| BAKER BROS. ADVISORS LP | US$9.0亿 | 5.19% |
| Avoro Capital Advisors LLC | US$3.9亿 | 3.82% |
| PERCEPTIVE ADVISORS LLC | US$3.6亿 | 6.97% |
| RTW INVESTMENTS, LP | US$3.5亿 | 3.45% |
| BlackRock, Inc. | US$3.1亿 | 0.01% |
| NEA Management Company, LLC | US$2.6亿 | 14.83% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.0亿 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$2.0亿 | 2.31% |
| STATE STREET CORP | US$1.7亿 | 0.01% |
| MORGAN STANLEY | US$1.5亿 | 0.01% |
| Soleus Capital Management, L.P. | US$1.5亿 | 5.94% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.5亿 | 0.02% |
| TANG CAPITAL MANAGEMENT LLC | US$1.2亿 | 6.09% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.0亿 | 0.01% |
| TORONTO DOMINION BANK | US$1.0亿 | 0.14% |
| GOLDMAN SACHS GROUP INC | US$8731.4万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$8153.4万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$7929.3万 | 0.01% |
| Sofinnova Investments, Inc. | US$7603.7万 | 2.89% |
| Caption Management, LLC | US$6848.4万 | 0.40% |
| Apis Capital Advisors, LLC | US$5878.2万 | 9.07% |
| Nearwater Capital Markets, Ltd | US$5400.0万 | 1.27% |
| Artisan Partners Limited Partnership | US$5217.0万 | 0.08% |
| LORD, ABBETT & CO. LLC | US$5013.3万 | 0.16% |
| WELLINGTON MANAGEMENT GROUP LLP | US$4896.1万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$4631.2万 | 0.01% |
| Holocene Advisors, LP | US$4222.9万 | 0.10% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$4085.1万 | 4.17% |
| Point72 Asset Management, L.P. | US$3652.8万 | 0.05% |
| NORTHERN TRUST CORP | US$3638.4万 | 0.00% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | US$3612.5万 | 0.23% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3354.5万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3323.4万 | 0.00% |
| JANE STREET GROUP, LLC | US$3314.8万 | 0.00% |
| Saturn V Capital Management LP | US$3217.7万 | 5.83% |
| CITADEL ADVISORS LLC | US$3205.1万 | 0.01% |
| Pfizer Inc | US$3134.5万 | 13.13% |
| VANGUARD FIDUCIARY TRUST CO | US$2891.9万 | 0.01% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2783.3万 | 0.46% |
| Driehaus Capital Management LLC | US$2757.0万 | 0.20% |
| Focus Partners Wealth | US$2663.9万 | 0.03% |
| JENNISON ASSOCIATES LLC | US$2638.2万 | 0.02% |
| Candriam S.C.A. | US$2632.1万 | 0.14% |
| Boxer Capital Management, LLC | US$2568.2万 | 3.37% |
| UBS Group AG | US$2512.9万 | 0.00% |
| First Turn Management, LLC | US$2403.5万 | 2.69% |
| Sio Capital Management, LLC | US$2212.5万 | 3.17% |
| Hennion & Walsh Asset Management, Inc. | US$2084.2万 | 0.70% |
| Ensign Peak Advisors, Inc | US$1700.6万 | 0.03% |
| Woodline Partners LP | US$1655.4万 | 0.06% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1520.2万 | 0.02% |
| FEDERATED HERMES, INC. | US$1358.8万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$1277.4万 | 0.00% |
| Walleye Capital LLC | US$1206.3万 | 0.05% |
| NAN FUNG TRINITY (HK) LTD | US$1184.5万 | 1.30% |
| AMERIPRISE FINANCIAL INC | US$1126.7万 | 0.00% |
| Patient Square Capital LP | US$1084.3万 | 1.92% |
| Bank of New York Mellon Corp | US$1073.1万 | 0.00% |
| Russell Investments Group, Ltd. | US$1052.7万 | 0.01% |
| Clearbridge Investments, LLC | US$1047.4万 | 0.01% |
| ACT CAPITAL MANAGEMENT, LLC | US$1046.4万 | 8.22% |
| Invesco Ltd. | US$1038.4万 | 0.00% |
| Granahan Investment Management, LLC | US$1013.9万 | 0.49% |
| TD Asset Management Inc | US$956.0万 | 0.01% |
| Integral Health Asset Management, LLC | US$913.1万 | 0.44% |
| Nuveen, LLC | US$874.9万 | 0.00% |
| Atom Investors LP | US$871.1万 | 0.62% |
| Alyeska Investment Group, L.P. | US$858.1万 | 0.02% |
| Freestone Grove Partners LP | US$805.1万 | 0.06% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$772.3万 | 0.01% |
| CITIGROUP INC | US$755.9万 | 0.00% |
| Balyasny Asset Management L.P. | US$735.3万 | 0.01% |
| CAPTRUST FINANCIAL ADVISORS | US$697.0万 | 0.01% |
| STEMPOINT CAPITAL LP | US$685.5万 | 1.31% |
| Harvest Investment Services, LLC | US$621.0万 | 1.14% |
| GAGNON SECURITIES LLC | US$608.8万 | 1.41% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$605.2万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$594.3万 | 0.01% |
| JPMORGAN CHASE & CO | US$583.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$576.6万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$565.0万 | 0.01% |
| E Fund Management Co., Ltd. | US$528.9万 | 0.16% |
| Tema ETFs LLC | US$521.9万 | 0.35% |
| Tidal Investments LLC | US$521.9万 | 0.01% |
| Atle Fund Management AB | US$514.1万 | 1.66% |
| Man Group plc | US$504.2万 | 0.01% |
| Informed Momentum Co LLC | US$497.5万 | 0.57% |
| RHUMBLINE ADVISERS | US$491.8万 | 0.00% |
| Swiss National Bank | US$470.3万 | 0.00% |
| Rafferty Asset Management, LLC | US$444.7万 | 0.02% |
| ALPS ADVISORS INC | US$429.9万 | 0.02% |
| FMR LLC | US$415.0万 | 0.00% |
| JNBA Financial Advisors | US$408.1万 | 0.34% |
| Creative Planning | US$402.0万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$396.7万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$395.0万 | 0.03% |
| Qube Research & Technologies Ltd | US$377.2万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$351.5万 | 0.00% |
| DEUTSCHE BANK AG\ | US$346.0万 | 0.00% |
| Affinity Asset Advisors, LLC | US$342.4万 | 0.18% |
| BRAIDWELL LP | US$333.3万 | 0.11% |
| BARCLAYS PLC | US$325.7万 | 0.00% |
| Nan Fung Group Holdings Ltd | US$323.0万 | 2.66% |
| NOMURA HOLDINGS INC | US$320.7万 | 0.01% |
| Accredited Investors Inc. | US$307.9万 | 0.17% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$292.0万 | 0.00% |
| MYDA Advisors LLC | US$285.4万 | 0.47% |
| MILLENNIUM MANAGEMENT LLC | US$273.1万 | 0.00% |
| Squarepoint Ops LLC | US$268.0万 | 0.00% |
| DIADEMA PARTNERS LP | US$262.7万 | 0.45% |
| Nicholas Investment Partners, LP | US$253.9万 | 0.18% |
| Quantinno Capital Management LP | US$252.9万 | 0.00% |
| SummitTX Capital, L.P. | US$237.5万 | 0.07% |
| D. E. Shaw & Co., Inc. | US$236.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$224.4万 | 0.00% |
| MetLife Investment Management, LLC | US$217.9万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$217.9万 | 0.00% |
| MARSHALL WACE, LLP | US$215.7万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$202.1万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$201.4万 | 0.00% |
| PROFUND ADVISORS LLC | US$201.0万 | 0.07% |
| FRED ALGER MANAGEMENT, LLC | US$200.3万 | 0.01% |
| Legal & General Group Plc | US$197.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$196.2万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | US$196.1万 | 0.01% |
| FRANKLIN RESOURCES INC | US$194.4万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$177.9万 | 0.00% |
| Artia Global Partners LP | US$177.8万 | 0.36% |
| XTX Topco Ltd | US$169.2万 | 0.03% |
| SEI INVESTMENTS CO | US$163.3万 | 0.00% |
| LPL Financial LLC | US$157.4万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$155.3万 | 0.00% |
| Kestra Advisory Services, LLC | US$155.3万 | 0.01% |
| HighVista Strategies LLC | US$149.6万 | 0.41% |
| COFG Advisors, LLC | US$140.3万 | 0.35% |
| INTEGRITY ALLIANCE, LLC. | US$133.4万 | 0.05% |
| IMC-Chicago, LLC | US$116.8万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$109.5万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$109.5万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$108.6万 | 0.01% |
| Odyssean, LLC | US$101.1万 | 0.37% |
| Focus Financial Network, Inc. | US$100.8万 | 0.04% |
| GUGGENHEIM CAPITAL LLC | US$97.9万 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$94.7万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$92.7万 | 0.00% |
| Jain Global LLC | US$91.0万 | 0.00% |
| ROYAL BANK OF CANADA | US$89.8万 | 0.00% |
| Swiss Life Asset Management Ltd | US$88.2万 | 0.00% |
| Cresset Asset Management, LLC | US$84.4万 | 0.00% |
| Ellsworth Advisors, LLC | US$82.4万 | 0.15% |