| FMR LLC | US$2.3亿 | 0.01% |
| BlackRock, Inc. | US$1.2亿 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$1.2亿 | 2.25% |
| TCG Crossover Management, LLC | US$8678.9万 | 2.48% |
| Commodore Capital LP | US$7853.5万 | 4.54% |
| JANUS HENDERSON GROUP PLC | US$6925.7万 | 0.03% |
| Saturn V Capital Management LP | US$6046.3万 | 10.95% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5756.8万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$4949.5万 | 0.08% |
| First Light Asset Management, LLC | US$4435.0万 | 3.97% |
| Driehaus Capital Management LLC | US$4152.1万 | 0.31% |
| GOLDMAN SACHS GROUP INC | US$3650.1万 | 0.00% |
| STATE STREET CORP | US$3284.8万 | 0.00% |
| FRANKLIN RESOURCES INC | US$3143.6万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3073.7万 | 0.00% |
| MORGAN STANLEY | US$3024.0万 | 0.00% |
| Almitas Capital LLC | US$2950.4万 | 6.67% |
| GREAT POINT PARTNERS LLC | US$2432.5万 | 5.59% |
| 683 Capital Management, LLC | US$2261.0万 | 1.18% |
| Jones Hill Capital LP | US$2222.3万 | 4.76% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2104.2万 | 0.35% |
| BANK OF AMERICA CORP /DE/ | US$1849.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$1762.2万 | 0.01% |
| Siren, L.L.C. | US$1709.7万 | 0.47% |
| Balyasny Asset Management L.P. | US$1539.1万 | 0.02% |
| ADAR1 Capital Management, LLC | US$1390.8万 | 0.82% |
| BARCLAYS PLC | US$1350.9万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1313.2万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1254.4万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1207.0万 | 0.03% |
| Woodline Partners LP | US$1175.7万 | 0.04% |
| Boxer Capital Management, LLC | US$1112.0万 | 1.46% |
| NORTHERN TRUST CORP | US$1084.1万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$995.6万 | 0.00% |
| Qube Research & Technologies Ltd | US$976.1万 | 0.01% |
| Logos Global Management LP | US$973.0万 | 0.49% |
| STEMPOINT CAPITAL LP | US$930.9万 | 1.78% |
| Parkman Healthcare Partners LLC | US$863.8万 | 0.89% |
| JUPITER ASSET MANAGEMENT LTD | US$823.8万 | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | US$814.8万 | 0.00% |
| Nantahala Capital Management, LLC | US$744.6万 | 0.27% |
| Rock Springs Capital Management LP | US$694.7万 | 0.41% |
| CITADEL ADVISORS LLC | US$652.8万 | 0.00% |
| FEDERATED HERMES, INC. | US$505.3万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$492.1万 | 0.00% |
| HighVista Strategies LLC | US$489.4万 | 1.35% |
| Cormorant Asset Management, LP | US$486.5万 | 0.24% |
| UBS Group AG | US$450.8万 | 0.00% |
| Tetragon Partners GP Ltd | US$441.8万 | 0.86% |
| iA Global Asset Management Inc. | US$423.7万 | 0.06% |
| Nuveen, LLC | US$368.2万 | 0.00% |
| Bank of New York Mellon Corp | US$349.0万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$335.8万 | 0.00% |
| SummitTX Capital, L.P. | US$315.5万 | 0.10% |
| Aldebaran Capital, LLC | US$275.1万 | 2.10% |
| Invesco Ltd. | US$238.6万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$225.1万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$218.4万 | 0.00% |
| ACUTA CAPITAL PARTNERS, LLC | US$210.0万 | 1.49% |
| JPMORGAN CHASE & CO | US$203.7万 | 0.00% |
| PFM Health Sciences, LP | US$201.9万 | 0.18% |
| Alpha Wave Global, LP | US$197.8万 | 0.25% |
| Swiss National Bank | US$181.1万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$168.9万 | 0.00% |
| Squarepoint Ops LLC | US$159.7万 | 0.00% |
| Elmind Capital, LP | US$155.7万 | 0.44% |
| RHUMBLINE ADVISERS | US$150.8万 | 0.00% |
| Point72 Asset Management, L.P. | US$148.1万 | 0.00% |
| ALPS ADVISORS INC | US$125.1万 | 0.01% |
| SEI INVESTMENTS CO | US$118.5万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$108.1万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$104.4万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$103.2万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$100.2万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$97.6万 | 0.00% |
| Walleye Capital LLC | US$97.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$90.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$82.5万 | 0.00% |
| Legal & General Group Plc | US$77.5万 | 0.00% |
| Campbell & CO Investment Adviser LLC | US$75.6万 | 0.04% |
| Informed Momentum Co LLC | US$74.0万 | 0.09% |
| MetLife Investment Management, LLC | US$71.7万 | 0.00% |
| Maven Securities LTD | US$69.5万 | 0.01% |
| Numerai GP LLC | US$67.5万 | 0.07% |
| Vanguard Global Advisers, LLC | US$66.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$60.2万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$59.1万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$56.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$53.9万 | 0.00% |
| Optimize Financial Inc | US$44.5万 | 0.22% |
| CITIGROUP INC | US$44.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$43.6万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$40.4万 | 0.00% |
| Integrated Quantitative Investments LLC | US$37.9万 | 0.07% |
| JANE STREET GROUP, LLC | US$35.6万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$35.5万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$34.6万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$33.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$33.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$31.3万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$30.4万 | 0.00% |
| PARSONS CAPITAL MANAGEMENT INC/RI | US$30.1万 | 0.01% |
| Virtus Investment Advisers, LLC | US$28.9万 | 0.08% |
| Premier Path Wealth Partners, LLC | US$28.2万 | 0.04% |
| BROWN ADVISORY INC | US$27.7万 | 0.00% |
| Headlands Technologies LLC | US$27.5万 | 0.03% |
| China Universal Asset Management Co., Ltd. | US$27.1万 | 0.02% |
| ProShare Advisors LLC | US$25.2万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$25.2万 | 0.00% |
| Creative Planning | US$24.9万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$24.6万 | 0.00% |
| Belvedere Trading LLC | US$24.5万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$24.2万 | 0.00% |
| PROFUND ADVISORS LLC | US$23.8万 | 0.01% |
| Seven Fleet Capital Management LP | US$23.2万 | 0.07% |
| VOYA INVESTMENT MANAGEMENT LLC | US$21.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$19.6万 | 0.00% |
| Verition Fund Management LLC | US$18.4万 | 0.00% |
| Amundi | US$17.9万 | 0.00% |
| ROYAL BANK OF CANADA | US$17.2万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$17.0万 | 0.01% |
| HSBC HOLDINGS PLC | US$15.7万 | 0.00% |
| PSP Research LLC | US$15.1万 | 0.11% |
| Pictet Asset Management Holding SA | US$15.0万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$14.8万 | 0.00% |
| GREAT LAKES ADVISORS, LLC | US$14.4万 | 0.00% |
| Valeo Financial Advisors, LLC | US$13.9万 | 0.00% |
| MAI Capital Management | US$12.5万 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$12.5万 | 0.10% |
| Tower Research Capital LLC (TRC) | US$11.0万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$10.0万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$8.0万 | 0.00% |
| STRS OHIO | US$4.7万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$3.4万 | 0.00% |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | US$2.9万 | 0.00% |
| US BANCORP \DE\ | US$2.9万 | 0.00% |
| State of Wyoming | US$2.6万 | 0.00% |
| KBC Group NV | US$2.6万 | 0.00% |
| Arax Advisory Partners | US$2.1万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2.0万 | 0.00% |
| Rockefeller Capital Management L.P. | US$1.8万 | 0.00% |
| CWM, LLC | US$1.8万 | 0.00% |
| Sterling Capital Management LLC | US$1.6万 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$1.4万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$1.3万 | 0.00% |
| Westfuller Advisors, LLC | US$1.1万 | 0.00% |
| FIFTH THIRD BANCORP | US$1.0万 | 0.00% |
| MEEDER ASSET MANAGEMENT INC | US$9188.0 | 0.00% |
| Dunhill Financial, LLC | US$8340.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$7339.0 | 0.00% |