| BAKER BROS. ADVISORS LP | US$11.2亿 | 6.44% |
| JANUS HENDERSON GROUP PLC | US$10.5亿 | 0.50% |
| RTW INVESTMENTS, LP | US$10.4亿 | 10.38% |
| Avoro Capital Advisors LLC | US$9.5亿 | 9.36% |
| BlackRock, Inc. | US$8.2亿 | 0.01% |
| PAULSON & CO. INC. | US$7.3亿 | 23.42% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$4.4亿 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4.3亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.6亿 | 0.07% |
| STATE STREET CORP | US$3.2亿 | 0.01% |
| CITADEL ADVISORS LLC | US$3.2亿 | 0.05% |
| FMR LLC | US$2.7亿 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.4亿 | 0.01% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$1.8亿 | 0.59% |
| Invesco Ltd. | US$1.7亿 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.7亿 | 0.02% |
| Polar Capital Holdings Plc | US$1.5亿 | 0.54% |
| GOLDMAN SACHS GROUP INC | US$1.5亿 | 0.02% |
| ARMISTICE CAPITAL, LLC | US$1.4亿 | 2.46% |
| Hood River Capital Management LLC | US$1.3亿 | 1.31% |
| LORD, ABBETT & CO. LLC | US$1.3亿 | 0.41% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1.3亿 | 0.01% |
| JANE STREET GROUP, LLC | US$1.3亿 | 0.02% |
| Point72 Asset Management, L.P. | US$1.2亿 | 0.16% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.1亿 | 0.02% |
| MORGAN STANLEY | US$1.0亿 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$9921.2万 | 0.01% |
| Pictet Asset Management Holding SA | US$9791.4万 | 0.10% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$9701.5万 | 0.15% |
| Artisan Partners Limited Partnership | US$9607.8万 | 0.15% |
| Fiera Capital Corp | US$9109.0万 | 0.31% |
| Rock Springs Capital Management LP | US$8951.3万 | 5.28% |
| AMERICAN CENTURY COMPANIES INC | US$8581.5万 | 0.04% |
| Erste Asset Management GmbH | US$8096.1万 | 0.75% |
| NORTHERN TRUST CORP | US$7810.9万 | 0.01% |
| Caption Management, LLC | US$7328.6万 | 0.43% |
| ALLIANCEBERNSTEIN L.P. | US$7305.3万 | 0.02% |
| Bank of New York Mellon Corp | US$7114.4万 | 0.01% |
| TORONTO DOMINION BANK | US$6829.2万 | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | US$6704.6万 | 0.02% |
| D. E. Shaw & Co., Inc. | US$6665.8万 | 0.04% |
| Woodline Partners LP | US$6590.4万 | 0.25% |
| UBS Group AG | US$6165.4万 | 0.01% |
| Driehaus Capital Management LLC | US$5808.4万 | 0.43% |
| Tri Locum Partners LP | US$5406.8万 | 7.59% |
| AMERIPRISE FINANCIAL INC | US$5139.6万 | 0.01% |
| DEUTSCHE BANK AG\ | US$5133.5万 | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$4963.2万 | 0.21% |
| 683 Capital Management, LLC | US$4711.2万 | 2.46% |
| Logos Global Management LP | US$4449.5万 | 2.22% |
| Candriam S.C.A. | US$4446.8万 | 0.23% |
| ALKEON CAPITAL MANAGEMENT LLC | US$4187.8万 | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$3932.8万 | 0.05% |
| FRANKLIN RESOURCES INC | US$3875.8万 | 0.01% |
| GROUP ONE TRADING LLC | US$3816.1万 | 0.07% |
| RENAISSANCE TECHNOLOGIES LLC | US$3762.2万 | 0.06% |
| Squarepoint Ops LLC | US$3668.7万 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | US$3412.8万 | 0.01% |
| CITIGROUP INC | US$3381.0万 | 0.01% |
| ArrowMark Colorado Holdings LLC | US$3268.6万 | 0.87% |
| Nuveen, LLC | US$3248.7万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$3139.3万 | 0.03% |
| Affinity Asset Advisors, LLC | US$2879.1万 | 1.49% |
| EULAV Asset Management | US$2565.0万 | 0.82% |
| Russell Investments Group, Ltd. | US$2329.7万 | 0.03% |
| Mirae Asset Global Investments Co., Ltd. | US$2142.4万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$2138.5万 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$2013.9万 | 0.02% |
| EMERALD ADVISERS, LLC | US$1971.1万 | 0.62% |
| GROUPAMA ASSET MANAGMENT | US$1844.6万 | 0.27% |
| JPMORGAN CHASE & CO | US$1835.1万 | 0.00% |
| PFM Health Sciences, LP | US$1787.4万 | 1.63% |
| Rockefeller Capital Management L.P. | US$1771.9万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1721.1万 | 0.02% |
| WELLS FARGO & COMPANY/MN | US$1686.2万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | US$1668.3万 | 0.24% |
| Vestal Point Capital, LP | US$1647.3万 | 0.46% |
| GILDER GAGNON HOWE & CO LLC | US$1538.5万 | 0.18% |
| Swiss National Bank | US$1529.6万 | 0.01% |
| SIMPLEX TRADING, LLC | US$1528.5万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1462.4万 | 0.03% |
| Integral Health Asset Management, LLC | US$1308.7万 | 0.63% |
| IMC-Chicago, LLC | US$1308.4万 | 0.00% |
| Clearbridge Investments, LLC | US$1279.7万 | 0.01% |
| SEI INVESTMENTS CO | US$1266.7万 | 0.01% |
| Rhenman & Partners Asset Management AB | US$1258.9万 | 1.55% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1245.6万 | 0.00% |
| California Public Employees Retirement System | US$1214.3万 | 0.01% |
| WCM INVESTMENT MANAGEMENT, LLC | US$1190.6万 | 0.03% |
| FIRST TRUST ADVISORS LP | US$1163.8万 | 0.01% |
| MARSHALL WACE, LLP | US$1146.5万 | 0.01% |
| RHUMBLINE ADVISERS | US$1139.3万 | 0.01% |
| Tao Capital Management LP | US$1099.3万 | 9.25% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$965.9万 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$892.4万 | 0.01% |
| FEDERATED HERMES, INC. | US$884.8万 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$863.7万 | 0.42% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$853.3万 | 0.01% |
| Assenagon Asset Management S.A. | US$839.3万 | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | US$835.6万 | 0.06% |
| AQR CAPITAL MANAGEMENT LLC | US$835.1万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$809.3万 | 0.00% |
| Cinctive Capital Management LP | US$802.3万 | 0.52% |
| Walleye Capital LLC | US$760.4万 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$737.6万 | 0.01% |
| HighTower Advisors, LLC | US$728.4万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$703.1万 | 0.02% |
| Rheos Capital Works Inc. | US$691.8万 | 0.46% |
| NEUBERGER BERMAN GROUP LLC | US$672.6万 | 0.01% |
| JOURNEY STRATEGIC WEALTH LLC | US$671.6万 | 0.17% |
| ROYAL BANK OF CANADA | US$655.7万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$641.8万 | 0.00% |
| TD Asset Management Inc | US$633.0万 | 0.01% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$631.8万 | 0.07% |
| Creative Planning | US$628.4万 | 0.00% |
| Legal & General Group Plc | US$618.1万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$608.8万 | 0.01% |
| Rafferty Asset Management, LLC | US$547.1万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$526.2万 | 0.01% |
| Eversept Partners, LP | US$523.5万 | 0.28% |
| PEAK6 LLC | US$518.3万 | 0.01% |
| EFG International AG | US$514.7万 | 0.11% |
| LPL Financial LLC | US$492.4万 | 0.00% |
| MetLife Investment Management, LLC | US$486.8万 | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | US$473.2万 | 0.75% |
| Hennion & Walsh Asset Management, Inc. | US$451.0万 | 0.15% |
| DIMENSIONAL FUND ADVISORS LP | US$446.0万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$442.6万 | 0.28% |
| ALGERT GLOBAL LLC | US$427.2万 | 0.06% |
| Vanguard Global Advisers, LLC | US$421.2万 | 0.00% |
| DekaBank Deutsche Girozentrale | US$411.1万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$366.4万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$363.3万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$327.2万 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | US$305.5万 | 0.00% |
| Nan Fung Group Holdings Ltd | US$296.9万 | 2.45% |
| Entropy Technologies, LP | US$294.5万 | 0.14% |
| ExodusPoint Capital Management, LP | US$291.6万 | 0.02% |
| Pathstone Holdings, LLC | US$285.7万 | 0.01% |
| Handelsbanken Fonder AB | US$280.6万 | 0.01% |
| BAMCO INC /NY/ | US$277.4万 | 0.01% |
| CASTLEARK MANAGEMENT LLC | US$277.2万 | 0.09% |
| State of New Jersey Common Pension Fund D | US$264.1万 | 0.01% |
| PROFUND ADVISORS LLC | US$254.5万 | 0.09% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$244.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$243.0万 | 0.02% |
| MARTINGALE ASSET MANAGEMENT L P | US$234.8万 | 0.06% |
| ASSETMARK, INC | US$229.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$223.6万 | 0.17% |
| INTECH INVESTMENT MANAGEMENT LLC | US$221.8万 | 0.02% |