| FMR LLC | US$2.2亿 | 0.01% |
| TRV GP V, LLC | US$2.2亿 | 55.68% |
| ARCH Venture Management, LLC | US$1.2亿 | 17.23% |
| Capital International Investors | US$9693.6万 | 0.02% |
| Cormorant Asset Management, LP | US$9254.1万 | 4.65% |
| GOLDMAN SACHS GROUP INC | US$9206.3万 | 0.01% |
| BlackRock, Inc. | US$7841.1万 | 0.00% |
| Sofinnova Investments, Inc. | US$5958.9万 | 2.26% |
| JOHNSON & JOHNSON | US$5583.8万 | 8.56% |
| Polar Capital Holdings Plc | US$5139.3万 | 0.18% |
| BAKER BROS. ADVISORS LP | US$4840.8万 | 0.28% |
| Vestal Point Capital, LP | US$4494.0万 | 1.26% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4146.2万 | 0.00% |
| TRV GP VI, LLC | US$3032.7万 | 22.37% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2875.1万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2711.2万 | 0.00% |
| STATE STREET CORP | US$2376.6万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2258.3万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$2208.3万 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$2108.7万 | 0.41% |
| Siren, L.L.C. | US$2007.2万 | 0.56% |
| T. Rowe Price Investment Management, Inc. | US$1941.9万 | 0.01% |
| Capital World Investors | US$1679.0万 | 0.00% |
| Sio Capital Management, LLC | US$1147.7万 | 1.65% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1004.1万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$999.9万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$805.5万 | 0.17% |
| Burkehill Global Management, LP | US$782.3万 | 0.39% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$750.7万 | 0.00% |
| NORTHERN TRUST CORP | US$744.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$702.5万 | 0.00% |
| Ensign Peak Advisors, Inc | US$607.7万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$592.2万 | 0.00% |
| Candriam S.C.A. | US$581.8万 | 0.03% |
| D. E. Shaw & Co., Inc. | US$549.0万 | 0.00% |
| Invesco Ltd. | US$537.4万 | 0.00% |
| MORGAN STANLEY | US$519.3万 | 0.00% |
| UBS Group AG | US$474.9万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$469.4万 | 0.01% |
| Artia Global Partners LP | US$433.4万 | 0.87% |
| Freestone Grove Partners LP | US$399.8万 | 0.03% |
| PRUDENTIAL FINANCIAL INC | US$359.3万 | 0.00% |
| Swedbank AB | US$354.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$346.8万 | 0.00% |
| TD Asset Management Inc | US$310.0万 | 0.00% |
| CITIGROUP INC | US$246.6万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$244.8万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$235.8万 | 0.00% |
| DAFNA Capital Management LLC | US$234.7万 | 0.53% |
| VOYA INVESTMENT MANAGEMENT LLC | US$228.3万 | 0.00% |
| Bank of New York Mellon Corp | US$226.3万 | 0.00% |
| Nuveen, LLC | US$223.7万 | 0.00% |
| Swiss National Bank | US$176.8万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$176.1万 | 0.00% |
| XTX Topco Ltd | US$149.9万 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$139.8万 | 0.00% |
| ALPS ADVISORS INC | US$121.7万 | 0.01% |
| Y-Intercept (Hong Kong) Ltd | US$112.1万 | 0.02% |
| RHUMBLINE ADVISERS | US$108.1万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$104.6万 | 0.00% |
| Russell Investments Group, Ltd. | US$103.0万 | 0.00% |
| SEI INVESTMENTS CO | US$96.4万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$87.9万 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | US$83.5万 | 0.69% |
| AQR CAPITAL MANAGEMENT LLC | US$79.8万 | 0.00% |
| DEUTSCHE BANK AG\ | US$75.6万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$74.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$71.3万 | 0.01% |
| Trexquant Investment LP | US$65.7万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$58.0万 | 0.00% |
| Vanguard Global Advisers, LLC | US$53.9万 | 0.00% |
| Legal & General Group Plc | US$53.7万 | 0.00% |
| MetLife Investment Management, LLC | US$50.1万 | 0.00% |
| Creative Planning | US$48.6万 | 0.00% |
| VARCOV Co. | US$48.4万 | 0.18% |
| Optimize Financial Inc | US$45.9万 | 0.23% |
| AMERIPRISE FINANCIAL INC | US$45.6万 | 0.00% |
| JPMORGAN CHASE & CO | US$43.9万 | 0.00% |
| PSP Research LLC | US$43.8万 | 0.31% |
| JANUS HENDERSON GROUP PLC | US$43.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$42.6万 | 0.00% |
| Allianz Asset Management GmbH | US$41.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$37.7万 | 0.03% |
| ACADIAN ASSET MANAGEMENT LLC | US$36.7万 | 0.00% |
| Walleye Capital LLC | US$34.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$34.8万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$34.4万 | 0.00% |
| CATALYST PRIVATE WEALTH, LLC | US$31.3万 | 0.17% |
| Soleus Capital Management, L.P. | US$31.3万 | 0.01% |
| GSA CAPITAL PARTNERS LLP | US$31.1万 | 0.02% |
| State of New Jersey Common Pension Fund D | US$30.6万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$30.4万 | 0.00% |
| BARCLAYS PLC | US$30.1万 | 0.00% |
| CLEAR WAVE WEALTH MANAGEMENT LLC | US$29.7万 | 0.06% |
| STIFEL FINANCIAL CORP | US$28.2万 | 0.00% |
| Virtus Investment Advisers, LLC | US$28.2万 | 0.08% |
| ARIZONA STATE RETIREMENT SYSTEM | US$24.6万 | 0.00% |
| Verition Fund Management LLC | US$23.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$23.4万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$22.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$22.0万 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$21.5万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$21.1万 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$20.7万 | 0.00% |
| Quantbot Technologies LP | US$20.3万 | 0.01% |
| AlphaCentric Advisors LLC | US$20.1万 | 0.20% |
| ProShare Advisors LLC | US$20.0万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$18.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$11.9万 | 0.00% |
| SG Americas Securities, LLC | US$11.8万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$7.8万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$7.2万 | 0.00% |
| STRS OHIO | US$6.6万 | 0.00% |
| CWM, LLC | US$4.6万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$4.2万 | 0.00% |
| Tidemark, LLC | US$3.4万 | 0.01% |
| GF FUND MANAGEMENT CO. LTD. | US$3.3万 | 0.00% |
| Sterling Capital Management LLC | US$3.1万 | 0.00% |
| KBC Group NV | US$3.0万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.6万 | 0.00% |
| GAMMA Investing LLC | US$1.2万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1.1万 | 0.00% |
| SIMPLEX TRADING, LLC | US$1.1万 | 0.00% |
| ROYAL BANK OF CANADA | US$7000.0 | 0.00% |
| SIGNATUREFD, LLC | US$6414.0 | 0.00% |
| Optiver Holding B.V. | US$6383.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$6164.0 | 0.00% |
| MassMutual Private Wealth & Trust, FSB | US$5100.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$4599.0 | 0.00% |
| FEDERATED HERMES, INC. | US$4474.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$3630.0 | 0.00% |
| Larson Financial Group LLC | US$3192.0 | 0.00% |
| SBI Securities Co., Ltd. | US$1971.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$1784.0 | 0.00% |
| Cornerstone Financial Management LLC | US$1533.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1502.0 | 0.00% |
| True Wealth Design, LLC | US$1377.0 | 0.00% |
| Essential Partners LLC | US$1252.0 | 0.00% |
| Versant Capital Management, Inc | US$845.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$626.0 | 0.00% |
| Sunbelt Securities, Inc. | US$344.0 | 0.00% |
| MAI Capital Management | US$188.0 | 0.00% |
| US BANCORP \DE\ | US$156.0 | 0.00% |
| Allworth Financial LP | US$126.0 | 0.00% |
| IFP Advisors, Inc | US$94.0 | 0.00% |
| Covestor Ltd | US$0.0 | 0.00% |