| BlackRock, Inc. | US$1.6亿 | 0.00% |
| PRIMECAP MANAGEMENT CO/CA/ | US$1.2亿 | 0.10% |
| BVF INC/IL | US$8603.3万 | 2.74% |
| RTW INVESTMENTS, LP | US$8173.6万 | 0.81% |
| RA CAPITAL MANAGEMENT, L.P. | US$5906.1万 | 0.63% |
| STATE STREET CORP | US$5248.6万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$4221.4万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3740.6万 | 0.00% |
| TCG Crossover Management, LLC | US$2957.3万 | 0.85% |
| EcoR1 Capital, LLC | US$2632.7万 | 1.12% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2190.1万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1882.0万 | 0.00% |
| MORGAN STANLEY | US$1879.3万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1561.3万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$1329.1万 | 0.08% |
| UBS Group AG | US$1305.4万 | 0.00% |
| Legal & General Group Plc | US$1286.5万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$971.3万 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$921.1万 | 0.00% |
| JOHNSON & JOHNSON | US$902.2万 | 1.38% |
| NORTHERN TRUST CORP | US$897.9万 | 0.00% |
| Jefferies Financial Group Inc. | US$868.9万 | 0.06% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$840.4万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$748.6万 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | US$735.4万 | 0.00% |
| Lynx1 Capital Management LP | US$646.9万 | 1.02% |
| TORONTO DOMINION BANK | US$592.1万 | 0.01% |
| Hudson Bay Capital Management LP | US$587.7万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$568.1万 | 0.00% |
| Erste Asset Management GmbH | US$488.3万 | 0.05% |
| Bank of New York Mellon Corp | US$477.5万 | 0.00% |
| CITADEL ADVISORS LLC | US$455.5万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$441.5万 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$418.6万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$353.5万 | 0.01% |
| ACADIAN ASSET MANAGEMENT LLC | US$351.5万 | 0.00% |
| Nantahala Capital Management, LLC | US$319.2万 | 0.12% |
| Invesco Ltd. | US$318.2万 | 0.00% |
| Public Sector Pension Investment Board | US$308.1万 | 0.01% |
| Velan Capital Investment Management LP | US$301.5万 | 1.89% |
| DEUTSCHE BANK AG\ | US$269.7万 | 0.00% |
| BARCLAYS PLC | US$263.3万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$241.2万 | 0.00% |
| JPMORGAN CHASE & CO | US$229.1万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$211.3万 | 0.00% |
| RHUMBLINE ADVISERS | US$205.6万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$195.9万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$166.6万 | 0.02% |
| Nuveen, LLC | US$162.5万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$155.0万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$146.3万 | 0.00% |
| FMR LLC | US$134.9万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$128.7万 | 0.08% |
| WINTON GROUP Ltd | US$126.3万 | 0.04% |
| CITIGROUP INC | US$125.8万 | 0.00% |
| DCF Advisers, LLC | US$125.1万 | 0.33% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$124.2万 | 0.00% |
| Swiss National Bank | US$119.2万 | 0.00% |
| Essex LLC | US$119.0万 | 0.21% |
| Man Group plc | US$113.0万 | 0.00% |
| ADAR1 Capital Management, LLC | US$113.0万 | 0.07% |
| XTX Topco Ltd | US$111.1万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$110.4万 | 0.00% |
| Russell Investments Group, Ltd. | US$99.5万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$97.6万 | 0.00% |
| ALGERT GLOBAL LLC | US$97.1万 | 0.01% |
| Seven Fleet Capital Management LP | US$96.5万 | 0.31% |
| Rafferty Asset Management, LLC | US$91.1万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$89.5万 | 0.00% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$82.2万 | 0.00% |
| SG Americas Securities, LLC | US$81.5万 | 0.00% |
| TD Asset Management Inc | US$75.0万 | 0.00% |
| Thrivent Financial for Lutherans | US$73.9万 | 0.00% |
| ALPS ADVISORS INC | US$72.0万 | 0.00% |
| HRT FINANCIAL LP | US$72.0万 | 0.00% |
| HSBC HOLDINGS PLC | US$71.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$70.9万 | 0.01% |
| CANADA LIFE ASSURANCE Co | US$68.9万 | 0.00% |
| Quantinno Capital Management LP | US$68.8万 | 0.00% |
| HighVista Strategies LLC | US$64.0万 | 0.18% |
| DRW Securities, LLC | US$58.4万 | 0.01% |
| ExodusPoint Capital Management, LP | US$58.0万 | 0.00% |
| Trexquant Investment LP | US$53.7万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$52.8万 | 0.00% |
| Campbell & CO Investment Adviser LLC | US$52.5万 | 0.03% |
| Brevan Howard Capital Management LP | US$51.5万 | 0.00% |
| Linden Thomas Advisory Services, LLC | US$50.8万 | 0.05% |
| FRANKLIN RESOURCES INC | US$49.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$49.5万 | 0.00% |
| MetLife Investment Management, LLC | US$47.9万 | 0.00% |
| CIBC Bancorp USA Inc. | US$46.6万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$45.8万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$44.9万 | 0.00% |
| PROFUND ADVISORS LLC | US$44.4万 | 0.02% |
| State of Alaska, Department of Revenue | US$42.5万 | 0.00% |
| Louisiana State Employees Retirement System | US$38.2万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$37.9万 | 0.00% |
| Cerity Partners LLC | US$36.8万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$36.5万 | 0.00% |
| Quinn Opportunity Partners LLC | US$36.2万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$33.8万 | 0.00% |
| State of Tennessee, Department of Treasury | US$33.7万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$33.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$33.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$32.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$31.5万 | 0.00% |
| EntryPoint Capital, LLC | US$30.5万 | 0.09% |
| JANUS HENDERSON GROUP PLC | US$28.9万 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$26.1万 | 0.00% |
| Diversified Trust Co | US$26.0万 | 0.00% |
| Qube Research & Technologies Ltd | US$25.3万 | 0.00% |
| LPL Financial LLC | US$24.9万 | 0.00% |
| AMALGAMATED BANK | US$24.8万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$22.9万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$22.6万 | 0.00% |
| Rockefeller Capital Management L.P. | US$22.2万 | 0.00% |
| Palumbo Wealth Management LLC | US$21.5万 | 0.05% |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | US$21.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$21.3万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$21.1万 | 0.00% |
| YOUSIF CAPITAL MANAGEMENT, LLC | US$20.8万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$20.6万 | 0.00% |
| FIFTH THIRD BANCORP | US$20.5万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$20.0万 | 0.00% |
| Virtus Investment Advisers, LLC | US$19.9万 | 0.05% |
| Creative Planning | US$19.7万 | 0.00% |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | US$19.7万 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$18.1万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$17.9万 | 0.00% |
| ProShare Advisors LLC | US$17.2万 | 0.00% |
| Sanctuary Advisors, LLC | US$16.8万 | 0.00% |
| Brooklyn Investment Group | US$16.8万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$16.6万 | 0.00% |
| EP Wealth Advisors, LLC | US$16.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$15.7万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$15.6万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$15.3万 | 0.00% |
| Centiva Capital, LP | US$14.8万 | 0.00% |
| NorthCrest Asset Manangement, LLC | US$13.9万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$13.1万 | 0.00% |
| Pictet Asset Management Holding SA | US$13.0万 | 0.00% |
| Jump Financial, LLC | US$12.7万 | 0.00% |
| Maryland State Retirement & Pension System | US$12.5万 | 0.00% |
| CWM, LLC | US$12.1万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$11.2万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$9.8万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$8.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$8.0万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$7.1万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$7.0万 | 0.00% |