| T. Rowe Price Investment Management, Inc. | US$8.7亿 | 0.60% |
| FMR LLC | US$7.8亿 | 0.04% |
| Venrock Adviser, LLC | US$7.1亿 | 26.68% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.7亿 | 0.07% |
| BlackRock, Inc. | US$3.4亿 | 0.01% |
| RTW INVESTMENTS, LP | US$2.3亿 | 2.33% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.1亿 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$2.0亿 | 0.09% |
| STATE STREET CORP | US$1.8亿 | 0.01% |
| Driehaus Capital Management LLC | US$1.6亿 | 1.19% |
| PERCEPTIVE ADVISORS LLC | US$1.3亿 | 2.53% |
| Paradigm Biocapital Advisors LP | US$1.1亿 | 2.32% |
| Affinity Asset Advisors, LLC | US$1.1亿 | 5.59% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.0亿 | 0.01% |
| UBS Group AG | US$9631.8万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$9622.1万 | 0.01% |
| Vestal Point Capital, LP | US$9258.7万 | 2.59% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$8959.8万 | 0.92% |
| JPMORGAN CHASE & CO | US$8741.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$7582.6万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$7474.8万 | 0.02% |
| MERCER GLOBAL ADVISORS INC /ADV | US$6998.1万 | 0.10% |
| CITADEL ADVISORS LLC | US$5493.0万 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$5492.9万 | 0.01% |
| MORGAN STANLEY | US$5008.4万 | 0.00% |
| JENNISON ASSOCIATES LLC | US$4924.1万 | 0.03% |
| Remedium Capital Partners, LLC | US$4912.1万 | 17.47% |
| First Light Asset Management, LLC | US$4853.9万 | 4.35% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$4691.8万 | 0.78% |
| Polar Capital Holdings Plc | US$4538.3万 | 0.16% |
| First Turn Management, LLC | US$4324.4万 | 4.83% |
| BRAIDWELL LP | US$4028.9万 | 1.34% |
| NOVO HOLDINGS A/S | US$3787.7万 | 3.07% |
| FEDERATED HERMES, INC. | US$3726.5万 | 0.06% |
| Balyasny Asset Management L.P. | US$3692.2万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3540.9万 | 0.01% |
| FRANKLIN RESOURCES INC | US$3413.4万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3335.9万 | 0.00% |
| Caption Management, LLC | US$3328.1万 | 0.19% |
| NORTHERN TRUST CORP | US$3290.0万 | 0.00% |
| Opaleye Management Inc. | US$3282.6万 | 4.32% |
| GREAT POINT PARTNERS LLC | US$3148.0万 | 7.23% |
| VANGUARD FIDUCIARY TRUST CO | US$3105.5万 | 0.01% |
| LOOMIS SAYLES & CO L P | US$3053.5万 | 0.04% |
| Capital World Investors | US$2934.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2680.0万 | 0.00% |
| Fairmount Funds Management LLC | US$2513.7万 | 1.82% |
| Deep Track Capital, LP | US$2398.8万 | 0.39% |
| TWO SIGMA INVESTMENTS, LP | US$2368.4万 | 0.02% |
| Woodline Partners LP | US$2197.8万 | 0.08% |
| Pictet Asset Management Holding SA | US$2197.3万 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2104.3万 | 0.03% |
| Candriam S.C.A. | US$1881.5万 | 0.10% |
| DIADEMA PARTNERS LP | US$1872.8万 | 3.19% |
| TD Asset Management Inc | US$1555.4万 | 0.01% |
| BARCLAYS PLC | US$1356.8万 | 0.00% |
| Aberdeen Group plc | US$1206.8万 | 0.02% |
| NOMURA HOLDINGS INC | US$1122.5万 | 0.03% |
| Nicholas Investment Partners, LP | US$1102.6万 | 0.80% |
| Nuveen, LLC | US$1078.3万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$1077.5万 | 0.02% |
| Bank of New York Mellon Corp | US$1066.9万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$1032.5万 | 0.22% |
| ArrowMark Colorado Holdings LLC | US$920.9万 | 0.24% |
| SEVEN GRAND MANAGERS, LLC | US$841.7万 | 0.56% |
| VICTORY CAPITAL MANAGEMENT INC | US$800.8万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$779.3万 | 0.00% |
| DEUTSCHE BANK AG\ | US$769.5万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$760.9万 | 0.01% |
| JANE STREET GROUP, LLC | US$739.0万 | 0.00% |
| Ensign Peak Advisors, Inc | US$692.7万 | 0.01% |
| MARSHALL WACE, LLP | US$675.1万 | 0.01% |
| SIMPLEX TRADING, LLC | US$654.9万 | 0.00% |
| Parkman Healthcare Partners LLC | US$653.9万 | 0.67% |
| Swiss National Bank | US$636.3万 | 0.00% |
| Granahan Investment Management, LLC | US$632.0万 | 0.31% |
| Alyeska Investment Group, L.P. | US$631.3万 | 0.02% |
| Rhenman & Partners Asset Management AB | US$631.3万 | 0.78% |
| WCM INVESTMENT MANAGEMENT, LLC | US$598.5万 | 0.01% |
| Boxer Capital Management, LLC | US$589.2万 | 0.77% |
| AMERIPRISE FINANCIAL INC | US$588.2万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$578.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$537.8万 | 0.01% |
| FIFTH THIRD BANCORP | US$537.0万 | 0.01% |
| Rafferty Asset Management, LLC | US$508.4万 | 0.02% |
| D. E. Shaw & Co., Inc. | US$495.2万 | 0.00% |
| Russell Investments Group, Ltd. | US$492.3万 | 0.01% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$490.8万 | 1.24% |
| Holocene Advisors, LP | US$483.8万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$474.3万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$458.2万 | 0.01% |
| Lisanti Capital Growth, LLC | US$439.9万 | 1.11% |
| RHUMBLINE ADVISERS | US$409.7万 | 0.00% |
| ALPS ADVISORS INC | US$383.7万 | 0.02% |
| XTX Topco Ltd | US$361.1万 | 0.06% |
| SEI INVESTMENTS CO | US$355.2万 | 0.00% |
| Man Group plc | US$352.0万 | 0.01% |
| FIRST TRUST ADVISORS LP | US$343.2万 | 0.00% |
| Invesco Ltd. | US$326.3万 | 0.00% |
| Squarepoint Ops LLC | US$322.8万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$321.2万 | 0.00% |
| KBC Group NV | US$318.5万 | 0.01% |
| HighVista Strategies LLC | US$301.0万 | 0.83% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$285.7万 | 0.00% |
| Burkehill Global Management, LP | US$252.5万 | 0.13% |
| MOODY ALDRICH PARTNERS LLC | US$244.8万 | 0.44% |
| VOYA INVESTMENT MANAGEMENT LLC | US$238.9万 | 0.00% |
| Legal & General Group Plc | US$230.8万 | 0.00% |
| PROFUND ADVISORS LLC | US$228.3万 | 0.08% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$218.6万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$215.9万 | 0.00% |
| Maven Securities LTD | US$210.4万 | 0.04% |
| Vanguard Global Advisers, LLC | US$205.3万 | 0.00% |
| MetLife Investment Management, LLC | US$204.1万 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$194.3万 | 0.01% |
| Persistent Asset Partners Ltd | US$193.4万 | 0.72% |
| Erste Asset Management GmbH | US$188.9万 | 0.02% |
| Handelsbanken Fonder AB | US$177.6万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$172.2万 | 0.00% |
| BANQUE PICTET & CIE SA | US$168.0万 | 0.01% |
| Humankind Investments LLC | US$147.3万 | 0.84% |
| WELLS FARGO & COMPANY/MN | US$139.1万 | 0.00% |
| Shay Capital LLC | US$138.9万 | 0.12% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$134.0万 | 0.00% |
| BAMCO INC /NY/ | US$126.3万 | 0.00% |
| CITIGROUP INC | US$117.7万 | 0.00% |
| Point72 Asset Management, L.P. | US$116.2万 | 0.00% |
| Creative Planning | US$114.7万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$112.9万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$108.1万 | 0.01% |
| Vestmark Advisory Solutions, Inc. | US$106.4万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$102.8万 | 0.01% |
| LMR Partners LLP | US$101.2万 | 0.00% |
| B. Metzler seel. Sohn & Co. AG | US$98.4万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$96.6万 | 0.00% |
| AlphaCentric Advisors LLC | US$95.7万 | 0.96% |
| Police & Firemen's Retirement System of New Jersey | US$93.7万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$93.2万 | 0.00% |
| GLENMEDE TRUST CO NA | US$90.9万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$88.5万 | 0.01% |
| SG Americas Securities, LLC | US$85.9万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$81.9万 | 0.06% |
| Vanguard Investments Australia, Ltd. | US$81.2万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$78.7万 | 0.00% |
| Birchview Capital, LP | US$75.8万 | 0.43% |
| ProShare Advisors LLC | US$74.8万 | 0.00% |
| Marks Group Wealth Management, Inc | US$69.4万 | 0.07% |
| AQR CAPITAL MANAGEMENT LLC | US$67.6万 | 0.00% |
| DNB Asset Management AS | US$67.3万 | 0.00% |
| Global Endowment Management, LP | US$65.6万 | 0.07% |