| FMR LLC | US$36.4亿 | 0.19% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$24.6亿 | 0.28% |
| JANUS HENDERSON GROUP PLC | US$18.5亿 | 0.88% |
| Capital World Investors | US$16.5亿 | 0.22% |
| Artisan Partners Limited Partnership | US$10.7亿 | 1.72% |
| WELLINGTON MANAGEMENT GROUP LLP | US$7.5亿 | 0.14% |
| Avoro Capital Advisors LLC | US$7.3亿 | 7.18% |
| BlackRock, Inc. | US$5.9亿 | 0.01% |
| RTW INVESTMENTS, LP | US$5.2亿 | 5.16% |
| Invesco Ltd. | US$4.3亿 | 0.07% |
| MORGAN STANLEY | US$4.1亿 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$3.6亿 | 0.12% |
| BANK OF AMERICA CORP /DE/ | US$2.9亿 | 0.02% |
| SANDS CAPITAL MANAGEMENT, LLC | US$2.5亿 | 0.97% |
| Bellevue Group AG | US$2.3亿 | 5.44% |
| CITADEL ADVISORS LLC | US$2.1亿 | 0.03% |
| SEI INVESTMENTS CO | US$2.1亿 | 0.19% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$1.9亿 | 0.64% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1.7亿 | 0.02% |
| JENNISON ASSOCIATES LLC | US$1.7亿 | 0.12% |
| FRANKLIN RESOURCES INC | US$1.7亿 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$1.7亿 | 0.02% |
| Clearbridge Investments, LLC | US$1.7亿 | 0.15% |
| Fiera Capital Corp | US$1.6亿 | 0.54% |
| AMERIPRISE FINANCIAL INC | US$1.6亿 | 0.04% |
| Allspring Global Investments Holdings, LLC | US$1.3亿 | 0.22% |
| AMERICAN CENTURY COMPANIES INC | US$1.3亿 | 0.07% |
| Checkpoint Capital L.P. | US$1.1亿 | 40.10% |
| LORD, ABBETT & CO. LLC | US$1.1亿 | 0.36% |
| Legal & General Group Plc | US$1.1亿 | 0.03% |
| Pictet Asset Management Holding SA | US$1.1亿 | 0.11% |
| DEUTSCHE BANK AG\ | US$1.0亿 | 0.03% |
| BAMCO INC /NY/ | US$1.0亿 | 0.31% |
| ORBIMED ADVISORS LLC | US$9997.1万 | 2.05% |
| D. E. Shaw & Co., Inc. | US$9787.0万 | 0.06% |
| LAZARD ASSET MANAGEMENT LLC | US$9737.7万 | 0.16% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$9431.0万 | 0.11% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$9173.6万 | 1.52% |
| AGF MANAGEMENT LTD | US$9133.2万 | 0.41% |
| TWO SIGMA INVESTMENTS, LP | US$7968.6万 | 0.06% |
| FIRST TRUST ADVISORS LP | US$7827.9万 | 0.06% |
| PINEBRIDGE INVESTMENTS LLC | US$7580.9万 | 0.64% |
| Rock Springs Capital Management LP | US$7193.0万 | 4.24% |
| FEDERATED HERMES, INC. | US$6955.9万 | 0.11% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$6572.3万 | 0.10% |
| BANK OF MONTREAL /CAN/ | US$6231.4万 | 0.02% |
| BRAIDWELL LP | US$6202.7万 | 2.07% |
| 1832 Asset Management L.P. | US$6148.7万 | 0.06% |
| TimesSquare Capital Management, LLC | US$6069.6万 | 1.03% |
| Aberdeen Group plc | US$5995.8万 | 0.10% |
| TD Asset Management Inc | US$5902.2万 | 0.05% |
| Eagle Health Investments LP | US$5574.4万 | 9.75% |
| Public Sector Pension Investment Board | US$5352.7万 | 0.17% |
| MILLENNIUM MANAGEMENT LLC | US$5284.5万 | 0.02% |
| Ensign Peak Advisors, Inc | US$5228.4万 | 0.10% |
| PGGM Investments | US$5222.3万 | 0.92% |
| Nuveen, LLC | US$4837.2万 | 0.01% |
| BESSEMER GROUP INC | US$4692.0万 | 0.07% |
| Amundi | US$4486.1万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$4485.1万 | 0.01% |
| Life Cycle Investment Partners Ltd | US$4298.8万 | 0.27% |
| NORTHERN TRUST CORP | US$4287.0万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$4262.8万 | 0.07% |
| JANE STREET GROUP, LLC | US$4121.4万 | 0.01% |
| Handelsbanken Fonder AB | US$4011.0万 | 0.13% |
| Candriam S.C.A. | US$3954.2万 | 0.21% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$3602.3万 | 0.03% |
| NOMURA ASSET MANAGEMENT CO LTD | US$3600.6万 | 0.09% |
| LMR Partners LLP | US$3058.9万 | 0.07% |
| VAN ECK ASSOCIATES CORP | US$2950.0万 | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$2879.9万 | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | US$2832.7万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$2782.5万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$2687.4万 | 0.01% |
| Patient Square Capital LP | US$2681.3万 | 4.76% |
| Davern Capital Partners, LP | US$2559.2万 | 7.02% |
| ROYAL BANK OF CANADA | US$2403.6万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$2355.4万 | 0.02% |
| UBS Group AG | US$2311.0万 | 0.00% |
| Tri Locum Partners LP | US$2310.1万 | 3.24% |
| Jefferies Financial Group Inc. | US$2191.1万 | 0.15% |
| Hudson Bay Capital Management LP | US$2190.8万 | 0.08% |
| Artia Global Partners LP | US$2171.7万 | 4.35% |
| Perpetual Ltd | US$2070.9万 | 0.32% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2008.6万 | 0.00% |
| Jones Hill Capital LP | US$1898.3万 | 4.07% |
| Qube Research & Technologies Ltd | US$1864.8万 | 0.02% |
| BAKER BROS. ADVISORS LP | US$1838.3万 | 0.11% |
| Squarepoint Ops LLC | US$1831.4万 | 0.02% |
| ODDO BHF ASSET MANAGEMENT SAS | US$1826.3万 | 0.72% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1721.1万 | 0.00% |
| LPL Financial LLC | US$1697.7万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$1654.1万 | 0.07% |
| BLAIR WILLIAM & CO/IL | US$1636.2万 | 0.05% |
| Caption Management, LLC | US$1606.6万 | 0.09% |
| NATIXIS ADVISORS, LLC | US$1488.2万 | 0.02% |
| HSBC HOLDINGS PLC | US$1488.2万 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1480.7万 | 0.01% |
| MIROVA | US$1448.3万 | 0.59% |
| HRT FINANCIAL LP | US$1369.5万 | 0.03% |
| Bank of New York Mellon Corp | US$1254.8万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$1162.2万 | 0.01% |
| Assenagon Asset Management S.A. | US$1079.7万 | 0.02% |
| DCF Advisers, LLC | US$1069.8万 | 2.85% |
| Allianz Asset Management GmbH | US$1051.6万 | 0.01% |
| CenterBook Partners LP | US$1017.5万 | 0.55% |
| Ilmarinen Mutual Pension Insurance Co | US$1007.7万 | 0.08% |
| Erste Asset Management GmbH | US$1000.5万 | 0.09% |
| Balyasny Asset Management L.P. | US$957.4万 | 0.01% |
| Thrivent Financial for Lutherans | US$926.1万 | 0.02% |
| JPMORGAN CHASE & CO | US$916.0万 | 0.00% |
| USS Investment Management Ltd | US$887.2万 | 0.04% |
| Tower Research Capital LLC (TRC) | US$884.5万 | 0.23% |
| CANADA LIFE ASSURANCE Co | US$848.4万 | 0.02% |
| Quantinno Capital Management LP | US$814.1万 | 0.01% |
| Optiver Holding B.V. | US$738.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$686.7万 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$684.3万 | 0.03% |
| ASSETMARK, INC | US$677.3万 | 0.01% |
| CITIGROUP INC | US$663.2万 | 0.00% |
| Campbell & CO Investment Adviser LLC | US$659.7万 | 0.38% |
| Crossmark Global Holdings, Inc. | US$633.0万 | 0.09% |
| CVFG LLC | US$622.0万 | 0.77% |
| Creative Planning | US$601.7万 | 0.00% |
| STIFEL FINANCIAL CORP | US$589.3万 | 0.01% |
| Cinctive Capital Management LP | US$561.3万 | 0.37% |
| MACKENZIE FINANCIAL CORP | US$543.0万 | 0.01% |
| Point72 Asset Management, L.P. | US$518.5万 | 0.01% |
| EFG International AG | US$517.5万 | 0.11% |
| NAVELLIER & ASSOCIATES INC | US$512.9万 | 0.53% |
| Trexquant Investment LP | US$511.8万 | 0.04% |
| Federation des caisses Desjardins du Quebec | US$505.3万 | 0.02% |
| Maryland State Retirement & Pension System | US$503.3万 | 0.10% |
| Cetera Investment Advisers | US$491.6万 | 0.01% |
| MML INVESTORS SERVICES, LLC | US$439.0万 | 0.01% |
| EAGLE GLOBAL ADVISORS LLC | US$438.3万 | 0.16% |
| iA Global Asset Management Inc. | US$438.2万 | 0.06% |
| Y-Intercept (Hong Kong) Ltd | US$429.7万 | 0.08% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$405.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$404.9万 | 0.00% |
| BARCLAYS PLC | US$401.6万 | 0.00% |
| SIH Partners, LLLP | US$395.6万 | 0.05% |
| HighTower Advisors, LLC | US$386.9万 | 0.00% |
| QVT Financial LP | US$381.0万 | 0.28% |
| STATE STREET CORP | US$373.4万 | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$369.1万 | 0.02% |
| China Universal Asset Management Co., Ltd. | US$367.7万 | 0.28% |
| M&T Bank Corp | US$365.3万 | 0.01% |
| Varma Mutual Pension Insurance Co | US$365.1万 | 0.02% |
| HighVista Strategies LLC | US$359.1万 | 0.99% |