| RA CAPITAL MANAGEMENT, L.P. | US$5.8亿 | 6.14% |
| BlackRock, Inc. | US$5.4亿 | 0.01% |
| BAKER BROS. ADVISORS LP | US$4.9亿 | 2.80% |
| PRIMECAP MANAGEMENT CO/CA/ | US$3.0亿 | 0.23% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.6亿 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.6亿 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$2.1亿 | 4.03% |
| STATE STREET CORP | US$2.0亿 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$1.7亿 | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$1.7亿 | 0.70% |
| FMR LLC | US$1.5亿 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.4亿 | 0.02% |
| Polar Capital Holdings Plc | US$1.4亿 | 0.50% |
| CITADEL ADVISORS LLC | US$1.3亿 | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.2亿 | 0.01% |
| JPMORGAN CHASE & CO | US$1.2亿 | 0.01% |
| FEDERATED HERMES, INC. | US$1.1亿 | 0.18% |
| Checkpoint Capital L.P. | US$1.1亿 | 38.30% |
| ALLIANCEBERNSTEIN L.P. | US$9745.1万 | 0.03% |
| Capital Research Global Investors | US$9701.2万 | 0.02% |
| JANUS HENDERSON GROUP PLC | US$7988.6万 | 0.04% |
| Point72 Asset Management, L.P. | US$7364.6万 | 0.09% |
| Woodline Partners LP | US$6600.1万 | 0.25% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$6311.8万 | 0.10% |
| Siren, L.L.C. | US$6309.8万 | 1.75% |
| MORGAN STANLEY | US$6122.5万 | 0.00% |
| Rock Springs Capital Management LP | US$5998.7万 | 3.54% |
| Pictet Asset Management Holding SA | US$5732.9万 | 0.06% |
| BANK OF AMERICA CORP /DE/ | US$5467.5万 | 0.00% |
| FRANKLIN RESOURCES INC | US$5451.7万 | 0.01% |
| Clearbridge Investments, LLC | US$5300.3万 | 0.05% |
| Integral Health Asset Management, LLC | US$5218.2万 | 2.50% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$4709.0万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4578.6万 | 0.01% |
| NORTHERN TRUST CORP | US$4335.6万 | 0.01% |
| LOOMIS SAYLES & CO L P | US$4045.0万 | 0.05% |
| Candriam S.C.A. | US$4038.4万 | 0.21% |
| MILLENNIUM MANAGEMENT LLC | US$3929.5万 | 0.02% |
| Sofinnova Investments, Inc. | US$3914.5万 | 1.49% |
| Logos Global Management LP | US$3913.7万 | 1.95% |
| Driehaus Capital Management LLC | US$3796.6万 | 0.28% |
| VANGUARD FIDUCIARY TRUST CO | US$3669.4万 | 0.01% |
| Opaleye Management Inc. | US$3532.3万 | 4.65% |
| Artisan Partners Limited Partnership | US$3397.6万 | 0.05% |
| AMERIPRISE FINANCIAL INC | US$3339.3万 | 0.01% |
| Invesco Ltd. | US$3168.4万 | 0.00% |
| LORD, ABBETT & CO. LLC | US$3034.8万 | 0.10% |
| ORBIMED ADVISORS LLC | US$2731.7万 | 0.56% |
| BRAIDWELL LP | US$2701.5万 | 0.90% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2661.3万 | 2.72% |
| Bank of New York Mellon Corp | US$2550.8万 | 0.00% |
| Qube Research & Technologies Ltd | US$2417.3万 | 0.03% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2380.9万 | 0.00% |
| Squarepoint Ops LLC | US$2287.0万 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | US$2243.9万 | 0.04% |
| Hood River Capital Management LLC | US$2086.5万 | 0.21% |
| VOYA INVESTMENT MANAGEMENT LLC | US$2033.4万 | 0.02% |
| UBS Group AG | US$2014.7万 | 0.00% |
| ADAR1 Capital Management, LLC | US$1839.0万 | 1.08% |
| SummitTX Capital, L.P. | US$1440.2万 | 0.45% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1320.6万 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1280.1万 | 0.00% |
| DEUTSCHE BANK AG\ | US$1231.5万 | 0.00% |
| M&G PLC | US$1205.5万 | 0.06% |
| PFM Health Sciences, LP | US$1188.2万 | 1.08% |
| NEXTBio Capital Management LP | US$1096.5万 | 5.09% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1088.9万 | 0.02% |
| Nuveen, LLC | US$1020.8万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1017.2万 | 0.01% |
| Russell Investments Group, Ltd. | US$1006.4万 | 0.01% |
| Capital World Investors | US$1006.2万 | 0.00% |
| Swiss National Bank | US$975.8万 | 0.01% |
| AXIOM INVESTORS LLC /DE | US$797.9万 | 0.09% |
| First Light Asset Management, LLC | US$758.2万 | 0.68% |
| FIRST TRUST ADVISORS LP | US$743.6万 | 0.01% |
| Aberdeen Group plc | US$690.2万 | 0.01% |
| Granahan Investment Management, LLC | US$675.8万 | 0.33% |
| NEUBERGER BERMAN GROUP LLC | US$638.7万 | 0.00% |
| WCM INVESTMENT MANAGEMENT, LLC | US$622.8万 | 0.01% |
| RHUMBLINE ADVISERS | US$607.6万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$572.4万 | 0.12% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$572.3万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$547.4万 | 0.01% |
| Blue Owl Capital Holdings LP | US$534.5万 | 1.44% |
| XTX Topco Ltd | US$517.5万 | 0.09% |
| AQR CAPITAL MANAGEMENT LLC | US$515.5万 | 0.00% |
| ALGERT GLOBAL LLC | US$508.9万 | 0.08% |
| Atom Investors LP | US$495.7万 | 0.35% |
| Balyasny Asset Management L.P. | US$460.7万 | 0.01% |
| CASTLEARK MANAGEMENT LLC | US$454.7万 | 0.15% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$441.5万 | 0.00% |
| JANE STREET GROUP, LLC | US$438.3万 | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | US$438.1万 | 0.03% |
| Rafferty Asset Management, LLC | US$435.8万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$434.2万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$432.1万 | 0.00% |
| Nan Fung Group Holdings Ltd | US$427.2万 | 3.52% |
| Harvest Investment Services, LLC | US$421.5万 | 0.77% |
| Legal & General Group Plc | US$409.0万 | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | US$407.8万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$381.6万 | 0.00% |
| Utah Retirement Systems | US$366.8万 | 0.04% |
| SEI INVESTMENTS CO | US$353.9万 | 0.00% |
| Exome Asset Management LLC | US$352.9万 | 1.83% |
| Hillsdale Investment Management Inc. | US$350.5万 | 0.10% |
| TD Asset Management Inc | US$337.3万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$318.1万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$298.1万 | 0.00% |
| EFG International AG | US$297.8万 | 0.06% |
| WELLS FARGO & COMPANY/MN | US$296.6万 | 0.00% |
| ASPIRIANT, LLC | US$287.1万 | 0.08% |
| LAZARD ASSET MANAGEMENT LLC | US$286.0万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$284.0万 | 0.00% |
| Alyeska Investment Group, L.P. | US$283.4万 | 0.01% |
| HARBOR CAPITAL ADVISORS, INC. | US$264.0万 | 0.21% |
| PRUDENTIAL FINANCIAL INC | US$262.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$258.3万 | 0.00% |
| Aquatic Capital Management LLC | US$258.0万 | 0.07% |
| STRS OHIO | US$251.5万 | 0.01% |
| MetLife Investment Management, LLC | US$251.2万 | 0.01% |
| PDT Partners, LLC | US$236.8万 | 0.14% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | US$213.4万 | 0.04% |
| PROFUND ADVISORS LLC | US$198.2万 | 0.07% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$195.9万 | 0.02% |
| Creative Planning | US$183.4万 | 0.00% |
| Liberty Mutual Group Asset Management Inc. | US$178.4万 | 0.14% |
| VICTORY CAPITAL MANAGEMENT INC | US$178.3万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$170.9万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$168.6万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$166.6万 | 0.00% |
| SG Americas Securities, LLC | US$163.2万 | 0.00% |
| Advisors Asset Management, Inc. | US$162.8万 | 0.03% |
| CAPTRUST FINANCIAL ADVISORS | US$157.8万 | 0.00% |
| ExodusPoint Capital Management, LP | US$154.6万 | 0.01% |
| Handelsbanken Fonder AB | US$152.4万 | 0.01% |
| HighVista Strategies LLC | US$146.1万 | 0.40% |
| GUGGENHEIM CAPITAL LLC | US$144.0万 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$135.7万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$135.6万 | 0.08% |
| ARIZONA STATE RETIREMENT SYSTEM | US$135.5万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$127.4万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$126.9万 | 0.01% |
| HSBC HOLDINGS PLC | US$122.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$121.1万 | 0.00% |
| Jasper Ridge Partners, L.P. | US$120.4万 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | US$119.5万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$108.7万 | 0.00% |
| Bridgefront Capital, LLC | US$108.7万 | 0.27% |
| STIFEL FINANCIAL CORP | US$107.3万 | 0.00% |
| CITIGROUP INC | US$107.3万 | 0.00% |