| BAKER BROS. ADVISORS LP | US$6.9亿 | 3.96% |
| FMR LLC | US$2.1亿 | 0.01% |
| BlackRock, Inc. | US$1.8亿 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.6亿 | 0.02% |
| STATE STREET CORP | US$1.3亿 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1亿 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$9922.2万 | 0.01% |
| UBS Group AG | US$7015.8万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6288.7万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$4570.7万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$4251.3万 | 0.03% |
| MORGAN STANLEY | US$3129.5万 | 0.00% |
| APEIRON CAPITAL Ltd | US$2482.1万 | 23.21% |
| Pictet Asset Management Holding SA | US$2396.3万 | 0.03% |
| CITADEL ADVISORS LLC | US$2011.5万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$1860.3万 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1821.8万 | 0.00% |
| TD Asset Management Inc | US$1814.3万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$1771.6万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$1692.9万 | 12.09% |
| Point72 Asset Management, L.P. | US$1518.9万 | 0.02% |
| Rock Springs Capital Management LP | US$1346.2万 | 0.79% |
| LMR Partners LLP | US$1298.0万 | 0.03% |
| Aberdeen Group plc | US$1261.5万 | 0.02% |
| Squarepoint Ops LLC | US$1163.9万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$1135.1万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1124.0万 | 0.01% |
| NORTHERN TRUST CORP | US$1102.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$1039.6万 | 0.01% |
| Candriam S.C.A. | US$1025.1万 | 0.05% |
| Invesco Ltd. | US$997.5万 | 0.00% |
| MARSHALL WACE, LLP | US$901.1万 | 0.01% |
| NOMURA HOLDINGS INC | US$826.4万 | 0.02% |
| AQR CAPITAL MANAGEMENT LLC | US$811.2万 | 0.00% |
| Bank of New York Mellon Corp | US$767.3万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$749.1万 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$688.0万 | 0.00% |
| QVT Financial LP | US$683.6万 | 0.50% |
| CITIGROUP INC | US$663.5万 | 0.00% |
| E Fund Management Co., Ltd. | US$591.2万 | 0.18% |
| GOLDMAN SACHS GROUP INC | US$589.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$568.6万 | 0.00% |
| Caption Management, LLC | US$493.0万 | 0.03% |
| Rafferty Asset Management, LLC | US$491.2万 | 0.02% |
| ExodusPoint Capital Management, LP | US$485.9万 | 0.04% |
| Nuveen, LLC | US$462.6万 | 0.00% |
| DEUTSCHE BANK AG\ | US$450.8万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$426.9万 | 0.00% |
| Woodline Partners LP | US$406.7万 | 0.02% |
| GRIFFIN ASSET MANAGEMENT, INC. | US$363.8万 | 0.41% |
| China Universal Asset Management Co., Ltd. | US$260.9万 | 0.20% |
| Polymer Capital Management (HK) LTD | US$252.2万 | 0.22% |
| VOYA INVESTMENT MANAGEMENT LLC | US$246.9万 | 0.00% |
| RHUMBLINE ADVISERS | US$245.6万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$239.4万 | 0.00% |
| Tidal Investments LLC | US$228.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$228.1万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$226.9万 | 0.04% |
| Tema ETFs LLC | US$226.6万 | 0.15% |
| Jump Financial, LLC | US$219.4万 | 0.03% |
| Cerity Partners LLC | US$215.7万 | 0.00% |
| PROFUND ADVISORS LLC | US$214.1万 | 0.08% |
| Illinois Municipal Retirement Fund | US$212.2万 | 0.03% |
| BANK OF MONTREAL /CAN/ | US$204.7万 | 0.00% |
| Jefferies Financial Group Inc. | US$189.6万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$182.0万 | 0.00% |
| Beacon Pointe Advisors, LLC | US$179.0万 | 0.01% |
| ADAR1 Capital Management, LLC | US$174.2万 | 0.10% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$172.5万 | 0.00% |
| NEXTBio Capital Management LP | US$170.1万 | 0.79% |
| DIMENSIONAL FUND ADVISORS LP | US$166.7万 | 0.00% |
| Focus Partners Wealth | US$159.2万 | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | US$153.2万 | 0.14% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$151.1万 | 0.00% |
| Quantinno Capital Management LP | US$140.0万 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | US$140.0万 | 1.16% |
| GUGGENHEIM CAPITAL LLC | US$125.9万 | 0.01% |
| Wealth Management Partners, LLC | US$120.9万 | 0.35% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$118.6万 | 0.00% |
| Havemeyer Place LP | US$117.5万 | 0.14% |
| Vanguard Global Advisers, LLC | US$115.9万 | 0.00% |
| Assenagon Asset Management S.A. | US$113.0万 | 0.00% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | US$110.5万 | 0.00% |
| JPMORGAN CHASE & CO | US$109.6万 | 0.00% |
| Longaeva Partners L.P. | US$108.6万 | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$102.3万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$102.0万 | 0.00% |
| SG Americas Securities, LLC | US$101.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$99.8万 | 0.01% |
| DNB Asset Management AS | US$95.9万 | 0.00% |
| Farther Finance Advisors, LLC | US$95.2万 | 0.01% |
| Treasurer of the State of North Carolina | US$94.8万 | 0.00% |
| Fieldview Capital Management, LLC | US$93.3万 | 0.27% |
| BARCLAYS PLC | US$93.1万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$90.4万 | 0.00% |
| AXQ CAPITAL, LP | US$89.6万 | 0.12% |
| Handelsbanken Fonder AB | US$84.6万 | 0.00% |
| GROUP ONE TRADING LLC | US$81.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$80.4万 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$73.7万 | 0.00% |
| LEVIN CAPITAL STRATEGIES, L.P. | US$71.4万 | 0.05% |
| Verition Fund Management LLC | US$68.6万 | 0.00% |
| ProShare Advisors LLC | US$65.8万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$64.5万 | 0.00% |
| Legal & General Group Plc | US$60.5万 | 0.00% |
| Cetera Investment Advisers | US$56.4万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$54.2万 | 0.00% |
| Machina Capital S.A.S. | US$49.7万 | 0.10% |
| GREAT VALLEY ADVISOR GROUP, INC. | US$48.6万 | 0.01% |
| CIBC Asset Management Inc | US$46.1万 | 0.00% |
| Banque Cantonale Vaudoise | US$45.3万 | 0.02% |
| Tower Research Capital LLC (TRC) | US$44.9万 | 0.01% |
| VARCOV Co. | US$44.6万 | 0.17% |
| Capstone Capital Management Ltd | US$43.9万 | 0.44% |
| Schonfeld Strategic Advisors LLC | US$42.7万 | 0.00% |
| WINTON GROUP Ltd | US$42.5万 | 0.01% |
| Allianz Asset Management GmbH | US$42.1万 | 0.00% |
| Entropy Technologies, LP | US$41.3万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$39.6万 | 0.00% |
| EVOKE WEALTH, LLC | US$39.2万 | 0.01% |
| XPONANCE LLC | US$38.1万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$37.9万 | 0.03% |
| VANCE WEALTH, LLC | US$37.9万 | 0.11% |
| Q3 Asset Management | US$37.8万 | 0.09% |
| SEI INVESTMENTS CO | US$37.3万 | 0.00% |
| New York Life Investment Management LLC | US$37.0万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$34.7万 | 0.00% |
| Russell Investments Group, Ltd. | US$34.1万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$31.7万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$31.2万 | 0.00% |
| Bellevue Group AG | US$30.1万 | 0.01% |
| Gotham Asset Management, LLC | US$29.8万 | 0.00% |
| Virtus Investment Advisers, LLC | US$29.4万 | 0.08% |
| Creative Planning | US$25.8万 | 0.00% |
| Three Seasons Wealth, LLC | US$24.4万 | 0.09% |
| Blankinship & Foster, LLC | US$24.2万 | 0.05% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$23.0万 | 0.20% |
| U.S. Capital Wealth Advisors, LLC | US$22.8万 | 0.01% |
| Lighthouse Investment Partners, LLC | US$22.7万 | 0.01% |
| DRW Securities, LLC | US$21.9万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$21.6万 | 0.00% |
| Advisors Asset Management, Inc. | US$20.8万 | 0.00% |
| Jain Global LLC | US$20.5万 | 0.00% |
| PSP Research LLC | US$19.4万 | 0.14% |
| Willis Investment Counsel | US$19.0万 | 0.01% |
| Federation des caisses Desjardins du Quebec | US$16.8万 | 0.00% |
| SIMPLEX TRADING, LLC | US$15.9万 | 0.00% |
| ROYAL BANK OF CANADA | US$14.1万 | 0.00% |
| MetLife Investment Management, LLC | US$13.6万 | 0.00% |
| Eurizon Capital SGR S.p.A. | US$13.1万 | 0.00% |