| DEERFIELD MANAGEMENT COMPANY, L.P. | US$17.7亿 | 20.85% |
| FMR LLC | US$9.5亿 | 0.05% |
| Paradigm Biocapital Advisors LP | US$5.5亿 | 11.15% |
| BlackRock, Inc. | US$4.9亿 | 0.01% |
| JPMORGAN CHASE & CO | US$3.0亿 | 0.02% |
| RA CAPITAL MANAGEMENT, L.P. | US$2.6亿 | 2.75% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.6亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2.5亿 | 0.05% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.5亿 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2.1亿 | 0.02% |
| STATE STREET CORP | US$2.1亿 | 0.01% |
| Polar Capital Holdings Plc | US$1.9亿 | 0.67% |
| PERCEPTIVE ADVISORS LLC | US$1.6亿 | 3.16% |
| T. Rowe Price Investment Management, Inc. | US$1.4亿 | 0.10% |
| Deep Track Capital, LP | US$1.4亿 | 2.30% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.3亿 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$1.3亿 | 0.06% |
| Bellevue Group AG | US$1.1亿 | 2.57% |
| Commodore Capital LP | US$8540.2万 | 4.94% |
| ALLIANCEBERNSTEIN L.P. | US$7886.5万 | 0.03% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$7672.4万 | 0.12% |
| BRAIDWELL LP | US$7175.9万 | 2.39% |
| Woodline Partners LP | US$6254.2万 | 0.24% |
| AMERIPRISE FINANCIAL INC | US$5775.8万 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$5503.2万 | 0.01% |
| Vestal Point Capital, LP | US$4935.2万 | 1.38% |
| Driehaus Capital Management LLC | US$4929.7万 | 0.36% |
| Hood River Capital Management LLC | US$4917.6万 | 0.49% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4618.5万 | 0.01% |
| FRANKLIN RESOURCES INC | US$4453.9万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$4416.3万 | 0.02% |
| NORTHERN TRUST CORP | US$4398.9万 | 0.01% |
| Pictet Asset Management Holding SA | US$4205.4万 | 0.04% |
| Invesco Ltd. | US$4182.9万 | 0.01% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$4052.4万 | 0.42% |
| Candriam S.C.A. | US$4008.9万 | 0.21% |
| First Turn Management, LLC | US$3794.2万 | 4.24% |
| VANGUARD FIDUCIARY TRUST CO | US$3730.9万 | 0.01% |
| UBS Group AG | US$3719.9万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$3636.1万 | 3.71% |
| Tri Locum Partners LP | US$3160.6万 | 4.44% |
| Jones Hill Capital LP | US$3082.0万 | 6.61% |
| Affinity Asset Advisors, LLC | US$3073.5万 | 1.59% |
| BANK OF AMERICA CORP /DE/ | US$2218.2万 | 0.00% |
| MORGAN STANLEY | US$2057.1万 | 0.00% |
| LORD, ABBETT & CO. LLC | US$2047.8万 | 0.07% |
| ArrowMark Colorado Holdings LLC | US$1914.3万 | 0.51% |
| CITADEL ADVISORS LLC | US$1889.9万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1828.1万 | 0.02% |
| Bank of New York Mellon Corp | US$1654.7万 | 0.00% |
| Nicholas Investment Partners, LP | US$1636.3万 | 1.18% |
| TD Asset Management Inc | US$1411.4万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$1408.0万 | 0.00% |
| Defilade Capital Management, L.P. | US$1331.3万 | 1.87% |
| Aberdeen Group plc | US$1266.0万 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1251.8万 | 0.00% |
| Nuveen, LLC | US$1125.1万 | 0.00% |
| Squarepoint Ops LLC | US$1073.7万 | 0.01% |
| Ensign Peak Advisors, Inc | US$1048.2万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$1046.2万 | 0.01% |
| Fisher Asset Management, LLC | US$999.1万 | 0.00% |
| Russell Investments Group, Ltd. | US$947.7万 | 0.01% |
| JANE STREET GROUP, LLC | US$942.9万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$911.8万 | 0.01% |
| Parkman Healthcare Partners LLC | US$902.4万 | 0.93% |
| DEUTSCHE BANK AG\ | US$899.0万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$838.7万 | 0.04% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$837.8万 | 0.01% |
| Rhenman & Partners Asset Management AB | US$831.9万 | 1.03% |
| Swiss National Bank | US$808.3万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$730.4万 | 0.01% |
| Burkehill Global Management, LP | US$717.2万 | 0.36% |
| NEUBERGER BERMAN GROUP LLC | US$661.8万 | 0.01% |
| RHUMBLINE ADVISERS | US$654.3万 | 0.01% |
| ExodusPoint Capital Management, LP | US$652.8万 | 0.05% |
| HighVista Strategies LLC | US$579.9万 | 1.60% |
| Tema ETFs LLC | US$547.2万 | 0.37% |
| Tidal Investments LLC | US$547.2万 | 0.01% |
| XTX Topco Ltd | US$546.6万 | 0.10% |
| Connor, Clark & Lunn Investment Management Ltd. | US$512.5万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$508.9万 | 0.01% |
| FIRST TRUST ADVISORS LP | US$487.8万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$475.2万 | 0.01% |
| Rafferty Asset Management, LLC | US$461.9万 | 0.02% |
| Granahan Investment Management, LLC | US$440.6万 | 0.21% |
| Walleye Capital LLC | US$429.0万 | 0.02% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$402.1万 | 0.00% |
| Creative Planning | US$393.6万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$376.5万 | 0.00% |
| CITIGROUP INC | US$375.9万 | 0.00% |
| Legal & General Group Plc | US$353.3万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$342.8万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$335.5万 | 0.00% |
| BARCLAYS PLC | US$316.0万 | 0.00% |
| SEI INVESTMENTS CO | US$302.6万 | 0.00% |
| Hudson Bay Capital Management LP | US$291.8万 | 0.01% |
| MetLife Investment Management, LLC | US$280.7万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$274.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$269.5万 | 0.00% |
| Man Group plc | US$248.5万 | 0.00% |
| FIFTH THIRD BANCORP | US$242.0万 | 0.00% |
| Ikarian Capital, LLC | US$241.7万 | 0.20% |
| ROYAL BANK OF CANADA | US$241.4万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$238.4万 | 0.01% |
| Vanguard Global Advisers, LLC | US$223.7万 | 0.00% |
| Legato Capital Management LLC | US$220.3万 | 0.20% |
| PROFUND ADVISORS LLC | US$210.5万 | 0.08% |
| Aquatic Capital Management LLC | US$209.0万 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | US$193.6万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$191.9万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$185.0万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$172.8万 | 0.00% |
| SG Americas Securities, LLC | US$170.6万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$167.2万 | 0.04% |
| ENVESTNET ASSET MANAGEMENT INC | US$162.0万 | 0.00% |
| Quantinno Capital Management LP | US$155.3万 | 0.00% |
| Bridgewater Associates, LP | US$153.9万 | 0.01% |
| Empowered Funds, LLC | US$150.1万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$146.7万 | 0.00% |
| Handelsbanken Fonder AB | US$142.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$140.1万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$138.7万 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$133.1万 | 0.10% |
| POLEN CAPITAL MANAGEMENT LLC | US$130.6万 | 0.01% |
| GUGGENHEIM CAPITAL LLC | US$129.6万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$126.0万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$122.0万 | 0.03% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$120.5万 | 0.01% |
| STRS OHIO | US$119.9万 | 0.00% |
| LPL Financial LLC | US$118.6万 | 0.00% |
| Corient Private Wealth LLC | US$115.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$112.6万 | 0.01% |
| Erste Asset Management GmbH | US$111.2万 | 0.01% |
| ProShare Advisors LLC | US$107.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$107.5万 | 0.00% |
| Trexquant Investment LP | US$103.0万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$101.8万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$101.8万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$96.6万 | 0.00% |
| Headlands Technologies LLC | US$95.2万 | 0.11% |
| EVERGREEN CAPITAL MANAGEMENT LLC | US$91.7万 | 0.02% |
| KLP KAPITALFORVALTNING AS | US$90.2万 | 0.00% |
| Shay Capital LLC | US$84.8万 | 0.07% |
| Entropy Technologies, LP | US$84.6万 | 0.04% |
| PRUDENTIAL FINANCIAL INC | US$80.5万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$80.2万 | 0.01% |
| FOX RUN MANAGEMENT, L.L.C. | US$79.0万 | 0.14% |
| Vanguard Personalized Indexing Management, LLC | US$73.2万 | 0.01% |
| INCEPTIONR LLC | US$71.7万 | 0.17% |
| ADAR1 Capital Management, LLC | US$71.1万 | 0.04% |