| BAKER BROS. ADVISORS LP | US$9.5亿 | 5.48% |
| BlackRock, Inc. | US$4.8亿 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1.9亿 | 0.01% |
| STATE STREET CORP | US$1.9亿 | 0.01% |
| RTW INVESTMENTS, LP | US$1.6亿 | 1.58% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.3亿 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7713.7万 | 0.00% |
| FIRST TRUST ADVISORS LP | US$7443.5万 | 0.05% |
| DIMENSIONAL FUND ADVISORS LP | US$7022.2万 | 0.01% |
| Palo Alto Investors LP | US$6394.6万 | 9.78% |
| Point72 Asset Management, L.P. | US$5799.4万 | 0.07% |
| BRAIDWELL LP | US$5500.9万 | 1.84% |
| Pictet Asset Management Holding SA | US$4473.6万 | 0.05% |
| RENAISSANCE TECHNOLOGIES LLC | US$3838.1万 | 0.06% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$3493.7万 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$3467.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$3458.7万 | 0.00% |
| Frazier Life Sciences Management, L.P. | US$3201.4万 | 0.82% |
| Artisan Partners Limited Partnership | US$2964.6万 | 0.05% |
| FRED ALGER MANAGEMENT, LLC | US$2842.9万 | 0.12% |
| NORTHERN TRUST CORP | US$2832.8万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2612.3万 | 0.00% |
| MORGAN STANLEY | US$2433.4万 | 0.00% |
| Nuveen, LLC | US$2308.3万 | 0.01% |
| Rockefeller Capital Management L.P. | US$2286.9万 | 0.04% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$2270.1万 | 0.01% |
| Allspring Global Investments Holdings, LLC | US$2131.2万 | 0.04% |
| Qube Research & Technologies Ltd | US$2115.4万 | 0.02% |
| JANE STREET GROUP, LLC | US$1961.9万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1949.4万 | 0.00% |
| DEUTSCHE BANK AG\ | US$1870.8万 | 0.01% |
| Invesco Ltd. | US$1862.1万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$1725.4万 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | US$1710.1万 | 0.01% |
| Logos Global Management LP | US$1669.5万 | 0.83% |
| Bank of New York Mellon Corp | US$1639.6万 | 0.00% |
| Fisher Asset Management, LLC | US$1631.4万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$1624.6万 | 0.01% |
| Allianz Asset Management GmbH | US$1573.0万 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$1570.4万 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | US$1532.9万 | 0.06% |
| Woodline Partners LP | US$1505.7万 | 0.06% |
| CITADEL ADVISORS LLC | US$1466.2万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1412.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$1390.3万 | 0.00% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1374.5万 | 0.77% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1366.3万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1272.8万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$1175.1万 | 0.01% |
| Caption Management, LLC | US$1159.5万 | 0.07% |
| JUPITER ASSET MANAGEMENT LTD | US$1093.2万 | 0.06% |
| UBS Group AG | US$998.5万 | 0.00% |
| Public Sector Pension Investment Board | US$997.1万 | 0.03% |
| Hudson Bay Capital Management LP | US$991.7万 | 0.03% |
| GLENMEDE TRUST CO NA | US$903.5万 | 0.04% |
| PRUDENTIAL FINANCIAL INC | US$862.9万 | 0.01% |
| Squarepoint Ops LLC | US$824.6万 | 0.01% |
| RHUMBLINE ADVISERS | US$791.3万 | 0.01% |
| FMR LLC | US$779.9万 | 0.00% |
| Balyasny Asset Management L.P. | US$696.7万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$655.0万 | 0.02% |
| Legal & General Group Plc | US$639.7万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$570.3万 | 0.91% |
| JPMORGAN CHASE & CO | US$554.3万 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$548.3万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$540.2万 | 0.00% |
| STEMPOINT CAPITAL LP | US$540.0万 | 1.03% |
| GREAT LAKES ADVISORS, LLC | US$538.3万 | 0.04% |
| Trexquant Investment LP | US$525.2万 | 0.04% |
| Swiss National Bank | US$521.8万 | 0.00% |
| FRANKLIN RESOURCES INC | US$512.1万 | 0.00% |
| ROYAL BANK OF CANADA | US$496.9万 | 0.00% |
| NORDEA INVESTMENT MANAGEMENT AB | US$494.3万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$460.5万 | 0.00% |
| Edgestream Partners, L.P. | US$425.9万 | 0.14% |
| Rafferty Asset Management, LLC | US$404.4万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$398.9万 | 0.00% |
| Birchview Capital, LP | US$380.6万 | 2.17% |
| ENVESTNET ASSET MANAGEMENT INC | US$378.3万 | 0.00% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$374.0万 | 0.81% |
| ALPS ADVISORS INC | US$362.4万 | 0.02% |
| CONGRESS ASSET MANAGEMENT CO | US$357.9万 | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$348.2万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$340.7万 | 0.00% |
| Axecap Investments, LLC | US$340.4万 | 2.34% |
| BESSEMER GROUP INC | US$335.0万 | 0.01% |
| Tetragon Partners GP Ltd | US$321.9万 | 0.62% |
| VICTORY CAPITAL MANAGEMENT INC | US$319.4万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$317.7万 | 0.01% |
| Bridgewater Associates, LP | US$315.7万 | 0.01% |
| ALGERT GLOBAL LLC | US$312.7万 | 0.05% |
| MARTINGALE ASSET MANAGEMENT L P | US$311.6万 | 0.08% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$307.7万 | 0.00% |
| Man Group plc | US$288.0万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$286.5万 | 0.01% |
| Erste Asset Management GmbH | US$281.7万 | 0.03% |
| Ishara Investments LP | US$273.8万 | 2.59% |
| SEGALL BRYANT & HAMILL, LLC | US$269.4万 | 0.04% |
| WELLS FARGO & COMPANY/MN | US$263.8万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$254.0万 | 0.00% |
| Emerald Investment Advisers, LLC | US$244.9万 | 0.22% |
| SEI INVESTMENTS CO | US$236.8万 | 0.00% |
| CANADA LIFE ASSURANCE Co | US$230.2万 | 0.00% |
| Nan Fung Group Holdings Ltd | US$229.2万 | 1.89% |
| MACKENZIE FINANCIAL CORP | US$225.6万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$224.2万 | 0.08% |
| NATIXIS ADVISORS, LLC | US$223.5万 | 0.00% |
| Stonepine Capital Management, LLC | US$222.6万 | 0.89% |
| State of Alaska, Department of Revenue | US$217.0万 | 0.02% |
| DekaBank Deutsche Girozentrale | US$216.9万 | 0.00% |
| Thrivent Financial for Lutherans | US$211.1万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$206.2万 | 0.00% |
| HOHIMER WEALTH MANAGEMENT, LLC | US$204.3万 | 0.24% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$190.5万 | 0.00% |
| PROFUND ADVISORS LLC | US$188.2万 | 0.07% |
| Phocas Financial Corp. | US$181.1万 | 0.28% |
| AMERICAN CENTURY COMPANIES INC | US$176.4万 | 0.00% |
| Sofinnova Investments, Inc. | US$174.9万 | 0.07% |
| WESBANCO BANK INC | US$174.1万 | 0.05% |
| Assenagon Asset Management S.A. | US$173.9万 | 0.00% |
| SG Americas Securities, LLC | US$171.9万 | 0.00% |
| MARSHALL WACE, LLP | US$169.6万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$159.6万 | 0.00% |
| Illinois Municipal Retirement Fund | US$158.5万 | 0.02% |
| MetLife Investment Management, LLC | US$152.9万 | 0.01% |
| Verdad Advisers, LP | US$152.0万 | 1.71% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$151.6万 | 0.00% |
| CITIGROUP INC | US$150.2万 | 0.00% |
| Engineers Gate Manager LP | US$147.0万 | 0.02% |
| NOMURA HOLDINGS INC | US$133.6万 | 0.00% |
| BURNEY CO/ | US$133.5万 | 0.04% |
| Handelsbanken Fonder AB | US$126.3万 | 0.00% |
| Louisiana State Employees Retirement System | US$123.5万 | 0.02% |
| GUGGENHEIM CAPITAL LLC | US$119.8万 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$114.5万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$114.0万 | 0.07% |
| WELLINGTON MANAGEMENT GROUP LLP | US$111.3万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$111.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$110.7万 | 0.00% |
| Empowered Funds, LLC | US$109.0万 | 0.01% |
| State of Tennessee, Department of Treasury | US$109.0万 | 0.00% |
| Creative Planning | US$105.7万 | 0.00% |
| Russell Investments Group, Ltd. | US$104.5万 | 0.00% |
| STRS OHIO | US$103.7万 | 0.00% |
| Freestone Grove Partners LP | US$103.4万 | 0.01% |
| Diversified Trust Co | US$99.8万 | 0.02% |
| HSBC HOLDINGS PLC | US$97.7万 | 0.00% |
| VIRTUS ADVISERS, LLC | US$95.7万 | 0.45% |
| State of New Jersey Common Pension Fund D | US$90.1万 | 0.00% |
| Gotham Asset Management, LLC | US$89.8万 | 0.00% |