| BlackRock, Inc. | US$17.6亿 | 0.03% |
| Dodge & Cox | US$7.2亿 | 0.40% |
| JPMORGAN CHASE & CO | US$7.0亿 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$6.5亿 | 0.30% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$6.2亿 | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5.9亿 | 0.01% |
| STATE STREET CORP | US$5.7亿 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$4.0亿 | 0.33% |
| RENAISSANCE TECHNOLOGIES LLC | US$3.2亿 | 0.50% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.8亿 | 0.02% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2.0亿 | 0.23% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.8亿 | 0.03% |
| Vestal Point Capital, LP | US$1.6亿 | 4.60% |
| MILLENNIUM MANAGEMENT LLC | US$1.6亿 | 0.07% |
| NORTHERN TRUST CORP | US$1.6亿 | 0.02% |
| UBS Group AG | US$1.6亿 | 0.02% |
| MORGAN STANLEY | US$1.6亿 | 0.01% |
| RTW INVESTMENTS, LP | US$1.4亿 | 1.39% |
| FIRST TRUST ADVISORS LP | US$1.3亿 | 0.09% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.2亿 | 0.02% |
| IEQ CAPITAL, LLC | US$1.0亿 | 0.47% |
| VICTORY CAPITAL MANAGEMENT INC | US$9638.2万 | 0.06% |
| ARMISTICE CAPITAL, LLC | US$9538.0万 | 1.70% |
| DIMENSIONAL FUND ADVISORS LP | US$9375.3万 | 0.02% |
| Bank of New York Mellon Corp | US$9254.6万 | 0.02% |
| BRAIDWELL LP | US$8591.0万 | 2.87% |
| Fiera Capital Corp | US$8579.6万 | 0.29% |
| VANGUARD FIDUCIARY TRUST CO | US$8356.8万 | 0.02% |
| FRANKLIN RESOURCES INC | US$8052.8万 | 0.02% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$8036.1万 | 0.95% |
| Pictet Asset Management Holding SA | US$7894.5万 | 0.08% |
| RAYMOND JAMES FINANCIAL INC | US$7832.5万 | 0.02% |
| GW&K Investment Management, LLC | US$7821.7万 | 0.69% |
| BANK OF AMERICA CORP /DE/ | US$7691.3万 | 0.01% |
| Swedbank AB | US$7633.4万 | 0.08% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$7531.8万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$7425.3万 | 0.02% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$6854.0万 | 0.29% |
| AMERIPRISE FINANCIAL INC | US$6745.5万 | 0.02% |
| MARSHALL WACE, LLP | US$6705.3万 | 0.07% |
| PRIMECAP MANAGEMENT CO/CA/ | US$6538.8万 | 0.05% |
| Squarepoint Ops LLC | US$6428.3万 | 0.08% |
| JANUS HENDERSON GROUP PLC | US$6151.5万 | 0.03% |
| Nuveen, LLC | US$5836.8万 | 0.02% |
| Man Group plc | US$5479.2万 | 0.10% |
| Hood River Capital Management LLC | US$5327.5万 | 0.53% |
| Hudson Bay Capital Management LP | US$5214.9万 | 0.18% |
| Legal & General Group Plc | US$5013.9万 | 0.01% |
| DEUTSCHE BANK AG\ | US$4813.1万 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$4780.6万 | 0.01% |
| Gotham Asset Management, LLC | US$4744.4万 | 0.15% |
| Invesco Ltd. | US$4690.1万 | 0.01% |
| ACADIAN ASSET MANAGEMENT LLC | US$4618.4万 | 0.07% |
| Allspring Global Investments Holdings, LLC | US$4406.4万 | 0.07% |
| ROYAL BANK OF CANADA | US$4377.7万 | 0.01% |
| Clearbridge Investments, LLC | US$4084.4万 | 0.04% |
| RHUMBLINE ADVISERS | US$4002.5万 | 0.03% |
| Swiss National Bank | US$3854.7万 | 0.02% |
| Rockefeller Capital Management L.P. | US$3716.3万 | 0.07% |
| Candriam S.C.A. | US$3623.7万 | 0.19% |
| JANE STREET GROUP, LLC | US$3536.0万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3516.5万 | 0.00% |
| RENAISSANCE GROUP LLC | US$3245.8万 | 1.36% |
| BARCLAYS PLC | US$3214.2万 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | US$3137.5万 | 0.02% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | US$3134.1万 | 0.12% |
| SEI INVESTMENTS CO | US$3099.2万 | 0.03% |
| WELLS FARGO & COMPANY/MN | US$3047.3万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$2964.8万 | 0.04% |
| California Public Employees Retirement System | US$2930.4万 | 0.02% |
| Sumitomo Mitsui Trust Group, Inc. | US$2904.2万 | 0.02% |
| Russell Investments Group, Ltd. | US$2893.3万 | 0.03% |
| ENVESTNET ASSET MANAGEMENT INC | US$2881.3万 | 0.01% |
| PFM Health Sciences, LP | US$2841.3万 | 2.59% |
| Defilade Capital Management, L.P. | US$2765.6万 | 3.88% |
| Amundi | US$2682.7万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$2578.7万 | 0.04% |
| Handelsbanken Fonder AB | US$2475.0万 | 0.08% |
| HSBC HOLDINGS PLC | US$2429.7万 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$2424.5万 | 0.36% |
| Trexquant Investment LP | US$2414.9万 | 0.17% |
| Ensign Peak Advisors, Inc | US$2390.8万 | 0.04% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$2302.5万 | 0.03% |
| Pacer Advisors, Inc. | US$2229.4万 | 0.06% |
| LOOMIS SAYLES & CO L P | US$2183.4万 | 0.03% |
| Mariner, LLC | US$2119.2万 | 0.02% |
| FMR LLC | US$2040.2万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$2025.6万 | 0.05% |
| PANAGORA ASSET MANAGEMENT INC | US$1995.2万 | 0.07% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1992.8万 | 0.00% |
| Rock Springs Capital Management LP | US$1982.0万 | 1.17% |
| AMERICAN CENTURY COMPANIES INC | US$1980.0万 | 0.01% |
| Integral Health Asset Management, LLC | US$1976.1万 | 0.95% |
| CAPITAL FUND MANAGEMENT S.A. | US$1971.2万 | 0.09% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$1964.4万 | 0.08% |
| CITIGROUP INC | US$1955.6万 | 0.01% |
| Andra AP-fonden | US$1952.3万 | 0.23% |
| Bridgewater Associates, LP | US$1951.6万 | 0.09% |
| Cerity Partners LLC | US$1904.0万 | 0.03% |
| DNB Asset Management AS | US$1860.6万 | 0.07% |
| PKO BP BANKOWY Universal Pension Society JSC | US$1828.6万 | 8.55% |
| Aware Super Pty Ltd as trustee of Aware Super | US$1802.0万 | 0.27% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1747.4万 | 0.02% |
| CWM, LLC | US$1669.7万 | 0.04% |
| C WorldWide Group Holding A/S | US$1646.8万 | 0.35% |
| LAZARD ASSET MANAGEMENT LLC | US$1639.9万 | 0.03% |
| Retirement Systems of Alabama | US$1620.9万 | 0.05% |
| Fisher Asset Management, LLC | US$1610.2万 | 0.01% |
| DekaBank Deutsche Girozentrale | US$1553.7万 | 0.03% |
| Sarissa Capital Management LP | US$1535.2万 | 9.74% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$1463.1万 | 0.01% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$1420.1万 | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$1343.1万 | 0.00% |
| Rhenman & Partners Asset Management AB | US$1328.5万 | 1.64% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1317.3万 | 0.73% |
| Parkman Healthcare Partners LLC | US$1305.1万 | 1.35% |
| Thrivent Financial for Lutherans | US$1271.1万 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1268.1万 | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1243.3万 | 0.03% |
| Caisse de depot et placement du Quebec | US$1233.4万 | 0.02% |
| Distillate Capital Partners LLC | US$1228.6万 | 0.65% |
| M&G PLC | US$1221.7万 | 0.06% |
| MACKENZIE FINANCIAL CORP | US$1207.8万 | 0.01% |
| Assenagon Asset Management S.A. | US$1205.1万 | 0.02% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$1181.8万 | 0.02% |
| D. E. Shaw & Co., Inc. | US$1174.9万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$1173.8万 | 0.01% |
| VAN ECK ASSOCIATES CORP | US$1173.3万 | 0.01% |
| CITADEL ADVISORS LLC | US$1161.5万 | 0.00% |
| Robeco Institutional Asset Management B.V. | US$1159.5万 | 0.02% |
| SEIZERT CAPITAL PARTNERS, LLC | US$1154.8万 | 0.53% |
| FULLER & THALER ASSET MANAGEMENT, INC. | US$1150.8万 | 0.04% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1143.2万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$1137.1万 | 0.11% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$1131.9万 | 0.02% |
| Empowered Funds, LLC | US$1106.2万 | 0.07% |
| Focus Partners Wealth | US$1058.3万 | 0.01% |
| SEB Asset Management AB | US$1048.3万 | 0.04% |
| GLENMEDE TRUST CO NA | US$1035.2万 | 0.05% |
| Impax Asset Management Group plc | US$988.1万 | 0.07% |
| Vinva Investment Management Ltd | US$966.6万 | 0.12% |
| CANADA LIFE ASSURANCE Co | US$957.0万 | 0.02% |
| Mitsubishi UFJ Trust & Banking Corp | US$947.3万 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$944.7万 | 0.01% |
| AVIVA PLC | US$939.4万 | 0.02% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$933.6万 | 0.02% |
| DAFNA Capital Management LLC | US$930.3万 | 2.12% |
| Korea Investment CORP | US$929.9万 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$926.9万 | 0.02% |
| Quantinno Capital Management LP | US$915.6万 | 0.02% |