| Rosalind Advisors, Inc. | US$3062.8万 | 12.31% |
| BlackRock, Inc. | US$1656.0万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1233.6万 | 0.00% |
| Propel Bio Management, LLC | US$915.9万 | 5.77% |
| GEODE CAPITAL MANAGEMENT, LLC | US$642.4万 | 0.00% |
| STATE STREET CORP | US$616.6万 | 0.00% |
| Private Wealth Advisors, LLC | US$548.9万 | 1.54% |
| MILLENNIUM MANAGEMENT LLC | US$545.7万 | 0.00% |
| Divisadero Street Capital Management, LP | US$463.8万 | 0.19% |
| Ikarian Capital, LLC | US$400.2万 | 0.32% |
| MORGAN STANLEY | US$357.8万 | 0.00% |
| Caption Management, LLC | US$304.6万 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$268.3万 | 0.00% |
| Simplify Asset Management Inc. | US$242.3万 | 0.04% |
| NORTHERN TRUST CORP | US$233.7万 | 0.00% |
| ADAR1 Capital Management, LLC | US$208.2万 | 0.12% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$193.0万 | 0.04% |
| Lane Generational LLC | US$190.3万 | 1.52% |
| VANGUARD FIDUCIARY TRUST CO | US$187.3万 | 0.00% |
| ROYCE & ASSOCIATES LP | US$181.0万 | 0.02% |
| MARSHALL WACE, LLP | US$177.8万 | 0.00% |
| CIBC WORLD MARKET INC. | US$176.1万 | 0.00% |
| CITADEL ADVISORS LLC | US$167.7万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$165.2万 | 0.00% |
| Diametric Capital, LP | US$145.2万 | 0.38% |
| RENAISSANCE TECHNOLOGIES LLC | US$144.1万 | 0.00% |
| ALGERT GLOBAL LLC | US$135.2万 | 0.02% |
| JANE STREET GROUP, LLC | US$134.5万 | 0.00% |
| Trexquant Investment LP | US$96.7万 | 0.01% |
| Nuveen, LLC | US$96.3万 | 0.00% |
| Man Group plc | US$94.9万 | 0.00% |
| Stonepine Capital Management, LLC | US$92.8万 | 0.37% |
| Bank of New York Mellon Corp | US$91.5万 | 0.00% |
| Capital Advisors Wealth Management, LLC | US$86.3万 | 0.12% |
| Jefferies Financial Group Inc. | US$77.9万 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$76.0万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$73.0万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$71.6万 | 0.00% |
| UBS Group AG | US$64.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$53.6万 | 0.00% |
| SEI INVESTMENTS CO | US$40.9万 | 0.00% |
| Pale Fire Capital SE | US$37.2万 | 0.03% |
| Creative Planning | US$36.7万 | 0.00% |
| Mariner, LLC | US$36.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$35.8万 | 0.00% |
| BARCLAYS PLC | US$35.1万 | 0.00% |
| Aquatic Capital Management LLC | US$33.7万 | 0.01% |
| ExodusPoint Capital Management, LP | US$33.4万 | 0.00% |
| RHUMBLINE ADVISERS | US$31.9万 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$30.6万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$29.8万 | 0.00% |
| ALPS ADVISORS INC | US$26.2万 | 0.00% |
| DEUTSCHE BANK AG\ | US$25.7万 | 0.00% |
| State of Alaska, Department of Revenue | US$24.0万 | 0.00% |
| XTX Topco Ltd | US$23.3万 | 0.00% |
| EntryPoint Capital, LLC | US$23.2万 | 0.07% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$22.5万 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$20.7万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$20.4万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$20.0万 | 0.00% |
| LPL Financial LLC | US$19.3万 | 0.00% |
| Tripletail Wealth Management, LLC | US$17.7万 | 0.24% |
| MetLife Investment Management, LLC | US$17.3万 | 0.00% |
| ROYAL BANK OF CANADA | US$17.0万 | 0.00% |
| WealthPlan Investment Management, LLC | US$16.2万 | 0.01% |
| Invesco Ltd. | US$15.9万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$14.9万 | 0.01% |
| GROUP ONE TRADING LLC | US$14.8万 | 0.00% |
| NOMURA HOLDINGS INC | US$14.6万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$14.1万 | 0.00% |
| SkyOak Wealth, LLC | US$13.9万 | 0.03% |
| Magnetar Financial LLC | US$13.9万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$13.1万 | 0.00% |
| Palisades Investment Partners, LLC | US$12.8万 | 0.05% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$12.0万 | 0.00% |
| JPMORGAN CHASE & CO | US$11.7万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$11.3万 | 0.00% |
| NBC SECURITIES, INC. | US$11.1万 | 0.01% |
| Hunting Hill Global Capital, LLC | US$10.5万 | 0.08% |
| WELLS FARGO & COMPANY/MN | US$10.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$9.9万 | 0.00% |
| Leonteq Securities AG | US$9.3万 | 0.00% |
| Quantbot Technologies LP | US$8.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$8.2万 | 0.00% |
| FMR LLC | US$4.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$4.5万 | 0.00% |
| CWM, LLC | US$2.9万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.9万 | 0.00% |
| Legal & General Group Plc | US$2.5万 | 0.00% |
| Russell Investments Group, Ltd. | US$2.4万 | 0.00% |
| Advisory Services Network, LLC | US$2.3万 | 0.00% |
| SIMPLEX TRADING, LLC | US$2.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.5万 | 0.00% |
| CITIGROUP INC | US$1.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.3万 | 0.00% |
| Activest Wealth Management | US$9280.0 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$9280.0 | 0.00% |
| Covestor Ltd | US$9000.0 | 0.01% |
| Geneos Wealth Management Inc. | US$8565.0 | 0.00% |
| Quent Capital, LLC | US$8296.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$5892.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$5819.0 | 0.00% |
| Rockefeller Capital Management L.P. | US$5150.0 | 0.00% |
| TD Waterhouse Canada Inc. | US$4755.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$3925.0 | 0.00% |
| GAMMA Investing LLC | US$3823.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$3285.0 | 0.00% |
| Pinnacle Wealth Planning Services, Inc. | US$2422.0 | 0.00% |
| Sterling Capital Management LLC | US$1800.0 | 0.00% |
| Essential Partners LLC | US$1522.0 | 0.00% |
| Allworth Financial LP | US$1402.0 | 0.00% |
| Ascentis Independent Advisors | US$1392.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1208.1 | 0.00% |
| EverSource Wealth Advisors, LLC | US$650.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$473.0 | 0.00% |
| SBI Securities Co., Ltd. | US$464.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$316.0 | 0.00% |
| Farther Finance Advisors, LLC | US$229.0 | 0.00% |
| MAI Capital Management | US$121.0 | 0.00% |
| SJS Investment Consulting Inc. | US$28.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$9.0 | 0.00% |
| Parallel Advisors, LLC | US$9.0 | 0.00% |