| EcoR1 Capital, LLC | US$5.8亿 | 24.41% |
| Rubric Capital Management LP | US$1.8亿 | 1.86% |
| BlackRock, Inc. | US$1.1亿 | 0.00% |
| BVF INC/IL | US$9350.3万 | 2.98% |
| PERCEPTIVE ADVISORS LLC | US$8789.2万 | 1.72% |
| MORGAN STANLEY | US$6211.3万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$4777.7万 | 0.06% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4270.8万 | 0.00% |
| CITADEL ADVISORS LLC | US$3131.3万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$2851.9万 | 0.01% |
| Nextech Invest, Ltd. | US$2789.3万 | 1.96% |
| STATE STREET CORP | US$2533.5万 | 0.00% |
| Capricorn Fund Managers Ltd | US$2522.1万 | 3.93% |
| DEUTSCHE BANK AG\ | US$2306.8万 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$1862.7万 | 0.01% |
| Assenagon Asset Management S.A. | US$1822.9万 | 0.03% |
| FMR LLC | US$1670.6万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1652.4万 | 0.00% |
| Nuveen, LLC | US$1631.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1501.1万 | 0.00% |
| MPM BIOIMPACT LLC | US$1415.4万 | 1.09% |
| Prosight Management, LP | US$1349.8万 | 2.21% |
| Qube Research & Technologies Ltd | US$1281.9万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1251.7万 | 0.00% |
| Redmile Group, LLC | US$1231.1万 | 0.82% |
| Hillsdale Investment Management Inc. | US$865.4万 | 0.24% |
| SummitTX Capital, L.P. | US$804.9万 | 0.25% |
| NORTHERN TRUST CORP | US$801.8万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$799.7万 | 0.00% |
| ROYCE & ASSOCIATES LP | US$749.2万 | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$688.4万 | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | US$642.8万 | 0.05% |
| Granahan Investment Management, LLC | US$627.9万 | 0.30% |
| HRT FINANCIAL LP | US$595.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$592.8万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$590.0万 | 0.00% |
| JANE STREET GROUP, LLC | US$568.3万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$518.0万 | 0.02% |
| Man Group plc | US$475.5万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$474.8万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$463.6万 | 0.00% |
| FEDERATED HERMES, INC. | US$456.8万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$441.7万 | 0.00% |
| UBS Group AG | US$430.1万 | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | US$409.8万 | 0.03% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$371.2万 | 0.08% |
| XTX Topco Ltd | US$360.3万 | 0.06% |
| DIADEMA PARTNERS LP | US$355.9万 | 0.61% |
| WELLINGTON MANAGEMENT GROUP LLP | US$347.3万 | 0.00% |
| Invesco Ltd. | US$314.6万 | 0.00% |
| Bank of New York Mellon Corp | US$310.8万 | 0.00% |
| CITIGROUP INC | US$286.3万 | 0.00% |
| JPMORGAN CHASE & CO | US$276.2万 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$263.4万 | 0.66% |
| Tidal Investments LLC | US$262.7万 | 0.01% |
| Tema ETFs LLC | US$262.7万 | 0.18% |
| Fisher Asset Management, LLC | US$254.0万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$249.9万 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$227.0万 | 0.00% |
| KORNITZER CAPITAL MANAGEMENT INC /KS | US$222.4万 | 0.05% |
| VANGUARD FIDUCIARY TRUST CO | US$211.3万 | 0.00% |
| Squarepoint Ops LLC | US$208.2万 | 0.00% |
| MACKENZIE FINANCIAL CORP | US$207.1万 | 0.00% |
| Verdad Advisers, LP | US$207.1万 | 2.33% |
| PRINCIPAL FINANCIAL GROUP INC | US$196.7万 | 0.00% |
| FRANKLIN RESOURCES INC | US$194.5万 | 0.00% |
| STIFEL FINANCIAL CORP | US$192.2万 | 0.00% |
| RHUMBLINE ADVISERS | US$188.8万 | 0.00% |
| CREDIT AGRICOLE S A | US$187.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$185.9万 | 0.00% |
| Swiss National Bank | US$185.8万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$177.4万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$165.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$147.2万 | 0.00% |
| Dana Investment Advisors, Inc. | US$140.5万 | 0.04% |
| Campbell & CO Investment Adviser LLC | US$137.4万 | 0.08% |
| DLD Asset Management, LP | US$132.8万 | 0.12% |
| MILLENNIUM MANAGEMENT LLC | US$125.2万 | 0.00% |
| Russell Investments Group, Ltd. | US$118.8万 | 0.00% |
| ROYAL BANK OF CANADA | US$118.7万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | US$114.5万 | 0.02% |
| North Growth Management Ltd. | US$114.0万 | 0.17% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$107.1万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$106.2万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$101.2万 | 0.00% |
| Manatuck Hill Partners, LLC | US$100.2万 | 0.27% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$99.5万 | 0.00% |
| Quantinno Capital Management LP | US$99.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$98.5万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$94.9万 | 0.00% |
| HSBC HOLDINGS PLC | US$94.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$93.6万 | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$93.0万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$92.3万 | 0.00% |
| HighTower Advisors, LLC | US$90.8万 | 0.00% |
| Persistent Asset Partners Ltd | US$90.0万 | 0.34% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$88.9万 | 0.00% |
| HighVista Strategies LLC | US$85.3万 | 0.24% |
| Vinva Investment Management Ltd | US$85.1万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$82.0万 | 0.02% |
| Creative Planning | US$81.1万 | 0.00% |
| MARSHALL WACE, LLP | US$80.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$79.1万 | 0.00% |
| Engineers Gate Manager LP | US$79.0万 | 0.01% |
| SBI Okasan Asset Management Co.Ltd. | US$77.5万 | 0.03% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$76.2万 | 0.00% |
| STRS OHIO | US$75.4万 | 0.00% |
| MetLife Investment Management, LLC | US$74.3万 | 0.00% |
| JOURNEY STRATEGIC WEALTH LLC | US$72.7万 | 0.02% |
| OXFORD ASSET MANAGEMENT LLP | US$69.6万 | 0.30% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$68.6万 | 0.00% |
| ExodusPoint Capital Management, LP | US$68.5万 | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$68.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$65.8万 | 0.00% |
| Legal & General Group Plc | US$65.6万 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$65.2万 | 0.00% |
| Walleye Capital LLC | US$61.5万 | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | US$60.7万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$58.5万 | 0.00% |
| Walleye Trading LLC | US$57.6万 | 0.00% |
| Headlands Technologies LLC | US$57.2万 | 0.07% |
| Duncan Williams Asset Management, LLC | US$55.3万 | 0.15% |
| PRUDENTIAL FINANCIAL INC | US$55.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$51.4万 | 0.03% |
| Jackson Creek Investment Advisors LLC | US$46.8万 | 0.14% |
| BARCLAYS PLC | US$46.0万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$45.6万 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$43.7万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$43.5万 | 0.00% |
| State of Wyoming | US$42.9万 | 0.05% |
| Quadrature Capital Ltd | US$41.9万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$38.4万 | 0.00% |
| AGF MANAGEMENT LTD | US$37.6万 | 0.00% |
| Amundi | US$35.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$34.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$33.3万 | 0.03% |
| Freestone Grove Partners LP | US$32.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$32.0万 | 0.00% |
| Northwest & Ethical Investments L.P. | US$31.6万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$31.4万 | 0.00% |
| Abacus Wealth Partners, LLC | US$29.2万 | 0.03% |
| Janney Montgomery Scott LLC | US$28.8万 | 0.00% |
| JAMES INVESTMENT RESEARCH, INC. | US$27.4万 | 0.03% |
| Ewing Morris & Co. Investment Partners Ltd. | US$27.2万 | 0.12% |
| Virtus Investment Advisers, LLC | US$26.8万 | 0.07% |
| LAZARD ASSET MANAGEMENT LLC | US$26.5万 | 0.00% |
| ProShare Advisors LLC | US$26.5万 | 0.00% |
| SG Americas Securities, LLC | US$26.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$25.7万 | 0.00% |
| PSP Research LLC | US$25.0万 | 0.18% |