
| Allworth Financial LP | US$2367.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1998.0 | 0.00% |
| MAI Capital Management | US$1539.0 | 0.00% |
| Torren Management, LLC | US$1458.0 | 0.00% |
| NATIXIS | US$1080.0 | 0.00% |
| N.E.W. Advisory Services LLC | US$1080.0 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$900.0 | 0.00% |
| Wealth Preservation Advisors, LLC | US$774.0 | 0.00% |
| Farther Finance Advisors, LLC | US$754.0 | 0.00% |
| Arax Advisory Partners | US$693.0 | 0.00% |
| SIGNATUREFD, LLC | US$594.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$549.0 | 0.00% |
| Ameritas Advisory Services, LLC | US$279.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$207.0 | 0.00% |
| Root Financial Partners, LLC | US$180.0 | 0.00% |
| SJS Investment Consulting Inc. | US$18.0 | 0.00% |
| Parallel Advisors, LLC | US$18.0 | 0.00% |
| Freestone Grove Partners LP | US$9.0 | 0.00% |
| IFP Advisors, Inc | US$9.0 | 0.00% |
| NOMURA ASSET MANAGEMENT CO LTD | US$0.0 | 0.00% |
| Covestor Ltd | US$0.0 | 0.00% |