| NEA Management Company, LLC | US$1.6亿 | 8.97% |
| BlackRock, Inc. | US$1.2亿 | 0.00% |
| Frazier Life Sciences Management, L.P. | US$1.2亿 | 3.05% |
| FMR LLC | US$9589.4万 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$6190.6万 | 0.01% |
| Vivo Capital, LLC | US$6077.9万 | 5.05% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5939.4万 | 0.00% |
| MARSHALL WACE, LLP | US$4731.5万 | 0.05% |
| Rubric Capital Management LP | US$4428.9万 | 0.47% |
| MPM BIOIMPACT LLC | US$3935.0万 | 3.04% |
| VIKING GLOBAL INVESTORS LP | US$3816.0万 | 0.11% |
| ALLIANCEBERNSTEIN L.P. | US$3562.5万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3315.0万 | 0.00% |
| STATE STREET CORP | US$3179.7万 | 0.00% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$3128.4万 | 0.52% |
| ORBIMED ADVISORS LLC | US$2928.1万 | 0.60% |
| Logos Global Management LP | US$2863.2万 | 1.43% |
| Vestal Point Capital, LP | US$2584.6万 | 0.72% |
| ACORN CAPITAL ADVISORS, LLC | US$2558.8万 | 7.27% |
| Artia Global Partners LP | US$2402.2万 | 4.81% |
| Affinity Asset Advisors, LLC | US$2386.2万 | 1.23% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$2379.2万 | 0.24% |
| EMERALD ADVISERS, LLC | US$2194.6万 | 0.69% |
| Siren, L.L.C. | US$2131.7万 | 0.59% |
| RAYMOND JAMES FINANCIAL INC | US$2093.8万 | 0.01% |
| Pictet Asset Management Holding SA | US$2035.3万 | 0.02% |
| Soleus Capital Management, L.P. | US$1932.7万 | 0.78% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$1853.6万 | 6.63% |
| Octagon Capital Advisors LP | US$1771.6万 | 1.96% |
| CITADEL ADVISORS LLC | US$1614.6万 | 0.00% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$1506.2万 | 0.73% |
| GOLDMAN SACHS GROUP INC | US$1464.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$1451.8万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$1363.5万 | 1.50% |
| FLPUTNAM INVESTMENT MANAGEMENT CO | US$1268.5万 | 0.19% |
| Woodline Partners LP | US$1193.9万 | 0.05% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1155.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1002.8万 | 0.00% |
| NORTHERN TRUST CORP | US$962.3万 | 0.00% |
| Candriam S.C.A. | US$922.9万 | 0.05% |
| MORGAN STANLEY | US$872.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$852.6万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$746.3万 | 0.03% |
| SPHERA FUNDS MANAGEMENT LTD. | US$684.8万 | 1.09% |
| MILLENNIUM MANAGEMENT LLC | US$681.2万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$675.3万 | 0.00% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$632.8万 | 0.23% |
| Burkehill Global Management, LP | US$626.3万 | 0.31% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$609.8万 | 0.62% |
| AMERIPRISE FINANCIAL INC | US$602.3万 | 0.00% |
| Balyasny Asset Management L.P. | US$565.3万 | 0.01% |
| Ensign Peak Advisors, Inc | US$554.4万 | 0.01% |
| UBS Group AG | US$532.3万 | 0.00% |
| KVP Capital Advisors, LP | US$493.9万 | 3.69% |
| Jones Hill Capital LP | US$441.6万 | 0.95% |
| Caption Management, LLC | US$429.5万 | 0.03% |
| Invesco Ltd. | US$421.1万 | 0.00% |
| Opaleye Management Inc. | US$411.7万 | 0.54% |
| GMT Capital Corp | US$379.0万 | 0.17% |
| Swiss Life Asset Management Ltd | US$366.5万 | 0.02% |
| JANE STREET GROUP, LLC | US$315.2万 | 0.00% |
| Bank of New York Mellon Corp | US$310.4万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$300.1万 | 2.14% |
| J. Goldman & Co LP | US$282.7万 | 0.08% |
| F/m Investments LLC | US$276.3万 | 0.18% |
| Propel Bio Management, LLC | US$264.7万 | 1.67% |
| Nuveen, LLC | US$224.5万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$216.3万 | 0.00% |
| Swiss National Bank | US$200.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$183.9万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$160.7万 | 0.00% |
| TRUST CO OF TOLEDO NA /OH/ | US$156.9万 | 0.15% |
| FIFTH THIRD BANCORP | US$153.1万 | 0.00% |
| RHUMBLINE ADVISERS | US$130.1万 | 0.00% |
| Squarepoint Ops LLC | US$124.0万 | 0.00% |
| OPPENHEIMER & CO INC | US$119.3万 | 0.01% |
| LMR Partners LLP | US$119.3万 | 0.00% |
| CITIGROUP INC | US$119.2万 | 0.00% |
| WEXFORD CAPITAL LP | US$108.3万 | 0.16% |
| DEUTSCHE BANK AG\ | US$101.1万 | 0.00% |
| Erste Asset Management GmbH | US$100.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$99.5万 | 0.00% |
| LPL Financial LLC | US$96.5万 | 0.00% |
| ExodusPoint Capital Management, LP | US$95.3万 | 0.01% |
| PFS Partners, LLC | US$94.2万 | 0.43% |
| SECTORAL ASSET MANAGEMENT INC | US$93.9万 | 0.78% |
| SEI INVESTMENTS CO | US$93.3万 | 0.00% |
| Russell Investments Group, Ltd. | US$81.3万 | 0.00% |
| JPMORGAN CHASE & CO | US$79.0万 | 0.00% |
| Simplify Asset Management Inc. | US$78.0万 | 0.01% |
| MAI Capital Management | US$77.7万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$77.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$77.0万 | 0.00% |
| Legal & General Group Plc | US$76.1万 | 0.00% |
| WealthTrust Axiom LLC | US$73.4万 | 0.18% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$73.1万 | 0.02% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$71.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$70.3万 | 0.00% |
| BARCLAYS PLC | US$63.9万 | 0.00% |
| HighVista Strategies LLC | US$63.9万 | 0.18% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$63.5万 | 0.00% |
| MetLife Investment Management, LLC | US$61.8万 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$61.5万 | 0.00% |
| Harbour Capital Advisors, LLC | US$60.2万 | 0.11% |
| Checkpoint Capital L.P. | US$59.7万 | 0.21% |
| FRANKLIN RESOURCES INC | US$59.5万 | 0.00% |
| Creative Planning | US$54.7万 | 0.00% |
| BIT Capital GmbH | US$53.7万 | 0.03% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$53.5万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$52.9万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$52.0万 | 0.00% |
| Campbell & CO Investment Adviser LLC | US$47.8万 | 0.03% |
| Z3 Capital Partners, LLC | US$47.2万 | 0.12% |
| TWO SIGMA INVESTMENTS, LP | US$45.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$45.4万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$44.3万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$43.5万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$39.1万 | 0.03% |
| ROYAL BANK OF CANADA | US$38.9万 | 0.00% |
| Optimize Financial Inc | US$38.0万 | 0.19% |
| UNITED BANK | US$37.2万 | 0.05% |
| PSP Research LLC | US$35.8万 | 0.25% |
| State of New Jersey Common Pension Fund D | US$34.8万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$33.6万 | 0.00% |
| SG Americas Securities, LLC | US$33.5万 | 0.00% |
| Persistent Asset Partners Ltd | US$33.3万 | 0.12% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$33.1万 | 0.00% |
| Seven Fleet Capital Management LP | US$32.4万 | 0.10% |
| GROUP ONE TRADING LLC | US$30.9万 | 0.00% |
| STIFEL FINANCIAL CORP | US$30.7万 | 0.00% |
| XTX Topco Ltd | US$29.5万 | 0.01% |
| IMC-Chicago, LLC | US$29.0万 | 0.00% |
| AlphaCentric Advisors LLC | US$28.6万 | 0.29% |
| Police & Firemen's Retirement System of New Jersey | US$28.4万 | 0.00% |
| Diversified Trust Co | US$28.0万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$27.9万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$26.1万 | 0.00% |
| DIADEMA PARTNERS LP | US$25.8万 | 0.04% |
| PROFUND ADVISORS LLC | US$25.2万 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$24.9万 | 0.00% |
| SIMPLEX TRADING, LLC | US$24.2万 | 0.00% |
| CHAPIN DAVIS, INC. | US$24.0万 | 0.05% |
| ProShare Advisors LLC | US$23.4万 | 0.00% |
| Brevan Howard Capital Management LP | US$22.5万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$21.8万 | 0.00% |
| HSBC HOLDINGS PLC | US$20.5万 | 0.00% |
| NBC SECURITIES, INC. | US$20.3万 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | US$19.2万 | 0.00% |
| Kingsview Wealth Management, LLC | US$18.8万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$17.6万 | 0.00% |