| SUVRETTA CAPITAL MANAGEMENT, LLC | US$1.1亿 | 2.73% |
| Cormorant Asset Management, LP | US$1.1亿 | 5.35% |
| BlackRock, Inc. | US$9251.6万 | 0.00% |
| FEDERATED HERMES, INC. | US$7308.1万 | 0.12% |
| FRANKLIN RESOURCES INC | US$6507.6万 | 0.02% |
| JANUS HENDERSON GROUP PLC | US$4641.9万 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4588.3万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$4253.7万 | 0.07% |
| Paradigm Biocapital Advisors LP | US$4050.6万 | 0.83% |
| Commodore Capital LP | US$3641.4万 | 2.11% |
| STATE STREET CORP | US$2703.3万 | 0.00% |
| CITADEL ADVISORS LLC | US$2584.8万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2557.4万 | 0.00% |
| Aberdeen Group plc | US$2240.8万 | 0.04% |
| Balyasny Asset Management L.P. | US$1854.5万 | 0.02% |
| Parkman Healthcare Partners LLC | US$1746.3万 | 1.80% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1605.6万 | 0.27% |
| MORGAN STANLEY | US$1412.9万 | 0.00% |
| Essex Woodlands Management, Inc. | US$1398.4万 | 5.58% |
| ORBIMED ADVISORS LLC | US$1378.1万 | 0.28% |
| 5AM Venture Management, LLC | US$1353.5万 | 3.76% |
| Rosalind Advisors, Inc. | US$1336.4万 | 5.37% |
| Blue Owl Capital Holdings LP | US$1176.3万 | 3.16% |
| HSBC HOLDINGS PLC | US$1074.3万 | 0.01% |
| STEMPOINT CAPITAL LP | US$1045.1万 | 2.00% |
| Patient Square Capital LP | US$1024.8万 | 1.82% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1023.3万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$992.3万 | 0.00% |
| Artia Global Partners LP | US$988.8万 | 1.98% |
| Ikarian Capital, LLC | US$954.9万 | 0.78% |
| Sio Capital Management, LLC | US$930.4万 | 1.33% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$892.4万 | 0.00% |
| NORTHERN TRUST CORP | US$872.4万 | 0.00% |
| Candriam S.C.A. | US$869.3万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$825.1万 | 0.00% |
| Alyeska Investment Group, L.P. | US$656.6万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$650.3万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$612.5万 | 0.00% |
| ExodusPoint Capital Management, LP | US$590.5万 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$554.7万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$545.6万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$516.5万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$494.3万 | 0.00% |
| MYDA Advisors LLC | US$425.4万 | 0.70% |
| Simplify Asset Management Inc. | US$420.4万 | 0.06% |
| Bleichroeder LP | US$408.0万 | 0.71% |
| Walleye Capital LLC | US$386.9万 | 0.02% |
| Granahan Investment Management, LLC | US$383.0万 | 0.19% |
| DIADEMA PARTNERS LP | US$367.2万 | 0.62% |
| Nuveen, LLC | US$335.5万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$333.8万 | 0.00% |
| Rock Springs Capital Management LP | US$333.5万 | 0.20% |
| Bank of New York Mellon Corp | US$329.2万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$316.3万 | 0.00% |
| DEUTSCHE BANK AG\ | US$308.2万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$279.2万 | 0.04% |
| Propel Bio Management, LLC | US$278.9万 | 1.76% |
| Schonfeld Strategic Advisors LLC | US$267.0万 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$259.0万 | 0.00% |
| Jump Financial, LLC | US$255.7万 | 0.03% |
| HighVista Strategies LLC | US$235.9万 | 0.65% |
| MARSHALL WACE, LLP | US$208.5万 | 0.00% |
| SILVERBACK ASSET MANAGEMENT LLC | US$193.4万 | 0.28% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$193.2万 | 0.00% |
| Swiss National Bank | US$190.0万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$179.7万 | 0.03% |
| PANAGORA ASSET MANAGEMENT INC | US$170.4万 | 0.01% |
| Invesco Ltd. | US$170.1万 | 0.00% |
| UBS Group AG | US$166.9万 | 0.00% |
| FMR LLC | US$166.8万 | 0.00% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$164.0万 | 0.26% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$163.3万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$151.2万 | 0.00% |
| Qube Research & Technologies Ltd | US$150.1万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$137.6万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$136.9万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$135.5万 | 0.00% |
| Woodline Partners LP | US$129.5万 | 0.00% |
| RHUMBLINE ADVISERS | US$124.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$121.8万 | 0.00% |
| E Fund Management Co., Ltd. | US$121.8万 | 0.04% |
| Squarepoint Ops LLC | US$103.3万 | 0.00% |
| Centiva Capital, LP | US$100.6万 | 0.01% |
| Waverly Advisors, LLC | US$100.4万 | 0.01% |
| Caption Management, LLC | US$93.5万 | 0.01% |
| Russell Investments Group, Ltd. | US$92.3万 | 0.00% |
| Persistent Asset Partners Ltd | US$91.4万 | 0.34% |
| WOODSTOCK CORP | US$88.3万 | 0.08% |
| XTX Topco Ltd | US$85.9万 | 0.01% |
| Marex Group plc | US$72.6万 | 0.00% |
| TWINBEECH CAPITAL LP | US$72.6万 | 0.08% |
| Legal & General Group Plc | US$68.5万 | 0.00% |
| SEI INVESTMENTS CO | US$65.1万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$63.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$61.6万 | 0.00% |
| Erste Asset Management GmbH | US$59.3万 | 0.01% |
| NISA INVESTMENT ADVISORS, LLC | US$57.3万 | 0.00% |
| MetLife Investment Management, LLC | US$56.0万 | 0.00% |
| SBI Okasan Asset Management Co.Ltd. | US$54.2万 | 0.02% |
| SCOTIA CAPITAL INC. | US$53.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$51.2万 | 0.04% |
| Vanguard Global Advisers, LLC | US$50.1万 | 0.00% |
| JPMORGAN CHASE & CO | US$47.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$46.8万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$46.5万 | 0.00% |
| Creative Planning | US$42.6万 | 0.00% |
| HighTower Advisors, LLC | US$41.9万 | 0.00% |
| LEVIN CAPITAL STRATEGIES, L.P. | US$40.6万 | 0.03% |
| Janney Montgomery Scott LLC | US$39.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$37.8万 | 0.00% |
| CITIGROUP INC | US$37.2万 | 0.00% |
| Baird Financial Group, Inc. | US$36.2万 | 0.00% |
| Cinctive Capital Management LP | US$35.9万 | 0.02% |
| Point72 Asset Management, L.P. | US$34.3万 | 0.00% |
| BARCLAYS PLC | US$33.7万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$32.8万 | 0.00% |
| Cyndeo Wealth Partners, LLC | US$30.2万 | 0.02% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$27.9万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$26.4万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$26.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$25.9万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$24.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$24.1万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$22.8万 | 0.00% |
| RWC Asset Management LLP | US$22.8万 | 0.01% |
| Virtus Investment Advisers, LLC | US$22.0万 | 0.06% |
| PROFUND ADVISORS LLC | US$21.8万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$21.1万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$20.8万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$20.5万 | 0.00% |
| ProShare Advisors LLC | US$19.3万 | 0.00% |
| MCF Advisors LLC | US$17.3万 | 0.01% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$15.8万 | 0.01% |
| Dynamic Technology Lab Private Ltd | US$15.6万 | 0.03% |
| PRUDENTIAL FINANCIAL INC | US$15.4万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$14.8万 | 0.00% |
| ROYAL BANK OF CANADA | US$14.7万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$14.3万 | 0.00% |
| Pictet Asset Management Holding SA | US$14.1万 | 0.00% |
| GREAT VALLEY ADVISOR GROUP, INC. | US$13.9万 | 0.00% |
| Scientech Research LLC | US$13.4万 | 0.11% |
| AMERICAN CENTURY COMPANIES INC | US$13.1万 | 0.00% |
| Winthrop Advisory Group LLC | US$13.0万 | 0.01% |
| PSP Research LLC | US$12.9万 | 0.09% |
| Caitong International Asset Management Co., Ltd | US$9.1万 | 0.02% |
| Aquatic Capital Management LLC | US$8.2万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$7.9万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$7.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$5.6万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$5.2万 | 0.00% |