| FMR LLC | US$18.4亿 | 0.10% |
| Capital World Investors | US$15.9亿 | 0.22% |
| BlackRock, Inc. | US$7.8亿 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$5.9亿 | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5.3亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$4.8亿 | 0.09% |
| T. Rowe Price Investment Management, Inc. | US$4.6亿 | 0.32% |
| TWO SIGMA INVESTMENTS, LP | US$4.4亿 | 0.35% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3.1亿 | 0.02% |
| STATE STREET CORP | US$3.0亿 | 0.01% |
| ROYAL BANK OF CANADA | US$2.9亿 | 0.05% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2.3亿 | 0.03% |
| JPMORGAN CHASE & CO | US$1.7亿 | 0.01% |
| Tweedy, Browne Co LLC | US$1.7亿 | 13.57% |
| Artisan Partners Limited Partnership | US$1.5亿 | 0.25% |
| BAKER BROS. ADVISORS LP | US$1.5亿 | 0.88% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$1.5亿 | 1.75% |
| Deep Track Capital, LP | US$1.5亿 | 2.39% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | US$1.4亿 | 3.74% |
| Bellevue Group AG | US$1.4亿 | 3.25% |
| GOLDMAN SACHS GROUP INC | US$1.3亿 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$1.2亿 | 0.06% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.2亿 | 0.02% |
| FRANKLIN RESOURCES INC | US$1.2亿 | 0.03% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.1亿 | 0.02% |
| Pictet Asset Management Holding SA | US$1.1亿 | 0.11% |
| CITADEL ADVISORS LLC | US$9807.8万 | 0.02% |
| Invesco Ltd. | US$9591.7万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$9179.4万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$7895.8万 | 0.03% |
| MORGAN STANLEY | US$7708.1万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$7692.0万 | 0.02% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$6813.6万 | 0.08% |
| Connor, Clark & Lunn Investment Management Ltd. | US$6563.5万 | 0.15% |
| NORTHERN TRUST CORP | US$6519.2万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$6312.1万 | 0.00% |
| Polar Capital Holdings Plc | US$6228.8万 | 0.22% |
| GROUPAMA ASSET MANAGMENT | US$6191.5万 | 0.90% |
| UBS Group AG | US$6070.6万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$5896.7万 | 0.10% |
| GW&K Investment Management, LLC | US$5852.1万 | 0.52% |
| JANE STREET GROUP, LLC | US$5709.2万 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$5540.6万 | 0.03% |
| Squarepoint Ops LLC | US$5220.8万 | 0.06% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$5052.5万 | 0.20% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$5001.9万 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$4957.0万 | 0.01% |
| Nuveen, LLC | US$4869.6万 | 0.01% |
| Eversept Partners, LP | US$4746.4万 | 2.50% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$4317.7万 | 0.71% |
| TD Asset Management Inc | US$3979.4万 | 0.03% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$3934.2万 | 0.16% |
| Bank of New York Mellon Corp | US$3864.3万 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$3784.5万 | 0.74% |
| BOONE CAPITAL MANAGEMENT LLC | US$3758.4万 | 11.51% |
| Candriam S.C.A. | US$3634.8万 | 0.19% |
| Alyeska Investment Group, L.P. | US$3552.9万 | 0.10% |
| FIRST TRUST ADVISORS LP | US$3516.9万 | 0.03% |
| NEUBERGER BERMAN GROUP LLC | US$3328.5万 | 0.03% |
| PINNACLE ASSOCIATES LTD | US$3277.4万 | 0.42% |
| D. E. Shaw & Co., Inc. | US$3225.9万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$3169.7万 | 0.01% |
| Davern Capital Partners, LP | US$2905.3万 | 7.97% |
| C WorldWide Group Holding A/S | US$2748.3万 | 0.59% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$2631.3万 | 0.04% |
| BARCLAYS PLC | US$2552.1万 | 0.01% |
| Capital Research Global Investors | US$2425.5万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$2294.4万 | 0.04% |
| Swiss National Bank | US$2286.5万 | 0.01% |
| Hudson Bay Capital Management LP | US$2215.9万 | 0.08% |
| Legal & General Group Plc | US$2212.7万 | 0.01% |
| Privium Fund Management B.V. | US$2177.8万 | 4.53% |
| ARK Investment Management LLC | US$2168.0万 | 0.17% |
| TimesSquare Capital Management, LLC | US$2070.0万 | 0.35% |
| DIMENSIONAL FUND ADVISORS LP | US$2005.6万 | 0.00% |
| CITIGROUP INC | US$1974.4万 | 0.01% |
| California Public Employees Retirement System | US$1918.4万 | 0.01% |
| J. Goldman & Co LP | US$1916.7万 | 0.56% |
| HRT FINANCIAL LP | US$1894.1万 | 0.05% |
| Zurich Insurance Group Ltd/FI | US$1799.5万 | 0.14% |
| Ikarian Capital, LLC | US$1795.7万 | 1.46% |
| DAVENPORT & Co LLC | US$1788.9万 | 0.10% |
| RAYMOND JAMES FINANCIAL INC | US$1765.5万 | 0.01% |
| ExodusPoint Capital Management, LP | US$1705.2万 | 0.14% |
| Orion Investment Co | US$1689.6万 | 5.36% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | US$1653.6万 | 0.25% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$1649.4万 | 0.03% |
| Handelsbanken Fonder AB | US$1606.3万 | 0.05% |
| Trexquant Investment LP | US$1604.3万 | 0.12% |
| Jump Financial, LLC | US$1551.9万 | 0.21% |
| STIFEL FINANCIAL CORP | US$1477.0万 | 0.01% |
| Corient Private Wealth LLC | US$1476.3万 | 0.02% |
| WELLS FARGO & COMPANY/MN | US$1425.6万 | 0.00% |
| HSBC HOLDINGS PLC | US$1396.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1325.2万 | 0.01% |
| NOMURA HOLDINGS INC | US$1302.7万 | 0.04% |
| RHUMBLINE ADVISERS | US$1302.4万 | 0.01% |
| SECTOR GAMMA AS | US$1272.5万 | 3.00% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$1258.9万 | 0.01% |
| Focus Partners Wealth | US$1243.1万 | 0.01% |
| ADAR1 Capital Management, LLC | US$1204.0万 | 0.71% |
| DEUTSCHE BANK AG\ | US$1200.6万 | 0.00% |
| Sicart Associates LLC | US$1197.0万 | 3.07% |
| SEI INVESTMENTS CO | US$1180.6万 | 0.01% |
| CenterBook Partners LP | US$1133.2万 | 0.61% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1122.9万 | 0.01% |
| Aquatic Capital Management LLC | US$1106.7万 | 0.32% |
| Artia Global Partners LP | US$1084.1万 | 2.17% |
| CAPITAL FUND MANAGEMENT S.A. | US$1067.8万 | 0.05% |
| Fisher Asset Management, LLC | US$1062.9万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$1032.5万 | 0.01% |
| EDMOND DE ROTHSCHILD HOLDING S.A. | US$1030.2万 | 0.15% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$1020.3万 | 0.02% |
| Engineers Gate Manager LP | US$1004.9万 | 0.13% |
| BRAIDWELL LP | US$982.6万 | 0.33% |
| Atle Fund Management AB | US$939.9万 | 3.03% |
| Integral Health Asset Management, LLC | US$938.6万 | 0.45% |
| GREAT LAKES ADVISORS, LLC | US$893.0万 | 0.07% |
| ALGERT GLOBAL LLC | US$875.3万 | 0.13% |
| SEB Asset Management AB | US$858.5万 | 0.04% |
| Aberdeen Group plc | US$854.8万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$839.7万 | 0.18% |
| Exome Asset Management LLC | US$826.5万 | 4.27% |
| VICTORY CAPITAL MANAGEMENT INC | US$816.6万 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$812.3万 | 0.11% |
| WINTON GROUP Ltd | US$799.9万 | 0.28% |
| Empowered Funds, LLC | US$774.5万 | 0.05% |
| Gotham Asset Management, LLC | US$743.2万 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$724.6万 | 0.02% |
| Susquehanna Portfolio Strategies, LLC | US$720.6万 | 0.11% |
| MARSHALL WACE, LLP | US$720.5万 | 0.01% |
| EFG International AG | US$705.7万 | 0.15% |
| ENVESTNET ASSET MANAGEMENT INC | US$701.2万 | 0.00% |
| Rhenman & Partners Asset Management AB | US$697.6万 | 0.86% |
| DekaBank Deutsche Girozentrale | US$691.9万 | 0.01% |
| SIG BROKERAGE, LP | US$638.3万 | 0.17% |
| Walleye Capital LLC | US$637.1万 | 0.03% |
| Sumitomo Mitsui Trust Group, Inc. | US$614.8万 | 0.00% |
| Amova Asset Management Americas, Inc. | US$613.4万 | 0.09% |
| CSS LLC/IL | US$608.9万 | 0.29% |
| XTX Topco Ltd | US$604.6万 | 0.11% |
| China Universal Asset Management Co., Ltd. | US$580.6万 | 0.44% |
| Lisanti Capital Growth, LLC | US$568.4万 | 1.43% |
| Vanguard Global Advisers, LLC | US$540.0万 | 0.00% |
| Hillsdale Investment Management Inc. | US$532.4万 | 0.14% |
| Erste Asset Management GmbH | US$520.7万 | 0.05% |
| VOYA INVESTMENT MANAGEMENT LLC | US$519.1万 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$518.5万 | 0.01% |
| Edgestream Partners, L.P. | US$513.4万 | 0.17% |
| JANUS HENDERSON GROUP PLC | US$512.1万 | 0.00% |