| EcoR1 Capital, LLC | US$4.4亿 | 18.55% |
| BlackRock, Inc. | US$9324.9万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | US$7381.1万 | 3.75% |
| MORGAN STANLEY | US$5512.2万 | 0.00% |
| STATE STREET CORP | US$5504.1万 | 0.00% |
| Affinity Asset Advisors, LLC | US$5213.2万 | 2.69% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4731.6万 | 0.00% |
| Palo Alto Investors LP | US$3539.2万 | 5.41% |
| 683 Capital Management, LLC | US$3466.3万 | 1.81% |
| D. E. Shaw & Co., Inc. | US$3212.8万 | 0.02% |
| First Light Asset Management, LLC | US$3135.9万 | 2.81% |
| Sanofi | US$3038.5万 | 9.04% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2885.9万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2883.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$2779.0万 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$2729.3万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$2637.5万 | 0.01% |
| FMR LLC | US$2621.6万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$2579.4万 | 0.02% |
| FEDERATED HERMES, INC. | US$2019.4万 | 0.03% |
| Woodline Partners LP | US$1909.2万 | 0.07% |
| GOLDMAN SACHS GROUP INC | US$1845.4万 | 0.00% |
| Synergy Asset Management, LLC | US$1758.7万 | 1.87% |
| Nuveen, LLC | US$1752.9万 | 0.00% |
| Squarepoint Ops LLC | US$1484.7万 | 0.02% |
| Qube Research & Technologies Ltd | US$1412.8万 | 0.02% |
| Sofinnova Investments, Inc. | US$1376.8万 | 0.52% |
| CITADEL ADVISORS LLC | US$1337.4万 | 0.00% |
| Apis Capital Advisors, LLC | US$1319.9万 | 2.04% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1068.6万 | 0.00% |
| NORTHERN TRUST CORP | US$1017.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$879.4万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$749.2万 | 0.00% |
| HSBC HOLDINGS PLC | US$713.7万 | 0.00% |
| Ensign Peak Advisors, Inc | US$696.8万 | 0.01% |
| Invesco Ltd. | US$671.6万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$600.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$531.5万 | 0.00% |
| HighMark Wealth Management LLC | US$521.6万 | 2.12% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$519.8万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$504.1万 | 0.01% |
| Trexquant Investment LP | US$472.3万 | 0.03% |
| UBS Group AG | US$441.8万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$437.9万 | 0.02% |
| CITIGROUP INC | US$407.1万 | 0.00% |
| MARSHALL WACE, LLP | US$377.4万 | 0.00% |
| Granahan Investment Management, LLC | US$367.0万 | 0.18% |
| FRANKLIN RESOURCES INC | US$365.0万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$355.2万 | 0.00% |
| Fisher Asset Management, LLC | US$313.9万 | 0.00% |
| Point72 Asset Management, L.P. | US$306.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$288.6万 | 0.00% |
| Bank of New York Mellon Corp | US$283.5万 | 0.00% |
| XTX Topco Ltd | US$280.3万 | 0.05% |
| WELLINGTON MANAGEMENT GROUP LLP | US$260.0万 | 0.00% |
| Penserra Capital Management LLC | US$240.8万 | 0.03% |
| Bleakley Financial Group, LLC | US$239.1万 | 0.04% |
| HRT FINANCIAL LP | US$224.6万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$219.5万 | 0.00% |
| MOODY ALDRICH PARTNERS LLC | US$218.8万 | 0.39% |
| Tidal Investments LLC | US$201.6万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$199.4万 | 0.03% |
| MACKENZIE FINANCIAL CORP | US$187.0万 | 0.00% |
| Virtu Financial LLC | US$184.8万 | 0.08% |
| WELLS FARGO & COMPANY/MN | US$184.0万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$180.1万 | 0.00% |
| Tema ETFs LLC | US$172.3万 | 0.12% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$170.4万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$164.7万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$158.8万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$156.1万 | 0.04% |
| Engineers Gate Manager LP | US$154.3万 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$153.2万 | 0.00% |
| Swiss National Bank | US$153.1万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$151.8万 | 0.00% |
| Rafferty Asset Management, LLC | US$151.1万 | 0.01% |
| Eversept Partners, LP | US$150.2万 | 0.08% |
| SG Americas Securities, LLC | US$137.8万 | 0.00% |
| Headlands Technologies LLC | US$136.2万 | 0.16% |
| RHUMBLINE ADVISERS | US$132.3万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$125.9万 | 0.02% |
| J. Goldman & Co LP | US$117.6万 | 0.03% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$116.5万 | 0.25% |
| CREDIT AGRICOLE S A | US$110.9万 | 0.00% |
| DCF Advisers, LLC | US$104.1万 | 0.28% |
| Walleye Capital LLC | US$102.2万 | 0.00% |
| PDT Partners, LLC | US$97.6万 | 0.06% |
| Creative Planning | US$93.4万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$86.9万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$82.6万 | 0.00% |
| TWINBEECH CAPITAL LP | US$80.5万 | 0.08% |
| VOYA INVESTMENT MANAGEMENT LLC | US$79.6万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$77.6万 | 0.00% |
| Gotham Asset Management, LLC | US$77.5万 | 0.00% |
| Cresset Asset Management, LLC | US$76.9万 | 0.00% |
| Legal & General Group Plc | US$76.7万 | 0.00% |
| Brookwood Investment Group LLC | US$74.1万 | 0.09% |
| Russell Investments Group, Ltd. | US$73.7万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$73.0万 | 0.00% |
| Orion Porfolio Solutions, LLC | US$72.8万 | 0.01% |
| OXFORD ASSET MANAGEMENT LLP | US$70.3万 | 0.30% |
| PROFUND ADVISORS LLC | US$67.7万 | 0.02% |
| Vanguard Global Advisers, LLC | US$65.2万 | 0.00% |
| JPMORGAN CHASE & CO | US$64.5万 | 0.00% |
| Brevan Howard Capital Management LP | US$61.2万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$58.1万 | 0.00% |
| MetLife Investment Management, LLC | US$56.4万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$56.4万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$53.7万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$53.2万 | 0.00% |
| SEI INVESTMENTS CO | US$42.4万 | 0.00% |
| Ground Swell Capital, LLC | US$42.2万 | 0.83% |
| JANUS HENDERSON GROUP PLC | US$41.4万 | 0.00% |
| BARCLAYS PLC | US$41.3万 | 0.00% |
| ExodusPoint Capital Management, LP | US$40.3万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$38.8万 | 0.00% |
| Duncan Williams Asset Management, LLC | US$36.2万 | 0.10% |
| Vinva Investment Management Ltd | US$35.4万 | 0.00% |
| GLENMEDE TRUST CO NA | US$35.4万 | 0.00% |
| Savant Capital, LLC | US$34.2万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$34.2万 | 0.03% |
| Quantinno Capital Management LP | US$33.7万 | 0.00% |
| Virtus Investment Advisers, LLC | US$33.6万 | 0.09% |
| Soleus Capital Management, L.P. | US$33.3万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$32.4万 | 0.00% |
| Ascent Group, LLC | US$31.2万 | 0.01% |
| Integrated Quantitative Investments LLC | US$31.1万 | 0.06% |
| FMB WEALTH MANAGEMENT | US$31.0万 | 0.13% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$30.6万 | 0.00% |
| Bayforest Capital Ltd | US$29.1万 | 0.33% |
| INTECH INVESTMENT MANAGEMENT LLC | US$28.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$27.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$27.4万 | 0.00% |
| Balyasny Asset Management L.P. | US$27.2万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$27.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$26.5万 | 0.00% |
| AXQ CAPITAL, LP | US$26.1万 | 0.03% |
| Hillsdale Investment Management Inc. | US$25.6万 | 0.01% |
| Latash Investments, LLC | US$24.4万 | 0.19% |
| Dynamic Technology Lab Private Ltd | US$24.2万 | 0.04% |
| ROYAL BANK OF CANADA | US$23.4万 | 0.00% |
| Allen Capital Group, LLC | US$22.9万 | 0.02% |
| Moran Wealth Management, LLC | US$22.5万 | 0.01% |
| Jump Financial, LLC | US$21.6万 | 0.00% |
| ProShare Advisors LLC | US$21.5万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$21.3万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$20.6万 | 0.02% |
| ADAR1 Capital Management, LLC | US$20.5万 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$19.8万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$16.6万 | 0.00% |