| a16z Capital Management, L.L.C. | US$5654.8万 | 4.38% |
| Cormorant Asset Management, LP | US$5055.7万 | 2.54% |
| Sofinnova Investments, Inc. | US$4011.8万 | 1.52% |
| BlackRock, Inc. | US$3966.3万 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$3659.7万 | 0.02% |
| Octagon Capital Advisors LP | US$3057.3万 | 3.38% |
| RA CAPITAL MANAGEMENT, L.P. | US$2887.0万 | 0.31% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2369.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$2321.9万 | 0.03% |
| BRAIDWELL LP | US$2099.8万 | 0.70% |
| Polar Capital Holdings Plc | US$1981.0万 | 0.07% |
| STATE STREET CORP | US$1488.2万 | 0.00% |
| Sands Capital Alternatives, LLC | US$1375.3万 | 3.27% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1310.9万 | 0.00% |
| ORBIMED ADVISORS LLC | US$1245.0万 | 0.26% |
| D. E. Shaw & Co., Inc. | US$1222.9万 | 0.01% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$1142.8万 | 4.08% |
| COSMIC MANAGEMENT, LLC | US$877.7万 | 3.84% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$874.5万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$752.9万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$734.8万 | 0.03% |
| ACADIAN ASSET MANAGEMENT LLC | US$685.6万 | 0.01% |
| STEMPOINT CAPITAL LP | US$592.3万 | 1.13% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$501.9万 | 0.00% |
| Comprehensive Financial Management LLC | US$475.5万 | 0.16% |
| FRANKLIN RESOURCES INC | US$464.1万 | 0.00% |
| MORGAN STANLEY | US$454.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$432.5万 | 0.00% |
| NORTHERN TRUST CORP | US$392.0万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$374.6万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$352.1万 | 0.07% |
| VANGUARD FIDUCIARY TRUST CO | US$342.7万 | 0.00% |
| MARSHALL WACE, LLP | US$333.1万 | 0.00% |
| FMR LLC | US$332.8万 | 0.00% |
| Invesco Ltd. | US$308.0万 | 0.00% |
| Ensign Peak Advisors, Inc | US$290.7万 | 0.01% |
| JPMORGAN CHASE & CO | US$274.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$273.6万 | 0.00% |
| Walleye Capital LLC | US$265.3万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$242.4万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$241.0万 | 0.00% |
| ADAR1 Capital Management, LLC | US$237.1万 | 0.14% |
| Alessandra Capital Management, LLC | US$188.6万 | 1.61% |
| Burkehill Global Management, LP | US$174.9万 | 0.09% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$153.7万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$151.3万 | 0.24% |
| Bank of New York Mellon Corp | US$132.2万 | 0.00% |
| Alyeska Investment Group, L.P. | US$131.2万 | 0.00% |
| UBS Group AG | US$121.5万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$121.3万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$118.4万 | 0.00% |
| ALGERT GLOBAL LLC | US$112.3万 | 0.02% |
| Russell Investments Group, Ltd. | US$110.6万 | 0.00% |
| SEI INVESTMENTS CO | US$109.1万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$107.6万 | 0.00% |
| Trexquant Investment LP | US$105.9万 | 0.01% |
| DIADEMA PARTNERS LP | US$104.9万 | 0.18% |
| AMERIPRISE FINANCIAL INC | US$103.4万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$100.7万 | 0.02% |
| Squarepoint Ops LLC | US$97.1万 | 0.00% |
| Stonepine Capital Management, LLC | US$87.5万 | 0.35% |
| SEVEN GRAND MANAGERS, LLC | US$87.5万 | 0.06% |
| Nuveen, LLC | US$85.2万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$82.1万 | 0.00% |
| XTX Topco Ltd | US$82.0万 | 0.01% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$63.8万 | 0.00% |
| RHUMBLINE ADVISERS | US$61.8万 | 0.00% |
| Informed Momentum Co LLC | US$60.9万 | 0.07% |
| Jump Financial, LLC | US$59.3万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$59.3万 | 0.00% |
| Militia Capital Management LLC | US$56.5万 | 0.13% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$51.2万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$50.6万 | 0.00% |
| BARCLAYS PLC | US$49.4万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$48.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$46.2万 | 0.00% |
| WEXFORD CAPITAL LP | US$45.1万 | 0.07% |
| Creative Planning | US$44.3万 | 0.00% |
| Vanguard Global Advisers, LLC | US$40.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$40.4万 | 0.00% |
| Quantinno Capital Management LP | US$40.4万 | 0.00% |
| STRS OHIO | US$39.4万 | 0.00% |
| Corient Private Wealth LLC | US$38.9万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$38.4万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$37.5万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$36.4万 | 0.32% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$31.6万 | 0.00% |
| CITADEL ADVISORS LLC | US$30.1万 | 0.00% |
| MetLife Investment Management, LLC | US$29.3万 | 0.00% |
| GREAT LAKES ADVISORS, LLC | US$27.9万 | 0.00% |
| Verdad Advisers, LP | US$26.6万 | 0.30% |
| Persistent Asset Partners Ltd | US$26.5万 | 0.10% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$24.8万 | 0.00% |
| CITIGROUP INC | US$23.4万 | 0.00% |
| Valor Management LLC | US$22.9万 | 0.13% |
| NISA INVESTMENT ADVISORS, LLC | US$22.3万 | 0.00% |
| Polymer Capital Management (US) LLC | US$20.4万 | 0.02% |
| WELLS FARGO & COMPANY/MN | US$19.9万 | 0.00% |
| BANK OF NOVA SCOTIA | US$18.0万 | 0.00% |
| WINTON GROUP Ltd | US$17.8万 | 0.01% |
| FOX RUN MANAGEMENT, L.L.C. | US$17.2万 | 0.03% |
| Police & Firemen's Retirement System of New Jersey | US$14.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$13.5万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$8.9万 | 0.00% |
| CWM, LLC | US$6.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$5.0万 | 0.00% |
| Legal & General Group Plc | US$4.6万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$4.3万 | 0.00% |
| SIMPLEX TRADING, LLC | US$4.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$4.0万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$3.6万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.9万 | 0.00% |
| Sterling Capital Management LLC | US$1.7万 | 0.00% |
| ANTIPODES PARTNERS Ltd | US$1.6万 | 0.00% |
| Aquatic Capital Management LLC | US$1.5万 | 0.00% |
| Parallel Advisors, LLC | US$1.5万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.4万 | 0.00% |
| MEEDER ASSET MANAGEMENT INC | US$1.1万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$5519.5 | 0.00% |
| TD Waterhouse Canada Inc. | US$4512.0 | 0.00% |
| US BANCORP \DE\ | US$3778.0 | 0.00% |
| Torren Management, LLC | US$3725.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$3638.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$2954.0 | 0.00% |
| MassMutual Private Wealth & Trust, FSB | US$2886.0 | 0.00% |
| Farther Finance Advisors, LLC | US$2411.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2343.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$2239.0 | 0.00% |
| Cornerstone Financial Management LLC | US$1924.0 | 0.00% |
| Essential Partners LLC | US$1889.0 | 0.00% |
| Cornerstone Planning Group LLC | US$1702.0 | 0.00% |
| True Wealth Design, LLC | US$1400.0 | 0.00% |
| GROUP ONE TRADING LLC | US$1277.0 | 0.00% |
| SIGNATUREFD, LLC | US$997.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$997.0 | 0.00% |
| Advisory Services Network, LLC | US$927.0 | 0.00% |
| GAMMA Investing LLC | US$647.0 | 0.00% |
| Fortitude Family Office, LLC | US$472.0 | 0.00% |
| Sunrise Financial Services, LLC | US$455.0 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$418.0 | 0.00% |
| Allworth Financial LP | US$193.0 | 0.00% |
| IFP Advisors, Inc | US$157.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$122.0 | 0.00% |
| MAI Capital Management | US$105.0 | 0.00% |
| Sunbelt Securities, Inc. | US$52.0 | 0.00% |