| Paradigm Biocapital Advisors LP | US$3549.7万 | 0.73% |
| BlackRock, Inc. | US$2933.6万 | 0.00% |
| Affinity Asset Advisors, LLC | US$2898.8万 | 1.50% |
| RA CAPITAL MANAGEMENT, L.P. | US$2870.0万 | 0.30% |
| JANUS HENDERSON GROUP PLC | US$2851.0万 | 0.01% |
| Vestal Point Capital, LP | US$2568.7万 | 0.72% |
| Frazier Life Sciences Management, L.P. | US$2539.8万 | 0.65% |
| CITADEL ADVISORS LLC | US$2207.4万 | 0.00% |
| ORBIMED ADVISORS LLC | US$2067.8万 | 0.42% |
| STATE STREET CORP | US$2048.2万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1726.1万 | 0.00% |
| Woodline Partners LP | US$1578.8万 | 0.06% |
| GOLDMAN SACHS GROUP INC | US$1119.2万 | 0.00% |
| Avoro Capital Advisors LLC | US$1076.3万 | 0.11% |
| Point72 Asset Management, L.P. | US$964.6万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$925.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$912.4万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$869.1万 | 0.00% |
| ADAR1 Capital Management, LLC | US$842.3万 | 0.50% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$717.5万 | 0.18% |
| Nantahala Capital Management, LLC | US$688.8万 | 0.25% |
| 683 Capital Management, LLC | US$688.8万 | 0.36% |
| DIMENSIONAL FUND ADVISORS LP | US$633.2万 | 0.00% |
| Octagon Capital Advisors LP | US$631.4万 | 0.70% |
| Spruce Street Capital LP | US$533.0万 | 1.28% |
| Blackstone Inc. | US$519.4万 | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$331.3万 | 0.00% |
| Ikarian Capital, LLC | US$294.5万 | 0.24% |
| NORTHERN TRUST CORP | US$283.4万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$282.1万 | 0.00% |
| Qube Research & Technologies Ltd | US$267.2万 | 0.00% |
| MORGAN STANLEY | US$231.3万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$220.8万 | 0.00% |
| DAFNA Capital Management LLC | US$216.4万 | 0.49% |
| AQR CAPITAL MANAGEMENT LLC | US$194.9万 | 0.00% |
| UBS Group AG | US$184.7万 | 0.00% |
| Squarepoint Ops LLC | US$183.2万 | 0.00% |
| Aberdeen Group plc | US$141.1万 | 0.00% |
| Privium Fund Management B.V. | US$117.7万 | 0.24% |
| Nuveen, LLC | US$105.0万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$104.5万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$104.3万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$99.1万 | 0.00% |
| Bank of New York Mellon Corp | US$91.2万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$81.8万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$78.3万 | 0.01% |
| Burkehill Global Management, LP | US$71.8万 | 0.04% |
| Susquehanna Portfolio Strategies, LLC | US$64.9万 | 0.01% |
| ExodusPoint Capital Management, LP | US$64.4万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$61.4万 | 0.00% |
| Rafferty Asset Management, LLC | US$57.9万 | 0.00% |
| XTX Topco Ltd | US$57.7万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$50.2万 | 0.00% |
| JPMORGAN CHASE & CO | US$49.1万 | 0.00% |
| RHUMBLINE ADVISERS | US$41.4万 | 0.00% |
| Creative Planning | US$38.5万 | 0.00% |
| Invesco Ltd. | US$36.5万 | 0.00% |
| DEUTSCHE BANK AG\ | US$36.2万 | 0.00% |
| DRW Securities, LLC | US$27.5万 | 0.00% |
| Bleakley Financial Group, LLC | US$27.5万 | 0.00% |
| PROFUND ADVISORS LLC | US$25.9万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$24.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$24.4万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$21.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$20.9万 | 0.00% |
| MetLife Investment Management, LLC | US$20.4万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$19.7万 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | US$19.7万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$17.5万 | 0.00% |
| Virtus Investment Advisers, LLC | US$16.0万 | 0.04% |
| AXQ CAPITAL, LP | US$15.0万 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$14.7万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$14.3万 | 0.00% |
| JANE STREET GROUP, LLC | US$14.3万 | 0.00% |
| FMR LLC | US$14.0万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$13.9万 | 0.00% |
| Cerity Partners LLC | US$12.1万 | 0.00% |
| Soltis Investment Advisors LLC | US$11.5万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$11.4万 | 0.00% |
| CWM, LLC | US$10.5万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$10.2万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$10.1万 | 0.00% |
| EntryPoint Capital, LLC | US$9.5万 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | US$9.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$9.4万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$9.1万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$8.9万 | 0.00% |
| CAXTON CORP | US$8.0万 | 1.99% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$7.8万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$7.7万 | 0.00% |
| CITIGROUP INC | US$7.6万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$7.4万 | 0.01% |
| ProShare Advisors LLC | US$7.4万 | 0.00% |
| E Fund Management Co., Ltd. | US$7.3万 | 0.00% |
| BARCLAYS PLC | US$7.0万 | 0.00% |
| Virtu Financial LLC | US$6.8万 | 0.00% |
| Ethic Inc. | US$6.4万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$6.1万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$5.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$3.8万 | 0.00% |
| Legal & General Group Plc | US$3.2万 | 0.00% |
| ROYAL BANK OF CANADA | US$3.0万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.9万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2.8万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.2万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2.1万 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$1.4万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1.3万 | 0.00% |
| Sterling Capital Management LLC | US$1.3万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$9345.0 | 0.00% |
| Larson Financial Group LLC | US$8357.0 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$7778.0 | 0.00% |
| GROUP ONE TRADING LLC | US$7508.0 | 0.00% |
| SIMPLEX TRADING, LLC | US$7117.0 | 0.00% |
| Rockefeller Capital Management L.P. | US$6549.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$5740.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$4599.0 | 0.00% |
| US BANCORP \DE\ | US$3674.0 | 0.00% |
| Optiver Holding B.V. | US$3444.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$2899.0 | 0.00% |
| Essential Partners LLC | US$2704.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2359.0 | 0.00% |
| Truvestments Capital LLC | US$2296.0 | 0.00% |
| Allworth Financial LP | US$2176.0 | 0.00% |
| GAMMA Investing LLC | US$1900.0 | 0.00% |
| True Wealth Design, LLC | US$1298.0 | 0.00% |
| SBI Securities Co., Ltd. | US$1188.0 | 0.00% |
| Fortitude Family Office, LLC | US$1177.0 | 0.00% |
| IFP Advisors, Inc | US$1165.0 | 0.00% |
| Key Financial Inc | US$1148.0 | 0.00% |
| SIGNATUREFD, LLC | US$1148.0 | 0.00% |
| Torren Management, LLC | US$1022.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$574.0 | 0.00% |
| Bare Financial Services, Inc | US$459.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$344.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$321.0 | 0.00% |
| Basecamp Wealth Advisors LLC | US$166.0 | 0.00% |
| Sunbelt Securities, Inc. | US$92.0 | 0.00% |
| MAI Capital Management | US$64.0 | 0.00% |
| Smartleaf Asset Management LLC | US$21.0 | 0.00% |