| BAKER BROS. ADVISORS LP | US$7.6億 | 4.36% |
| BlackRock, Inc. | US$1.5億 | 0.00% |
| STATE STREET CORP | US$8580.5萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$7774.1萬 | 0.01% |
| BRAIDWELL LP | US$6932.8萬 | 2.31% |
| GOLDMAN SACHS GROUP INC | US$6629.1萬 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$6545.5萬 | 0.00% |
| RTW INVESTMENTS, LP | US$5672.0萬 | 0.56% |
| TCG Crossover Management, LLC | US$5510.4萬 | 1.58% |
| Ikarian Capital, LLC | US$5206.4萬 | 4.23% |
| Boxer Capital Management, LLC | US$5188.1萬 | 6.81% |
| JANUS HENDERSON GROUP PLC | US$5054.0萬 | 0.02% |
| ICONIQ Capital, LLC | US$4828.1萬 | 1.08% |
| CITADEL ADVISORS LLC | US$3973.6萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3814.3萬 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$3781.2萬 | 3.86% |
| T. Rowe Price Investment Management, Inc. | US$3190.5萬 | 0.02% |
| Balyasny Asset Management L.P. | US$2769.6萬 | 0.04% |
| Board of Trustees of The Leland Stanford Junior University | US$2637.0萬 | 3.11% |
| Artisan Partners Limited Partnership | US$2631.5萬 | 0.04% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2191.9萬 | 0.03% |
| MORGAN STANLEY | US$1966.5萬 | 0.00% |
| Point72 Asset Management, L.P. | US$1752.5萬 | 0.02% |
| DIADEMA PARTNERS LP | US$1677.5萬 | 2.85% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1663.3萬 | 0.00% |
| NORTHERN TRUST CORP | US$1491.8萬 | 0.00% |
| Squadron Capital Management LLC | US$1448.6萬 | 5.31% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1391.6萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1358.1萬 | 0.18% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1333.4萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1200.8萬 | 0.00% |
| Invesco Ltd. | US$1162.9萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$1145.0萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$1121.9萬 | 0.02% |
| BOONE CAPITAL MANAGEMENT LLC | US$1072.4萬 | 3.29% |
| VANGUARD FIDUCIARY TRUST CO | US$984.0萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$925.7萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$876.6萬 | 0.01% |
| FEDERATED HERMES, INC. | US$801.3萬 | 0.01% |
| Atom Investors LP | US$727.2萬 | 0.52% |
| FMR LLC | US$701.1萬 | 0.00% |
| TD Asset Management Inc | US$618.7萬 | 0.01% |
| UBS Group AG | US$583.9萬 | 0.00% |
| ALGERT GLOBAL LLC | US$563.9萬 | 0.08% |
| Bruce & Co., Inc. | US$552.7萬 | 1.58% |
| Trexquant Investment LP | US$470.4萬 | 0.03% |
| JANE STREET GROUP, LLC | US$467.7萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$459.8萬 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$437.6萬 | 0.69% |
| PFM Health Sciences, LP | US$437.3萬 | 0.40% |
| Bank of New York Mellon Corp | US$424.4萬 | 0.00% |
| Resolute Capital Asset Partners LLC | US$381.2萬 | 2.01% |
| TWO SIGMA INVESTMENTS, LP | US$379.2萬 | 0.00% |
| Nuveen, LLC | US$363.3萬 | 0.00% |
| Informed Momentum Co LLC | US$336.9萬 | 0.39% |
| AQR CAPITAL MANAGEMENT LLC | US$327.1萬 | 0.00% |
| RIA Advisory Group LLC | US$322.8萬 | 0.77% |
| PRUDENTIAL FINANCIAL INC | US$305.8萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$294.0萬 | 0.00% |
| Rafferty Asset Management, LLC | US$272.6萬 | 0.01% |
| Harvest Investment Services, LLC | US$272.0萬 | 0.50% |
| Squarepoint Ops LLC | US$270.9萬 | 0.00% |
| JPMORGAN CHASE & CO | US$268.3萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$266.3萬 | 0.00% |
| National Philanthropic Trust | US$253.1萬 | 0.03% |
| Jefferies Financial Group Inc. | US$252.6萬 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$249.7萬 | 0.00% |
| Persistent Asset Partners Ltd | US$236.9萬 | 0.88% |
| Maven Securities LTD | US$224.7萬 | 0.04% |
| Swiss National Bank | US$218.8萬 | 0.00% |
| Jain Global LLC | US$200.4萬 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$187.8萬 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$184.4萬 | 0.01% |
| RHUMBLINE ADVISERS | US$182.8萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$166.8萬 | 0.00% |
| HighVista Strategies LLC | US$166.1萬 | 0.46% |
| POLEN CAPITAL MANAGEMENT LLC | US$157.6萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$157.3萬 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$156.1萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$143.5萬 | 0.00% |
| PROFUND ADVISORS LLC | US$121.4萬 | 0.04% |
| Vanguard Global Advisers, LLC | US$116.6萬 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$113.3萬 | 0.00% |
| Walleye Capital LLC | US$112.3萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$112.1萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$111.9萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$107.6萬 | 0.00% |
| Aries Wealth Management | US$95.3萬 | 0.21% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$84.8萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$84.4萬 | 0.01% |
| Headlands Technologies LLC | US$78.5萬 | 0.09% |
| MetLife Investment Management, LLC | US$77.6萬 | 0.00% |
| Legal & General Group Plc | US$76.9萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$75.3萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$73.1萬 | 0.00% |
| Russell Investments Group, Ltd. | US$71.0萬 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$69.4萬 | 0.01% |
| XTX Topco Ltd | US$68.5萬 | 0.01% |
| Optimize Financial Inc | US$68.0萬 | 0.33% |
| SG Americas Securities, LLC | US$65.3萬 | 0.00% |
| Artia Global Partners LP | US$64.9萬 | 0.13% |
| Palumbo Wealth Management LLC | US$58.3萬 | 0.14% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$57.6萬 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$57.1萬 | 0.01% |
| Cerity Partners LLC | US$56.7萬 | 0.00% |
| Continuum Advisory, LLC | US$56.6萬 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | US$54.4萬 | 0.00% |
| SIG BROKERAGE, LP | US$51.1萬 | 0.01% |
| Campbell & CO Investment Adviser LLC | US$50.4萬 | 0.03% |
| Engineers Gate Manager LP | US$45.8萬 | 0.01% |
| LPL Financial LLC | US$45.6萬 | 0.00% |
| Caption Management, LLC | US$43.8萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$43.7萬 | 0.12% |
| Quantinno Capital Management LP | US$43.4萬 | 0.00% |
| BARCLAYS PLC | US$43.1萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$41.8萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$41.4萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$41.3萬 | 0.03% |
| CITIGROUP INC | US$40.7萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$40.6萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$39.5萬 | 0.00% |
| SEI INVESTMENTS CO | US$39.2萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$38.1萬 | 0.01% |
| PSP Research LLC | US$38.1萬 | 0.27% |
| State of New Jersey Common Pension Fund D | US$37.8萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$36.8萬 | 0.00% |
| Virtu Financial LLC | US$35.5萬 | 0.01% |
| Verdad Advisers, LP | US$34.7萬 | 0.39% |
| Brooklyn Investment Group | US$34.6萬 | 0.01% |
| E Fund Management Co., Ltd. | US$34.3萬 | 0.01% |
| Creative Planning | US$32.1萬 | 0.00% |
| ALLSTATE CORP | US$32.1萬 | 0.00% |
| ProShare Advisors LLC | US$31.3萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$31.3萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$30.4萬 | 0.00% |
| Quadrature Capital Ltd | US$30.0萬 | 0.00% |
| J. Goldman & Co LP | US$29.0萬 | 0.01% |
| Brevan Howard Capital Management LP | US$26.3萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$24.4萬 | 0.00% |
| Cetera Investment Advisers | US$22.8萬 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | US$21.4萬 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$21.2萬 | 0.02% |
| Tower Research Capital LLC (TRC) | US$21.0萬 | 0.01% |
| CANADA LIFE ASSURANCE Co | US$18.9萬 | 0.00% |
| CWM, LLC | US$13.1萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$12.1萬 | 0.00% |
| STRS OHIO | US$11.8萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$11.8萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$11.7萬 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$10.9萬 | 0.00% |