| ORBIMED ADVISORS LLC | US$4.9亿 | 10.02% |
| RA CAPITAL MANAGEMENT, L.P. | US$3.3亿 | 3.48% |
| Paradigm Biocapital Advisors LP | US$2.3亿 | 4.74% |
| BAKER BROS. ADVISORS LP | US$2.1亿 | 1.19% |
| BlackRock, Inc. | US$2.0亿 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$1.9亿 | 0.09% |
| NOVO HOLDINGS A/S | US$1.7亿 | 13.65% |
| Driehaus Capital Management LLC | US$1.4亿 | 1.04% |
| Siren, L.L.C. | US$1.4亿 | 3.87% |
| PERCEPTIVE ADVISORS LLC | US$1.4亿 | 2.72% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.2亿 | 0.00% |
| Cormorant Asset Management, LP | US$1.0亿 | 5.16% |
| BRAIDWELL LP | US$7394.9万 | 2.47% |
| MORGAN STANLEY | US$7075.0万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5639.1万 | 0.00% |
| STATE STREET CORP | US$5408.0万 | 0.00% |
| MPM BIOIMPACT LLC | US$5231.2万 | 4.04% |
| Integral Health Asset Management, LLC | US$5040.0万 | 2.41% |
| Bellevue Group AG | US$4814.8万 | 1.15% |
| Soleus Capital Management, L.P. | US$4567.2万 | 1.85% |
| ALLIANCEBERNSTEIN L.P. | US$4273.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$4181.2万 | 0.00% |
| UBS Group AG | US$4130.0万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$3841.3万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$3613.6万 | 0.02% |
| FMR LLC | US$3203.7万 | 0.00% |
| First Light Asset Management, LLC | US$3155.8万 | 2.83% |
| Aberdeen Group plc | US$2602.1万 | 0.04% |
| Qube Research & Technologies Ltd | US$2601.6万 | 0.03% |
| VICTORY CAPITAL MANAGEMENT INC | US$2485.5万 | 0.02% |
| Artisan Partners Limited Partnership | US$2076.1万 | 0.03% |
| MARSHALL WACE, LLP | US$2042.4万 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$1983.9万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1878.4万 | 0.00% |
| NORTHERN TRUST CORP | US$1816.2万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1755.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1643.4万 | 0.00% |
| Opaleye Management Inc. | US$1575.0万 | 2.07% |
| CITADEL ADVISORS LLC | US$1523.8万 | 0.00% |
| Candriam S.C.A. | US$1409.4万 | 0.07% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$1273.2万 | 0.02% |
| Sofinnova Investments, Inc. | US$1217.5万 | 0.46% |
| Squadron Capital Management LLC | US$1102.5万 | 4.04% |
| MILLENNIUM MANAGEMENT LLC | US$1080.0万 | 0.00% |
| Nuveen, LLC | US$1057.7万 | 0.00% |
| Parkman Healthcare Partners LLC | US$1016.9万 | 1.05% |
| STEMPOINT CAPITAL LP | US$916.2万 | 1.75% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$892.4万 | 0.02% |
| Sio Capital Management, LLC | US$847.3万 | 1.22% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$832.2万 | 0.18% |
| JANE STREET GROUP, LLC | US$778.9万 | 0.00% |
| Woodline Partners LP | US$706.5万 | 0.03% |
| DEUTSCHE BANK AG\ | US$698.9万 | 0.00% |
| DIADEMA PARTNERS LP | US$669.4万 | 1.14% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$657.3万 | 0.24% |
| SEB Asset Management AB | US$650.5万 | 0.03% |
| Granahan Investment Management, LLC | US$632.7万 | 0.31% |
| AMERIPRISE FINANCIAL INC | US$632.1万 | 0.00% |
| Bank of New York Mellon Corp | US$606.2万 | 0.00% |
| Caption Management, LLC | US$594.3万 | 0.03% |
| BARCLAYS PLC | US$558.3万 | 0.00% |
| NEUBERGER BERMAN GROUP LLC | US$531.3万 | 0.00% |
| Ally Bridge Group (NY) LLC | US$507.2万 | 4.10% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$472.1万 | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$471.2万 | 0.00% |
| Freestone Grove Partners LP | US$467.5万 | 0.03% |
| JPMORGAN CHASE & CO | US$446.9万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$439.9万 | 0.00% |
| Invesco Ltd. | US$436.0万 | 0.00% |
| KVP Capital Advisors, LP | US$419.0万 | 3.13% |
| Quantum Private Wealth, LLC | US$367.4万 | 1.13% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$361.4万 | 0.00% |
| MOODY ALDRICH PARTNERS LLC | US$359.5万 | 0.65% |
| DAFNA Capital Management LLC | US$353.5万 | 0.80% |
| D. E. Shaw & Co., Inc. | US$330.3万 | 0.00% |
| Swiss National Bank | US$327.3万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$312.1万 | 0.02% |
| HighVista Strategies LLC | US$289.6万 | 0.80% |
| ADAR1 Capital Management, LLC | US$285.4万 | 0.17% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$280.2万 | 0.00% |
| ALPS ADVISORS INC | US$275.1万 | 0.01% |
| Centiva Capital, LP | US$264.4万 | 0.02% |
| RHUMBLINE ADVISERS | US$263.2万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$257.4万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$231.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$218.7万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$212.3万 | 0.00% |
| Artia Global Partners LP | US$206.3万 | 0.41% |
| J. Goldman & Co LP | US$193.5万 | 0.06% |
| FEDERATED HERMES, INC. | US$178.9万 | 0.00% |
| HighMark Wealth Management LLC | US$167.5万 | 0.68% |
| TWO SIGMA INVESTMENTS, LP | US$160.2万 | 0.00% |
| Ishara Investments LP | US$155.0万 | 1.47% |
| SEI INVESTMENTS CO | US$154.6万 | 0.00% |
| Jain Global LLC | US$146.2万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$134.2万 | 0.14% |
| Legal & General Group Plc | US$134.0万 | 0.00% |
| FRANKLIN RESOURCES INC | US$131.4万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$123.3万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$121.0万 | 0.07% |
| MetLife Investment Management, LLC | US$120.0万 | 0.01% |
| Longaeva Partners L.P. | US$116.3万 | 0.04% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$112.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$111.7万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$103.6万 | 0.00% |
| ALGERT GLOBAL LLC | US$102.4万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$99.6万 | 0.00% |
| Creative Planning | US$98.5万 | 0.00% |
| Handelsbanken Fonder AB | US$98.0万 | 0.00% |
| DLD Asset Management, LP | US$97.9万 | 0.09% |
| TUDOR INVESTMENT CORP ET AL | US$94.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$92.4万 | 0.00% |
| Persistent Asset Partners Ltd | US$90.8万 | 0.34% |
| WELLINGTON MANAGEMENT GROUP LLP | US$86.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$80.1万 | 0.06% |
| WELLS FARGO & COMPANY/MN | US$79.5万 | 0.00% |
| LMR Partners LLP | US$63.0万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$62.0万 | 0.00% |
| GLENMEDE TRUST CO NA | US$60.6万 | 0.00% |
| XTX Topco Ltd | US$60.2万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$59.4万 | 0.01% |
| CITIGROUP INC | US$58.3万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$58.2万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$57.0万 | 0.00% |
| Odyssean, LLC | US$56.3万 | 0.21% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$53.1万 | 0.00% |
| Brooklyn Investment Group | US$51.1万 | 0.02% |
| ENVESTNET ASSET MANAGEMENT INC | US$49.5万 | 0.00% |
| AlphaCentric Advisors LLC | US$49.2万 | 0.49% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$46.4万 | 0.00% |
| Point72 Asset Management, L.P. | US$46.0万 | 0.00% |
| ProShare Advisors LLC | US$45.9万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$45.8万 | 0.00% |
| Headlands Technologies LLC | US$43.4万 | 0.05% |
| Vanguard Investments Australia, Ltd. | US$43.1万 | 0.00% |
| Verdad Advisers, LP | US$41.1万 | 0.46% |
| Hudson Bay Capital Management LP | US$40.7万 | 0.00% |
| Bridgefront Capital, LLC | US$37.2万 | 0.09% |
| Seven Fleet Capital Management LP | US$36.9万 | 0.12% |
| Virtus Investment Advisers, LLC | US$36.4万 | 0.10% |
| GUGGENHEIM CAPITAL LLC | US$36.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$35.6万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$33.4万 | 0.00% |
| Elmind Capital, LP | US$31.5万 | 0.09% |
| SFMG, LLC | US$31.5万 | 0.02% |
| Atom Investors LP | US$31.3万 | 0.02% |
| Connecticut Capital Management Group, LLC | US$31.0万 | 0.29% |
| AXQ CAPITAL, LP | US$30.0万 | 0.04% |
| FIRST TRUST ADVISORS LP | US$28.8万 | 0.00% |
| Lion Point Capital, LP | US$28.7万 | 1.71% |