| Nextech Invest, Ltd. | US$9075.1万 | 6.39% |
| EcoR1 Capital, LLC | US$8524.5万 | 3.62% |
| BlackRock, Inc. | US$7582.4万 | 0.00% |
| VIKING GLOBAL INVESTORS LP | US$7379.7万 | 0.21% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6826.4万 | 0.01% |
| SR One Capital Management, LP | US$5847.7万 | 6.39% |
| Pfizer Inc | US$5765.2万 | 24.14% |
| ALKEON CAPITAL MANAGEMENT LLC | US$5706.7万 | 0.10% |
| Venrock Adviser, LLC | US$5473.1万 | 2.04% |
| NEA Management Company, LLC | US$5218.3万 | 2.97% |
| STATE STREET CORP | US$4690.7万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4671.4万 | 0.00% |
| Column Group LLC | US$4486.2万 | 44.55% |
| Siren, L.L.C. | US$3798.7万 | 1.05% |
| ORBIMED ADVISORS LLC | US$3413.2万 | 0.70% |
| AIHC Capital Management Ltd | US$3116.3万 | 26.04% |
| FMR LLC | US$3084.0万 | 0.00% |
| CITADEL ADVISORS LLC | US$3082.3万 | 0.00% |
| First Turn Management, LLC | US$2555.9万 | 2.86% |
| Vivo Capital, LLC | US$2342.4万 | 1.95% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2330.2万 | 0.00% |
| MPM BIOIMPACT LLC | US$2285.6万 | 1.77% |
| Paradigm Biocapital Advisors LP | US$2155.4万 | 0.44% |
| MORGAN STANLEY | US$2131.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1869.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1863.7万 | 0.00% |
| FRANKLIN RESOURCES INC | US$1840.7万 | 0.00% |
| Integral Health Asset Management, LLC | US$1773.8万 | 0.85% |
| Woodline Partners LP | US$1580.6万 | 0.06% |
| ROYCE & ASSOCIATES LP | US$1529.6万 | 0.15% |
| BRAIDWELL LP | US$1429.2万 | 0.48% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1393.7万 | 1.42% |
| BANK OF AMERICA CORP /DE/ | US$1321.7万 | 0.00% |
| Euclidean Capital LLC | US$1253.6万 | 3.20% |
| ArrowMark Colorado Holdings LLC | US$1217.0万 | 0.32% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1207.9万 | 0.20% |
| Logos Global Management LP | US$1203.7万 | 0.60% |
| Qube Research & Technologies Ltd | US$1089.0万 | 0.01% |
| Defilade Capital Management, L.P. | US$1068.0万 | 1.50% |
| NORTHERN TRUST CORP | US$900.7万 | 0.00% |
| Sofinnova Investments, Inc. | US$861.0万 | 0.33% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$766.6万 | 0.00% |
| Candriam S.C.A. | US$727.4万 | 0.04% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$723.1万 | 0.00% |
| LORD, ABBETT & CO. LLC | US$687.5万 | 0.02% |
| Polar Capital Holdings Plc | US$683.4万 | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | US$681.2万 | 1.08% |
| Balyasny Asset Management L.P. | US$663.6万 | 0.01% |
| NEXTBio Capital Management LP | US$663.4万 | 3.08% |
| Connor, Clark & Lunn Investment Management Ltd. | US$661.5万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$642.7万 | 0.00% |
| Redmile Group, LLC | US$526.7万 | 0.35% |
| VICTORY CAPITAL MANAGEMENT INC | US$513.5万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$436.2万 | 0.01% |
| JPMORGAN CHASE & CO | US$394.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$333.3万 | 0.00% |
| TD Asset Management Inc | US$327.6万 | 0.00% |
| Atom Investors LP | US$287.4万 | 0.21% |
| UBS Group AG | US$246.7万 | 0.00% |
| Bank of New York Mellon Corp | US$241.3万 | 0.00% |
| ExodusPoint Capital Management, LP | US$235.8万 | 0.02% |
| WELLINGTON MANAGEMENT GROUP LLP | US$235.8万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$230.8万 | 0.00% |
| Boxer Capital Management, LLC | US$223.6万 | 0.29% |
| AQR CAPITAL MANAGEMENT LLC | US$215.5万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$202.8万 | 0.07% |
| Nuveen, LLC | US$193.9万 | 0.00% |
| Blue Owl Capital Holdings LP | US$190.1万 | 0.51% |
| AMERICAN CENTURY COMPANIES INC | US$186.0万 | 0.00% |
| Alyeska Investment Group, L.P. | US$174.2万 | 0.00% |
| ALGERT GLOBAL LLC | US$172.8万 | 0.03% |
| JANE STREET GROUP, LLC | US$162.6万 | 0.00% |
| Rafferty Asset Management, LLC | US$146.3万 | 0.01% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$146.0万 | 1.04% |
| Y-Intercept (Hong Kong) Ltd | US$141.9万 | 0.03% |
| Invesco Ltd. | US$138.0万 | 0.00% |
| Ishara Investments LP | US$129.9万 | 1.23% |
| PRUDENTIAL FINANCIAL INC | US$121.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$119.5万 | 0.00% |
| Abu Dhabi Investment Council Co P.J.S.C | US$113.3万 | 0.12% |
| Swiss National Bank | US$109.2万 | 0.00% |
| RHUMBLINE ADVISERS | US$100.2万 | 0.00% |
| DAFNA Capital Management LLC | US$94.5万 | 0.22% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$78.5万 | 0.01% |
| MOORE CAPITAL MANAGEMENT, LP | US$75.5万 | 0.02% |
| Tidal Investments LLC | US$73.0万 | 0.00% |
| Tema ETFs LLC | US$72.5万 | 0.05% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$68.7万 | 0.00% |
| PROFUND ADVISORS LLC | US$65.3万 | 0.02% |
| DEUTSCHE BANK AG\ | US$65.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$61.3万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$58.4万 | 0.04% |
| D. E. Shaw & Co., Inc. | US$56.2万 | 0.00% |
| XTX Topco Ltd | US$54.8万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$54.7万 | 0.00% |
| SummitTX Capital, L.P. | US$53.8万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$52.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$50.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$49.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$49.3万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$48.5万 | 0.00% |
| MetLife Investment Management, LLC | US$45.2万 | 0.00% |
| LMR Partners LLP | US$44.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$43.1万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$42.7万 | 0.00% |
| Optimize Financial Inc | US$41.0万 | 0.20% |
| Campbell & CO Investment Adviser LLC | US$37.8万 | 0.02% |
| Graham Capital Management, L.P. | US$37.3万 | 0.01% |
| Legal & General Group Plc | US$37.2万 | 0.00% |
| Virtus Investment Advisers, LLC | US$36.8万 | 0.10% |
| SECTORAL ASSET MANAGEMENT INC | US$33.3万 | 0.28% |
| Quantinno Capital Management LP | US$32.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$31.9万 | 0.00% |
| Trexquant Investment LP | US$30.4万 | 0.00% |
| STIFEL FINANCIAL CORP | US$30.3万 | 0.00% |
| Quarry LP | US$27.7万 | 0.05% |
| Jasper Ridge Partners, L.P. | US$26.4万 | 0.01% |
| Brevan Howard Capital Management LP | US$25.0万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$24.5万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$24.2万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$23.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$22.6万 | 0.02% |
| CITIGROUP INC | US$21.5万 | 0.00% |
| Creative Planning | US$20.9万 | 0.00% |
| SG Americas Securities, LLC | US$20.4万 | 0.00% |
| Palumbo Wealth Management LLC | US$19.7万 | 0.05% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$19.6万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$19.0万 | 0.00% |
| E Fund Management Co., Ltd. | US$18.4万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$18.2万 | 0.00% |
| ProShare Advisors LLC | US$17.8万 | 0.00% |
| PSP Research LLC | US$16.5万 | 0.12% |
| GSA CAPITAL PARTNERS LLP | US$16.2万 | 0.01% |
| BARCLAYS PLC | US$15.7万 | 0.00% |
| Hudson Bay Capital Management LP | US$15.7万 | 0.00% |
| CWM, LLC | US$15.3万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$15.3万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$14.4万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$14.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$14.2万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$13.5万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$11.8万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$11.4万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$10.4万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$10.1万 | 0.00% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$9.5万 | 0.09% |
| CANADA LIFE ASSURANCE Co | US$7.1万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$6.9万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$6.6万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$4.2万 | 0.00% |