| TANG CAPITAL MANAGEMENT LLC | US$8882.3万 | 4.51% |
| ORBIMED ADVISORS LLC | US$8051.4万 | 1.65% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$7568.6万 | 1.93% |
| Vivo Capital, LLC | US$5049.6万 | 4.20% |
| BlackRock, Inc. | US$5028.7万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$4489.4万 | 0.07% |
| ENAVATE SCIENCES GP, LLC | US$4119.9万 | 11.72% |
| BVF INC/IL | US$4107.6万 | 1.31% |
| STATE STREET CORP | US$3541.6万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3193.7万 | 0.00% |
| RTW INVESTMENTS, LP | US$2214.7万 | 0.22% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$1907.6万 | 0.23% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1886.8万 | 0.00% |
| Rock Springs Capital Management LP | US$1748.5万 | 1.03% |
| Logos Global Management LP | US$1666.4万 | 0.83% |
| Blue Owl Capital Holdings LP | US$1556.1万 | 4.18% |
| Sofinnova Investments, Inc. | US$1352.2万 | 0.51% |
| Qube Research & Technologies Ltd | US$1349.1万 | 0.02% |
| UBS Group AG | US$1265.0万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1055.6万 | 0.00% |
| BRAIDWELL LP | US$1039.5万 | 0.35% |
| Blackstone Inc. | US$982.8万 | 0.04% |
| FMR LLC | US$953.1万 | 0.00% |
| ROYCE & ASSOCIATES LP | US$856.9万 | 0.08% |
| AMERIPRISE FINANCIAL INC | US$844.7万 | 0.00% |
| Palo Alto Investors LP | US$801.2万 | 1.23% |
| Birchview Capital, LP | US$775.4万 | 4.41% |
| Caption Management, LLC | US$719.3万 | 0.04% |
| GREAT POINT PARTNERS LLC | US$714.2万 | 1.64% |
| Fisher Asset Management, LLC | US$713.2万 | 0.00% |
| Balyasny Asset Management L.P. | US$592.0万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$572.7万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$569.2万 | 0.04% |
| NORTHERN TRUST CORP | US$554.7万 | 0.00% |
| Ally Bridge Group (NY) LLC | US$529.0万 | 4.27% |
| VANGUARD FIDUCIARY TRUST CO | US$528.0万 | 0.00% |
| BARCLAYS PLC | US$527.5万 | 0.00% |
| CITADEL ADVISORS LLC | US$471.4万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$457.9万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$454.4万 | 0.46% |
| ACUTA CAPITAL PARTNERS, LLC | US$449.2万 | 3.19% |
| NEXTBio Capital Management LP | US$448.7万 | 2.08% |
| MILLENNIUM MANAGEMENT LLC | US$447.7万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$438.5万 | 0.08% |
| JPMORGAN CHASE & CO | US$432.3万 | 0.00% |
| Burkehill Global Management, LP | US$370.3万 | 0.18% |
| CITIGROUP INC | US$316.5万 | 0.00% |
| Atle Fund Management AB | US$305.1万 | 0.99% |
| Seven Fleet Capital Management LP | US$273.5万 | 0.87% |
| ArrowMark Colorado Holdings LLC | US$272.3万 | 0.07% |
| KVP Capital Advisors, LP | US$264.5万 | 1.98% |
| Connor, Clark & Lunn Investment Management Ltd. | US$263.3万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$261.5万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$232.4万 | 0.00% |
| DV Trading LLC | US$224.1万 | 0.05% |
| Trexquant Investment LP | US$223.1万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$207.2万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$198.5万 | 0.00% |
| Jump Financial, LLC | US$196.5万 | 0.03% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$196.3万 | 0.00% |
| MORGAN STANLEY | US$190.6万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$190.5万 | 0.00% |
| Atom Investors LP | US$182.5万 | 0.13% |
| Bank of New York Mellon Corp | US$157.3万 | 0.00% |
| Nuveen, LLC | US$153.9万 | 0.00% |
| Monashee Investment Management LLC | US$136.9万 | 0.74% |
| Swiss National Bank | US$116.8万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$106.0万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$105.9万 | 0.00% |
| Rafferty Asset Management, LLC | US$103.6万 | 0.00% |
| RHUMBLINE ADVISERS | US$77.8万 | 0.00% |
| ALPS ADVISORS INC | US$77.6万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$73.9万 | 0.00% |
| ADAR1 Capital Management, LLC | US$73.5万 | 0.04% |
| Tidal Investments LLC | US$73.1万 | 0.00% |
| Tema ETFs LLC | US$73.1万 | 0.05% |
| DEUTSCHE BANK AG\ | US$70.5万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$64.5万 | 0.00% |
| Rhenman & Partners Asset Management AB | US$60.9万 | 0.08% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$59.4万 | 0.00% |
| Creative Planning | US$56.2万 | 0.00% |
| Invesco Ltd. | US$53.5万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$52.7万 | 0.00% |
| Vanguard Global Advisers, LLC | US$50.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$47.0万 | 0.00% |
| PROFUND ADVISORS LLC | US$46.4万 | 0.02% |
| Harvest Investment Services, LLC | US$46.4万 | 0.08% |
| ALLIANCEBERNSTEIN L.P. | US$45.1万 | 0.00% |
| Optimize Financial Inc | US$42.6万 | 0.21% |
| AMERICAN CENTURY COMPANIES INC | US$41.4万 | 0.00% |
| DRW Securities, LLC | US$40.5万 | 0.01% |
| Legal & General Group Plc | US$39.7万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$39.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$38.9万 | 0.00% |
| Aquatic Capital Management LLC | US$38.8万 | 0.01% |
| Persistent Asset Partners Ltd | US$38.2万 | 0.14% |
| Engineers Gate Manager LP | US$38.0万 | 0.00% |
| XTX Topco Ltd | US$37.1万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$35.7万 | 0.00% |
| FRANKLIN RESOURCES INC | US$35.2万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$34.9万 | 0.00% |
| MetLife Investment Management, LLC | US$34.0万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$29.4万 | 0.00% |
| Virtus Investment Advisers, LLC | US$28.0万 | 0.08% |
| Squarepoint Ops LLC | US$26.6万 | 0.00% |
| Cinctive Capital Management LP | US$25.8万 | 0.02% |
| WELLS FARGO & COMPANY/MN | US$25.3万 | 0.00% |
| SG Americas Securities, LLC | US$25.2万 | 0.00% |
| ExodusPoint Capital Management, LP | US$23.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$23.2万 | 0.00% |
| Virtu Financial LLC | US$22.8万 | 0.01% |
| State of New Jersey Common Pension Fund D | US$20.2万 | 0.00% |
| ALGERT GLOBAL LLC | US$19.5万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$19.0万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$18.8万 | 0.00% |
| LPL Financial LLC | US$18.8万 | 0.00% |
| SmartHarvest Portfolios, LLC | US$18.4万 | 0.08% |
| Vanguard Investments Australia, Ltd. | US$17.7万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$17.5万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$16.3万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$16.2万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$16.2万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$16.1万 | 0.00% |
| VARCOV Co. | US$16.1万 | 0.06% |
| GROUP ONE TRADING LLC | US$16.0万 | 0.00% |
| LMR Partners LLP | US$15.9万 | 0.00% |
| PSP Research LLC | US$15.9万 | 0.11% |
| INTECH INVESTMENT MANAGEMENT LLC | US$15.8万 | 0.00% |
| EntryPoint Capital, LLC | US$15.5万 | 0.05% |
| Simplicity Wealth,LLC | US$15.0万 | 0.01% |
| STIFEL FINANCIAL CORP | US$14.5万 | 0.00% |
| SIMPLEX TRADING, LLC | US$13.7万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$13.3万 | 0.00% |
| AXQ CAPITAL, LP | US$13.3万 | 0.02% |
| Walleye Trading LLC | US$13.2万 | 0.00% |
| E Fund Management Co., Ltd. | US$13.0万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$13.0万 | 0.00% |
| Graham Capital Management, L.P. | US$12.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$12.3万 | 0.00% |
| INDEPENDENT FINANCIAL GROUP, LLC | US$12.1万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$11.5万 | 0.00% |
| HRT FINANCIAL LP | US$10.5万 | 0.00% |
| Welch & Forbes LLC | US$10.1万 | 0.00% |
| ProShare Advisors LLC | US$9.9万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$9.5万 | 0.01% |
| Ikarian Capital, LLC | US$9.5万 | 0.01% |
| Cygnus Capital Advisors, LLC | US$9.5万 | 0.06% |
| Independent Advisor Alliance | US$9.5万 | 0.00% |
| Strategic Wealth Partners, Ltd. | US$8.9万 | 0.01% |
| Scientech Research LLC | US$8.8万 | 0.07% |