| FMR LLC | US$5.9亿 | 0.03% |
| BlackRock, Inc. | US$2.8亿 | 0.00% |
| RTW INVESTMENTS, LP | US$2.1亿 | 2.09% |
| Fairmount Funds Management LLC | US$2.0亿 | 14.64% |
| PERCEPTIVE ADVISORS LLC | US$1.9亿 | 3.73% |
| Venrock Adviser, LLC | US$1.9亿 | 6.94% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.5亿 | 0.00% |
| Driehaus Capital Management LLC | US$1.4亿 | 1.03% |
| STATE STREET CORP | US$1.3亿 | 0.00% |
| Paradigm Biocapital Advisors LP | US$9872.4万 | 2.02% |
| Commodore Capital LP | US$9646.0万 | 5.58% |
| TCG Crossover Management, LLC | US$9586.5万 | 2.74% |
| TANG CAPITAL MANAGEMENT LLC | US$9544.3万 | 4.85% |
| WELLINGTON MANAGEMENT GROUP LLP | US$9204.3万 | 0.02% |
| Capital International Investors | US$8807.5万 | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | US$8681.9万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$8358.7万 | 0.04% |
| RA CAPITAL MANAGEMENT, L.P. | US$8179.5万 | 0.87% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$8064.1万 | 0.01% |
| Remedium Capital Partners, LLC | US$7345.2万 | 26.13% |
| Affinity Asset Advisors, LLC | US$6452.0万 | 3.33% |
| BANK OF AMERICA CORP /DE/ | US$6194.5万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$5044.0万 | 0.29% |
| BRAIDWELL LP | US$4705.2万 | 1.57% |
| FRANKLIN RESOURCES INC | US$4453.0万 | 0.01% |
| JPMORGAN CHASE & CO | US$4448.0万 | 0.00% |
| Caligan Partners LP | US$4429.3万 | 2.95% |
| Siren, L.L.C. | US$4129.0万 | 1.14% |
| Polar Capital Holdings Plc | US$3999.1万 | 0.14% |
| UBS Group AG | US$3385.7万 | 0.01% |
| Capital World Investors | US$3362.1万 | 0.00% |
| EMERALD ADVISERS, LLC | US$3093.8万 | 0.98% |
| Candriam S.C.A. | US$3078.3万 | 0.16% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2951.4万 | 0.00% |
| NORTHERN TRUST CORP | US$2920.0万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2838.0万 | 0.00% |
| Pictet Asset Management Holding SA | US$2479.9万 | 0.03% |
| VANGUARD FIDUCIARY TRUST CO | US$2343.7万 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$2058.5万 | 1.00% |
| SAMLYN CAPITAL, LLC | US$2000.8万 | 0.34% |
| ADAR1 Capital Management, LLC | US$1706.5万 | 1.00% |
| Blackstone Inc. | US$1477.1万 | 0.06% |
| VICTORY CAPITAL MANAGEMENT INC | US$1473.5万 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$1361.6万 | 0.00% |
| Woodline Partners LP | US$1341.2万 | 0.05% |
| MORGAN STANLEY | US$1244.5万 | 0.00% |
| Caption Management, LLC | US$1199.5万 | 0.07% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1045.7万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$973.6万 | 0.13% |
| Bank of New York Mellon Corp | US$965.4万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$941.3万 | 0.96% |
| FIRST TRUST ADVISORS LP | US$899.8万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$859.4万 | 0.01% |
| STEMPOINT CAPITAL LP | US$845.4万 | 1.62% |
| AMERIPRISE FINANCIAL INC | US$803.1万 | 0.00% |
| Nuveen, LLC | US$776.3万 | 0.00% |
| Ensign Peak Advisors, Inc | US$749.2万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$739.6万 | 0.00% |
| HighVista Strategies LLC | US$737.8万 | 2.04% |
| MARSHALL WACE, LLP | US$702.4万 | 0.01% |
| TD Asset Management Inc | US$693.0万 | 0.01% |
| Invesco Ltd. | US$667.8万 | 0.00% |
| DEUTSCHE BANK AG\ | US$651.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$648.0万 | 0.00% |
| CITADEL ADVISORS LLC | US$622.6万 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$610.0万 | 0.11% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$569.2万 | 0.00% |
| B Group, Inc. | US$504.4万 | 3.74% |
| SEVEN GRAND MANAGERS, LLC | US$504.4万 | 0.34% |
| F/m Investments LLC | US$501.7万 | 0.33% |
| Swiss National Bank | US$486.7万 | 0.00% |
| ExodusPoint Capital Management, LP | US$439.2万 | 0.04% |
| RHUMBLINE ADVISERS | US$429.3万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$358.6万 | 0.01% |
| Atle Fund Management AB | US$348.6万 | 1.13% |
| Rockefeller Capital Management L.P. | US$322.8万 | 0.01% |
| ALPS ADVISORS INC | US$322.5万 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$300.4万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$299.9万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$298.8万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$289.3万 | 0.00% |
| Rafferty Asset Management, LLC | US$287.1万 | 0.01% |
| Balyasny Asset Management L.P. | US$279.8万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$272.2万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$267.8万 | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | US$240.6万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$232.3万 | 0.00% |
| BARCLAYS PLC | US$230.9万 | 0.00% |
| Legal & General Group Plc | US$225.9万 | 0.00% |
| MetLife Investment Management, LLC | US$193.7万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$181.2万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$167.6万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$167.5万 | 0.00% |
| Vanguard Global Advisers, LLC | US$157.1万 | 0.00% |
| Cinctive Capital Management LP | US$138.4万 | 0.09% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$133.8万 | 0.00% |
| PROFUND ADVISORS LLC | US$131.4万 | 0.05% |
| Waverly Advisors, LLC | US$131.0万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$130.1万 | 0.01% |
| XTX Topco Ltd | US$123.3万 | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$112.3万 | 0.00% |
| Ellsworth Advisors, LLC | US$110.8万 | 0.21% |
| AQR CAPITAL MANAGEMENT LLC | US$105.3万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$99.6万 | 0.00% |
| Seven Fleet Capital Management LP | US$99.3万 | 0.32% |
| Assenagon Asset Management S.A. | US$94.1万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$92.6万 | 0.01% |
| Global Endowment Management, LP | US$91.7万 | 0.10% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$85.1万 | 0.02% |
| State of New Jersey Common Pension Fund D | US$84.3万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$82.9万 | 0.01% |
| Creative Planning | US$78.1万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$70.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$70.3万 | 0.05% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$70.1万 | 0.00% |
| ProShare Advisors LLC | US$68.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$67.8万 | 0.00% |
| SG Americas Securities, LLC | US$67.6万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$64.6万 | 0.00% |
| BROWN ADVISORY INC | US$62.5万 | 0.00% |
| CITIGROUP INC | US$60.6万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$55.0万 | 0.00% |
| Russell Investments Group, Ltd. | US$50.1万 | 0.00% |
| Carlyle Group Inc. | US$48.5万 | 0.00% |
| Man Group plc | US$48.2万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$45.8万 | 0.01% |
| SEI INVESTMENTS CO | US$45.3万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$44.3万 | 0.01% |
| Bridgefront Capital, LLC | US$43.6万 | 0.11% |
| TUDOR INVESTMENT CORP ET AL | US$42.2万 | 0.00% |
| RWC Asset Management LLP | US$41.2万 | 0.02% |
| Virtus Investment Advisers, LLC | US$40.9万 | 0.11% |
| Virtu Financial LLC | US$40.8万 | 0.02% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$38.0万 | 0.00% |
| E Fund Management Co., Ltd. | US$36.1万 | 0.01% |
| Scientech Research LLC | US$35.8万 | 0.30% |
| TWO SIGMA SECURITIES, LLC | US$34.6万 | 0.04% |
| AlphaCentric Advisors LLC | US$33.5万 | 0.33% |
| XPONANCE LLC | US$32.5万 | 0.00% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$31.7万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$31.0万 | 0.28% |
| High Net Worth Advisory Group LLC | US$30.3万 | 0.07% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$29.5万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$28.2万 | 0.01% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$26.2万 | 0.02% |
| PSP Research LLC | US$26.0万 | 0.18% |
| Persistent Asset Partners Ltd | US$24.2万 | 0.09% |
| Quantinno Capital Management LP | US$23.0万 | 0.00% |
| STRS OHIO | US$22.7万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$22.2万 | 0.00% |