| RTW INVESTMENTS, LP | US$1.8亿 | 1.82% |
| BlackRock, Inc. | US$1.8亿 | 0.00% |
| FMR LLC | US$1.8亿 | 0.01% |
| Lynx1 Capital Management LP | US$1.6亿 | 24.51% |
| Redmile Group, LLC | US$1.4亿 | 8.98% |
| MORGAN STANLEY | US$1.1亿 | 0.01% |
| BAKER BROS. ADVISORS LP | US$1.1亿 | 0.62% |
| TORONTO DOMINION BANK | US$1.0亿 | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.0亿 | 0.02% |
| BVF INC/IL | US$8294.8万 | 2.64% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$7669.8万 | 0.00% |
| STATE STREET CORP | US$7412.3万 | 0.00% |
| Siren, L.L.C. | US$6496.8万 | 1.80% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6297.7万 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$5937.3万 | 0.70% |
| JANUS HENDERSON GROUP PLC | US$5245.6万 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4306.1万 | 0.00% |
| Polar Capital Holdings Plc | US$3687.5万 | 0.13% |
| DIMENSIONAL FUND ADVISORS LP | US$3222.9万 | 0.01% |
| Assenagon Asset Management S.A. | US$2953.2万 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$2704.8万 | 0.00% |
| MPM BIOIMPACT LLC | US$2497.5万 | 1.93% |
| Opaleye Management Inc. | US$2279.2万 | 3.00% |
| Troluce Capital Advisors LLC | US$2125.5万 | 1.30% |
| BAILLIE GIFFORD & CO | US$1872.8万 | 0.02% |
| BANK OF AMERICA CORP /DE/ | US$1768.3万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$1667.5万 | 0.01% |
| Candriam S.C.A. | US$1634.6万 | 0.08% |
| TANG CAPITAL MANAGEMENT LLC | US$1628.0万 | 0.83% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1506.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1423.4万 | 0.00% |
| Erste Asset Management GmbH | US$1416.9万 | 0.13% |
| NORTHERN TRUST CORP | US$1405.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1162.2万 | 0.00% |
| Parkman Healthcare Partners LLC | US$1095.7万 | 1.13% |
| Granahan Investment Management, LLC | US$1092.7万 | 0.53% |
| Artisan Partners Limited Partnership | US$1027.2万 | 0.02% |
| JPMORGAN CHASE & CO | US$843.4万 | 0.00% |
| T. Rowe Price Investment Management, Inc. | US$817.0万 | 0.01% |
| Caption Management, LLC | US$765.7万 | 0.04% |
| Birchview Capital, LP | US$683.8万 | 3.89% |
| CITADEL ADVISORS LLC | US$584.2万 | 0.00% |
| FIRST TRUST ADVISORS LP | US$532.2万 | 0.00% |
| UBS Group AG | US$515.4万 | 0.00% |
| Invesco Ltd. | US$488.5万 | 0.00% |
| Bank of New York Mellon Corp | US$466.9万 | 0.00% |
| FRANKLIN RESOURCES INC | US$464.9万 | 0.00% |
| DAFNA Capital Management LLC | US$426.1万 | 0.97% |
| Susquehanna Portfolio Strategies, LLC | US$388.2万 | 0.06% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$370.8万 | 0.00% |
| GILDER GAGNON HOWE & CO LLC | US$366.7万 | 0.04% |
| Nuveen, LLC | US$353.7万 | 0.00% |
| EcoR1 Capital, LLC | US$325.6万 | 0.14% |
| JANE STREET GROUP, LLC | US$281.5万 | 0.00% |
| Palo Alto Investors LP | US$275.6万 | 0.42% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$273.5万 | 0.59% |
| Rhenman & Partners Asset Management AB | US$270.2万 | 0.33% |
| Swiss National Bank | US$257.5万 | 0.00% |
| Quantedge Capital Pte Ltd | US$255.9万 | 1.40% |
| TD Asset Management Inc | US$242.2万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$225.4万 | 0.00% |
| RHUMBLINE ADVISERS | US$219.2万 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$208.2万 | 0.00% |
| Harvest Investment Services, LLC | US$204.6万 | 0.37% |
| HighVista Strategies LLC | US$203.9万 | 0.56% |
| Rafferty Asset Management, LLC | US$195.0万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$189.5万 | 0.00% |
| Informed Momentum Co LLC | US$169.3万 | 0.20% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$168.0万 | 0.00% |
| Woodline Partners LP | US$163.2万 | 0.01% |
| Privium Fund Management B.V. | US$162.8万 | 0.34% |
| D. E. Shaw & Co., Inc. | US$162.7万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$160.5万 | 0.01% |
| Creative Planning | US$156.6万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$155.8万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$154.0万 | 0.02% |
| ALPS ADVISORS INC | US$151.4万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$151.3万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$135.1万 | 0.01% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$132.9万 | 0.33% |
| ALLIANCEBERNSTEIN L.P. | US$132.8万 | 0.00% |
| DEUTSCHE BANK AG\ | US$132.2万 | 0.00% |
| Moran Wealth Management, LLC | US$132.0万 | 0.04% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$127.5万 | 0.00% |
| LPL Financial LLC | US$117.4万 | 0.00% |
| SG Americas Securities, LLC | US$110.7万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$110.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$110.0万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$108.3万 | 0.00% |
| Legal & General Group Plc | US$104.3万 | 0.00% |
| Blackstone Inc. | US$99.6万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$99.2万 | 0.00% |
| PROFUND ADVISORS LLC | US$87.9万 | 0.03% |
| NOMURA HOLDINGS INC | US$87.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$86.7万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$85.3万 | 0.00% |
| MetLife Investment Management, LLC | US$85.0万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$81.8万 | 0.00% |
| Cresset Asset Management, LLC | US$79.8万 | 0.00% |
| Balyasny Asset Management L.P. | US$77.7万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$76.2万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$73.7万 | 0.00% |
| HSBC HOLDINGS PLC | US$68.6万 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$68.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$64.7万 | 0.00% |
| CANADA LIFE ASSURANCE Co | US$61.3万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$59.0万 | 0.00% |
| Jefferies Financial Group Inc. | US$53.1万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$52.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$49.3万 | 0.04% |
| Campbell & CO Investment Adviser LLC | US$49.0万 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | US$47.2万 | 0.00% |
| CIM, LLC | US$46.3万 | 0.07% |
| State of New Jersey Common Pension Fund D | US$44.5万 | 0.00% |
| State of Wyoming | US$43.2万 | 0.05% |
| CITIGROUP INC | US$41.4万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$40.8万 | 0.00% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$39.8万 | 0.00% |
| PSP Research LLC | US$39.1万 | 0.28% |
| Virtu Financial LLC | US$36.0万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$35.8万 | 0.00% |
| HARBOR CAPITAL ADVISORS, INC. | US$35.4万 | 0.03% |
| Dorsey & Whitney Trust CO LLC | US$35.2万 | 0.02% |
| OSAIC HOLDINGS, INC. | US$33.6万 | 0.00% |
| Quadrature Capital Ltd | US$33.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$33.2万 | 0.00% |
| Vestcor Inc | US$33.1万 | 0.01% |
| BARCLAYS PLC | US$32.9万 | 0.00% |
| SEI INVESTMENTS CO | US$32.5万 | 0.00% |
| Quantinno Capital Management LP | US$31.8万 | 0.00% |
| ProShare Advisors LLC | US$31.4万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$31.2万 | 0.00% |
| AVIVA PLC | US$30.2万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$29.6万 | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | US$29.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$28.7万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$28.4万 | 0.00% |
| Tema ETFs LLC | US$27.8万 | 0.02% |
| Tidal Investments LLC | US$27.8万 | 0.00% |
| Virtus Investment Advisers, LLC | US$27.4万 | 0.08% |
| VOYA INVESTMENT MANAGEMENT LLC | US$26.7万 | 0.00% |
| XTX Topco Ltd | US$26.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$24.9万 | 0.00% |
| Pictet Asset Management Holding SA | US$24.7万 | 0.00% |
| E Fund Management Co., Ltd. | US$24.5万 | 0.01% |
| STRS OHIO | US$22.8万 | 0.00% |
| Generali Investments, Management Co LLC | US$22.5万 | 0.05% |
| Swiss Life Asset Management Ltd | US$21.3万 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$18.4万 | 0.03% |
| Tower Research Capital LLC (TRC) | US$14.4万 | 0.00% |