| RTW INVESTMENTS, LP | US$3485.4万 | 0.35% |
| BlackRock, Inc. | US$3283.3万 | 0.00% |
| Deep Track Capital, LP | US$3042.7万 | 0.50% |
| ARMISTICE CAPITAL, LLC | US$2433.8万 | 0.43% |
| Nantahala Capital Management, LLC | US$1900.0万 | 0.70% |
| STATE STREET CORP | US$1863.8万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1761.1万 | 0.00% |
| Stonepine Capital Management, LLC | US$1750.2万 | 7.01% |
| Foresite Capital Management VI LLC | US$1667.7万 | 3.62% |
| MILLENNIUM MANAGEMENT LLC | US$1278.3万 | 0.01% |
| CITADEL ADVISORS LLC | US$1259.4万 | 0.00% |
| MORGAN STANLEY | US$1191.1万 | 0.00% |
| Rosalind Advisors, Inc. | US$1133.4万 | 4.55% |
| Alyeska Investment Group, L.P. | US$1086.5万 | 0.03% |
| AIGH Capital Management LLC | US$1060.0万 | 1.45% |
| GEODE CAPITAL MANAGEMENT, LLC | US$910.5万 | 0.00% |
| J. Goldman & Co LP | US$890.8万 | 0.26% |
| GOLDMAN SACHS GROUP INC | US$786.5万 | 0.00% |
| Qube Research & Technologies Ltd | US$782.3万 | 0.01% |
| ACORN CAPITAL ADVISORS, LLC | US$778.7万 | 2.21% |
| NEXTBio Capital Management LP | US$692.6万 | 3.22% |
| FRANKLIN RESOURCES INC | US$586.1万 | 0.00% |
| Logos Global Management LP | US$530.0万 | 0.26% |
| Ishara Investments LP | US$434.6万 | 4.11% |
| Longaeva Partners L.P. | US$428.1万 | 0.16% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$401.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$382.7万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$353.5万 | 0.00% |
| Exome Asset Management LLC | US$337.5万 | 1.75% |
| BAKER BROS. ADVISORS LP | US$309.9万 | 0.02% |
| Jefferies Financial Group Inc. | US$294.7万 | 0.02% |
| UBS Group AG | US$288.2万 | 0.00% |
| NORTHERN TRUST CORP | US$273.4万 | 0.00% |
| Pinnacle Financial Partners, Inc. | US$262.5万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$262.2万 | 0.00% |
| FMR LLC | US$251.0万 | 0.00% |
| TORONTO DOMINION BANK | US$244.0万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$221.0万 | 0.00% |
| Balyasny Asset Management L.P. | US$217.2万 | 0.00% |
| XTX Topco Ltd | US$209.8万 | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$204.0万 | 0.00% |
| CANTOR FITZGERALD, L. P. | US$192.5万 | 0.03% |
| Y-Intercept (Hong Kong) Ltd | US$183.2万 | 0.03% |
| SPHERA FUNDS MANAGEMENT LTD. | US$182.1万 | 0.29% |
| ALGERT GLOBAL LLC | US$161.8万 | 0.02% |
| Torray Investment Partners LLC | US$158.4万 | 0.23% |
| Squarepoint Ops LLC | US$143.4万 | 0.00% |
| Palo Alto Investors LP | US$130.4万 | 0.20% |
| PANAGORA ASSET MANAGEMENT INC | US$129.4万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$117.3万 | 0.04% |
| SG Americas Securities, LLC | US$114.0万 | 0.00% |
| Ikarian Capital, LLC | US$113.3万 | 0.09% |
| Caption Management, LLC | US$112.6万 | 0.01% |
| Nuveen, LLC | US$109.2万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$105.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$104.1万 | 0.00% |
| ExodusPoint Capital Management, LP | US$97.5万 | 0.01% |
| Bank of New York Mellon Corp | US$85.7万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$80.2万 | 0.00% |
| Birchview Capital, LP | US$79.5万 | 0.45% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$76.7万 | 0.06% |
| Seven Fleet Capital Management LP | US$65.4万 | 0.21% |
| Jump Financial, LLC | US$62.8万 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$60.9万 | 0.01% |
| ROYAL BANK OF CANADA | US$58.7万 | 0.00% |
| Rafferty Asset Management, LLC | US$57.8万 | 0.00% |
| Invesco Ltd. | US$55.1万 | 0.00% |
| Knott David M Jr | US$55.1万 | 0.33% |
| Quarry LP | US$53.0万 | 0.10% |
| ALLIANCEBERNSTEIN L.P. | US$51.9万 | 0.00% |
| Man Group plc | US$51.3万 | 0.00% |
| Western Wealth Management, LLC | US$51.3万 | 0.02% |
| BARCLAYS PLC | US$47.9万 | 0.00% |
| Quantinno Capital Management LP | US$39.4万 | 0.00% |
| RHUMBLINE ADVISERS | US$38.1万 | 0.00% |
| ADAR1 Capital Management, LLC | US$37.7万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$36.3万 | 0.00% |
| Graham Capital Management, L.P. | US$35.5万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$35.0万 | 0.00% |
| DEUTSCHE BANK AG\ | US$33.3万 | 0.00% |
| Quadrature Capital Ltd | US$27.6万 | 0.00% |
| Brevan Howard Capital Management LP | US$27.1万 | 0.00% |
| PROFUND ADVISORS LLC | US$25.8万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$24.9万 | 0.00% |
| WINTON GROUP Ltd | US$24.5万 | 0.01% |
| Cetera Investment Advisers | US$23.0万 | 0.00% |
| Aquatic Capital Management LLC | US$22.7万 | 0.01% |
| Vanguard Global Advisers, LLC | US$22.6万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$22.5万 | 0.00% |
| HSBC HOLDINGS PLC | US$21.0万 | 0.00% |
| STIFEL FINANCIAL CORP | US$20.6万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$20.3万 | 0.00% |
| Dauntless Investment Group, LLC | US$19.5万 | 0.13% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$19.2万 | 0.17% |
| FOX RUN MANAGEMENT, L.L.C. | US$18.9万 | 0.03% |
| MetLife Investment Management, LLC | US$17.5万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$17.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$15.9万 | 0.00% |
| MIZUHO SECURITIES USA LLC | US$15.9万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$15.6万 | 0.00% |
| Virtus Investment Advisers, LLC | US$15.0万 | 0.04% |
| D. E. Shaw & Co., Inc. | US$14.1万 | 0.00% |
| JPMORGAN CHASE & CO | US$14.0万 | 0.00% |
| Aries Wealth Management | US$13.9万 | 0.03% |
| Verdad Advisers, LP | US$13.8万 | 0.16% |
| NewEdge Wealth, LLC | US$13.7万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$11.5万 | 0.00% |
| Scientech Research LLC | US$10.3万 | 0.09% |
| Police & Firemen's Retirement System of New Jersey | US$10.3万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$9.5万 | 0.00% |
| Polymer Capital Management (US) LLC | US$9.1万 | 0.01% |
| Point72 Asset Management, L.P. | US$8.2万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$8.1万 | 0.00% |
| Russell Investments Group, Ltd. | US$7.7万 | 0.00% |
| E Fund Management Co., Ltd. | US$7.3万 | 0.00% |
| Creative Planning | US$7.1万 | 0.00% |
| CITIGROUP INC | US$6.5万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$6.1万 | 0.00% |
| Engineers Gate Manager LP | US$5.5万 | 0.00% |
| Virtu Financial LLC | US$5.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$4.3万 | 0.00% |
| Legal & General Group Plc | US$3.1万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.9万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$2.8万 | 0.00% |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | US$2.4万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.9万 | 0.00% |
| Rockefeller Capital Management L.P. | US$1.4万 | 0.00% |
| GROUP ONE TRADING LLC | US$1.0万 | 0.00% |
| Cygnus Capital Advisors, LLC | US$1.0万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$9816.0 | 0.00% |
| Advisory Services Network, LLC | US$8830.0 | 0.00% |
| CWM, LLC | US$8454.0 | 0.00% |
| Quantbot Technologies LP | US$6683.0 | 0.00% |
| Sterling Capital Management LLC | US$6461.0 | 0.00% |
| GAMMA Investing LLC | US$5358.0 | 0.00% |
| SIGNATUREFD, LLC | US$4516.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$4510.0 | 0.00% |
| Optiver Holding B.V. | US$2841.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$2528.0 | 0.00% |
| Clearstead Advisors, LLC | US$2205.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$1177.0 | 0.00% |
| Allworth Financial LP | US$1087.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1008.3 | 0.00% |
| MAI Capital Management | US$806.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$758.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$758.0 | 0.00% |
| Physician Wealth Advisors, Inc. | US$589.0 | 0.00% |
| Farther Finance Advisors, LLC | US$305.0 | 0.00% |
| Sunbelt Securities, Inc. | US$249.0 | 0.00% |
| Root Financial Partners, LLC | US$233.0 | 0.00% |