| FMR LLC | US$4.2亿 | 0.02% |
| Deep Track Capital, LP | US$2.9亿 | 4.68% |
| BlackRock, Inc. | US$1.6亿 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$1.4亿 | 2.41% |
| BAKER BROS. ADVISORS LP | US$1.4亿 | 0.78% |
| STATE STREET CORP | US$1.1亿 | 0.00% |
| TCG Crossover Management, LLC | US$1.1亿 | 3.17% |
| MORGAN STANLEY | US$9630.2万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$9203.0万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8992.2万 | 0.00% |
| T. Rowe Price Investment Management, Inc. | US$8974.4万 | 0.06% |
| Two Seas Capital LP | US$7953.7万 | 1.11% |
| JENNISON ASSOCIATES LLC | US$7940.6万 | 0.05% |
| RTW INVESTMENTS, LP | US$7893.8万 | 0.79% |
| ADAR1 Capital Management, LLC | US$6654.7万 | 3.92% |
| Alpine Global Management, LLC | US$6550.1万 | 9.81% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5197.7万 | 0.00% |
| Woodline Partners LP | US$4908.1万 | 0.19% |
| GOLDMAN SACHS GROUP INC | US$4434.2万 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$3967.9万 | 0.78% |
| FARALLON CAPITAL MANAGEMENT LLC | US$3840.3万 | 0.22% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3025.8万 | 0.00% |
| Aberdeen Group plc | US$2883.3万 | 0.05% |
| Logos Global Management LP | US$2670.3万 | 1.33% |
| BANK OF AMERICA CORP /DE/ | US$2219.9万 | 0.00% |
| STEMPOINT CAPITAL LP | US$1879.8万 | 3.60% |
| UBS Group AG | US$1700.4万 | 0.00% |
| Candriam S.C.A. | US$1690.0万 | 0.09% |
| NORTHERN TRUST CORP | US$1671.2万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1640.5万 | 0.00% |
| GREAT POINT PARTNERS LLC | US$1355.3万 | 3.11% |
| VANGUARD FIDUCIARY TRUST CO | US$1352.6万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1251.1万 | 0.03% |
| Pictet Asset Management Holding SA | US$1173.4万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1029.0万 | 1.05% |
| Trails Edge Capital Partners, LP | US$1028.5万 | 2.36% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1025.9万 | 0.02% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$888.3万 | 6.35% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$843.6万 | 0.00% |
| Granahan Investment Management, LLC | US$607.2万 | 0.29% |
| Nuveen, LLC | US$599.1万 | 0.00% |
| Soleus Capital Management, L.P. | US$571.3万 | 0.23% |
| HighVista Strategies LLC | US$559.2万 | 1.54% |
| Tetragon Partners GP Ltd | US$542.8万 | 1.05% |
| CITADEL ADVISORS LLC | US$539.8万 | 0.00% |
| Bank of New York Mellon Corp | US$537.1万 | 0.00% |
| Assenagon Asset Management S.A. | US$509.8万 | 0.01% |
| XTX Topco Ltd | US$504.3万 | 0.09% |
| RENAISSANCE TECHNOLOGIES LLC | US$478.2万 | 0.01% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$451.5万 | 1.14% |
| Prosight Management, LP | US$436.7万 | 0.72% |
| MARSHALL WACE, LLP | US$410.6万 | 0.00% |
| Swiss National Bank | US$395.9万 | 0.00% |
| DAFNA Capital Management LLC | US$373.9万 | 0.85% |
| JANE STREET GROUP, LLC | US$367.2万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$352.1万 | 0.00% |
| Erste Asset Management GmbH | US$340.3万 | 0.03% |
| Rafferty Asset Management, LLC | US$339.4万 | 0.01% |
| TD Asset Management Inc | US$326.3万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$303.3万 | 0.01% |
| Blackstone Inc. | US$266.5万 | 0.01% |
| ALGERT GLOBAL LLC | US$262.7万 | 0.04% |
| Affinity Asset Advisors, LLC | US$248.4万 | 0.13% |
| RHUMBLINE ADVISERS | US$242.2万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$234.2万 | 0.00% |
| Invesco Ltd. | US$233.2万 | 0.00% |
| DME Capital Management, LP | US$232.3万 | 0.07% |
| ALLIANCEBERNSTEIN L.P. | US$229.8万 | 0.00% |
| JPMORGAN CHASE & CO | US$228.2万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$226.1万 | 0.08% |
| BANQUE PICTET & CIE SA | US$220.2万 | 0.02% |
| DEUTSCHE BANK AG\ | US$196.2万 | 0.00% |
| Legal & General Group Plc | US$184.9万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$180.9万 | 0.11% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$177.1万 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$173.9万 | 0.05% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$172.5万 | 0.00% |
| Amundi | US$166.1万 | 0.00% |
| HRT FINANCIAL LP | US$165.1万 | 0.00% |
| PROFUND ADVISORS LLC | US$151.5万 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | US$141.8万 | 0.00% |
| HighTower Advisors, LLC | US$141.0万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$134.8万 | 0.00% |
| Alchemi Wealth, LLC | US$134.2万 | 0.74% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$127.7万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$126.7万 | 0.00% |
| SIMPLEX TRADING, LLC | US$124.9万 | 0.00% |
| Creative Planning | US$113.6万 | 0.00% |
| MetLife Investment Management, LLC | US$110.4万 | 0.01% |
| Jump Financial, LLC | US$109.8万 | 0.01% |
| Quantinno Capital Management LP | US$99.4万 | 0.00% |
| NOMURA HOLDINGS INC | US$99.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$93.7万 | 0.07% |
| Quinn Opportunity Partners LLC | US$93.2万 | 0.05% |
| JANUS HENDERSON GROUP PLC | US$83.8万 | 0.00% |
| Vanguard Global Advisers, LLC | US$83.5万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$83.3万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$82.5万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$82.4万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$81.1万 | 0.00% |
| Handelsbanken Fonder AB | US$80.2万 | 0.00% |
| Ellsworth Advisors, LLC | US$80.2万 | 0.15% |
| INTECH INVESTMENT MANAGEMENT LLC | US$74.5万 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$70.9万 | 0.00% |
| Bridgefront Capital, LLC | US$69.1万 | 0.17% |
| State of New Jersey Common Pension Fund D | US$68.4万 | 0.00% |
| LMR Partners LLP | US$64.7万 | 0.00% |
| Trexquant Investment LP | US$63.8万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$63.7万 | 0.00% |
| CITIGROUP INC | US$63.0万 | 0.00% |
| INCEPTIONR LLC | US$60.3万 | 0.15% |
| Corient Private Wealth LLC | US$59.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$59.2万 | 0.00% |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | US$59.1万 | 0.06% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$57.6万 | 0.00% |
| SG Americas Securities, LLC | US$56.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$55.7万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$55.0万 | 0.00% |
| AXQ CAPITAL, LP | US$54.8万 | 0.07% |
| ExodusPoint Capital Management, LP | US$54.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$53.2万 | 0.00% |
| ProShare Advisors LLC | US$52.0万 | 0.00% |
| GROUP ONE TRADING LLC | US$51.1万 | 0.00% |
| Hudson Bay Capital Management LP | US$47.8万 | 0.00% |
| PSP Research LLC | US$47.7万 | 0.34% |
| KLP KAPITALFORVALTNING AS | US$46.9万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$46.2万 | 0.01% |
| SEI INVESTMENTS CO | US$44.1万 | 0.00% |
| E Fund Management Co., Ltd. | US$44.0万 | 0.01% |
| Marex Group plc | US$39.7万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$39.2万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$37.0万 | 0.01% |
| BARCLAYS PLC | US$37.0万 | 0.00% |
| Empowered Funds, LLC | US$36.2万 | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | US$35.3万 | 0.03% |
| Kestra Advisory Services, LLC | US$34.6万 | 0.00% |
| KEYBANK NATIONAL ASSOCIATION/OH | US$34.2万 | 0.00% |
| Allianz Asset Management GmbH | US$32.0万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$31.8万 | 0.00% |
| OXFORD ASSET MANAGEMENT LLP | US$30.9万 | 0.13% |
| GUGGENHEIM CAPITAL LLC | US$30.8万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$26.4万 | 0.00% |
| CANADA LIFE ASSURANCE Co | US$25.9万 | 0.00% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$25.8万 | 0.00% |
| Virtus Investment Advisers, LLC | US$25.6万 | 0.07% |
| VICTORY CAPITAL MANAGEMENT INC | US$23.9万 | 0.00% |
| Vident Advisory, LLC | US$22.4万 | 0.00% |
| PEAK6 LLC | US$21.6万 | 0.00% |
| Engineers Gate Manager LP | US$21.5万 | 0.00% |
| Walleye Trading LLC | US$21.4万 | 0.00% |