| WELLINGTON MANAGEMENT GROUP LLP | US$2.7亿 | 0.05% |
| Kynam Capital Management, LP | US$1.9亿 | 11.43% |
| BlackRock, Inc. | US$1.7亿 | 0.00% |
| FMR LLC | US$1.2亿 | 0.01% |
| Point72 Asset Management, L.P. | US$1.0亿 | 0.13% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$9392.0万 | 0.00% |
| STATE STREET CORP | US$8894.8万 | 0.00% |
| Commodore Capital LP | US$8553.7万 | 4.95% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6617.9万 | 0.01% |
| Eversept Partners, LP | US$5671.6万 | 2.99% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5355.6万 | 0.00% |
| BRAIDWELL LP | US$4301.5万 | 1.43% |
| Deep Track Capital, LP | US$4072.8万 | 0.67% |
| MILLENNIUM MANAGEMENT LLC | US$3976.2万 | 0.02% |
| Vestal Point Capital, LP | US$3883.1万 | 1.09% |
| Bellevue Group AG | US$3806.4万 | 0.91% |
| NOVO HOLDINGS A/S | US$3806.4万 | 3.08% |
| DIMENSIONAL FUND ADVISORS LP | US$3359.6万 | 0.01% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$3289.4万 | 0.54% |
| Fisher Asset Management, LLC | US$3215.3万 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$3135.3万 | 0.00% |
| Pictet Asset Management Holding SA | US$2930.0万 | 0.03% |
| Elmind Capital, LP | US$2743.8万 | 7.79% |
| AMERICAN CENTURY COMPANIES INC | US$2716.2万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$2247.8万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$2110.6万 | 0.12% |
| Rock Springs Capital Management LP | US$2062.7万 | 1.22% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1996.0万 | 0.00% |
| NORTHERN TRUST CORP | US$1831.1万 | 0.00% |
| Ikarian Capital, LLC | US$1824.7万 | 1.48% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1730.3万 | 0.00% |
| Woodline Partners LP | US$1586.4万 | 0.06% |
| Affinity Asset Advisors, LLC | US$1586.0万 | 0.82% |
| 5AM Venture Management, LLC | US$1577.3万 | 4.38% |
| Logos Global Management LP | US$1427.4万 | 0.71% |
| VANGUARD FIDUCIARY TRUST CO | US$1362.7万 | 0.00% |
| ADAR1 Capital Management, LLC | US$1357.0万 | 0.80% |
| TSP Capital Management Group, LLC | US$1189.9万 | 2.90% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$1117.5万 | 0.24% |
| SEGALL BRYANT & HAMILL, LLC | US$1100.4万 | 0.16% |
| Rosalind Advisors, Inc. | US$1046.8万 | 4.21% |
| PFM Health Sciences, LP | US$1030.8万 | 0.94% |
| Foresite Capital Management VI LLC | US$1002.1万 | 2.18% |
| Tetragon Partners GP Ltd | US$990.7万 | 1.92% |
| UBS Group AG | US$942.0万 | 0.00% |
| Palo Alto Investors LP | US$940.2万 | 1.44% |
| Candriam S.C.A. | US$884.6万 | 0.05% |
| Redmile Group, LLC | US$829.5万 | 0.55% |
| STEMPOINT CAPITAL LP | US$806.5万 | 1.54% |
| SPHERA FUNDS MANAGEMENT LTD. | US$772.6万 | 1.23% |
| CITADEL ADVISORS LLC | US$770.5万 | 0.00% |
| SummitTX Capital, L.P. | US$750.6万 | 0.23% |
| MORGAN STANLEY | US$690.1万 | 0.00% |
| CITIGROUP INC | US$689.4万 | 0.00% |
| ALGERT GLOBAL LLC | US$682.5万 | 0.10% |
| Nuveen, LLC | US$640.6万 | 0.00% |
| Bank of New York Mellon Corp | US$603.9万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$584.0万 | 0.01% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$571.1万 | 4.08% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$565.8万 | 0.58% |
| Mirador Capital Partners LP | US$564.8万 | 0.80% |
| GordonMD Global Investments LP | US$540.2万 | 3.76% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$533.7万 | 0.07% |
| JPMORGAN CHASE & CO | US$485.8万 | 0.00% |
| Assenagon Asset Management S.A. | US$464.8万 | 0.01% |
| DEUTSCHE BANK AG\ | US$453.7万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$451.5万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$434.6万 | 0.00% |
| Propel Bio Management, LLC | US$413.5万 | 2.61% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$388.3万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$383.2万 | 0.00% |
| Swiss National Bank | US$374.0万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$366.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$350.9万 | 0.00% |
| PDT Partners, LLC | US$310.3万 | 0.18% |
| Invesco Ltd. | US$297.2万 | 0.00% |
| HighVista Strategies LLC | US$283.6万 | 0.78% |
| RHUMBLINE ADVISERS | US$272.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$269.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$252.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$246.7万 | 0.00% |
| TD Asset Management Inc | US$223.0万 | 0.00% |
| Birchview Capital, LP | US$222.3万 | 1.27% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$222.2万 | 0.00% |
| Simplify Asset Management Inc. | US$218.8万 | 0.03% |
| DAFNA Capital Management LLC | US$217.3万 | 0.49% |
| FIRST TRUST ADVISORS LP | US$217.2万 | 0.00% |
| Quantinno Capital Management LP | US$208.5万 | 0.00% |
| Rafferty Asset Management, LLC | US$206.3万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$178.0万 | 0.00% |
| Legal & General Group Plc | US$174.7万 | 0.00% |
| ALPS ADVISORS INC | US$171.9万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$167.7万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$150.7万 | 0.05% |
| HRT FINANCIAL LP | US$148.2万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$143.3万 | 0.03% |
| Cinctive Capital Management LP | US$130.8万 | 0.09% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$130.3万 | 0.00% |
| SEI INVESTMENTS CO | US$121.0万 | 0.00% |
| SG Americas Securities, LLC | US$120.6万 | 0.00% |
| MetLife Investment Management, LLC | US$116.3万 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$112.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$111.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$111.1万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$108.2万 | 0.00% |
| Creative Planning | US$106.1万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$105.0万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$104.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$97.3万 | 0.00% |
| PROFUND ADVISORS LLC | US$93.7万 | 0.03% |
| Seven Fleet Capital Management LP | US$92.9万 | 0.29% |
| VICTORY CAPITAL MANAGEMENT INC | US$87.0万 | 0.00% |
| Vanguard Global Advisers, LLC | US$82.6万 | 0.00% |
| Handelsbanken Fonder AB | US$82.2万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$81.4万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$79.8万 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$79.3万 | 0.02% |
| Quadrature Capital Ltd | US$77.5万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$70.5万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$70.4万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$67.7万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$64.8万 | 0.00% |
| Virtu Financial LLC | US$62.9万 | 0.03% |
| Apella Capital, LLC | US$58.8万 | 0.01% |
| FRED ALGER MANAGEMENT, LLC | US$58.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$57.5万 | 0.00% |
| DNB Asset Management AS | US$57.4万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$52.1万 | 0.00% |
| SBI Okasan Asset Management Co.Ltd. | US$48.3万 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$46.1万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$45.5万 | 0.00% |
| BARCLAYS PLC | US$44.3万 | 0.00% |
| PSP Research LLC | US$41.2万 | 0.29% |
| BANK OF MONTREAL /CAN/ | US$41.2万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$40.6万 | 0.00% |
| AlphaCentric Advisors LLC | US$40.0万 | 0.40% |
| Corient Private Wealth LLC | US$39.3万 | 0.00% |
| XTX Topco Ltd | US$38.3万 | 0.01% |
| Marex Group plc | US$38.1万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$37.2万 | 0.00% |
| Overbrook Management Corp | US$36.6万 | 0.07% |
| TWINBEECH CAPITAL LP | US$36.3万 | 0.04% |
| GLENMEDE TRUST CO NA | US$35.7万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$33.0万 | 0.00% |
| Virtus Investment Advisers, LLC | US$31.4万 | 0.09% |
| Scientech Research LLC | US$30.1万 | 0.25% |
| ProShare Advisors LLC | US$30.1万 | 0.00% |
| Amundi | US$29.7万 | 0.00% |
| Brevan Howard Capital Management LP | US$29.4万 | 0.00% |
| Jump Financial, LLC | US$28.0万 | 0.00% |