| RA CAPITAL MANAGEMENT, L.P. | US$4.7亿 | 4.95% |
| FMR LLC | US$3.0亿 | 0.02% |
| Nextech Invest, Ltd. | US$1.6亿 | 10.93% |
| JANUS HENDERSON GROUP PLC | US$1.5亿 | 0.07% |
| Alta Partners Management Company, L.P. | US$1.5亿 | 96.97% |
| FARALLON CAPITAL MANAGEMENT LLC | US$1.4亿 | 0.78% |
| TCG Crossover Management, LLC | US$1.2亿 | 3.56% |
| Commodore Capital LP | US$9479.3万 | 5.48% |
| BlackRock, Inc. | US$8494.7万 | 0.00% |
| Paradigm Biocapital Advisors LP | US$7870.6万 | 1.61% |
| BVF INC/IL | US$7568.8万 | 2.41% |
| Caligan Partners LP | US$4890.8万 | 3.25% |
| STATE STREET CORP | US$4657.6万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4312.5万 | 0.00% |
| 5AM Venture Management, LLC | US$3942.2万 | 10.94% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3776.7万 | 0.00% |
| Logos Global Management LP | US$3255.5万 | 1.63% |
| BARCLAYS PLC | US$3191.9万 | 0.01% |
| Canaan Partners XI LLC | US$2872.5万 | 37.76% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2522.6万 | 0.00% |
| JENNISON ASSOCIATES LLC | US$2422.2万 | 0.02% |
| Sio Capital Management, LLC | US$2318.8万 | 3.33% |
| GOLDMAN SACHS GROUP INC | US$2107.8万 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$2102.7万 | 0.25% |
| Balyasny Asset Management L.P. | US$1346.2万 | 0.02% |
| Elmind Capital, LP | US$1340.5万 | 3.81% |
| Woodline Partners LP | US$1153.0万 | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1046.6万 | 0.14% |
| MILLENNIUM MANAGEMENT LLC | US$1001.9万 | 0.00% |
| Affinity Asset Advisors, LLC | US$986.3万 | 0.51% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$947.0万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$946.4万 | 0.00% |
| Point72 Asset Management, L.P. | US$838.6万 | 0.01% |
| NORTHERN TRUST CORP | US$836.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$804.0万 | 0.00% |
| Sofinnova Investments, Inc. | US$781.4万 | 0.30% |
| STEMPOINT CAPITAL LP | US$768.9万 | 1.47% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$762.6万 | 0.00% |
| MARSHALL WACE, LLP | US$757.4万 | 0.01% |
| Seven Fleet Capital Management LP | US$749.5万 | 2.38% |
| ALGERT GLOBAL LLC | US$720.1万 | 0.11% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$621.2万 | 0.03% |
| VANGUARD FIDUCIARY TRUST CO | US$604.3万 | 0.00% |
| Trexquant Investment LP | US$564.2万 | 0.04% |
| AMERIPRISE FINANCIAL INC | US$555.0万 | 0.00% |
| HighVista Strategies LLC | US$502.9万 | 1.39% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$493.5万 | 0.01% |
| MORGAN STANLEY | US$461.5万 | 0.00% |
| Invesco Ltd. | US$417.7万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$389.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$368.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$351.7万 | 0.00% |
| OPPENHEIMER & CO INC | US$322.5万 | 0.04% |
| XTX Topco Ltd | US$321.3万 | 0.06% |
| Schonfeld Strategic Advisors LLC | US$304.8万 | 0.02% |
| Cinctive Capital Management LP | US$298.8万 | 0.19% |
| WELLINGTON MANAGEMENT GROUP LLP | US$295.6万 | 0.00% |
| Kalehua Capital Management LLC | US$285.2万 | 2.02% |
| Ensign Peak Advisors, Inc | US$283.7万 | 0.01% |
| Bank of New York Mellon Corp | US$276.6万 | 0.00% |
| Russell Investments Group, Ltd. | US$269.7万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$261.4万 | 0.00% |
| Catalio Capital Management, LP | US$257.7万 | 0.54% |
| UBS Group AG | US$235.8万 | 0.00% |
| JPMORGAN CHASE & CO | US$231.1万 | 0.00% |
| Vestal Point Capital, LP | US$206.8万 | 0.06% |
| Nuveen, LLC | US$194.7万 | 0.00% |
| TD Asset Management Inc | US$191.5万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$183.6万 | 0.00% |
| CITADEL ADVISORS LLC | US$183.1万 | 0.00% |
| Arkadios Wealth Advisors | US$182.2万 | 0.03% |
| Susquehanna Portfolio Strategies, LLC | US$180.1万 | 0.03% |
| ALPS ADVISORS INC | US$168.0万 | 0.01% |
| PDT Partners, LLC | US$161.9万 | 0.10% |
| Jump Financial, LLC | US$158.5万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$154.1万 | 0.00% |
| RHUMBLINE ADVISERS | US$151.9万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$146.9万 | 0.00% |
| Brevan Howard Capital Management LP | US$146.3万 | 0.01% |
| Rafferty Asset Management, LLC | US$133.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$127.4万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$112.7万 | 0.00% |
| Fisher Asset Management, LLC | US$110.3万 | 0.00% |
| Eversept Partners, LP | US$103.6万 | 0.05% |
| Swiss National Bank | US$101.1万 | 0.00% |
| Creative Planning | US$91.7万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$84.1万 | 0.00% |
| Auour Investments LLC | US$80.5万 | 0.25% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$78.6万 | 0.00% |
| DEUTSCHE BANK AG\ | US$78.5万 | 0.00% |
| Squarepoint Ops LLC | US$78.5万 | 0.00% |
| Walleye Capital LLC | US$71.7万 | 0.00% |
| Quadrature Capital Ltd | US$69.7万 | 0.01% |
| STRS OHIO | US$69.3万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$62.4万 | 0.00% |
| PSP Research LLC | US$61.3万 | 0.43% |
| PROFUND ADVISORS LLC | US$60.0万 | 0.02% |
| Vanguard Global Advisers, LLC | US$59.3万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$58.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$55.1万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$54.8万 | 0.00% |
| ExodusPoint Capital Management, LP | US$53.9万 | 0.00% |
| MetLife Investment Management, LLC | US$53.6万 | 0.00% |
| FRANKLIN RESOURCES INC | US$49.7万 | 0.00% |
| Virtus Investment Advisers, LLC | US$46.1万 | 0.13% |
| WELLS FARGO & COMPANY/MN | US$44.7万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$40.6万 | 0.00% |
| Soleus Capital Management, L.P. | US$38.3万 | 0.02% |
| Legal & General Group Plc | US$36.5万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$36.3万 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$34.4万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$30.9万 | 0.27% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$30.8万 | 0.00% |
| Bridgefront Capital, LLC | US$30.3万 | 0.08% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$30.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$28.4万 | 0.00% |
| SG Americas Securities, LLC | US$27.6万 | 0.00% |
| Allianz Asset Management GmbH | US$26.8万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$24.7万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$24.3万 | 0.00% |
| ProShare Advisors LLC | US$23.5万 | 0.00% |
| CITIGROUP INC | US$22.9万 | 0.00% |
| Graham Capital Management, L.P. | US$22.0万 | 0.01% |
| Persistent Asset Partners Ltd | US$17.3万 | 0.06% |
| Tower Research Capital LLC (TRC) | US$11.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$11.2万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$11.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$10.7万 | 0.00% |
| Chung Wu Investment Group, LLC | US$7.7万 | 0.07% |
| Ameritas Investment Partners, Inc. | US$7.6万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$7.3万 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$7.2万 | 0.01% |
| Steward Partners Investment Advisory, LLC | US$6.0万 | 0.00% |
| CWM, LLC | US$6.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$5.4万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$4.6万 | 0.00% |
| Sterling Capital Management LLC | US$3.3万 | 0.00% |
| Versant Capital Management, Inc | US$3.1万 | 0.00% |
| Hilton Head Capital Partners, LLC | US$3.0万 | 0.02% |
| FEDERATED HERMES, INC. | US$2.7万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2.1万 | 0.00% |
| GAMMA Investing LLC | US$1.9万 | 0.00% |
| Rockefeller Capital Management L.P. | US$1.6万 | 0.00% |
| Larson Financial Group LLC | US$1.1万 | 0.00% |
| Quantbot Technologies LP | US$9307.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$8542.0 | 0.00% |
| True Wealth Design, LLC | US$5439.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$4903.0 | 0.00% |
| Smartleaf Asset Management LLC | US$4394.0 | 0.00% |
| Optiver Holding B.V. | US$4060.0 | 0.00% |