| BAKER BROS. ADVISORS LP | US$8449.7万 | 0.49% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6213.0万 | 0.01% |
| RTW INVESTMENTS, LP | US$5628.0万 | 0.56% |
| BlackRock, Inc. | US$4773.0万 | 0.00% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$3229.7万 | 0.82% |
| STATE STREET CORP | US$2893.4万 | 0.00% |
| FCPM III SERVICES B.V. | US$2148.4万 | 2.97% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2110.7万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$1787.4万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1775.5万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1742.1万 | 0.00% |
| FMR LLC | US$1564.8万 | 0.00% |
| Erste Asset Management GmbH | US$1526.4万 | 0.14% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1378.5万 | 0.00% |
| ADAR1 Capital Management, LLC | US$1287.5万 | 0.76% |
| TORONTO DOMINION BANK | US$1217.1万 | 0.02% |
| Caption Management, LLC | US$1089.7万 | 0.06% |
| Boxer Capital Management, LLC | US$898.9万 | 1.18% |
| DIMENSIONAL FUND ADVISORS LP | US$871.9万 | 0.00% |
| Sofinnova Investments, Inc. | US$776.8万 | 0.30% |
| EcoR1 Capital, LLC | US$765.0万 | 0.32% |
| CITADEL ADVISORS LLC | US$630.2万 | 0.00% |
| DIADEMA PARTNERS LP | US$586.0万 | 1.00% |
| JPMORGAN CHASE & CO | US$568.8万 | 0.00% |
| Sio Capital Management, LLC | US$550.8万 | 0.79% |
| Jefferies Financial Group Inc. | US$546.4万 | 0.04% |
| TUDOR INVESTMENT CORP ET AL | US$521.7万 | 0.01% |
| JANE STREET GROUP, LLC | US$500.5万 | 0.00% |
| MORGAN STANLEY | US$494.4万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$468.0万 | 0.00% |
| NORTHERN TRUST CORP | US$450.7万 | 0.00% |
| UBS Group AG | US$444.6万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$422.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$369.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$363.5万 | 0.00% |
| Candriam S.C.A. | US$301.4万 | 0.02% |
| Eversept Partners, LP | US$295.9万 | 0.16% |
| RENAISSANCE TECHNOLOGIES LLC | US$291.8万 | 0.00% |
| Woodline Partners LP | US$291.5万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$263.7万 | 0.00% |
| BARCLAYS PLC | US$256.0万 | 0.00% |
| MOORE CAPITAL MANAGEMENT, LP | US$238.0万 | 0.05% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$235.1万 | 0.00% |
| Ikarian Capital, LLC | US$229.5万 | 0.19% |
| SummitTX Capital, L.P. | US$221.0万 | 0.07% |
| Quinn Opportunity Partners LLC | US$220.2万 | 0.11% |
| AQR CAPITAL MANAGEMENT LLC | US$195.5万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$193.9万 | 0.00% |
| ALGERT GLOBAL LLC | US$191.1万 | 0.03% |
| Omega Fund Management, LLC | US$191.0万 | 1.17% |
| Ally Bridge Group (NY) LLC | US$188.9万 | 1.53% |
| DLD Asset Management, LP | US$185.8万 | 0.17% |
| TD Asset Management Inc | US$185.6万 | 0.00% |
| Bank of New York Mellon Corp | US$156.7万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$151.1万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$150.2万 | 0.16% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$147.1万 | 0.00% |
| Invesco Ltd. | US$146.1万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$138.7万 | 0.01% |
| J. Goldman & Co LP | US$134.2万 | 0.04% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$131.5万 | 0.13% |
| ACADIAN ASSET MANAGEMENT LLC | US$129.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$116.9万 | 0.02% |
| SG Americas Securities, LLC | US$116.0万 | 0.00% |
| Engineers Gate Manager LP | US$115.1万 | 0.01% |
| READYSTATE ASSET MANAGEMENT LP | US$105.9万 | 0.05% |
| XTX Topco Ltd | US$100.5万 | 0.02% |
| Hudson Bay Capital Management LP | US$100.2万 | 0.00% |
| Seven Fleet Capital Management LP | US$92.1万 | 0.29% |
| Rafferty Asset Management, LLC | US$90.6万 | 0.00% |
| Quantinno Capital Management LP | US$83.0万 | 0.00% |
| Tidal Investments LLC | US$81.8万 | 0.00% |
| Tema ETFs LLC | US$81.8万 | 0.05% |
| SIMPLEX TRADING, LLC | US$80.2万 | 0.00% |
| Jump Financial, LLC | US$79.8万 | 0.01% |
| RHUMBLINE ADVISERS | US$67.1万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$66.9万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$66.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$60.4万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$55.2万 | 0.00% |
| Walleye Capital LLC | US$54.8万 | 0.00% |
| ZACKS INVESTMENT MANAGEMENT | US$53.8万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$52.8万 | 0.01% |
| Persistent Asset Partners Ltd | US$52.6万 | 0.20% |
| ACT CAPITAL MANAGEMENT, LLC | US$47.0万 | 0.37% |
| Corient Private Wealth LLC | US$44.8万 | 0.00% |
| Nuveen, LLC | US$44.1万 | 0.00% |
| DEUTSCHE BANK AG\ | US$42.0万 | 0.00% |
| PROFUND ADVISORS LLC | US$40.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$40.1万 | 0.00% |
| Creative Planning | US$37.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$32.7万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$31.2万 | 0.00% |
| MetLife Investment Management, LLC | US$29.3万 | 0.00% |
| FEDERATED HERMES, INC. | US$28.5万 | 0.00% |
| Brevan Howard Capital Management LP | US$27.5万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$25.7万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$24.3万 | 0.00% |
| Russell Investments Group, Ltd. | US$24.1万 | 0.00% |
| Balyasny Asset Management L.P. | US$23.6万 | 0.00% |
| GROUP ONE TRADING LLC | US$23.5万 | 0.00% |
| Vanguard Global Advisers, LLC | US$22.4万 | 0.00% |
| Quadrature Capital Ltd | US$21.9万 | 0.00% |
| Virtus Investment Advisers, LLC | US$20.5万 | 0.06% |
| DRW Securities, LLC | US$20.2万 | 0.00% |
| AXQ CAPITAL, LP | US$19.9万 | 0.03% |
| B Group, Inc. | US$19.9万 | 0.15% |
| Graham Capital Management, L.P. | US$19.5万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$19.4万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$17.7万 | 0.00% |
| Ballentine Partners, LLC | US$16.6万 | 0.00% |
| Velan Capital Investment Management LP | US$15.3万 | 0.10% |
| Virtu Financial LLC | US$14.4万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$14.1万 | 0.00% |
| Cerity Partners LLC | US$14.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$13.9万 | 0.00% |
| Centiva Capital, LP | US$13.8万 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$13.6万 | 0.00% |
| INCEPTIONR LLC | US$13.2万 | 0.03% |
| CITIGROUP INC | US$11.9万 | 0.00% |
| Blueshift Asset Management, LLC | US$11.9万 | 0.04% |
| OSAIC HOLDINGS, INC. | US$11.6万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$11.6万 | 0.00% |
| E Fund Management Co., Ltd. | US$11.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$11.2万 | 0.01% |
| GRIFFIN ASSET MANAGEMENT, INC. | US$11.0万 | 0.01% |
| ProShare Advisors LLC | US$10.8万 | 0.00% |
| Magnetar Financial LLC | US$10.3万 | 0.00% |
| HORIZON KINETICS ASSET MANAGEMENT LLC | US$10.1万 | 0.00% |
| LPL Financial LLC | US$10.0万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$9.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$9.6万 | 0.00% |
| CWM, LLC | US$9.5万 | 0.00% |
| Polymer Capital Management (US) LLC | US$9.0万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$8.9万 | 0.00% |
| Summit Financial, LLC | US$8.7万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$8.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$8.4万 | 0.00% |
| Walleye Trading LLC | US$8.3万 | 0.00% |
| LETKO, BROSSEAU & ASSOCIATES INC | US$8.3万 | 0.00% |
| Scientech Research LLC | US$8.2万 | 0.07% |
| Quadcap Wealth Management, LLC | US$7.7万 | 0.01% |
| Ameritas Investment Partners, Inc. | US$4.7万 | 0.00% |
| Legal & General Group Plc | US$4.6万 | 0.00% |
| Essential Partners LLC | US$4.3万 | 0.01% |
| Allworth Financial LP | US$4.0万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$3.3万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$3.0万 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$2.9万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$2.6万 | 0.00% |