| Merck & Co., Inc. | US$8946.6万 | 25.60% |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | US$5198.4万 | 5.26% |
| ARK Investment Management LLC | US$5060.4万 | 0.39% |
| AMERIPRISE FINANCIAL INC | US$4836.6万 | 0.01% |
| BlackRock, Inc. | US$3433.4万 | 0.00% |
| T. Rowe Price Investment Management, Inc. | US$3031.0万 | 0.02% |
| Aberdeen Group plc | US$2222.1万 | 0.04% |
| Deep Track Capital, LP | US$1911.0万 | 0.31% |
| AIGH Capital Management LLC | US$1847.3万 | 2.52% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1827.2万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$1390.9万 | 0.29% |
| Blue Water Life Science Advisors, LP | US$1067.8万 | 8.56% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1051.3万 | 0.00% |
| Casdin Capital, LLC | US$1019.2万 | 0.77% |
| GEODE CAPITAL MANAGEMENT, LLC | US$826.8万 | 0.00% |
| STATE STREET CORP | US$722.5万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$679.1万 | 0.00% |
| PFM Health Sciences, LP | US$554.3万 | 0.51% |
| GOLDMAN SACHS GROUP INC | US$469.6万 | 0.00% |
| Portolan Capital Management, LLC | US$469.3万 | 0.25% |
| JPMORGAN CHASE & CO | US$359.1万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$357.1万 | 0.00% |
| HOWLAND CAPITAL MANAGEMENT LLC | US$348.5万 | 0.14% |
| STATE OF MICHIGAN RETIREMENT SYSTEM | US$314.5万 | 0.02% |
| Sumitomo Mitsui Trust Group, Inc. | US$308.5万 | 0.00% |
| Amova Asset Management Americas, Inc. | US$307.5万 | 0.04% |
| MILLENNIUM MANAGEMENT LLC | US$267.0万 | 0.00% |
| NORTHERN TRUST CORP | US$258.5万 | 0.00% |
| UBS Group AG | US$244.3万 | 0.00% |
| Nuveen, LLC | US$218.8万 | 0.00% |
| Wellington Shields Capital Management, LLC | US$216.4万 | 0.32% |
| VANGUARD FIDUCIARY TRUST CO | US$216.3万 | 0.00% |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | US$206.0万 | 0.16% |
| Balyasny Asset Management L.P. | US$196.6万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$191.1万 | 0.00% |
| Wellington Shields & Co., LLC | US$186.3万 | 0.47% |
| Swiss Life Asset Management Ltd | US$158.7万 | 0.01% |
| PERKINS CAPITAL MANAGEMENT INC | US$152.2万 | 1.43% |
| MORGAN STANLEY | US$151.2万 | 0.00% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$149.7万 | 1.40% |
| Bruce & Co., Inc. | US$148.4万 | 0.42% |
| FIRST MANHATTAN CO. LLC. | US$146.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$143.8万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$133.7万 | 0.00% |
| HRT FINANCIAL LP | US$133.0万 | 0.00% |
| ROYCE & ASSOCIATES LP | US$99.4万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$92.1万 | 0.00% |
| SEI INVESTMENTS CO | US$88.6万 | 0.00% |
| Williams Jones Wealth Management, LLC. | US$85.4万 | 0.01% |
| LPL Financial LLC | US$84.1万 | 0.00% |
| Bank of New York Mellon Corp | US$79.4万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$73.1万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$70.9万 | 0.00% |
| TD Asset Management Inc | US$67.3万 | 0.00% |
| Swiss National Bank | US$67.1万 | 0.00% |
| Russell Investments Group, Ltd. | US$64.9万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$57.8万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$52.3万 | 0.03% |
| ROYAL BANK OF CANADA | US$50.2万 | 0.00% |
| Janney Montgomery Scott LLC | US$47.8万 | 0.00% |
| Green Alpha Advisors, LLC | US$42.3万 | 0.42% |
| Aquatic Capital Management LLC | US$40.9万 | 0.01% |
| AlphaCentric Advisors LLC | US$40.8万 | 0.41% |
| RHUMBLINE ADVISERS | US$40.2万 | 0.00% |
| Invesco Ltd. | US$40.0万 | 0.00% |
| FMR LLC | US$39.9万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$39.0万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$37.6万 | 0.00% |
| BARCLAYS PLC | US$32.9万 | 0.00% |
| CITADEL ADVISORS LLC | US$25.4万 | 0.00% |
| Quadrature Capital Ltd | US$24.7万 | 0.00% |
| Pathstone Holdings, LLC | US$24.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$22.8万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$22.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$22.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$22.3万 | 0.00% |
| DEUTSCHE BANK AG\ | US$22.2万 | 0.00% |
| Virtu Financial LLC | US$21.9万 | 0.01% |
| Cerity Partners LLC | US$21.7万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$19.8万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$19.2万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$18.5万 | 0.00% |
| MetLife Investment Management, LLC | US$17.8万 | 0.00% |
| Legal & General Group Plc | US$17.6万 | 0.00% |
| Bridgefront Capital, LLC | US$16.3万 | 0.04% |
| ADAR1 Capital Management, LLC | US$15.9万 | 0.01% |
| CAPTRUST FINANCIAL ADVISORS | US$15.0万 | 0.00% |
| Persistent Asset Partners Ltd | US$13.3万 | 0.05% |
| China Universal Asset Management Co., Ltd. | US$11.8万 | 0.01% |
| Tower Research Capital LLC (TRC) | US$11.5万 | 0.00% |
| SG Americas Securities, LLC | US$11.3万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$11.1万 | 0.00% |
| US BANCORP \DE\ | US$11.0万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$10.3万 | 0.00% |
| XTX Topco Ltd | US$10.2万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$10.1万 | 0.00% |
| Creative Planning | US$10.0万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$9.7万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$9.3万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$9.0万 | 0.00% |
| Scientech Research LLC | US$8.6万 | 0.07% |
| GUGGENHEIM CAPITAL LLC | US$8.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$8.3万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$8.2万 | 0.00% |
| AXQ CAPITAL, LP | US$7.9万 | 0.01% |
| ProShare Advisors LLC | US$7.6万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$7.5万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$7.3万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$7.0万 | 0.00% |
| CITIGROUP INC | US$4.7万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$3.5万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.7万 | 0.00% |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | US$2.6万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2.3万 | 0.00% |
| Opal Wealth Advisors, LLC | US$2.2万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.7万 | 0.00% |
| Farther Finance Advisors, LLC | US$1.5万 | 0.00% |
| Quantbot Technologies LP | US$1.4万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.3万 | 0.00% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$1.3万 | 0.00% |
| Sterling Capital Management LLC | US$1.1万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$7001.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$6759.0 | 0.00% |
| Berbice Capital Management LLC | US$4522.0 | 0.00% |
| CANADA LIFE ASSURANCE Co | US$4000.0 | 0.00% |
| GAMMA Investing LLC | US$3797.0 | 0.00% |
| Physician Wealth Advisors, Inc. | US$2784.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$1832.0 | 0.00% |
| CWM, LLC | US$1497.0 | 0.00% |
| Sound Income Strategies, LLC | US$1312.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1096.0 | 0.00% |
| SBI Securities Co., Ltd. | US$1032.0 | 0.00% |
| HUNTINGTON NATIONAL BANK | US$917.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$868.5 | 0.00% |
| Keating Financial Advisory Services, Inc. | US$637.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$541.0 | 0.00% |
| Allworth Financial LP | US$510.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$490.0 | 0.00% |
| TWIN PEAKS WEALTH ADVISORS, LLC | US$459.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$342.0 | 0.00% |
| MAI Capital Management | US$198.0 | 0.00% |