| RA CAPITAL MANAGEMENT, L.P. | US$2.0亿 | 2.07% |
| GSK plc | US$1.3亿 | 22.08% |
| BlackRock, Inc. | US$1.0亿 | 0.00% |
| MAVERICK CAPITAL LTD | US$8205.1万 | 0.95% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6310.9万 | 0.01% |
| Driehaus Capital Management LLC | US$3937.5万 | 0.29% |
| FEDERATED HERMES, INC. | US$3855.2万 | 0.06% |
| FMR LLC | US$3764.8万 | 0.00% |
| 683 Capital Management, LLC | US$3552.5万 | 1.85% |
| PRIMECAP MANAGEMENT CO/CA/ | US$3503.9万 | 0.03% |
| M28 Capital Management LP | US$3326.5万 | 61.83% |
| STATE STREET CORP | US$2663.7万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2595.4万 | 0.00% |
| CITADEL ADVISORS LLC | US$2043.2万 | 0.00% |
| Siren, L.L.C. | US$1776.3万 | 0.49% |
| Squarepoint Ops LLC | US$1386.5万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$1361.6万 | 0.01% |
| First Light Asset Management, LLC | US$1336.9万 | 1.20% |
| MARSHALL WACE, LLP | US$1297.7万 | 0.01% |
| Pfizer Inc | US$1193.4万 | 5.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1168.6万 | 0.00% |
| Affinity Asset Advisors, LLC | US$1016.3万 | 0.52% |
| GOLDMAN SACHS GROUP INC | US$1003.1万 | 0.00% |
| MORGAN STANLEY | US$986.7万 | 0.00% |
| RTW INVESTMENTS, LP | US$978.8万 | 0.10% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$954.0万 | 0.01% |
| ALGERT GLOBAL LLC | US$953.8万 | 0.14% |
| EMERALD ADVISERS, LLC | US$914.4万 | 0.29% |
| NORTHERN TRUST CORP | US$862.2万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$855.0万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$852.8万 | 0.00% |
| Pictet Asset Management Holding SA | US$820.2万 | 0.01% |
| Trexquant Investment LP | US$790.0万 | 0.06% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$725.0万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$724.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$704.9万 | 0.00% |
| Kynam Capital Management, LP | US$699.8万 | 0.43% |
| VANGUARD FIDUCIARY TRUST CO | US$637.2万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$596.4万 | 0.03% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$590.5万 | 0.29% |
| SymBiosis Capital Partners, LLC | US$543.8万 | 10.30% |
| Caption Management, LLC | US$515.5万 | 0.03% |
| Nuveen, LLC | US$476.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$452.9万 | 0.01% |
| JPMORGAN CHASE & CO | US$443.7万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | US$435.0万 | 0.22% |
| RENAISSANCE TECHNOLOGIES LLC | US$433.0万 | 0.01% |
| Aberdeen Group plc | US$398.8万 | 0.01% |
| SPHERA FUNDS MANAGEMENT LTD. | US$397.5万 | 0.63% |
| UBS Group AG | US$390.8万 | 0.00% |
| Walleye Capital LLC | US$386.8万 | 0.02% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$376.8万 | 0.08% |
| CITIGROUP INC | US$363.6万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$327.1万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$301.2万 | 0.01% |
| BARCLAYS PLC | US$276.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$272.5万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$271.0万 | 0.00% |
| Bank of New York Mellon Corp | US$261.9万 | 0.00% |
| Jump Financial, LLC | US$261.0万 | 0.03% |
| Woodline Partners LP | US$254.1万 | 0.01% |
| TD Asset Management Inc | US$245.6万 | 0.00% |
| Aquatic Capital Management LLC | US$234.6万 | 0.07% |
| HRT FINANCIAL LP | US$232.9万 | 0.01% |
| Newtyn Management, LLC | US$217.5万 | 0.23% |
| Hudson Bay Capital Management LP | US$215.0万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$212.7万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$209.2万 | 0.01% |
| GSA CAPITAL PARTNERS LLP | US$205.0万 | 0.13% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$199.6万 | 0.50% |
| MOODY ALDRICH PARTNERS LLC | US$197.6万 | 0.36% |
| Privium Fund Management B.V. | US$174.7万 | 0.36% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$174.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$171.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$163.2万 | 0.00% |
| Swiss National Bank | US$159.3万 | 0.00% |
| Balyasny Asset Management L.P. | US$153.0万 | 0.00% |
| Scientech Research LLC | US$145.2万 | 1.21% |
| Invesco Ltd. | US$144.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$142.0万 | 0.02% |
| Sofinnova Investments, Inc. | US$137.2万 | 0.05% |
| CAPITAL FUND MANAGEMENT S.A. | US$132.9万 | 0.01% |
| Caitong International Asset Management Co., Ltd | US$131.2万 | 0.24% |
| Elmind Capital, LP | US$128.9万 | 0.37% |
| J. Goldman & Co LP | US$127.2万 | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$126.4万 | 0.02% |
| Duquesne Family Office LLC | US$125.4万 | 0.04% |
| RHUMBLINE ADVISERS | US$121.5万 | 0.00% |
| F/m Investments LLC | US$119.6万 | 0.08% |
| Y-Intercept (Hong Kong) Ltd | US$113.8万 | 0.02% |
| Qube Research & Technologies Ltd | US$113.0万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$109.0万 | 0.00% |
| Burkehill Global Management, LP | US$108.8万 | 0.05% |
| TWINBEECH CAPITAL LP | US$105.7万 | 0.11% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$105.3万 | 0.00% |
| Advisory Services Network, LLC | US$105.1万 | 0.01% |
| Capstone Capital Management Ltd | US$104.4万 | 1.05% |
| FRED ALGER MANAGEMENT, LLC | US$100.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$98.7万 | 0.00% |
| James J. Burns & Company, LLC | US$83.2万 | 0.11% |
| DEUTSCHE BANK AG\ | US$82.7万 | 0.00% |
| XTX Topco Ltd | US$79.7万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$78.4万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$71.0万 | 0.00% |
| SIMPLEX TRADING, LLC | US$64.7万 | 0.00% |
| Quadrature Capital Ltd | US$62.8万 | 0.01% |
| PEAK6 LLC | US$62.7万 | 0.00% |
| Ikarian Capital, LLC | US$61.8万 | 0.05% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$59.4万 | 0.00% |
| Engineers Gate Manager LP | US$58.2万 | 0.01% |
| SEI INVESTMENTS CO | US$58.1万 | 0.00% |
| Legal & General Group Plc | US$57.3万 | 0.00% |
| a16z Perennial Management, L.P. | US$56.3万 | 0.05% |
| Virtu Financial LLC | US$55.7万 | 0.02% |
| MetLife Investment Management, LLC | US$55.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$54.2万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$52.4万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$50.1万 | 0.00% |
| Handelsbanken Fonder AB | US$47.5万 | 0.00% |
| WINTON GROUP Ltd | US$47.2万 | 0.02% |
| Man Group plc | US$46.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$42.1万 | 0.00% |
| Vanguard Global Advisers, LLC | US$41.0万 | 0.00% |
| Verition Fund Management LLC | US$39.1万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$37.7万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$37.5万 | 0.00% |
| Quantinno Capital Management LP | US$34.7万 | 0.00% |
| Matisse Capital | US$33.9万 | 0.14% |
| Walleye Trading LLC | US$32.7万 | 0.00% |
| ADAR1 Capital Management, LLC | US$32.6万 | 0.02% |
| GLENMEDE TRUST CO NA | US$32.1万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$29.3万 | 0.00% |
| Knott David M Jr | US$29.0万 | 0.17% |
| RAYMOND JAMES FINANCIAL INC | US$28.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$28.6万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$27.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$27.7万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$27.6万 | 0.00% |
| Point72 Asset Management, L.P. | US$26.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$26.0万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$24.2万 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$23.9万 | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | US$23.8万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$22.2万 | 0.00% |
| HighTower Advisors, LLC | US$21.2万 | 0.00% |
| AlphaCentric Advisors LLC | US$21.2万 | 0.21% |
| ProShare Advisors LLC | US$20.8万 | 0.00% |
| Entropy Technologies, LP | US$20.6万 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$20.1万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$20.1万 | 0.00% |